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1.
Chinese Journal of Immunology ; (12): 161-169, 2017.
Artigo em Chinês | WPRIM | ID: wpr-508291

RESUMO

Mycobacterium tuberculosis ( Mtb) is an extremely successful intracellular bacterial pathogen that engages multiple strategies to escape host immune surveillance,so as to survive within host macrophages for long period. Upon the invasion of pathogenic bacteria,the host ubiquitin system plays a critical role in activating the host innate immune responses and associated signaling pathways such as inflammatory and immune responses, autophagy, phagosome maturation and cell death, etc. On the other hand, recent studies have demonstrated that intracellular pathogenic bacteria such as Mtb can secrete a variety of effector proteins into host cells to hijack or co-opt the ubiquitin system to suppress host immune responses. Those pathogen-host interacting interfaces could provide potential novel targets for the development of anti-tuberculosis drugs.

2.
Chinese Journal of Zoonoses ; (12): 277-280,288, 2015.
Artigo em Chinês | WPRIM | ID: wpr-600403

RESUMO

Salmonella is a pathogenic bacteria to human and animals ,which can cause seriously complication and death . Salmonella pathogenicity is from the reactions of SP‐1 and SP‐2 T3SS effector proteins .In this paper ,the functions of different T3ss effector proteins in different infection periods is reviewed to provide a reference for further understanding the pathogenesis mechanisms of Salmonella .

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