Mechanism of Yang-tonifying herbs distributing along kidney meridians in molecular level by network pharmacology / 中草药

Objective: To predict the unique mechanism of Yang-tonifying herbs distributing along kidney meridians in molecular level through network pharmacology technology. Methods: Eight kidney-yang tonifying herbs with common clinical effects and clear therapeutic effects were selected in study. The chemical ingredients of traditional Chinese medicines were searched by TCMSP database. OB and DL values were applied to screen the active substance and the chemical similarity target prediction methods of Pub Chem database were used to predict the target proteins of TCM; The PPI between the target proteins of the kidney-yang tonifying herbs and the KEGG signal pathway were searched by the STRING database; The nodes in the PPI network were evaluated by the weighted PageRank algorithm and then the core target protein was screened. Using the Cytoscape 3.6.0 software, a compound-target network, a herb-target-PPI network, and a target-pathway network were constructed. Results: Through the network analysis, 21 key targets and 40 signal pathways of the kidney-yang tonifying herbs were screened. The medicinal played the role of warming and tonifying kidney-yang by T cell regulation, sex hormone regulation, immune response, and delaying aging. The mechanism may be related to thyroid hormone signaling pathway, neurotrophin signaling pathway, TNF signaling pathway and estrogen signaling pathway. Conclusion: The method based on network pharmacology could help to find the key targets and signal pathways of the kidney-yang tonifying herbs, which provides useful information and data support for further interpretation of the classification meaning of the kidney-yang tonifying herbs in TCM

Analysis and investigation of the distribution of endemic arsenism in Shanxi Province / 中华地方病学杂志

Objective To investigate the distribution of endemic arsenism and to provide a scientific basis for control and prevention of the disease.Methods According to previous investigation,in the high-arsenic water areas,the arsenic diseased areas and the surrounding lands,35 counties were investigated.Water arsenic was screened in all the survey sites,villages with water arsenic exceeding the standard were quantitative surveyed of water arsenic and the disease conditions.Screening of arsenic content in drinking water was done by the method of half-quantitative fast reagent kit.Quantitative determination of arsenic in water was done by hydride generationatomic fluorescence spectrometry (HG-AFS).Patients of endemic arsenism were diagnosed by the Standard of Diagnosis for Endemic Arsenism (WS/T 211-2001).Identification of area was done by Definition and Division Standard for Endemic Arsenism (WS 277-2007).The data were analyzed using SPSS 13.0 for windows.Results Water arsenic of 151 villages in 15 counties among 1 771 villages were higher than the national drinking water quality level(0.05 mg/L).Exposure population of high arsenic was 177 018 people.The census results of high arsenic water sources indicated that the ratio of drinking water arsenic levels higher than the national standard was 35.10％ (2 355/6 709) and the highest contents of arsenic was 1.733 0 mg/L.The disease census indicated that there were 33 latency arsenism districts and 118 arsenism districts.There was totally 39 757 patients with latency arsenism.Totally 137 261 people lived in arsenism districts.Light,moderate and severe arsenism districts was 82,29 and 7,respectively.Totally 1 244 suspicious patients with endemic arsenism were discovered,and 3 473 light and more severe patients were discovered and the detected rate of light and more severe patients was 2.54％ (3 473/136 924).Most patient were not serious.Conclusions High arsenic areas and endemic arsenism areas are distributed in 15 counties of Shanxi Province.In the future primary task in prevention and control of endemic arsenism is comprehensive prevention and control measures.

Recording, Editing, and Distributing the Movies of Anatomy Lectures / 대한해부학회지

In order to review anatomy lectures, medical students use the lecture materials, lecture notebooks, or recorded voices of lectures. These learning materials are not so effective as the movies of anatomy lectures. The purpose of this research is to help medical students review anatomy lectures by giving them the chance to replay the movies of anatomy lectures conveniently on the computer. For the purpose, an anatomy professor presented board lectures (about 14 hours) according to the anatomy units (introduction, back, upper limb, neck, head, thorax, abdomen, pelvis, perineum, and lower limb), which were recorded by camcorders to make movies. The movies were transferred to the computer; subsequently, edited suitably on the Adobe Premiere. The movies were compressed to make MPEG files (size 28.0 GBytes) and WMV files (size 1.4 GBytes). In case of the slide lecture, we made a program, on which lecture movies and slides could be watched concomitantly and conveniently. The movies of anatomy lectures were distributed off-line or on-line to help medical students review the anatomy lectures. This report about techniques of making movies will promote other anatomy professors to make movies of their own anatomy lectures.

Investigation of Distributing Characteristics of Blood Stasis Syndrome on 300 Cases of Advanced Stage Lung Cancer Patiens / 中国中医药信息杂志

Objective To investigate the distributing characteristics of blood stasis syndrome on 300 cases of advanced stage lung cancer patiens. Method Through filling in the table-syndrome of distributing characteristics of primary pulmonary carcinoma for stage Ⅲ and Ⅳ patients,the distributing characteristics of blood stasis syndrome in advanced lung cancer patiens were observed. Result The constituent ratio of blood stasis syndrome increased significantly following the worse patho-typing degree,the cell differentiation degree,the occurrence of hepatic metastasis,opposite pulmonary metastasis,osseous metastasis and troisier sign. Conclusion The syndrome of blood stasis of lung cancer has the distinct feature. Accordingly,the diagnostic standard which can be qualified of syndrome of blood stasis should be established. Only in that way can we guide the clinical diagnosis,the evaluation of therapeutic effect and the clinical trial of new drug of TCM preferably.

On the Strategy of Commodity Circulation of Pharmaceutical Wholesale Enterprises in China / 中国药房

OBJECTIVE: To discuss the strategy of commodity circulation of our pharmaceutical wholesale enterprises in new period. METHODS: To describe the present conditions of pharmaceutical wholesale enterprises:high cost and low beneficial result.To discuss the need of commodity distributing of pharmaceutical manufacturers and retails.To analyses the status of wholesale enterprises in supply chain.RESULTS & CONCLUSION: Our pharmaceutical wholesale enterprises must develop their commodity distributing strategy on the basis of the status of wholesale enterprises in supply chain.