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Background: Cancer is a challenge for majority of population抯 health-related quality of life (HRQoL), compromising their physical health and emotional well-being. QoL is equally distributed among different social groups. The aim of this study to analyze the impact of clinical characteristics and social determinants of health on the QoL of a cohort of persons diagnosed and/or treated for cancer. Methods: We performed a cross-sectional study in a cohort of 155 with various stages of cancer at different stages of their disease. Data were obtained using questionnaires QLQ-C30 from the European Organization for Research and Treatment of Cancer (EORTC), which include a set of functional and symptomatic scales. We conducted descriptive and bivariate analysis using the Chi-Square test, Anova Test and adjusted for relevant variables using logistic regression. The dependent variables were the functional scales of QoL and the independent variables were socio-demographic and clinical variables. Results: Among the participants, 80(51.6%) were male and 75(48.4%) were female and majority 66(42.6%) in between the age of 40-60 years. Large proportion of patients were diagnosed with Oral cancer 67(43.2%), and Breast cancer 23(14.8%), and the clinical stages during the beginning of therapy were maximum at stage II a 104(67.1%). The mean of global health status/QoL was 52.34 (SD= 23.34). Quality of life was found to be significantly associated with some functional scales as role functioning (P?0.001), social function, (P=0.00), and symptom scales as pain (P=0.00), loss of appetite (P=0.004) and financial impact (P=0.02) as well as associations were noted in relation to socio demographic characteristics. Women from the most disadvantaged class, and showed the poorest results for most of the function scales. In contrast, age, education, occupation and social status had differential effects depending on the function studied. The highest functional status was cognitive functioning (54.58�.68). Conclusions: The cancer diagnosis has become more prevalent and carries significant changes to the method of living with physical and emotional changes in term of quality of life (QoL) because of inconvenience, torment, disfigurement, reliance and loss of confidence. In addition, addressing the unmet needs of these patients and ensuring higher satisfaction rate are recommended to maintain adequate HRQoL.
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Background: Quality of life (QOL) analysis following cancer surgery is a sensitive issue among patients. The present study tried to find the status of these QOL parameters in patients who had undergone oncogenic resection of rectum.Methods: Patients were given the short form 36 (SF-36), The European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-C29 questionnaires to fill at three time points in their treatment (prior to surgery, 3 months and 6 months following surgery). The prospectively collected questionnaires were analysed retrospectively.Results: On comparing SF-36 questionnaire, there was significant improvement as we proceeded from baseline to first and second visit except for the energy level. On EORTC-30 questionnaire, there was significant improvement in all scales as we proceeded from baseline to first visit and then to second visit. On comparing EORTC-29 questionnaire, among all visits of abdominoperineal resection (APR), symptoms like pain and blood or mucus in stools significantly improved, low anterior resection (LAR) showed significant improvement in all 4 scales, high anterior resection (HAR) patients showed worst micturition complaints during first visit and gradually improving scores for other scales from baseline to first and second visit.Conclusions: The three-questionnaire used in the study comprehensively included all issues from general health after cancer surgery to problems faced by the patients specifically after various modalities of rectal surgery. Such studies should be planned routinely to assess comprehensive outcome of oncogenic surgeries.
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Background: Cervical cancer is one of many health care ironies. Better survival rates demand better quality of life (QoL). The aim of present study was to determine the change in QoL of cervical cancer patients due to treatment.Methods: An observational prospective study was conducted from July 2017 to June 2018 among 80 new cervical cancer patients without any prior history of treatment for cervical cancer, attending radiotherapy department of a tertiary care centre of West Bengal using a semi-structured schedule and European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ). Information was collected on socio-demographic and clinical aspects and QoL domains. Those with history of surgery for cervical cancer, advanced stage of disease were excluded. EORTC QLQ was administered at baseline and one month after completion of treatment. Data was analysed by percentage, means±standard deviation, range and Wilcoxon signed rank test etc. using SPSS-16.Results: Only 60 patients could be analysed as 10 patients died and 10 lost to follow-up. After treatment there was a significant improvement in global health, physical, emotional and cognitive functioning as well as decrease in symptoms like fatigue, pain, insomnia, appetite loss and constipation along with worsening of financial difficulties. There was significant improvement in body image, decrease in problems of symptom experience, peripheral neuropathy and menopausal symptoms after treatment.Conclusions: The cervical cancer patients show an overall improvement in their QoL in most of the domains after one month of treatment except worsening of financial difficulties.
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Background: Assessment of quality of life (QOL) helps to find out factors associated with disease progression and response to treatment, identify vulnerable groups. The objective of this study was to assess the QOL (based on physical, mental, social, emotional and spiritual dimensions) of oral and oropharyngeal cancer patients.Methods: A hospital based cross sectional study was conducted among 126 oral and oropharyngeal cancer patients attending radio therapy department of Calcutta Medical College. QOL was assessed by using validated Bengali version of two self-administered questionnaires: European Organization for the Research and Treatment of Cancer (EORTC)-30 and EORTC-35.Results: Among total 81 patients, most of the patients (45.67%) had stage III diseases. Median global health score (GHS) for all patients were 41.67. GHS deteriorated with advancement of the diseases (p=0.000), GHS significantly improved with increasing level of education (p=0.019). GHS was poorer among female patients (median for male was 45.66 and for female was 36.45; p=0.178) and patients with oropharyngeal cancer (median for oral cancer was 50.00, oropharyngeal cancer was 41.67, p=0.215). As per EORTC-35, pain was the major symptom for both type of cancer and was more among patients with oropharyngeal cancer.Conclusions: QOL deteriorates with advancement of the disease and is poorer among females. Co-morbidity status does not affect the QOL. Pain is a major problem of cancer patients, which is more with oropharyngeal cancer patients. Early detection of the cancer and proper pain management and counselling with special focus on females can improve the quality of life.
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@#Prostate cancer is forth most common diagnosed tumors in Malaysian male. The use of a self-reported, quality of life assessment is important for clinical practice, care taker and researcher to evaluate the level of quality of life. The aim of this study was to measure the internal consistency of the translated Malay Language EORTC QLQ-C30 and EORTC PR-25 questionnaires among prostate cancer patient at National University of Malaysia hospital in Kuala Lumpur, Malaysia. Methods This was a cross sectional study conducted between July 2017 and Dec 2017. The respondent comprised of 110 Malaysian prostate cancer patients who were under follow up at Urology and Oncology Clinic. Sets of translated Malay language EORTC QLQ C30 and EORTC PR-25 consisted of functional, symptom and global health status domains were administered to assess their quality of life. Results The translated questionnaires were acceptable by 110 respondents. Cronbach`s α coefficient result were 0.913 (EORTC QLQ-C30) and 0.829 (EORTC PR25) respectively suggested that this instrument had good internal consistency. Conclusions Our study confirmed that translated Malay language EORTC QLQ-C30 and QLQ-PR25 questionnaires are acceptable, reliable and valid instrument to be used among Malaysian prostate cancer patients.
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@#This study aimed to assess the validity and reliability of the Bahasa Malaysia (BM) version of European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire core (QLQ-C30) (version 3.0) in Malaysian patients with colorectal cancer. A cross sectional study design was used to obtain data from patients receiving treatment at two teaching hospitals in Kuala Lumpur, Malaysia. Self-administered method was used. Statistical analysis included reliability, convergent and discriminant validity and known-groups comparisons. Statistical significance was based on p value ≤ 0.05. The internal consistency Cronbach’s alpha coefficient (α) was acceptable (> 0.70) in all scales but cognitive (α = 0.56) and pain in patients with stoma bag (α = 0.35). Test-retest coefficients were high (r = 0.93 to 1.00). All items showed adequate convergent validity (r > 0.40) except for questionnaire item 5 “needs help in eating/dressing/washing”. Similarly, criteria for discriminant validity were achieved in all but item 10 “need rest”. Patients with high Karnofsky Performance Scores (KPS) scores reported significantly less dyspnoea (p = 0.021) and appetite loss (p = 0.047) compared to patients with low KPS scores. There was no significant difference between patients with and without stomas. The psychometric properties of the BM version of the QLQ-C30 were comparable to previous studies in other settings. Therefore, the questionnaire could be used to measure quality of life in Malaysian patients with colorectal cancer.
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Objective: Identify the quality of life and its association with health parameters for breast cancer women survivors in Popayan, Colombia. Methods: Analytic crosssectional descriptive correlated study, with nonprobability sampling, according to the inclusion criteria of 39 women who survived breast cancer, who received a survey made by the authors which included sociodemographic aspects, evaluation of the quality of life through the questionnaire EORTC QLQ BR23 and measurements such as the Body Mass Index (BMI), blood pressure and blood sugar levels, according to international standards. Results: The health indicators (blood pressure and blood sugar) are found under the normal ranges, while the BMI has a tendency for overweight. Regarding quality of life, high measurements for body image and sexual function were evidenced, while the dimensions of sexual pleasure and future perception showed intermediate measures. Regarding association, moderate correlations were observed between blood pressure and blood sugar levels, with body image and the sexual aspect. Conclusions: An association between the health indicators and the quality of life was observed, demonstrating the need to formulate prevention and intervention actions from an interdisciplinary vision. Also, it was observed that the quality of life requires a review toward self-confidence and relationship with oneself, through workshops or talks that allow to overcome limitations proper of the disease and to move on.
Objetivo: Identificar la calidad de vida y su asociación con parámetros de salud en mujeres sobrevivientes al cáncer de mama en Popayán, Colombia. Métodos: Estudio descriptivo-correlacional de corte transversal analítico, con una muestra no probabilística, de acuerdo con criterios de inclusión de 39 mujeres sobrevivientes al cáncer, a quienes se les aplicó una encuesta de elaboración propia con aspectos socio-demográficos, valoración de la calidad de vida mediante el cuestionario EORTC QLQ - BR23 y mediciones como el Índice de Masa corporal (IMC), presión arterial y niveles de glucemia, según estándares internacionales. Resultados: Los índices de salud (presión arterial y glucemia) se encontraron bajo los rangos de normalidad, mientras que para IMC hay tendencia de sobrepeso. Respecto a la calidad de vida, se evidenciaron mediciones elevadas para la imagen corporal y la función sexual, mientras que las dimensiones de disfrute sexual y percepción a futuro presentaron mediciones intermedias. Respecto a la asociación, se observaron correlaciones moderadas entre la presión arterial y los niveles de glucemia, con la imagen corporal y la parte sexual. Conclusiones: Se evidenció una asociación entre los indicadores de salud y calidad de vida, demostrando la necesidad de plantear acciones de prevención e intervención desde una visión interdisciplinaria. De la misma manera, se observó que la calidad de vida requiere una revisión hacia la autoconfianza y relación consigo misma, a través de talleres o charlas que permitan superar las limitaciones propias de la enfermedad y salir adelante.
Objetivo: Identificar a qualidade de vida e a sua associação com parâmetro de saúde em mulheres sobreviventes ao câncer de mama em Popayán, Colômbia. Métodos: Estudo descritivo-correlacional de corte transversal analítico, estudando uma a mostra probabilística de 39 mulheres sobreviventes ao câncer de mama, que responderam um instrumento de formulação própria com aspectos sociais e demográficos, avaliação da qualidade de vida empregando o questionário EORTC QLQ - BR23 e foram estabelecidos o índice de massa corporal (IMC), a pressão arterial e níveis de glicemia segundo padrões internacionais. Resultados: Os níveis de pressão arterial e glicemia encontraram-se nos rangos de normalidade, entretanto, o IMC mostrou a tendência ao sobrepeso. Na aferição da qualidade de vida, observaram-se medições elevadas na imagem corporal e função sexual, enquanto que as dimensões desfrute sexual e percepção do futuro presentaram aferições intermediarias. Na associação de variáveis houve uma moderada relação entre a pressão arterial e os níveis de glicemia com a imagem corporal e a parte sexual. Conclusões: Evidenciou-se a associação entre os indicadores de saúde e a qualidade de vida, demostrando a necessidade de formular ações de prevenção e intervenção desde uma perspectiva interdisciplinar. Do mesmo modo, observou-se que a qualidade de vida requer uma revisão dirigida à autoconfiança e relação com se mesma, através de oficinas ou conferencias que permitam superar as limitações próprias da doença e seguir em frente.
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Qualidade de Vida , Mulheres , Glicemia , Pressão Sanguínea , Neoplasias da MamaRESUMO
Introduction - Les facteurs influençant la qualité de vie (QDV) des patients tunisiens atteints d'un cancer du poumon (CDP) sont méconnus.L'objectif de cette étude est d'identifier les facteurs influençant la QDV des patients tunisiens atteints d'un CDP. Méthodes - Un questionnaire médical a évalué les caractéristiques générales et spécifiques de 100 patients dont 90 hommes, et les questionnaires QLQ-C30 et QLQLC13 ont évalué la QDV. Résultats - Les femmes, les sujets âgés, les mariés et les analphabètes avaient une mauvaise QDV. Comparativement aux patients indemnes de comorbidités, ceux ayant une à deux comorbidités avaient des scores d'activités physiques et professionnelles/loisirs plus bas. Comparativement aux patients ayant un cancer datant de moins d'un an, ceux dont le cancer datait de plus d'un an avaient des scores de santé globale et d'activité physique plus bas, et des scores de nausées/vomissements, d'insomnie et d'anorexie plus élevés. Les patients en stade avancé avaient une mauvaise QDV en termes d'activités physique et émotionnelle, d'insomnie et de constipation. Les patients ayant des métastases avaient une mauvaise QDV en termes de score global, d'activité physique, de fatigue, d'insomnie, d'anorexie et de diarrhée. Le type histologique et le type de traitement n'influençaient pas la QDV. Le sexe n'influençait pas les scores du QLQ-LC13. Comparativement aux patients traités par chimiothérapie, ceux traités par la combinaison chimiothérapie et chirurgie avaient des scores de dyspnée et de neuropathie périphérique plus élevés. Conclusion - Les facteurs suivants influencent la QDV des Tunisiens atteints d'un CDP: le sexe, l'âge, l'état civil, le niveau de scolarisation, les comorbidités, le stade et la durée d'évolution du cancer, et les métastases. Comparativement aux patients traités par chimiothérapie, ceux traités par chimiothérapie et chirurgie avaient des scores de dyspnée et de neuropathie périphérique plus élevés
Introduction - No previous study has established the factors that influence the quality of life (QOL) of tunisian patients with lung cancer (LC).This study aims to identify the factors that influence QOL of tunisian patients with LC. Methods. A medical questionnaire assessed the general and specific characteristics of 100 patients (90 men), and structured questionnaires (QLQ-C30 and QLQ-LC13) assessed QOL. Results -Women, elderly, married and illiterate patients had poor QOL. Compared to patients free from comorbidity, those with one to two comorbidities had lower scores of physical and life-role activities. Compared to patients with cancer discovered less than one year ago, those who's cancer appeared more than one year ago had lower scores of global health, physical activity, nausea/vomiting, and higher scores of insomnia and anorexia. Patients with advanced cancer had poor QOL in terms of physical and emotional activities, and insomnia and constipation items. Patients with metastases had a poor QOL in terms of global health, physical activity, fatigue symptom, insomnia, anorexia, and diarrhea. The histological and treatment types did not influence QOL. The QLQ-LC13 scores were not influenced by sex. However, compared to patients treated with chemotherapy, those treated with chemotherapy and surgery had higher scores of dyspnea and peripheral neuropathy. Conclusion - The following factors influenced QOL of Tunisian patients with LC: sex, age, civil status, schooling level, comorbidities, LC stage and duration, metastases. Compared to patients treated with chemotherapy, those treated with chemotherapy and surgery had higher scores of dyspnea and peripheral neuropathy
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Física , Qualidade de Vida , Saúde Global , Gerenciamento Clínico , Atividades de Lazer , Neoplasias Pulmonares , Fatores Socioeconômicos , Terapêutica , Exercício FísicoRESUMO
Background: Oral cancer is a commonly occurring cancer among Indians, who are mostly habituated to chewing tobacco. It accounts for around 30–40% of all malignant tumors in India and has one of the lowest five years survival rates, as most of them are diagnosed in advanced stages. More so, after the treatment is completed, the patients’ still suffers from a number of symptoms, which are often not taken seriously. The objective of this study was to evaluate the impact of severity of symptomatology of oral cancer after completion of cancer treatment.Methods: EORTC (European organization for research and treatment of cancer) H and N 35 questionnaire (Marathi version) was used to assess the severity of clinical symptoms. 100 consecutive patients of oral cancer who had completed their treatment and came for follow up after 1 to 3 months of treatment completion were enrolled for the study after taking informed written consent. The study was initiated after obtaining ethical approval from the institutional ethics committee. Statistical analysis was done using R software.Results: Age of the patient, status of insurance, time gap between symptom onset and diagnosis, socio-economic status and stage of oral cancer were included in the final model of multivariate analysis. Time gap between symptom onset and diagnosis (in months) was also found to be associated significantly to head and neck symptoms. Participants from higher socio-economic status were found to have fewer head and neck symptoms and this association was found statistically significant.Conclusions: Assessment of severity of symptomatology should be routinely practiced among patients who had completed their treatment and come for follow up. This needs to be followed by guidance and individualized interventions for improving the quality of life of the treated patients.
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Introduction: Nasopharyngeal carcinoma (NPC) is a malignant epithelial cell that lines the nasopharyngeal surface and is aneck head malignancy that has received much attention due to the relatively high mortality rate. Evaluating the quality of lifefor patients with malignancies is important as an “end-point” for treatment and an indicator of patient monitors.Method: This study is an analytical study with cross-sectional research design by analyzing the EORTC QLQ-H and N35 andKarnofsky Scale on 60 NPC patients.Results: Most NPC patients were male, most in Stages III and IV. The most histopathological type is non crystallizing SCC.Based on EORTC QLQ-H and N35, the most complaints of patients with NPC were found to be weight loss and the use ofpainkillers Karnofsky scores of NPC patients who were assessed as having a mean of 70.33.Conclusion: There is a significant correlation between EORTC QLQ - H and N35 with Karnofsky scores (r = −0.612; P = 0.000).The greater the Karnofsky value, the smaller the value of EORTC QLQ - H and N35 means that the quality of life of the patientis getting better, and vice versa