RESUMO
Abstract Objective: The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol®) and with intermittent hypothermic blood solution. Methods: Two homogenous groups of 25 children with acyanotic congenital heart disease who underwent total correction with mean aortic clamping time of 60 minutes were evaluated in this randomized study. Troponin and creatine kinase-MB curves, vasoactive-inotropic score, and left ventricular function were obtained by echocardiogram in each group. The values were correlated and presented through graphs and tables after adequate statistical treatment. Results: It was observed that values of all the studied variables varied over time, but there was no difference between the groups. Conclusion: We conclude that in patients with acyanotic congenital cardiopathies submitted to total surgical correction, mean aortic clamping time around one hour, and cardiopulmonary bypass with moderate hypothermia, the HTK crystalloid cardioplegic solution offers the same myocardial protection as the cold-blood hyperkalemic cardioplegic solution analyzed, according to the variables considered in our study model.
Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Soluções Cardioplégicas/uso terapêutico , Cardiopatias Congênitas/cirurgia , Cloreto de Potássio/uso terapêutico , Procaína/uso terapêutico , Valores de Referência , Fatores de Tempo , Troponina/análise , Ecocardiografia , Método Duplo-Cego , Estudos Prospectivos , Reprodutibilidade dos Testes , Análise de Variância , Função Ventricular Esquerda , Resultado do Tratamento , Estatísticas não Paramétricas , Substâncias Protetoras/uso terapêutico , Creatina Quinase Forma MB/análise , Duração da Cirurgia , Glucose/uso terapêutico , Cardiopatias Congênitas/fisiopatologia , Manitol/uso terapêuticoRESUMO
Bacillus cereus adherence to stainless steel used to milk contact surfaces was observed, depending on the cleaning and sanitizing procedures applied and the physicochemical properties of the surfaces. Numbers of surviving B. cereus after hygiene procedures were affected by temperature, the concentrations of both alkaline and acid washes, and the pH of the chlorine solution. The adhesion of B. cereus to the stainless steel was not thermodynamically favorable, and the adherence of this microorganism occurred in lower number, in accordance to the thermodynamic aspect of adhesion.
Foi observada a adesão de Bacillus cereus em superfície de aço inoxidável em contato com o leite, segundo o procedimento de limpeza, a sanitização e as propriedades físico-químicas da superfície. O número de B. cereus viáveis, após os procedimentos de higienização, foi afetado pela temperatura, pela concentração das soluções alcalinas e ácidas e pelo pH da solução clorada. A adesão de B. cereus em aço inoxidável não foi termodinamicamente favorável, e ocorreu pouca adesão desse microrganismo, de acordo com os aspectos termodinâmicos da adesão.