Relationship Between Long-, Short-term Systolic Blood Pressure Variability and Renal Damage in Elder Population / 中国循环杂志

Objective: To investigate the relationship between long-, short-term systolic blood pressure variability (SBPV) and renal damage in elder population. Methods: Our research was conducted in the 3rd physical examination of healthy population from Kailuan group by cohort study. Cluster sampling was used by 25% ratio in subjects≥60 years of age to monitor their 24-hour ambulatory blood pressure and finally, 2464/3064 participants with inclusion criteria were recruited. SBPV indexes as standard deviation of systolic blood pressure (SSD), variability independent of the mean (VIM), maximum-minimum difference (MMD) and average real variability (ARV) were examined; renal damage indexes as estimated glomerular filtration rate (eGFR) and microalbuminuria (ALBU) were detected. Relationships between different long-term, short-term SBPV indexes and eGFR, ALBU were studied by multi-liner regression analysis. Results:①The mean age of 2464 participants was (67.41 ± 6.05) years including 1667 (67.7%) male and 797 (32.3%) female.②Multi-liner regression analysis indicated that different long-term SBPV indexes were not related to eGFR and ALBU; 24h SBPV in all 4 indexes and day-time SSD, MMD, ARV were negatively related to eGFR; 24h ARV and day-time MMD, ARV were positively related to ALBU; night-time SBPV indexes were not related to eGFR and ALBU.Conclusion: Different short-term SBPV indexes were, at certain point related to eGFR and ALBU

Epidemiological study on type 2 diabetes mellitus andimpaired glucose tolerance of eldler population in Chongqing region / 重庆医科大学学报

Objective:To investigate the prevalence and the related diseases of type 2 diabetes mellitus and impaired glucose tolerance among the old population in Chongqing region.Methods:A cross-section suvery with multiple-stage and random sampling was performed among 1791 elder people over 60 years in Chongqing region.Results:(1)The prevalence of type 2 diabetes mellitus and impaired glucose tolerance were 15.6% and 20.5%,respectively.Postprandial plasma glucose was a sensitive diagnostic standard for type 2 diabetes mellitus of the elder population.(2)The prevalence of type 2 diabetes mellitus and impaired glucose tolerance were significantly different between the over-70-years-old group and the 60～69-years-old group,especially the prevalence of impaired glucose tolerance.(3)Logistic regression analysis showed that hypertension,hypertriglyceridemia,obesity and centric obesity were the risk factors for the prevalence of type 2 diabetes mellitus and impaired glucose tolerance.Conclusion:The prevalence of type 2 diabetes mellitus and impaired glucose tolerance grow with aging,and the postprandial plasma glucose is a sensitive diagnostic standard for type 2 diabetes mellitus of the elder population.Hypertension,hypertriglyceridemia,obesity and centric obesity are the main diseases leading to the prevalence of type 2 diabetes mellitus of the elder population.