Study on Determination Method for Dissolution of Pentoxyverine Citrate and Guaifenesin Tablets / 中国药房

OBJECTIVE:To establish a method for the dissolution determination of Pentoxyverine citrate and guaifenesin tab-lets,and to compare the difference of preparations from different manufactures. METHODS:The paddle method was used to deter-mine the dissolution,using water as medium with medium volume of 1000 mL and rotation speed of 75 r/min,sampling at 45 min. HPLC method was used to determine the accumulative dissolution of pentoxyverine citrate and guaifenesin:CAPCELL PAK C18 MGⅡ S-5 column;mobile phase of acetonitrile-triethylamine phosphoric buffer solution(pH 2.6±0.05)(33:67,V/V),flow rate of 1.0 mL/min,detection wavelength of 215 nm(pentoxyverine citrate)and 275 nm(guaifenesin),column temperature of 35 ℃,sample size of 20 μL. RESULTS:The linear range of pentoxyverine citrate and guaifenesin were 5.0916-50.9155 μg/mL(r=0.9999)and 29.9995-299.9952 μg/mL(r=0.9999),respectively. RSDs of precision,stability and reproducibility tests were all lower than 2.0%. Average recoveries were 97.90%-100.68%(RSD=0.95%,n=9)and 97.09%-101.85%(RSD=1.32%,n=9). Average accu-mulative dissolution of pentoxyverine citrate in 6 manufactures of samples were 12%,98%,66%,97%,91%,32%(n=3);those of guaifenesin were 8%,95%,68%,90%,93%,18%(n=3),respectively. CONCLUSIONS:The method is simple,ac-curate,sensitive,specific and suitable for the dissolution determination of Pentoxyverine citrate and guaifenesin tablets. The dissolu-tion of samples between different manufactures and the same manufactures different batches are quite different.

On the myth called 'African Bioethics': further reflections on Segun Gbadegesin's account.

ABSTRACT: This paper examines, and further reflects, on Segun Gbadegesin‟s position on the question of African bioethics. In an attempt to situate bioethical discourse within the garb of cultural appropriateness, Gbadegesin gives an African perspective of bioethics by exploring the attitudes of the Yoruba people (an example of an African culture) towards bioethical issues. Through this, he calls for a transcultural bioethics, which will underscore the universality of bioethics without undermining the significance of cultural identities. This paper challenges as a „myth‟, the assumptions and positions of Gbadegesin in his recent discourse on African bioethics. By raising and adducing reasons to fundamental questions (such as: How authentic is Gbadegesin‟s reportage on the Yoruba attitude to bioethical issues? How plausible is the possibility of a universal/global bioethics that is anchored on the recognition of all cultures in bioethical discourse? Is there a distinctive African bioethics? If yes, what is the nature of such an inquiry? What are the bioethical principles employed in solving bioethical issues in African culture?), this paper defends the position that there is not yet an African bioethics.

Treatment of radial neck fracture with elastic stable intramedullary nail / 中国矫形外科杂志

[Objective]To investigate the effect and complications of treating radial neck fractures in children with elastic stable intramedullary nail(ESIN).[Method]A retrospective study was applied in 35 children(5~13 years) with displaced radial neck fractures,that were corrected with ESIN in our hospital from 2005 to 2008.[Result]All cases were successfully followed up,with an average time of 7.5 months.Ninteen cases were evaluated as excellent,6 cases were good,the excellent and good rate was 68%.Avascular necrosis was found in 9 cases,including 4 cases of radial head bulk formation,1 case showed ossification and delayed union was proved in 2 cases.[Conclusion]Treating the radial neck fracture with ESIN is a simple and minimally invasive method,the overall effect is good while the complications are limited.