RESUMO
Objective:To study the disturbance creatd by the variable transformation within regression parameters of nonlinear biology models and find a new method removing or reducing the disturbance.Methods:To use the space transformation,Taylor series and weight method to remove or reduce the serious disturbance created by the variable transformation within regression parameters of nonlinear biology models.Results:Giving a new method calculating regression parameters of nonlinear biology models.Conclusion:The new method can remove or reduce the serious disturbance created by the variable transformation and remain the advantage of variable transformation.It can not only improve regression precision of the nonlinear biology models but also can find problems hidden in the original data.