Recent Development of Eslicarbazepine Acetate, a New Drug against Epilepsy / 中国药师

The latest literatures on eslicarbazepine acetate in the treatment of epilepsy from home and abroad were referred. The results showed that the oral absorption of eslicarbazepine acetate is quick with long half life, linear pharmacokinetics and low potential of drug-drug interactions. Compared with carbamazepine and oxcarbazepine, eslicarbazepine acetate is more effective against epilepsy.

Identification, synthesis and characterization of an unknown process related impurity in eslicarbazepine acetate active pharmaceutical ingredient by LC/ESI-IT/MS, 1H, 13C and 1H-1H COSY NMR / 药物分析学报

A new impurity was detected during high performance liquid chromatographic (HPLC) analysis of eslicarbazepine acetate active pharmaceutical ingredient. The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer (LC/ESI-IT/MS) analysis. Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using 1H, 13C nuclear magnetic resonance spectrometry (NMR), 1H-1H correlation spectro-scopy (COSY) and infrared spectroscopy (IR). Based on the spectroscopic and spectrometric data, unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl propionate.

Determination of the Dissolution of Eslicarbazepine Acetate Tablets / 中国药房

OBJECTIVE: To establish the method for the dissolution determination of Eslicarbazepine acetate tablets.METHODS: Samples were collected at 30 min with phosphate buffer solution(pH=4.5) as solvent and rotation speed of 50 r?min-1 according to second dissolution determination method(slurry method) stated in Chinese Pharmacopeia(2010 edition).The absorbance of 3 batches of samples was determined by UV spectrophotometry at detection wavelength of 288 nm.RESULTS: The method showed a good linear relationship in the range of 5～30 ?g?mL-1(r=0.999 8) with an average recovery of 99.74%(RSD=0.47%).The dissolutions of 3 batches of samples were 82.06%,82.72% and 82.64%,respectively.CONCLUSIONS: Established method is simple and reliable for the dissolution determination of Eslicarbazepine acetate tablets.