RESUMO
Objective: To provide a scientific basis for establishing a standard reference value of FEV1. 0% for aged Chinese males. Methods: The reference values of FEV1. 0% of 4 342 healthy aged Chinese males were collected from hospitals, research units, and higher institutions of 72 counties or cities. Correlation analysis, factor analysis and GIS software were used to investigate the relationship between the reference values of FEV1. 0% with six geographical factors. Results: It was found that the reference values of FEV1. 0% in aged Chinese males were significantly associated with geographical factors. Factor analysis and regression analysis yielded a regression equation as: y = 79.279 8 + 0.000 901 5X1 -0. 001 931 4X2 + 0. 001 966 8X 3 - 0.002 615X4+0.001 293 4X5+0.001 650 3X 6 ±1.032 8. The fitting degree between the predicted and the measured values was high. With the aid of geostatistical analysis module of GIS spatial analysis and Kriging interpolation method, we interpolated the geographical distribution map of the reference value of FEV1. 0% in aged Chinese males. Conclusion: The regression equation can be used to accurately calculate the reference value of FEV1. 0% for aged Chinese males, if the geographical values for an area are available. The reference value of FEV1. 0% can also be obtained by the geography Trend-surface distribution map of an area.
RESUMO
Characteristics of low attenuation area (LAA) of the lungs on HRCT were studied in 132 patients with asthma, and long-term spa therapy on the LAA of the lungs was observed in 5 patients with asthma, whose me an %LAA was more than 30%.<br>1. The morphology of LAA of the lungs on HRCT observed in asthma was different from that in pulmonary emphysema. 2. The LAA of the lungs in asthma was closely related to residual volume (RV). 3. The mean %LAA value significantly decreased from 33.5% before spa therapy to 24.5% at 24 months after beginning of the therapy. CT number also significantly increased after long-term spa therapy. 4. %FEV1.0 value significantly improved from 52.1% before spa therapy to 72.1% at 24 months after spa therapy. The RV value also decreased by spa therapy, however, the decrease was not significant. These results suggest that LAA of the lungs in asthma is associated with hyperinflation, and the LAA of the lungs decreases after long-term spa therapy.
RESUMO
This study was performed to investigate associations between serum alpha(1)-antitrypsin(AAT) concentration and radiological categories of coal workers' pneumoconlosis(CWP), between AAT concentration and pulmonary complications such as tuberculosis and emphysema, and to study associations between AAT concentration and FEV(1.0)% in CWP patients, We classified 254 CWP patients in D Hospital into categories of small opacity profusion. And we selected 86 subjects by with or without emphysematous finding in each categories by proportional stratified sampling method. Semm AAT concentrations were quantkated by single radial immunodiffusion method, and the findings of chest radiographs were evaluated by radilogist. The results were as follows: 1. Serum AAT concentrations were not significantly different among groups of radiological categories of small opacities. 2. Complication of emphysema was associated with smoking habits sigmficantlyl(chi square=12.16, p<0,01). And AAT concentraLion was higher in smokers and ex-smokers than in non-smokers. Serum AAT concentration was significantly higher in the cases with emphysema than in the cdses without emphybema{p<0.01). 3. Serum AAT concentration of the group with active pulmonary tuberculosis was significantly higher than with inactive or without: pulmonary tuberculosis group(p<0.1). 4. Serum AAT concentration of the group with low FEV(1.0)% was significantly higher than with high or normal group(p<0.05).