Abnormal semantic and syntactic processing in patients with schizophrenia: an event-related potential study / 上海交通大学学报（医学版）

Objective • To explore the differences of event-related potential components (N400 and P600) in response to language processing between schizophrenia (SZ) patients with formal thought disorder (FTD), SZ patients without FTD, genetic high-risk subjects and healthy controls (HC). Methods • Thirty SZ patients with FTD (SZ-FTD group) and 29 SZ patients without FTD (SZ-nFTD group), who were hospitalized in Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 22 subjects at genetic high risk who were first degree relatives of SZ patients, and 31 healthy controls (HC) were recruited. Four different types of sentences (syntactically and semantically correct, syntactically correct but semantically incorrect, syntactically incorrect but semantically correct, and syntactically and semantically incorrect) were presented to the four groups respectively with electroencephalogram recording. Repeated measurement analysis of variance was used to compare the response accuracy of the four groups and to analyze the differences in the amplitude and latency of N400 and P600 components in response to each kind of sentence among the four groups. Results • SZFTD group showed a lower accuracy rate compared with the HC group (P=0.000). Compared with the HC group, N400 amplitude in SZ-FTD group was lower in statistically significance (P=0.003), while SZ-FTD group did not show a prominent N400 component. P600 component was well evoked in four groups, and there was an interaction between semantics, syntax and group (P=0.022). By further analysis, neither SZ-FTD nor SZ-nFTD group showed significant differences in P600 amplitudes evoked by syntactically correct and syntactically incorrect sentences. There was no significant difference in P600 amplitudes evoked by semantically correct and incorrect sentences in SZ-FTD group, whereas P600 amplitudes evoked by semantically correct sentences were greater than those evoked by semantically incorrect ones in the other three groups. Conclusion • Neural activity is impaired during semantic processing in SZ. In particular, SZ-FTD patients have impairments in both semantic and syntactic processing.

Effect of Motor Relearning Program on Recovery of Event-related Potential of Cerebral Infarction / 中国康复理论与实践

@#Objective To explore event-related potential(ERP) P300 of cerebral infarction patients during motor relearning program. Methods 99 cerebral infarction patients were divided into observation group(52 cases, receiving motor relearning program) and control group(47 cases, no treatment), and 50 healthy subjects as normal control. After 12 weeks, they were measured by: 1)Berg balance scale; 2)Sheikh body control scale; 3)Fugl-Meyer movement assessment; 4) walk ability and 5) ERP P300.Results The scores of Berg balance scale, Fugl-Meyer movement assessment, Sheikh body control scale and walk ability scale increased significantly, and the latency of ERP P300 decreased significantly(P<0.01), and the amplitude of ERP P300 increased significantly in the observation group. ERP P300 of the observation group has significantly difference(P<0.01) from the normal control group.Conclusion Motor relearning program can effectively retrieve the ERP P300 and motor ability of cerebral infarction patients.

Effect of different attention states on auditory ERP and EEG power / 中华物理医学与康复杂志

Objective To study the effect of different attention states on auditory ERP and EEG power in normal subjects. Methods In three different states such as passive attention,active attention with target counting and active attention without target counting,EEG were recorded using oddball paradigm in 8 normal subjects while the test tones were presented;Then the peak-peak amplitude and latency of ERP were evaluated and the EEG power spectra were observed. Results The condition of active attention with target counting resulted in the smallest peak-peak amplitude of P 2-N 1 and the largest one of P 3-N 2,and it led to the increment of EEG power at the frequency of 10Hz,while the latencies did not differ among the three different attention states. Conclusion Reduced P 2-N 1 amplitude and increased P 3-N 2 amplitude reflected the allocation changes of attention resource in different states,and increased EEG power reflected more energy consumption in the process of recognition and memory,but the latency was relatively stable and not affected significantly by subject's attention condition.

Changes of Components of Topographic Event Related Potential P300 in Aging Process / 신경정신의학

OBJECTS: This study was to examine the changes of components of topographic auditory event related potential P300 in normal aging process. METHODS: The subjects were consisted of 85(range of age ; 18-68), who were right handed and had education level at least over 12 years. They had no history of medico-surgical and psychiatric illness which could cause brain dysfunction, and had not any physical and mental illness on examination. The topographic auditory event related P300 was recorded in oddball paradigm and the components of P300 including latency, amplitude, and location of maximum amplitude in X-Y cordinates were analized by computerized EP mapping system. The latency of P300 was determined by both Global Field Power Measurement and classic method. RESULTS: In global field power measurement, the latency has been increased about by 1m sec per year(latency=299.9+1 X AGE). The location of maximum amplitude in X coordinate was moved by 0.018 per year toward left side(X=3.6-0.018 X AGE) and in Y coordinate by 0.017 toward frontal direction(Y=2.15+0.017 X AGE). In classic method the latency has been increased about by 0.82m sec per year(latency=304.76+0.82 X AGE). The location of maximum amplitude in X coordinate was moved by 0.011 per year toward left side(X=3.35-0.011 X AGE) and in Y coordinate by 0.025 toward frontal direction(Y=1.86+0.025 X AGE). The amplitudes were not changed in both methods. CONCLUSION: The results showed strong positive correlation between latency of P300 and aging process, and slight left frontal displacement of the location of maximum amplitude. These finding implicate that psychophysiological function expressed by P300 was declined in aging process and database of formal controls should be necessary for both research and clinical application.

How to Determine P300 Component in Auditory Event Related Potential Brain Topography / 신경정신의학

OBJECTS: This study was designed to make a comparison between methods to determine the components of topographic auditory event related potential P300. METHODS: The subjects were consisted of 44 normal controls and 44 patients with schizophrenia diagnosed by DSM-IV. The topographic auditory event related P300 was recorded in oddball paradigm. The components of P300, including latency, amplitude, and location of maximum amplitude in X-Y coordinates, were analized by computerized EP mapping system. The latency of P300 was determined by both global field power measurement and classic method. RESULTS: There was difference between two groups in latency(DF=1, F=35.28, P= 0.0001) and amplitude(DF=1, F=36.62, P=0.0001), but not in X coordinate(DF=1, F=0.37, P=0.55) and Y coordinate(DF=1, F=2.00, P=0.16). There was no difference between two mothods in latency(DF=1, F=0.04, P=0.85), in amplitude(DF=1, F=0.07, P=0.79), in X coordinate(DF=1, F=0.07, P=0.79), and in Y coordinate(DF=1, F=0.03, P=0.86). CONCLUSION: The results suggested that two methods to determine the components of topographic auditory event related potential P300 should be available for both research and clinical application to date.

Topographic Auditory Event-Related Potential P300 and Psychopathology of the Patients with Schizophrenia / 신경정신의학

OBJECTS: This study was designed to investigate the characteristics of components of topographic auditory event-related potential P300 in the patients with schizophrenia and to evaluate the correlation between the findings of components of P300 and psychopathology. METHODS: The subjects consisted of 28 patients with schizophrenia and 28 normal controls who were matched by age and sex. The topographic auditory event-related P300 was recorded in oddball paradigm and analyzed by computerized brain mapping system. The latency of P300 was determined by global field power measurement. The psychopathology of the patients with chizophrenia were rated by PANSS. RESULTS: There were significant differences in both latency(schizophrenia 369.5+/-40.6msec, normal controls 332.6+/-34.8msec) and amplitude(schizophrenia: 4.1+/-3.1micro V, normal controls 6.7+/-3.2micro V). However, there was no difference in the electrode location of maximum area of P300 between the patients with schizophrenia and normal controls. The latency of P300 showed positive correlation and the amplitude showed negative correlation with PANSS scores of the patients with schizophrenia. CONCLUSION: The results implicate that the patients with schizoprenia might have mental dysfunction in the aspects of cognise process affected by both positive and negative symptoms.