Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis / 대한치과교정학회지

OBJECTIVE: To date, only a few studies have investigated the relationships between genetic polymorphisms and external apical root resorption (EARR). Hence, the aim of this systematic review was to explore the relationship between different gene polymorphisms and their association with EARR. METHODS: A complete literature search was conducted by two independent reviewers. The PubMed, Science Direct, and Scopus databases were searched. In addition, the bibliographies of all textbooks and relevant articles were searched manually. A meta-analysis was performed using data entered into the electronic databases until February 28, 2017. RESULTS: On the basis of the search, we identified 17 and 7 publications for the systematic review and meta-analysis, respectively. Odds ratio (OR) was used to evaluate the association of the interleukin 1B (+3954) polymorphism and the risk of EARR. The overall OR from the studies was used to estimate the risk of EARR. However, no association was found and no publication bias was apparent for the risk of EARR in patients receiving orthodontic treatment. CONCLUSIONS: More research on the relationship between gene polymorphism and EARR is necessary to determine better specificity of possible interactions.

Ortodontia baseada em evidência científica: incorporando ciência na prática clínica / Scientific evidence-based orthodontics: incorporating science within clinic practice

O objetivo deste artigo é despertar o ortodontista e conscientizá-lo sobre a importância da tomada de decisão baseada em evidência científica no cuidado aos pacientes. Serão descritos os passos essenciais para a prática da Odontologia baseada em evidência (OBE), assim como os princípios da ciência e da pesquisa. Existem caminhos adequados para a busca da informação de qualidade, sendo esses a única garantia de encontrar artigos válidos. Na seleção de artigos científicos, o primeiro passo é definir o seu desenho, pois para cada dúvida clínica há um delineamento adequado capaz de respondê-la. Dessa maneira, questões sobre tratamento, etiologia, diagnóstico, prognóstico ou prevenção só podem ser respondidas por um artigo que tenha sido delineado para tal. O conhecimento da alocação randomizada, do mascaramento e do grupo-controle é fundamental para que possamos realizar uma leitura crítica dos artigos científicos, reconhecendo os que merecem credibilidade. Em meio a tantas publicações, precisamos definir, com segurança, o que deve ser incorporado ao nosso conhecimento e o que deve ser incorporado à prática clínica, mudando a nossa conduta. Desse modo, poderemos oferecer aos nossos pacientes opções terapêuticas mais consistentes e previsíveis.

The aim of this article is to warn the orthodontist about the importance of making decision based on scientific evidence when taking care of the patients. It describes the main steps for the Dentistry practices based in evidence (EBD) as well as the science and research principles. There are adequate ways for the search of quality information. While selecting the scientific articles, the first step would be defining its design, since for each question there is an adequate delineation able to answer it. Questions about treatment, etiology, diagnostic, prognostic or prevention could be answered in the article if it has been delineated for that. Understanding the meaning of randomized allocation, blinding and control group is essential for a critical reading; selecting those articles that deserve credibility. Among so many publications one needs to identify precisely about what must be incorporated to his knowledge as well as to the clinical practices.