RESUMO
Background: Cancer is a public health problem among women, but preventive actions are effective. Aim: To outline the reasons and factors associated with abstention from pap smears and mammography examinations among women. Material and Methods: Using official databases of the WHO and the Ministry of Social Development of Chile, inferential statistical analyses and modeling of abstention through binomial logistic regression were carried out. Results: Breast and cervical cancer had the highest incidence and mortality among women over 35 years old in Chile, even when there are effective screening methods for their early detection. Abstention is conditioned by personal reasons such as low risk perception. There is a high concomitance of abstention for pap smears and mammography. Conclusions: Health promotion actions should encourage women to undergo preventive actions for breast and cervical cancer.
Assuntos
Humanos , Feminino , Adulto , Detecção Precoce de Câncer , Teste de Papanicolaou , Mamografia , Chile/epidemiologia , PrevalênciaRESUMO
PURPOSE: Little is known about the clinical value of peripheral blood immune profiling. Here, we aimed to identify colorectal cancer (CRC)-related peripheral blood immune cells and develop liquid biopsy-based immune profiling models for CRC diagnosis. METHODS: Peripheral blood from 131 preoperative patients with CRC and 174 healthy controls was analyzed by flow cytometry and automated hematology. CRC-related immune factors were identified by comparing the mean values of immune cell percentages and counts. Subsequently, CRC diagnostic algorithms were constructed using binary logistic regression. RESULTS: Significant differences were observed in percentages and counts of white blood cells, lymphocytes, neutrophils, regulatory T cells, and myeloid-derived suppressor cells (MDSCs) of patients and controls. The neutrophil/lymphocyte and Th1/Th2 ratios were also significantly different. Likewise, the percentages and counts of peripheral blood programed death 1, cytotoxic T lymphocyte antigen 4, B-and T-lymphocyte attenuator, and lymphocyte activation gene-3 were higher in patients with CRC. The binary logistic regression model included 12 variables, age, CD3+%, NK%, CD4+CD279+%, CD4+CD25+%, CD4+CD152+%, CD3+CD366+%, CD3+CD272+%, CD3+CD223+%, CD158b−CD314+CD3−CD56+%, Th2%, and MDSCs cells/µL, for the prediction of cancer. Results of retrospective and prospective evaluation of the area under the curve, sensitivity, and specificity were 0.980 and 0.940, 91.53% and 85.80%, and 93.50% and 86.20%, respectively. CONCLUSION: Peripheral blood immune profiling may be valuable in evaluating the immunity of CRC patients. Our liquid biopsy-based immune diagnostic method and its algorithms may serve as a novel tool for CRC diagnosis. Future largescale studies are needed for better characterization of its diagnostic value and potential for clinical application.