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Background: Anaemia has significant impact on health of the fetus as well as that of mother. Increased need of iron during pregnancy especially after 2nd trimester makes iron supplementation mandatory. Ferrous ascorbate is known to exist intact inside the gastrointestinal tract due to the stable chelation of iron with ascorbate. This compound does not dissociate due to any of the food inhibitors. The aim is to study the effec-tiveness of Ferrous Ascorbate and Ferrous sulphate in terms of compliance and cost effectiveness of manage-ment of anaemia in pregnancy. Methodology: Study design: Quasi Experimental study, Study area: District Vidisha, Study participants: Preg-nant women of first trimester registered during the study period in the selected Anganwadis/ Gram Arogya Kendra (GAK), Sample size: 240 antenatal mothers. Results: Baseline mean haemoglobin was 11.31±1.05 gm/dl. The mean increase in Ferrous Sulphate was 0.55 gm/dl, and in Ferrous ascorbate was 1.27 gm/dl. Ferrous Sulphate was less compliant than Ferrous ascorbate, and has higher efficacy and lesser side effects. Only Rs. 10.2 additional cost per antenatal mothers for increase of ≥1gm% in Hb will be borne by government if Ferrous Sulphate is replaced by Ferrous Ascorbate. Conclusions: Study results show statistically significant difference in rise of haemoglobin amongst the ante-natal mothers consuming Ferrous ascorbate over Ferrous Sulphate
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@#Objective - （ ） To evaluate the effect of job rotation on pain in wrist work related musculoskeletal disorders WMSDs （ ）Methods of physical therapists PTs . A total of 100 PTs from nine medical institutions were selected as the research subjects ， using judgment sampling method and they were divided into control group and intervention group by stratified random sampling ， method with 50 person in each group. The individuals in control group perform routine works. People in the intervention group were rotated between posts or added mobile shift replacements in daily work for 30 minutes. The duration of intervention was ， ， （ ） once a day five days a week for ten weeks. Visual Analogue Scale VAS score and pain duration were used as the evaluation ， indexes of intervention effect. The changes of indexes before intervention five weeks and ten weeks after intervention were Results ， compared between the two groups. Before intervention there was no significant difference in the VAS score and pain （ P ） duration between the control group and the intervention group all >0.05 . There was no significant difference in VAS score （ P ） and pain duration among the control group at three time points after intervention all >0.05 . The VAS score of PTs in the （P ）， intervention group at ten weeks was lower than that in the control group at the same time point <0.05 and it was lower than （ P ） that before intervention and at five weeks of intervention in the same group all <0.05 . The pain duration of PTs in the （ P ）， intervention group was lower than that in the control group at five and ten weeks after intervention all <0.05 and was lower （ P ） Conclusion ， than that before intervention at the same group all <0.05 . Rotating schedule can relieve WMSDs of PTs and the effect of intervention for ten weeks is more effective than that of intervention for five weeks.
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Objective To observe the clinical efficacy of different dialysis frequency and methods in the treatment of chronic renal failure uremia patients ,and to provide a reliable reference for clinical practice.Methods From February 2016 to February 2017,140 chronic renal failure uremic patients who admitted to the Department of Nephrology at Taizhou Central Hospital were selected and divided into the observation group and the control group by complete random distribution method ,with 70 cases in each group.The patients in the control group received 3 times of regular hemodialysis treatment per week , while the observation group received 3 times of regular hemodialysis combined with 1 time of hemodiafiltration treatment per week.The clinical treatment effects and complications of the two groups were compared.Results Compared with blood uric acid ( BUA) [(532.09 ±71.05) mmol／L],serum creatinine(Scr) [(734.34 ±63.08) μmol／L],blood urea ( BUN) [(23.84 ±2.58) mmol／L],serum phosphorus [(1.98 ±0.37)mmol／L],parathyroid hormone ( PTH) [(464.37 ±113.92) ng／L],β2 microglobulin ( β2 -MG) [(13.48 ±6.38)mg／L]in the control group,BUA[(495.89 ±58.23) mmol／L],Scr[(684.34 ±77.32)μmol／L], BUN[(20.62 ±1.77) mmol／L],serum phosphorus [(1.74 ±0.44) mmol／L],PTH[(352.14 ±123.25) ng／L], β2 -MG[(9.58 ±5.45) mg／L] were significantly lower in the observation group ,the differences were statistically significant (t＝3.29,4.19,8.61,3.49,5.59,3.88,all P＜0.01).Compared with the incidence rate of pruritus in the control group(61.43%),the incidence rate of pruritus in the observation group (34.29%) was significantly lower (χ2 ＝9.72,P＜0.01),the incidence of other complications had no statistically significant differences ( χ2 ＝1.14, 1.58,3.08,all P＞0.05).Conclusion Hemodialysis 3 times combined with 1 time of hemodiafiltration per week has significant advantage in the treatment of chronic renal failure uremia patients ,which can effectively remove urine toxin molecules and reduce the incidence of complications ,and it is worthy of clinical application.
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Objective To discuss the application and effect evaluation of the standard operation procedure ( SOP ) teaching method during applying surgical practice teaching in local medical college . Method 123 undergraduate students from Grade 2011 clinical medical major in Medical College of Shaoguan University were selected as objects of study. The students were divided into test (odd) group and control (even) group by draw. The two groups were taught by the same teachers, while the SOP method was applied to the test group (n=62) and the traditional surgical clinical teaching method was applied to the control group (n=61). Meanwhile, we used a combined method of the formative assessment and final assess-ment to compare and analyze the teaching feedback. After their graduate internship, we compared their autonomous study capability, clinical evaluation thought, normativity of the operation and capability in their intern positions as well as the degree of satisfaction of the test of two groups by doing a survey among them. All these were analyzed by SPSS 18.0 software, and t test was used to compare two groups' measurement in-formation and count data with chi-square. Results The comprehensive evaluation scores of the test group were significantly higher than the control group, in which the margin was of statistical value [(79.394 ± 8.049) vs. (71.703±10.462), t=39.632, P=0.000]. The percentage of excellence of the test group was signif-icantly higher than the control group, in which the margin was of statistical value (59.68% vs. 39.35%, χ2=5.082, P=0.024). The percentage of failure of the test group was lower than the group taught by the tradi-tional method, in which the margin was of statistical value (3.22%vs. 16.39%, χ2=4.652, P=0.031). Its for-mative assessment result on the evaluation of the experimental teaching process and summative assessment scores were higher than the control group, and the difference was statistically significant [formative scores points: (46.018 ±5.749) vs. (42.771 ±6.459), t=19.445, P=0.000; summative scores: (33.659 ±3.437) vs. (29.063±4.366), t=36.249, P=0.000]. As far as their clinical graduate internship adaptation capabilities were concerned, students from the test group had more satisfaction on the teaching feedback over 4 perspectives than the other group, in which the margin was of statistical value. Experimental groups' satisfaction showed that: 93.55% of students thought the standard operation procedure (SOP) teaching method was beneficial to improving their clinical practice skills, 91.94%thought that it improved their surgical clinical work ability to adapt, 85.48% thought it helped to cultivate their surgical clinical thinking and innovation ability. Conclusions The SOP teaching method in surgical practice teaching helps to enhance students' clinical operation and adaptation capability and promote the teaching quality.
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Objective To analyze the economic effects of different rehabilitation patterns for children suffering from cerebral palsy. Methods A total of 153 cerebral palsy patients were divided into a hospital-community-family rehabilitation group(n = 52), a hospital rehabilitation group (n = 50) and a non-intervention control group (n = 51). Those in the first group were provided with a hospital-community-family rehabilitation therapy pattern, those in the sec-ond only hospital rehabilitation and the third no intervention. All the patients were evaluated using the Gross Motor Function Measure-88 (GMFM-88) Scale and the Cost Measure Scale at admission, and at the end of the 3rd and 6th months of treatment. Results There were no significant differences in gross motor function among the three groups at admission. At the end of the 3rd month and the 6th month there were significant differences between the children in the hospital-community-family rehabilitation program and those in the hospital rehabilitation program in terms of gross motor function. Their general percentage, monthly percentage and monthly relative percentage results were all significantly different. But there was no significant difference in the non-interventian control group since admission. Every unit of improvement in gross motor function cost $101.87±97.59, $75.11±45.75 in the hospital-community-family reha-bilitation program and $387.21±54.76, $170.31±123.16 in the hospital rehabilitation program at the end of the 3rd and the 6th month respectively. So the cost of the former was only about 30% of the latter. Conclusion Hospital rehabilitation is suitable for the early rehabilitation of cerebral palsy children. Hospital-community-family rehabilitation is better for long-term rehabilitation of cerebral palsy children, and what is more, it can decrease the rehabilitation ther-apy cost substantially. So a hospital-community-family rehabilitation pattern is more compatible with China's national situation.
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Aloe barbadensis is the most widely used both commercially and therapeutic properties. It has been used for an array of ailments since ancient times as a medicinal plant. There are more than 360 different species of Aloe. Its products have been used in health foods for medical and preservative purposes. The objective of this study was to search the effects of Aloe barbadensis on the rat's placenta. Gel form of Aloe barbadensis is used in the study. It is commercial, preserved but otherwise untreated form of Aloe Barbadensis gel capsul. Female Wistar Albino rats were divided into three groups. Placenta specimens from each groups were processed for the microscopic examination. Trophoblastic giant cells and spongiotrophoblasts were decreased in number after Aloe barbadensis: trophoblastic giant cells which showed degenerative changes. The nuclei of these giant cells were going degeneration characterized by pyknosis and bizarrely shaped. Extracellular matrix production around the cells was increased, thicker and more irregular basal membrane like formation around the cells. Decreased and ab normal vessel formation in labyrinth área was clear and reduced functional capacity of the trophoblastic barier. The study shows that, in the presence of Aloe barbadensis, relevant alterations associated with a possible compensatory adjustment to maintain adequate metabolic exchange take place in the structure of placenta. Our results also demonstrated that the exposure to Aloe barbadensis during pregnancy not led to fetal growth retardation, fetal death, abortion or teratogenic effect.
Aloe barbadensis es ampliamente utilizada comercialmente, debido a sus propiedades terapéuticas. Desde la antigüedad, se ha utilizado como planta medicinal para combatir una variedad de enfermedades. Hay más de 360 especies diferentes de Aloe. Sus productos han sido utilizados en los alimentos saludables para propósitos médicos y preventivos. El objetivo de este estudio fue buscar los efectos del Aloe barbadensis en la placenta de la rata. Se utilizó gel de Aloe barbadensis en el estudio. Su presentación comercial, cápsulas de gel de Aloe barbadensis de uso preventivo, no de tratamiento. Ratas Wistar albinas hembras se dividieron en tres grupos. Las placentas de cada uno de los especímenes de los grupos fueron procesadas para el examen microscópico. Las células gigantes trofoblásticas y los espongioblastos disminuyeron de número después de ser expuestas aAloe barbadensis; las células trofoblásticas gigantes mostraron cambios degenerativos. Los núcleos de estas células gigantes se caracterizaron por la degeneración, mostrando picnosis y forma extraña. La producción de matriz extracelular alrededor de las células se incrementó, hubo engrosamiento y formación de una membrana basal más irregular alrededor de las células. La disminución y formación de vasos anormales en la zona del laberinto eran evidentes y además hubo reducción de la capacidad funcional de la barrera trofoblástica. El estudio mostró que, en presencia de Aloe barbadensis, las alteraciones asociadas con un posible ajuste compensatorio paraman tener un nivel adecuado de intercambio metabólico, tienen lugar en la estructura de la placenta. Nuestros resultados también demostraron que la exposición al Aloe barbadensis durante el embarazo no produjo retraso del crecimiento fetal, muerte fetal, aborto ni efecto teratogénico.
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Animais , Feminino , Gravidez , Ratos , Aloe/química , Placenta , Placenta/ultraestrutura , Extratos Vegetais/química , Géis , Microscopia , Ratos Wistar , TrofoblastosRESUMO
Objective Study of the feasibility that the former changing trend of tumour after the first BAI can forecast the later curative effect on tumour.Methods Bronchus artery and relational body arteries opacification and BAI have been introduced in 82 primary pulmonary carcinoma cases.In the statistic analysis,SPSS 13.0 for Windows Stat.Software Package has been used.At the meanwhile chi square test,one-sample t-test,GLM-univariate analysis have been adopted as well to study the relationship between the former changing trend of tumour and Later Curative Effect after BAI in mid-advanced stage pulmonary carcinoma.Result There are significance statistical significances between the former changing trend of tumour and the later curative effect after the first BAI in mid-advanced stage pulmonary carcinoma.Conclusion The former changing trend of tumour after the first BAI is the factor influencing the later curative effect.
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0.05).The most common adverse reactions of imiquimod were erythema,erosion,itching,excoriation,scabbing and oedema,those of podophyllotoxin were burning sensation,inflammation,erosion,pain,itching and bleeding.The incidence of ADR of podophyllotoxin was higher.Cost-effectiveness analysis indicated that the C/E of imiquimod and podophyllotoxin was36.88and8.15respectively.CONCLUSION:Imiquimod and podophyllotoxin possessed similar curative effect on condylo?ma acuminatum,but the cost and C/E of podophyllotoxin were lower.At the same time,podophyllotoxin had more serious ad?verse reactions.
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AIM: To study the antitumor e ff ects of losartan in EAC mice. METHODS: The inhibitory rates of t umor growth and the ratio of extending viability were observed in EAC mice in th ree groups given losartan, 5-FU and NS, respectively. RESULTS: Comparing with the control groups, the inhibition to tumor growth was 46.3 % in losartan ( 12.5 mg?kg -1 ) group. But losartan did not lengthen life time in EAC mice. The inhibition to tumor growth was was 31.5 % in 5-F U (5 mg?kg -1 ) group. CONCLUSION: Losartan can inhibit the tumor growth of EAC, but not lengthen life time of the animals.
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AIM Mechanism of icariin (ICA) and pseudomonas jinanensis agent (PJA) on anti-metasta-sis of a highly metastatic human lung tumor cell line (PG) and the effect type of the combination of ICA,PJA were studied. METHODS PG cells were treated with ICA、PJA, or the combination of both in vitro. Adhesion assay, invasion assay, migration assay, flow cytometry (FCM) and immunohistochemical straining were used. The effects of ICA and PJA combination were evaluated with Q method of Jin Zheng-Jun. RESULTS ICA、PJA could decrease PG cells adhesive ratio to laminin substrate in a time-dependent manner ( P