Research progress on non-drug intervention for patients with perimenopausal depression / 四川精神卫生

This article gives a review on domestic and foreign researches on the non-drug intervention for patients with perimenopausal depression published from 2012 to 2022， so as to provide a reference for clinical treatment and nursing. Currently， pharmacotherapy is the mainstay of treatment for perimenopausal depression， while many existing problems remain to be solved such as the variation in treatment effect and the difficulty in maintaining emotional stability. however，high safety and relatively low cost are the characteristics of non-drug intervention， so this article expounds on the non-drug intervention measures for perimenopausal depression， such as music therapy， dietary therapy， exercise therapy， acupuncture therapy and repetitive transcranial magnetic stimulation （rTMS）.

Proposed drug interventions for SARS CoV 2 infection

As the pandemic has already taken lots of lives across the globe, there’s an urgent need for finding treatment options that might help in protection of infected people by either slowing or preventing the progression of the disease. It’s important to understand the structure of virus, the mechanism by which it enters the host cell, replicates and infects other cells causing progression of the disease. This article focuses on use of already available and approved drugs for treatment of corona virus based on their mechanism of action and the structure and the life cycle of the virus.

Analysis of 30 clinical trials on rare neurological diseases in children / 中华实用儿科临床杂志

Objective@#To explore the methods for generating evidence on health outcomes in children with rare diseases.@*Methods@#The data from 30 clinical trials on rare neurological diseases in children from January 2008 to December 2018 were collected and analyzed.Statistical analysis was conducted on the relationship between the study sponsor and the study center, the number of participants and the prevalence rate.@*Results@#Thirty studies involved 6 types of diseases, including 14 kinds of diseases.(1) All global multicenter studies (14 items) were initiated by pharmaceutical companies, whereas most of single-center studies (6/7 kinds, 86%) and multiple centers within one country(7/9 kinds, 78%) were initiated by investigators.There was a significant correlation between the research center and the research sponsor(P<0.001). (2) Most of the drugs studied were selected based on previous clinical trials (9/30 items) and animal experiments (9/30 items). (3) The median number of participants included 39 cases (10-215 cases), and 60%(18/30 items) of the studies was fewer than 50 cases.(4) Study design: 53%(16/30 items) of studies were randomized controlled studies, 33%(10/30 items) studies were open-label single-arm studies, and 14% (4/30 items) were randomized cross-over trials.Seventy-five percent(12/16 items)of randomized controlled studies were initiated by pharmaceutical companies, 50%(5/10 items) open-label single-arm studies and all randomized cross-over trials were initiated by investigators.There was a statistical correlation between the study sponsors and the study design method (χ2=7.602, P=0.022). (5) Outcome index: Scale score was used as the primary outcome in half of studies.Other studies used symptom improvement or pathological changes.@*Conclusions@#Clinical trials in rare diseases enrolled fewer participants than that in non-rare diseases, and the study design method was relatively simple.Therefore, it is necessary to further improve the level of evidence of clinical research of rare diseases through global and multi-center recruitment, initiation of pharmaceutical companies and improving the study design method.

Metabolomics approach to evaluation of plateau hypoxia / 中草药

Under plateau environment, inadequate oxygen makes people breathe less oxygen, reducing the level of oxygen metabolism and energy supply in the body. Subsequently, the peripheral circulation, the contractile efficiency of myocardial cells, the pump of blood stream, the flow rate of blood in various tissues, and the excretion rate of waste in the body could be greatly reduced, which are key reasons for causing plateau disease. Due to the reason that many metabolic pathways are affected in vivo, the level of endogenous small molecular metabolites can also be changed greatly. Therefore, metabolomics has been gradually applied to the study of plateau diseases, pathogenesis and even pharmacodynamics. This article summarizes the pathogenesis of plateau hypoxia and metabolomics of the associated therapeutic agents based on the preclinical and clinical research reviewed from the altitude sickness-associated metabolic research literature at home and abroad. Previous studies have confirmed that the endogenous metabolites and metabolic pathways altered significantly under plateau hypoxia, and some drugs showed a certain regulatory effect on the pathway metabolism. Moreover, the article summarizes the problems existing in the application of metabolomics in plateau hypoxia disease and the prospect of its future application. It was suggested that metabolomics was a promising tool for the study on the mechanism and the primary assessment of candidate drugs for plateau disease.

Function of N-Methyl-D-Aspartic Acid Receptors in Cerebral Stroke / 中国药学杂志

Cerebral stroke is caused by the interrupt of blood supply either by the blockage or by the rupture of the brain blood vessels. After the activation of the ischemic cascades, a series of neurochemical reactions might occur which involves the excess release of the excitatory amino acids. The ionotropic glutamate receptor of N-methyl-D-aspartic acid subtype (NMDA receptor) has been proven to play dual roles in the ischemic insults. On one hand, NMDA receptor has been proven to initiate the ischemic impairment, leading to the neuronal death. On the other hand, NMDA receptor is involved in the endo-neurogenesis process after the ischemic onset. Herein, we summarized the recent studies about the structures and functions of NMDA receptor in ischemic stroke pathogenesis.

Analysis of the effect of combination therapy combined with psychological intervention on lumbar disc herniation / 中国生化药物杂志

Objective To explore the drugs combined with psychological therapy for lumbar disc herniation, summarize the clinical experience.Methods For 60 cases of lumbar disc herniation were treated with drug therapy, and classified as the control group, the other 60 patients in the control group on the basis of psychological intervention therapy, and classified as the observation group, two groups of patients were in our hospital from January 2016 to January 2017 were treated.Results No significant difference between the two groups of patients before treatment, the pain score, after grouping after the intervention in the observation group were obvious pain relief;compared two groups of patients with the emotional state of the visible, before treatment had no significant difference after The observation group after the intervention group were improved more significantly, shows significant difference(P<0.05).Conclusion The analysis showed that the drugs combined with psychological therapy for lumbar disc herniation, which can help patients to improve the clinical situation, adjust the patient's psychological anxiety and depression, improve the clinical effect of intervention, so it is worthy of reference.

Research progress of the role of autophagy in alzheimer's disease and drug intervention / 中国药学杂志

Autophagy is a specific phenomenon of life which is widespread in eukaryotic cells and is also a main cell metabolic pathway of long-lived proteins and cytoplasmic organelles degradation. Alzheimer's disease (AD), also known as senile dementia, is a degenerative disease of the central nervous system. There are a large number of autophagy vesicles in neurocytes in the AD patients or transgenic mice, which indicating that autophagy may participate in the cleaning and deposition of abnormal protein, neuronal survival, and injury at different stages in the development of AD. Recognizing the role of autophagy in AD has great significance for further understanding the pathogenesis of AD and slowing the progress of AD through regulating autophagy by drug intervention. This review has researched the articles at home and abroad in recent years to summarize the progress of the role of autophagy in AD and analysis the drug intervention in AD based on the autophagy to provide a theoretical foundation for the treatment strategies of AD.

Therapeutic Observation of Conjunctiva Valve Combined with Tarsorrhaphy and Standardized Drug Intervention Treating Refractory Kera-tohelcosis / 浙江中医药大学学报

[Objective] To discuss the cure effect of conjunctiva valve combined with tarsorrhaphy and standardized medication on refractory keratohelcosis. [Method] Choose 37 cases with 37 eyes of the disease above, divide them into control group, n=17, and observation group, n=20; the control one take conjunctiva valve combined with tarsorrhaphy and routine medicine intervention; other group, standardized drug intervention instead of routine medicine. Observe the therapeutic effect after 6m. [Result] In observation group, 18 cases were cured(90%), 2 better(10%); for other group, they were 9(52.9%) and 4(23.5%) respectively, and 4 cases had no effect(23.5%). Comparing both cure effects, the difference had statistical meaning. [Conclusion] The conjunctiva valve combined with tarsorrhaphy could markedly improve the cure effect if intervened with standardized drug.

Influence of psychological nursing on gastroesophageal reflux disease recurrence / 中国实用护理杂志

Objective To retrospectively analyze the feasibility and effect of psychological nursing on patients with gastroesophageal reflux disease (GERD). Methods 121 patients diagnosed with GERD were divided into the psychological nursing group(60 cases) and the drug treatment group(61 cases).The data of these patients were collected and the RDQ score was assessed. Results The treatment effect of the drug treatment group was better than that of the psychological nursing group.34 cases relapsed in the drug treatment group and 14 cases relapsed in the psychological nursing group during half a year followup. Conclusions Both the psychological nursing group and the drug treatment group can control the symptoms of GERD,although drug intervention is better than non-drug intervention.However in a long run drug intervention has a higher recurrence and is more expensive.So non-drug intervention is an effective and feasible method for the treatment of gastroesophageal reflux disease (GERD).

Expression of Gq in bronchopulmonary tissues in rats after inhalation of cigarette smoke / 第三军医大学学报

Objective To study the expression of Gq protein in bronchopulmonary tissues of rats of chronic obstructive pulmonary disease (COPD) model and the roles of inflammation in airway of COPD rats. Methods A total of 44 Wistar rats were divided randomly into 4 groups: nonsmoking control group, 1 month smoking group, 2 month smoking group, and intervention group (dexamethasone + smoking for 2 months). The pathological changes of lung tissues and the total and differential count of white blood cells in bronchoalveolar lavage fluid (BALF) in all groups were observed. The expression of Gq in bronchopulmonary tissues was detected by immunohistochemical method and Western blot analysis. Results More significant increases in total number of leukocytes and neutrophils in BALF were found in the model group than those in the control group. Gq was mainly expressed in airway epithelial cells, inflammatory cells, and pulmonary capillary endothelia. Weak expression of Gq was found in bronchopulmonary tissues in the control group, but overexpression of Gq in the model group. The ratios of Gq positive cells in bronchopulmonary tissues were significantly correlated with the number of white blood cells and neutrophils in BALF. The levels of expression of Gq were significantly higher in the model groups and intervention group than those in the control group. More significant decrease in Gq expression was found in the intervention group as compared with that in 3 month smoking group. Conclusion Gq may be involved in the process of airway inflammation in COPD. Inhibition of the Gq overexpression might be a new approach to the treatment of COPD. Corticosteroid might have some effects on the inhibition of the airway inflammation.

Molecule mechanism of aseptic loosening and drug intervention / 医学研究生学报

Joint prosthesis is one of the most successful procedures in orthopaedic surgery and has considerably improved the quality of life for patients affected by terminal joint disease. However,a number of joint prosthesis ultimately failed because of aseptic loosening. There have been major advances in the understanding of aseptic loosening. The RANKL-RANK-OPG-NF-?B system has been shown to play a fundamental role in aseptic loosening. We review how the RANKL-RANK-OPG-NF-?B system regulates aseptic loosening and aseptic loosening drug intervention.

Effects of a Full Body Massage on Uterine Contraction, Length of Labor, Type of Delivery, and Drug Intervention for Primipara during Labor / 여성건강간호학회지

This study was designed to test the effects of a full body massage on uterine contraction, length of labor, type of delivery, and drug intervention for primipara during labor. Data were collected using a quasi-experiment method (nonequivalent control group, pre-post test design) from November 1, 2001 to July 31, 2002. The subjects of this experiment consisted of 28 women in the experimental group and 29 in the control group, out of 57 primipara hospitalized at the U OB & GYN hospital in Inchon. The experimental group was given a 20 minute full body massage for each of the three delivery phases (latent, active, and transition). The control group was given conventional delivery care. Three (3) parameters were analyzed in this experiment. (1) The interval, duration, and strength of uterine contraction, using an electric tocodynamometer (2) The elapsed time for stage 1 and stage 2 labor. (3) The types of deliveries and drug interventions, using postpartum medical records The data collected were analyzed using the repeated measures analysis of variance (ANOVA), t-test, and X(2) test of the SPSS program. The results of the experiment are as follows: 1) Uterine contraction interval was signifi- cantly reduced (F=3.210, p=.050). Duration of uterine contraction showed significant increase only during the transition phase (t=-2.319, p=.023). Strength of uterine contraction showed no significant difference. 2) Total length of labor was significantly shortened (t=-5.245, p=.000). The length of 1st stage labor was signifi- cantly shortened (t=-5.164, p=.000), with latent phase showing (t=-4.709, p=.000), active phase (t=-2.973, p=.005), and transition phase (t=-2.031, p=.047). The length of 2nd stage labor showed no significant difference. 3) The number of natural deliveries were significantly increased (X(2)=13.127, p=.004). 4) The number of drug interventions were significantly fewer (X(2)= 4.493, p=.034). In conclusion, this study shows that a full body massage has a significantly positive effect on uterine contraction interval, length of labor, type of delivery, and drug intervention. Therefore, this study suggests that a full body massage be used clinically to help primipara during labor.