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1.
Artigo | IMSEAR | ID: sea-220214

RESUMO

The solid pseudopapillary epithelial neoplasm (SPEN) of the pancreas is a relatively uncommon entity. The aim of the present study was to summarize our experiences with regard to diagnostic dilemma, surgery, postoperative follow-up, and management. This retrospective data were collected during the period from January 1, 2018 to December 31, 2020. A total of four patients (three females and one male) were identified within an age range of 13 to 25 years. All the patients were presented with nonspecific symptoms such as abdomen lumps, swelling in the abdomen, and abdominal pain. To reach a definite diagnosis, imaging studies were conducted along with endoscopic ultrasound fine-needle aspiration (EUS-FNA) and biopsy. After confirmation of SPEN on biopsy, all the patients underwent surgery without any complications. Patients are on follow-up, and to date, no metastasis has been detected. SPEN is a rare pancreatic tumor with unusual pathological features leading to a diagnostic dilemma. The pathologist should be familiar with SPEN and its salient histological characteristics that differentiate it from other look-alike pancreatic tumors and can help in timely surgery and management.

2.
Artigo em Espanhol | LILACS | ID: biblio-1020671

RESUMO

RESUMEN: El Tumor Odontogénico Epitelial Calcificante (TOEC), también denominado Tumor de Pindborg, se define como una neoplasia benigna, caracterizada por la proliferación epitelial; presenta secreción de una proteína tipo amiloide con tendencia a la calcificación. Representa menos del 1% de los tumores odontogénicos. Reportamos un caso en paciente de 75 años con un TOEC en la región maxilar izquierda en relación a una pieza dentaria incluida. El caso no mostró sintomatología específica, sólo una expansión de corticales vestibular y palatina. El diagnóstico se confirmó histológicamente mediante biopsia incisional y extirpación quirúrgica de la lesión, mostrando una histomorfología clásica para este tipo de lesiones. Reportamos este caso para resaltar la edad de presentación inusual, especialmente su localización e ilustrar su abordaje terapéutico y seguimiento.


ABSTRACT: The Calcifying Epithelial Odontogenic Tumor (CEOT), also called Pindborg Tumor, is defined as a benign neoplasm, characterized by epithelial proliferation; secretion of an amyloid-like protein is present with a tendency to calcification. It represents less than 1% of odontogenic tumors. We report a case of a 75-year-old patient with a TOEC in the left maxillary region in relation to an included tooth. The case did not show specific symptomatology, only an expansion of vestibular and palatal corticals. The diagnosis was confirmed histologically by incisional biopsy and surgical removal of the lesion, showing a classic histomorphology for this type of lesions. We report this case to highlight the unusual age of presentation, especially its location and to illustrate its therapeutic approach and follow-up.


Assuntos
Humanos , Masculino , Idoso , Tumores Odontogênicos , Maxila , Neoplasias
3.
Arq. bras. med. vet. zootec ; 68(1): 147-154, jan.-fev. 2016. graf
Artigo em Português | LILACS | ID: lil-771879

RESUMO

O carcinoma de células escamosas (CCE) é uma neoplasia epitelial maligna que acomete cães e diversas outras espécies, incluindo a humana. O CCE afeta vários sítios anatômicos e pode desenvolver metástase. O objetivo deste estudo foi a caracterização das fibras de colágenos tipos I e III no estroma do CCE cutâneo de cães. Para este trabalho, utilizaram-se 44 amostras de pele incluídas em parafina e que tiveram prévio diagnóstico de CCE. As amostras foram processadas histologicamente e coradas com hematoxilina/eosina para confirmação do diagnóstico e classificação do grau de diferenciação tumoral e com a coloração histoquímica de picrosirius para observação dos colágenos tipos I e III. O colágeno tipo III mostrou maior expressão nos CCEs cutâneos bem diferenciados. O papel do colágeno do tipo III nas neoplasias não está bem esclarecido, e outros fatores além do grau de diferenciação celular podem estar envolvidos em sua expressão e determinar sua importância na biologia tumoral.


Squamous cell carcinoma (SCC) is a malignant epithelial tumor that affects dogs and several other species, including humans. The SCC occurs in various anatomical sites and can develop metastasis. The aim of this study was to characterize types I and III collagen fibers in the stroma of cutaneous SCC in dogs. For this work 44 paraffin-embedded samples with previous diagnostic of SCC were used. Samples were processed and evaluated histologically with hematoxylin/eosin to confirm the diagnosis and classification of cell differentiation degree and with Picrosirius for observation of types I and III collagen. Type III collagen expression was higher in well-differentiated SCC. The role of type III collagen in cancer is not very clear and factors other than cell differentiation degree may be involved in its expression and determine its importance in tumor biology.


Assuntos
Animais , Cães , Colágeno Tipo I , Colágeno Tipo III , Carcinoma/veterinária , Hematoxilina , Neoplasias Cutâneas/veterinária , Metástase Neoplásica , Dermatopatias
4.
Rev. gastroenterol. Perú ; 31(1): 56-60, ene.-mar. 2011. ilus
Artigo em Espanhol | LILACS, LIPECS | ID: lil-587347

RESUMO

Nosotros reportamos un caso de neoplasia sólida pseudopapilar de páncreas en una mujer de 35 años. Ella refirió haber iniciado desde hace tres meses una enfermedad progresiva caracterizada por dolor epigástrico y baja de peso. En el examen físico solo mostró dolor moderado a la palpación profunda de mesogastrio, no se palpó alguna masa abdominal. Los exámenes auxiliares mostraron hemoglobina 13.3gr; leucocitos, plaquetas, perfil de coagulación, bioquímica, electrolitos, albúmina, globulinas, bilirrubinas, transaminasas y fosfatasa alcalina fueron normales. Examen de orina: leucocitos 14-16 por campo, urocultivo: negativo, Ca 19.9: 21.2 (0-37). Arco V (anticuerpos IgG E. granulosus):, 17.3 (nivel dudoso), Inmunoblot quiste hidatídico: negativo. La ecografía abdominal mostro entre cuerpo y cola de páncreas una imagen hipoecogénica de aspecto sólido. En la tomografía abdominal se detectó en el cuerpo del páncreas la presencia de dos nódulos hipodensos con densidad promedio de 25 U.H. y que medían 50 y 22 mm de diámetro. Las imágenes por resonancia magnetica nuclear determinaron en el cuerpo del páncreas un quiste bilobulado de 45 y 25 mm de diámetro, con isointensidad en T1, hiperintensidad en T2, sin cambios tras la saturación grasa, con realce periférico por el contraste. Intervenida quirúrgicamente, se encontró una tumoración quística en el cuerpo del páncreas; sin signos de infiltración a otros órganos. Se realizó pancreatectomía distal y esplenectomía. La tumoración era ovalada y medía 60x46x35 mm, encapsulada, de consistencia irregular, que al corte dejaba fluir material de aspecto necrótico. El estudio histológico demostró el típico patrón pseudopapilar con estroma perivascular hialinizado; en los estudios de inmunohistoquimica se observo inmunoreactividad positiva a ciclina D1 y al receptor de progesterona; también hubo positividad para vimentina, enolasa neuronoespecífica y CD-56...


We report a case of solid and papillary epithelial neoplasm of the pancreas in a 35-year-old female. She presented with epigastric pain and weight loss, these symptoms developed 3 months before. Physical examination revealed mild pain on deep palpation of mesogastrium, without palpable abdominal mass; rest of the examination was normal. The laboratory data showed hemoglobin 13.3gr/dl; WBC, platelets, blood coagulation test, blood biochemistry, electrolytes, liver function test were normals. Urine test: 14-16 leukocytes per field, urocultive negative, Ca 19.9: 21.2 (0-37). Her serology for hydatic cyst (arc V and inmunoblot) was negative. Abdominal ultrasound showed between body and tail of the pancreas a solid hypoechoic image. In abdominal CT was detected in the body of the pancreas the presence of two hypodense lesions with average density of 25 UH and mediate 50 and 22 mm in diameter. The nuclear magnetic resonance imaging identified the body of the pancreas, bilobed cyst of 45 and 25 mm in diameter, with isointensity in T1, hyperintensity in T2, unchanged after fat saturation, with peripheral contrast enhancement. Operation findings showed a cystic tumor in the body of pancreas without signs of infiltration to other organs. Therefore, distal pancreatectomy and splenectomy were carried out. The tumor was 60x46x35 mm and a half oval, encapsulated, irregular consistency, which the court left necrotic-looking material flow. The study showed the pattern typical hyalinized perivascular pseudopapillary with stroma, in immunohistochemical studies positive imunoreactivity was observed in cyclin D1 and progesterone receptor, also were positive for vimentin, enolase neuronoespecífica and CD-56. The proliferation index assessed by Ki-67 was less than 1% in tumor cells...


Assuntos
Humanos , Feminino , Adulto , Neoplasias Pancreáticas , Pseudocisto Pancreático/diagnóstico , Pseudocisto Pancreático/terapia
5.
MedUNAB ; 12(1): 14-18, 2009.
Artigo em Espanhol | LILACS | ID: biblio-1005781

RESUMO

Objetivo: Determinar la frecuencia de lesiones premalignas y malignas de cérvix en adolescentes y mujeres jóvenes. Métodos: Estudio descriptivo transversal de 136 historias clínicas de pacientes entre 14 y 24 años remitidas al Servicio de Patología Cervical de Clínica Maternidad Rafael Calvo. Se evaluaron citología, colposcopia y estudio histopatológico. Resultados: La edad media fue de 21,0 (DE 2,4) años, la de inicio de vida sexual de 16,0 (DE 1,9) y la del primer embarazo 15,0 (DE 6,1) años. El 51,4% informaron dos o más compañeros sexuales. Treinta y seis (26,4%) eran adolescentes y 100 (73,6%) adultas jóvenes de 20 a 24 años. El 48,5% de toda la población tuvo citología anormal. Se observaron hallazgos colposcópicos de lesiones premalignas en 48 pacientes (35,3%): 12 adolescentes y 36 adultas. Se realizaron 50 biopsias: 39 (78,0%) resultaron con lesiones de bajo grado, nueve (18,0%) lesiones de alto grado y una (2%) con cáncer de cérvix infiltrante. No se observó diferencia estadísticamente significativa entre la frecuencia de LIE de bajo o alto grado entre adolescentes y adultas jóvenes. En las pacientes con lesiones de alto grado y cáncer se observó una mayor frecuencia de inicio de vida sexual antes de 16 años y más de un compañero sexual. Conclusión. Se observó una mayor frecuencia de lesiones premalignas y malignas que las descritas en otros estudios. Nuevas evaluaciones deben inferir las causas que influyen en el incremento en la presencia de LIE a edades tempranas. [Romero IM, Ceballos C, Monterrosa A. Lesiones premalignas y malignas de cérvix en adolescentes y mujeres jóvenes. Clínica Materniada Rafael Calvo, Cartagena. MedUNAB 2009; 12:14-18].


Objetive: to establish frequency of cervical premalignant lesions and cancer in adolescents and young women. Methods: This is a descriptive cross-sectional study of 136 patients between 14 and 24 years old who were referred to Cervical Pathology Unit, Clínica Maternidad Rafael Calvo, Cartagena, Colombia. Results of cytology, colposcopy and biopsies were evaluated. Results: Mean age was 21,0 (SD 2,4) years; initiation of intercourse were a mean age of 16,0 (SD 1,9), and mean age of first pregnancy was 15,0 (SD 6,1) years. Fifty one percent of patients had two or more sexual partners. Thirty six (26,4%) were adolescents and 100 (73,6%) were young adult (20¿24 years old). Abnormal cytology was found in 48,5% of patients. There were 48 patients (35,3%) with premalignant lesions on colposcopy: 12 adolescents and 36 adults. Fifty biopsies were performed: 39 (78,0%) resulted with low grade lesions, 9 (18,0%) with high grade lesions, and one (2,0%) infiltrating carcinoma. Differences between frequencies of premalignant lesions in adolescents and young women were not statiscally significant. Patients with high grade lesions and cervical cancer initiated intercourse at 16 years old or less and they had more than one sexual partner. Conclusion: It was observed a higher frequency of premalignant and malignant lesions in this study than other reports. Additional studies should look for causes of increasing presentation of these lesions at earlier ages. [Romero IM, Ceballos C, Monterrosa A. Cervical malignant and premalignant lesions in adolescents and young women. Clínica Maternidad Rafael Calvo, Cartagena. MedUNAB 2009; 12:14-18].


Assuntos
Mulheres , Adolescente , Colposcopia , Biologia Celular
6.
Journal of the Korean Surgical Society ; : 440-446, 2006.
Artigo em Coreano | WPRIM | ID: wpr-89807

RESUMO

PURPOSE: Most cystic tumors of the pancreas are composed of serous cystic tumor, mucinous cystic tumor, solid pseudo- papillary epithelial neoplasm (SPEN) and intraductal papillary mucinous tumor (IPMT). With advancements in diagnostic imaging, cystic lesions of the pancreas are being detected with increasing frequency; however, there is still difficulty determining the appropriate diagnostic and therapeutic plan. METHODS: A retrospective review was performed of 15 cases that underwent surgery for pancreatic cystic tumors in our department between July 1995 and August 2005. All 15 cases identified had their records and radiological images reviewed. Radiological findings were characterized and analyzed by one radiologist. RESULTS: The median age was 55.9 years. Six cases were male and nine were female. Common symptoms included: epigastirc pain 6/14 (43%) and palpable mass 2/14 (14%). The accuracy of the preop radiological diagnosis including abdominal CT and US was 12/15 (80%). One case of serous cystic tumor, one of chronic pancreatitis and one SPEN were misdiagnosed; the preoperative diagnosis for these cases was mucinous cystic tumor. Serous cystic tumors were seen with central calcification 2/3 (67%), external lobulation 3/3 (100%); however, the mucinous cystic tumors were seen with peripheral calcification 4/5 (80%), no external lobulation 5/5 (100%) by radiological evaluation. There was no calcification, but external lobulation was common in the IPMT. The SPEN had no specific radiological findings except for peripheral calcification. CONCLUSION: Future multicenter studies with endoscopic sonography and aspiration cytology is needed for improved accuracy of diagnosis.


Assuntos
Feminino , Humanos , Masculino , Diagnóstico , Diagnóstico por Imagem , Mucinas , Neoplasias Epiteliais e Glandulares , Pâncreas , Cisto Pancreático , Pancreatite Crônica , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
7.
Journal of the Korean Association of Pediatric Surgeons ; : 32-40, 2006.
Artigo em Coreano | WPRIM | ID: wpr-131250

RESUMO

Four children with solid and papillary epithelial neoplasm of the pancreas are reported. Three were girls. Mean age at operation was 12 years and 7 months (10-13 years). Clinical presentation included nausea, vomiting, and apalpable mass. One had hemoperitoneum due to tumor rupture. In two cases, tumors were in the body of the pancreas, and one the body and tail, and in one,the tail. Mean diameter of the tumors was 10.8 cm (8-15cm). Surgical procedures were distal pancreatectomy and splenectomy in 2 cases, distal pancreatectomy in one, and subtotal pancreatectomy and splenectomy in one. Mean follow-up period was 61 months (6-121 months). Three patients are still alive without any recurrence. However, in the one case of ruptured tumor, portal vein thrombosis and liver metastasis developed after subtotal pancreatectomy and splenectomy during the course of postoperative adjuvant chemotherapy.


Assuntos
Criança , Feminino , Humanos , Quimioterapia Adjuvante , Tratamento Farmacológico , Seguimentos , Hemoperitônio , Fígado , Náusea , Metástase Neoplásica , Neoplasias Epiteliais e Glandulares , Pâncreas , Pancreatectomia , Recidiva , Ruptura , Esplenectomia , Trombose Venosa , Vômito
8.
Journal of the Korean Association of Pediatric Surgeons ; : 32-40, 2006.
Artigo em Coreano | WPRIM | ID: wpr-131247

RESUMO

Four children with solid and papillary epithelial neoplasm of the pancreas are reported. Three were girls. Mean age at operation was 12 years and 7 months (10-13 years). Clinical presentation included nausea, vomiting, and apalpable mass. One had hemoperitoneum due to tumor rupture. In two cases, tumors were in the body of the pancreas, and one the body and tail, and in one,the tail. Mean diameter of the tumors was 10.8 cm (8-15cm). Surgical procedures were distal pancreatectomy and splenectomy in 2 cases, distal pancreatectomy in one, and subtotal pancreatectomy and splenectomy in one. Mean follow-up period was 61 months (6-121 months). Three patients are still alive without any recurrence. However, in the one case of ruptured tumor, portal vein thrombosis and liver metastasis developed after subtotal pancreatectomy and splenectomy during the course of postoperative adjuvant chemotherapy.


Assuntos
Criança , Feminino , Humanos , Quimioterapia Adjuvante , Tratamento Farmacológico , Seguimentos , Hemoperitônio , Fígado , Náusea , Metástase Neoplásica , Neoplasias Epiteliais e Glandulares , Pâncreas , Pancreatectomia , Recidiva , Ruptura , Esplenectomia , Trombose Venosa , Vômito
9.
Korean Journal of Pathology ; : 274-281, 2006.
Artigo em Coreano | WPRIM | ID: wpr-204587

RESUMO

BACKGROUND: Disturbances of the cell cycle regulatory proteins are key events underlying the development and/or progression of human malignancies. The aim of this study was to evaluate the expression of G1/S cell cycle regulatory proteins in ovarian epithelial tumor. METHODS: We simultaneously evaluated the expression of cyclin D1, cyclin E, CDK4, CDK2, p16, Rb, E2F1, p53 and the Ki67 labelling index (LI) by immunohistochemical methods in 148 cases of ovarian epithelial tumor of the benign (n=47), borderline (n=29), and malignant type (n=72). RESULTS: The expression of cyclin E, CDK2, p16, Rb, E2F1, p53 and the Ki67 LI gradually increased from the benign type, through the borderline type, to the malignant tumors. Between the borderline and malignant tumors, the increased expression of cyclin E, E2F1, and p53, and the decreased expression of Rb were significantly associated with malignancy. The reduced Rb expression and the increased E2F1 expression were correlated with the FIGO stage and the histologic grade in the malignant ovarian epithelial tumors. CONCLUSIONS: Cyclin E, E2F1, and p53 overexpressions and the loss of Rb are the important components during carcinogenesis of ovarian epithelial tumors. Our results suggest that in- creased expression of E2F1 should be considered as a new parameter for the prognosis of patients with malignant ovarian epithelial tumors.


Assuntos
Feminino , Humanos , Carcinogênese , Proteínas de Ciclo Celular , Ciclo Celular , Ciclina D1 , Ciclina E , Ciclinas , Fator de Transcrição E2F1 , Neoplasias Epiteliais e Glandulares , Ovário , Prognóstico
10.
Journal of the Korean Association of Pediatric Surgeons ; : 46-52, 2005.
Artigo em Coreano | WPRIM | ID: wpr-61734

RESUMO

Solid and papillary epithelial neoplasm (SPEN) of the pancreas is a rare tumor with low malignant potentiality that usually occurs in young females. Preoperative evaluation, especially radiologic tests, including ultrasonography and CT scan, is helpful in the diagnosis. These studies demonstrate a well-demarcated large mass with solid and cystic portions, frequently in the tail or body of the pancreas. Complete resection is usually curative, however local invasion and/or metastasis may occur. The authors report a case of a solid and papillary epithelial neoplasm of the pancreatic body in a 14-year old child at St. Benedict Hospital and review the literature.


Assuntos
Adolescente , Criança , Feminino , Humanos , Diagnóstico , Metástase Neoplásica , Neoplasias Epiteliais e Glandulares , Pâncreas , Tomografia Computadorizada por Raios X , Ultrassonografia
11.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 139-143, 2003.
Artigo em Coreano | WPRIM | ID: wpr-95898

RESUMO

BACKGROUND/AIMS: Solid and papillary epithelial neoplasm (SPEN) of the pancreas is a rare malignant tumor with a characteristic female predominance. This tumor has a low- grade malignant potential biologically, and shows favorable prognosis with surgical treatment clinically. METHODS: Nine patients with SPEN of the pancreas who were pathologically confirmed at the Dong-A University Medical Center were analyzed retrospectively. Clinical data, including clinical manifestation, diagnostic maneuvers, surgical treatment modality, and prognosis were evaluated. RESULTS: Six out of nine patients were females with a mean age of 28 (range, 15~52) years. Except in 2 cases, all patients presented with either a palpable abdominal mass (5 cases) or abdominal pain (2 cases). The tumors ranged in size from 3.8 to 18 (average size, 11.4) cm. Five were located in the body, 3 in the tail, and 1 in the head. SPEN was diagnosed preoperatively in 6 patients by abdominal ultrasonography and/or CT. All patients underwent surgical resection, which included subtotal pancreatectomies (4 cases), distal pancreatectomies (4 cases, 1 by laparoscopically) and local excision (1 case). All patiests are survived without evidence of recurrence with a mean follow up of 53.1 (range, 26~69) months. CONCLUSION: SPEN of the pancreas is low-malignant in character, and complete surgical excision is the treatment of choice which warrants a long-term survival.


Assuntos
Feminino , Humanos , Dor Abdominal , Centros Médicos Acadêmicos , Seguimentos , Cabeça , Neoplasias Epiteliais e Glandulares , Pâncreas , Pancreatectomia , Prognóstico , Recidiva , Estudos Retrospectivos , Ultrassonografia
12.
Academic Journal of Xi&#39 ; an Jiaotong University;(4): 82-85, 2003.
Artigo em Chinês | WPRIM | ID: wpr-845123

RESUMO

Objective: To study the relevance of expression of basic fibroblast growth factor (bFGF), fibroblast growth factor receptor-1 (FGFR-1) and carcinogenesis and progression of ovarian epithelial neoplasm. Methods: Ten cases of normal ovarian tissues and 75 cases of ovarian epithelial neoplasm tissues were detected by immunohistochemical methods: S-P for bFGF, FGFR-1, double immunohistochemistry Lab-SA for Ki-67 antigen and bFGF. Results: The expression level of bFGF, FGFR-1 in ovarian epithelium and ovarian epithelial neoplasm showed a step-wise increase in the following order: normal 〈benign 〈borderline 〈malignant; The expression level and intensity of bFGF and FGFR-1 were increased with the decrease of differentiation degree and increase of clinical stage in ovarian carcinoma; There was no statistical difference between the expression of bFGF, FGFR-1 in serous cystadenocarcinoma and that of mucinous cystadenocarcinoma; The expression of bFGF was correlated with that of FGFR-1 in neoplastic tissues; There were positive expression rates of bFGF and Ki-67 antigen in ovarian epithelial neoplasm. Conclusion: As an important proliferative factor, bFGF plays an important role in carcinogenisis and progression of ovarian epithelial neoplasm.

13.
Korean Journal of Pediatric Gastroenterology and Nutrition ; : 108-112, 2002.
Artigo em Coreano | WPRIM | ID: wpr-19920

RESUMO

Solid and papillary epithelial neoplasm (SPEN) of the pancreas is an uncommon tumor and is found predominantly in young females. The most common clinical presentation is an abdominal mass. The tumor has a low grade malignant potential and complete removal is the treatment of choice. We report a case of SPEN in a 13-year-old girl who presented with abdominal pain and increasing size of an abdominal mass after abdominal trauma. CT and sonographic findings showed a well-demarcated mass in the pancreas tail with solid and cystic portion. She got a distal pancreatectomy and pathologic finding was SPEN of pancreas.


Assuntos
Adolescente , Criança , Feminino , Humanos , Dor Abdominal , Neoplasias Epiteliais e Glandulares , Pâncreas , Pancreatectomia , Ultrassonografia
14.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 189-195, 2000.
Artigo em Coreano | WPRIM | ID: wpr-27338

RESUMO

BACKGROUND: Solid and papillary epithelial neoplasm(SPEN) is a rare malignant tumor of the pancreas that typically occurs in young females and has an excellent prognosis. This tumor has a low malignant potential, and is highly curable with surgical treatment. METHODS AND MATERIALS: From January 1986 to July 1999, ten patients of solid and papillary epithelial neoplasm of the pancreas pathologically verified at Kyung Hee University Hospital were retrospectively analyzed. Pre-, intra-, and post-operative data were evaluated in all patients to determine optimal management with specific reference to surgical strategy. RESULTS: Nine patients out of ten were females, with a mean age of 21.8 years (range 12-38). Six patients presented with a palpable abdominal mass and four patients with abdominal pain. Remaining patients presented with fever, low back pain, and no specific symptom. Abdominal ultrasonography and/or CT scan showed an abdominal mass in all patients. The correct preoperative diagnosis of SPEN was made in six patients. Incorrect diagnosis included pseudocysts in two and cystadenoma in two. The tumor size ranged from 5 to 14.5 cm in diameter (average 8.85 cm). Four patients with tumor in the pancreatic head had a pylorus preserving pancreaticoduodenectomy (PPPD). Four patients with tumor in the pancreatc tail underwent distal pancreatectomy and splenectomy(without in one). Two patients were performed mass enucleation only. The histologic diagnosis was confirmed in all patients. There were no nuclear atypia and pleomorphism in microscopic findings. Postoperative complications were intraabdominal abscess in one, lymphatics leakages in one, and wound infection in one. All ten patients are alive without sign of recurrence with a mean follow-up of 5.36 years (range 0.1 to 13 years). CONCLUSIONS: SPEN is an indolent tumor of the pancreas with low malignant potential and excellent long-term prognosis and should be considered in the differential diagnosis of large pancreatic masses, especially in young females. Resection is the treatment of choice that is resectable.


Assuntos
Feminino , Humanos , Dor Abdominal , Abscesso , Cistadenoma , Diagnóstico , Diagnóstico Diferencial , Febre , Seguimentos , Cabeça , Dor Lombar , Neoplasias Epiteliais e Glandulares , Pâncreas , Pancreatectomia , Pancreaticoduodenectomia , Complicações Pós-Operatórias , Prognóstico , Piloro , Recidiva , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Ultrassonografia , Infecção dos Ferimentos
15.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 197-204, 2000.
Artigo em Coreano | WPRIM | ID: wpr-27337

RESUMO

BACKGROUND: Solid and papillary epithelial neoplasm(SPEN) of the pancreas is a rare tumor with low grade malignant potential and usually found in young female patients. The prognosis of this lesion is reported to be much more favorable than other pancreatic neoplasms. METHODS: We report four cases of SPENs of the pancreas treated at the department of surgery, Keimyung University Dongsan Medical Center. Three were women and one was a man and their mean age at the time of surgery was 19 years with the ranges between 11 and 29 years of age. Two patients were admitted with a palpable abdominal mass and another two patients with abdominal pain. Results of laboratory studies including serum amylases and tumor markers were all within normal limits. Diagnosis was made preoperatively in three patients by MRI and needle biopsies. Tumors were located in the head portion in three patients and in the body of the pancreas in one patient. RESULTS: All patients underwent complete resection which involved three enucleations and one pancreaticoduodenectomy. All patients are alive at the time of this report with mean follow up period of 69.5 month (the ranges between 8 and 105 months) without evidence of recurrence. CONCLUSION: In our experience, complete resection of this neoplasm is the treatment of choice and the prognosis is excellent.


Assuntos
Feminino , Humanos , Dor Abdominal , Amilases , Biópsia por Agulha , Diagnóstico , Seguimentos , Cabeça , Imageamento por Ressonância Magnética , Neoplasias Epiteliais e Glandulares , Pâncreas , Neoplasias Pancreáticas , Pancreaticoduodenectomia , Prognóstico , Recidiva , Biomarcadores Tumorais
16.
Korean Journal of Pediatric Gastroenterology and Nutrition ; : 116-121, 2000.
Artigo em Coreano | WPRIM | ID: wpr-167712

RESUMO

Solid and Papillary epithelial neoplasm of pancreas is a rare and low grade malignant tumor. It develops in 2nd or 3rd decades of young female and located in tail of pancreas predominantly. Prognosis is good despite its various histologic features, which suggest a malignant appearance. We report one case of solid and papillary epithelial neoplasm in head of pancreas in a 11-year-old girl who had been suffered from vomiting and right upper abdominal pain for 3 weeks.


Assuntos
Criança , Feminino , Humanos , Dor Abdominal , Cabeça , Neoplasias Epiteliais e Glandulares , Pâncreas , Prognóstico , Vômito
17.
Korean Journal of Gastrointestinal Endoscopy ; : 239-242, 2000.
Artigo em Coreano | WPRIM | ID: wpr-184878

RESUMO

The solid and papillary epithelial neoplasm of the pancreas is a relatively uncommon disease. It accounts for approximately 1 to 2 percent of all exocrine pancreatic tumors. This benign or low grade malignant tumor is reported to occur predominantly in young women and rarely in men. Recurrence and development of metastasis after resection are found only in a small fraction of the general population. A case is herein reported involving a solid and papillary epithelial neoplasm of the pancreas which extensively spread to nearby organs, in a 34 year-old man. Chief complaints were black stool. Physical examination revealed tenderness on the left upper quadrant of the abdomen. Esophagogastroduodenoscopy revealed multiple cardiac variceal bleeding. Abdominal sonography and CAT scan findings showed a huge lobulated mass on the left upper quadrant area with an internal necrotic portion. Surgical findings showed determined a splenic vein tumor thromboembolus, portal vein involvement, distal stomach involvement, and multiple colonic invasion. Therefore, distal pancreatectomy, wedge resection of the stomach, splenetomy, segmental resection of the transverse colon, and excision of the mass were all performed. Pathologic examination revealed a solid and papillary epithelial neoplasm in the pancreatic tail with a marked dilated splenic vein filled with tumor thromboembolus. The patient has been under chemotherapy since then, and is being closely observed.


Assuntos
Adulto , Animais , Gatos , Feminino , Humanos , Masculino , Abdome , Colo , Colo Transverso , Tratamento Farmacológico , Endoscopia do Sistema Digestório , Varizes Esofágicas e Gástricas , Metástase Neoplásica , Neoplasias Epiteliais e Glandulares , Pâncreas , Pancreatectomia , Exame Físico , Veia Porta , Recidiva , Veia Esplênica , Estômago
18.
Korean Journal of Pediatric Gastroenterology and Nutrition ; : 217-221, 2000.
Artigo em Coreano | WPRIM | ID: wpr-741338

RESUMO

Solid and papillary epithelial neoplasm of the pancreas is an uncommon low-grade malignant tumor found predominantly in young females. It is rare in childhood. The origin of the tumor is probably from a multipotential stem cell of the pancreas. Neoplasm usually behave like a very low grade malignancy, so that complete removal is the treatment of choice for the tumor arising anywhere in the pancreas. We report a case of solid and papillary epithelial neoplasm of the pancreas in a 14 year-old girl who presented with intermittent abdominal pain and abdominal mass. CT scan shows a large, about 7×6 cm sized, well-marginated hypodense round mass in the head of the pancreas with some ill defined enhancing solid internal portion. She had taken complete excision of the pancereatic mass and Roux-en-Y pancreaticojejunostomy and histologically comfirmed solid and papillary epithelial neoplasm of the pancreas. A brief review of literature was made.


Assuntos
Feminino , Humanos , Dor Abdominal , Cabeça , Neoplasias Epiteliais e Glandulares , Pâncreas , Pancreaticojejunostomia , Células-Tronco , Tomografia Computadorizada por Raios X
19.
Journal of the Korean Surgical Society ; : 403-409, 1999.
Artigo em Coreano | WPRIM | ID: wpr-85025

RESUMO

BACKGROUND: Solid and papillary neoplasms of the pancreas are very rare tumors that occur predominantly in young women. Most of them are diagnosed because of their large sizes and because they are present with an asymptomatic abdominal mass. Most reports indicate that these large palpable, abdominal masses occur in females in their second and third decades of life. Only a few cases of solid and papillary epithelial neoplasms of the pancreas have been reported. METHOD: Here in, eight cases were reviewed which were treated at the Department of Surgery, Catholic University Medical College affiliated hospital from 1988 to 1996. RESULT: The diagnosis is often implied by radiologic examination with ultrasonography, UGI, ERCP, and computed tomography. Most cases showed well-encapsulated, round, or lobulated masses consisting of both cystic and solid areas. The hallmark histologic pattern of this tumor is a solid and papillary epithelial pattern in a pancreatic neoplasm. There is no specific marker for this neoplasm which could elucidate the obscure histogenetic origin and the phenotypic differentiation. Concluion: Therefore, surgical excision is the primary form of treatment and has favorable results.


Assuntos
Feminino , Humanos , Colangiopancreatografia Retrógrada Endoscópica , Diagnóstico , Neoplasias Epiteliais e Glandulares , Pâncreas , Neoplasias Pancreáticas , Ultrassonografia
20.
Korean Journal of Gastrointestinal Endoscopy ; : 983-989, 1999.
Artigo em Coreano | WPRIM | ID: wpr-47322

RESUMO

A solid and papillary epithelial neoplasm of the pancreas is a very rare and low-grade type of malignancy, although an increasing number of cases have been reported in recent years. Patients with a solid and papillary epithelial neoplasm of the pancreas have a good prognosis and may be cured if the disease is diagnosed before metastasis and diffuse local invasion. A 23-year-old female who had a 4-year history of recurrent abdominal pain, was admitted due to lower abdominal pain. Incidentally a calcified, 6 4 cm sized ovoid mass was found in the right upper quadrant, from a simple abdominal X-ray. An ERCP, abdominal sonography, and CT were performed, as well as a pylorus preserving pancreatoduodenectomy. Gross pathologic examination revealed a well encapsulated mass with cystic degeneration and hemorrhagic necrosis. Microscopically, the tumor had papillary fronds with a fibrovascular connective tissue core. There was focal infiltration of tumor cells into the duodenal wall and heterotropic pancreatic tissue in the submucosa. Immunohistochemistry revealed positivity for neuron-specific enolase. The patient maintained a healthy status for one year since the operation.


Assuntos
Feminino , Humanos , Adulto Jovem , Dor Abdominal , Colangiopancreatografia Retrógrada Endoscópica , Tecido Conjuntivo , Duodeno , Imuno-Histoquímica , Necrose , Metástase Neoplásica , Neoplasias Epiteliais e Glandulares , Pâncreas , Pancreaticoduodenectomia , Fosfopiruvato Hidratase , Prognóstico , Piloro
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