Marcha de orientación, una vía para mejorar las funciones cognitivas en el adulto mayor

La utilidad de la recreación física con carácter lúdico resulta un medio fundamental para mejorar la salud, las funciones cognitivas y la calidad de vida. A partir de un diagnóstico aplicado a una muestra de 19 adultos mayores, estos presentaron insuficiencias en los procesos de la memoria; en tal sentido, se comprobó que las propuestas de actividades físico-recreativas dirigidas a este grupo etario fueron muy generales, no atendieron las características morfofuncionales y estuvieron limitadas en la variedad de ofertas recreativas. La presente investigación tuvo como objetivo mejorar las funciones cognitivas, que se relacionan con la memorización, en los adultos mayores de la comunidad Matahambre, del municipio Songo la Maya, a través de la marcha de orientación. Se emplearon como métodos teóricos el analítico-sintético e inductivo-deductivo; y empíricos, el análisis documental, la observación, la encuesta y la entrevista que permitieron obtener los datos e informaciones necesarias para la correcta realización de la marcha de orientación al tomar en cuenta las características de este grupo poblacional. La propuesta demostró la marcha de orientación como una importante herramienta que estimuló las capacidades memorísticas y los recuerdos, al tomar en cuenta los gustos, preferencias, necesidades e intereses del adulto mayor, resultarles atractiva y permitirles recordar aspectos o emociones vitales de su vida personal.

A utilidade da recreação física de caráter recreativo é um meio fundamental para melhorar a saúde, as funções cognitivas e a qualidade de vida. A partir de diagnóstico aplicado a uma amostra de 19 idosos, estes apresentavam insuficiências nos processos de memória; Neste sentido, constatou-se que as propostas de atividades físico-recreativas dirigidas a esta faixa etária eram muito generalistas, não tinham em conta as características morfofuncionais e limitavam-se na variedade de ofertas recreativas. O objetivo desta pesquisa foi melhorar as funções cognitivas relacionadas à memorização em idosos da comunidade Matahambre, no município de Songo la Maya, por meio da caminhada de orientação. Os métodos analítico-sintético e indutivo-dedutivo foram utilizados como métodos teóricos; e empírica, análise documental, observação, inquérito e entrevista que permitiram obter os dados e informações necessários à correta implementação da marcha de orientação tendo em conta as características deste grupo populacional. A proposta demonstrou a caminhada de orientação como uma importante ferramenta que estimulou habilidades de memória e lembranças, ao levar em conta os gostos, preferências, necessidades e interesses do idoso, tornando-a atrativa para ele e permitindo-lhe relembrar aspectos vitais ou emoções de sua vida. vida pessoal.

The usefulness of physical recreation with a playful character for this group of people is a fundamental means to improve their health, their cognitive functions and their quality of life. From a diagnosis applied to a sample of 19 older adults, it was possible to know the insufficiencies in memoristic events that these subjects had. In this sense, it was also found that the proposal of physical-recreational activities aimed at this age group in the community are very general and do not take into account their morpho-functional characteristics. They are limited in terms of the variety of recreational offers for this population group. The objective of this research is to improve cognitive functions, which are related to memorization, in older adults of the "Matahambre" community of the Songo la Maya municipality through orientation walking. For the solution of the objective, theoretical methods such as: analytical-synthetic and inductive-deductive were used. Among the empirical methods, documentary analysis, observation, survey and interview were used to obtain the necessary data and information for the correct implementation of the orientation walk, taking into account the characteristics of this population group. The proposal showed that the orientation walk is an important tool that stimulates the memory and memory capacities of these people, by taking into account their tastes, preferences, needs and preferences.

Preparation of Lir@BSA-PMF nanoparticles and verification of their cell functions / 基础医学与临床

Objective To synthesize bovine serum albumin(BSA)-loaded liraqlutide(Lir)-nanoparticles coated with platelet membrane fragments(PMF)using a"bottom-up"nano-engineering chemistry technique,and to evaluate their cyto-compatibility and potential function of anti-oxidative stress.Methods PMF was extracted as reported previously.Lir@BSA nanoparticles were prepared by self-assembly method.PMF was coated on the sur-face of Lir@BSA nanoparticles by co-extrusion to prepare Lir@BSA-PMF.The physical and chemical properties of Lir@BSA-PMF particles were characterized as particle size,Zeta potential,transmission electron microscopy and particle size stability.The encapsulation efficiency,loading efficiency and cumulative release efficiency of liraglu-tide were calculated by enzyme-linked immunosorbent assay.Further,SDS-PAGE was used to analyze whether there was a similar membrane protein distribution of platelet membrane on Lir@BSA-PMF bionicnanocarrier.CCK-8 assay was used to verify the biocompatibility of the materials.Reactive oxygen species(ROS)experi-ment was used to explore the effect of Lir@BSA-PMF on cell oxidative damage.The uptake of cells on Lir@BSA-PMF bionic nano capsules was verified by cell phagocytosis experiment.Results Lir@BSA-PMF nanop-articles had a stable particle size of 25 nm with a spherical morphology,and a Zeta potential value of-25.5 mV.The encapsulation efficiency,loading efficiency and cumulative release efficiency of liraglutide were 85.56％,7.96％and 77.06％,respectively.SDS-PAGE analysis showed that the Lir@BSA-PMF bio-mimetic nano capsules retained the similar membrane protein distribution as platelet membrane.CCK-8 assay verified that the nanomaterials were non-cytotoxic.ROS results showed that Lir@BSA-PMF nanomaterials had obvious antioxidant properties.The results of cell phagocytosis showed that the cells had a good phagocytosis effect on Lir@BSA-PMF nanoparticles.Conclusions The nanoparticles Lir@BSA-PMF are successfully syn-thesized and have no effects on cells viability in vitro.The particles are taken up by cells and show a significant function of antioxidant damage.

Expression and biological function of TRP signaling pathway in hepatocellular carcinoma / 实用医学杂志

In recent years,the morbidity and mortality of hepatocellular carcinoma(HCC)have been increasing worldwide,and the treatment strategies for HCC are still insufficient,which highlights the importance of exploring the pathogenesis and progression of HCC.Transient receptor potential(TRP)pathway is an important non-selective cation pathway,which is closely related to inflammatory response and sensory conduction.At present,a number of studies have shown that TRP pathway is also involved in the occurrence and development of HCC,inducing HCC invasion and migration.However,the overall potential mechanism and possible signal transduction pathways of TRP pathway in HCC remain unclear.Therefore,this article discusses the abnormal expression of TRP pathway in HCC,and reviews the key biological events of TRP pathway involved in the formation and progression of HCC,such as chronic liver inflammation-fibrosis progression,HCC cell proliferation,migration,apoptosis and HCC stem cell generation,and looks forward to its application prospect in HCC treatment.The aim is to better un-derstand the significance of TRP pathway in HCC,help to find new therapeutic targets and effective drugs,and open up a new situation for future clinical treatment.

A meta-analysis of dose-response relationship between executive function and single exercise in children and adolescents / 中国心理卫生杂志

Objective:To examine the dose-response relationship between acute exercise and executive func-tion in children and adolescents.Methods:The experimental studies on the effect of acute exercise on the executive function of children and adolescents in CNKI,Weipu,PubMed,Scopus,Web of Science and EBSCO databases were searched,and meta-analysis was performed by using Review Manager 5.4 software.Results:A total of 14 articles containing 691 participants were included.Single exercise had a significant effect on improving the response of in-hibitory function[SMD=-0.78(-1.35,-0.25),P＜0.01]and accuracy[SMD=0.91(0.27,1.55),P＜0.01],and also had a significant effect on improving the refresh function response[SMD=-1.04(-2.01,-0.07),P＜0.05]and the accuracy[SMD=1.16(0.39,1.93),P＜0.01].The effect of static exercise,30 min and moderate intensity on improving the response of inhibition function in children and adolescents(-5.86,-1.41,-0.76),the effect of inhibition function accuracy(2.98,5.64,1.62)and the effect of refresh function accuracy(6.27,7.39,2.57)was the largest(Ps＜0.05).Conclusion:Single exercise could improve inhibition and refresh function in the executive function in children and adolescents.

Advances in the study of exosomes in ophthalmic applications / 国际眼科杂志(Guoji Yanke Zazhi)

Exosomes are commonly found in blood, urine, saliva, ascites, amniotic fluid and other body fluids, and are involved in intercellular communication, signal transduction, transport of genetic material, maintenance of internal environmental homeostasis and immune regulation, with a wide range of important biological functions. Exosomes transport proteins, lipids, and nucleic acids to target cells and facilitate intercellular communication.As research continues, they have been found to play important roles in physiological and pathological processes, and are important biomarkers for the diagnosis and treatment of diseases. It plays an important role in immunomodulation, inflammatory response, and angiogenesis in many diseases such as cancer, cardiovascular diseases, and brain diseases. More researches suggest that exosomes also play an important role in the development and progression of ophthalmic diseases. In this review, the research history and biological functions of exosomes, as well as their pathogenesis and prospects for the application in ophthalmic diseases, including corneal diseases, glaucoma, ocular trauma, age-related macular degeneration, uveitis and intraocular tumors, were discussed

The bioprotective role of irradiated hibiscus against harmful effects of using repeatedly frying edible oil / O papel bioprotetor do hibisco irradiado contra os efeitos nocivos do uso de óleo comestível para fritar

Abstract Repeatedly frying process of dietary edible oil has a potential role in the generation of free radicals. Therefore, questions have always been raised as to whether, there is an efficient and economical method to reduce the harmful effects of repeated use of frying edible oil. Since hibiscus has been stated to have a wide variety of therapeutic effects, it was important to investigate its properties against harmful effects of free radicals. The current study aspires to find out whether irradiated powder of hibiscus has a protective role against adverse effects of repeated use of frying edible oil. Thirty-five adult male albino rats were equally assigned into five groups. First group"G1" was fed with normal diet as control group, meanwhile, group"G2" the diet mixed with fresh oil, "G3" diet mixed with repeatedly frying oil only, "G4" diet mixed with frying oil treated with hibiscus and "G5" diet mixed with frying oil treated with irradiated hibiscus. Feeding duration was six weeks. Fatty acid analyses of oil as well as peroxide values were determined. Blood and liver samples were collected for biochemical analyses as well as histological study. Repeatedly heated cooked oil has significant increases in peroxide value, acid value, free fatty acid and both conjugated diene and triene compared with repeatedly frying oil treated with hibiscus. Also there are significant increases in cholesterol and triglyceride and impaired in liver functions in "G3"compared with others. In addition, relative to the hibiscus groups, there is a substantial reduction in oxygen consumption in "G3". Both hibiscus as well as irradiated hibiscus attract attention in order to play a vital and economical role against harmful effects of frequent use of frying edible oil on some biological functions but, irradiated hibiscus was more effective.

Resumo O processo de fritura repetida de óleo comestível da dieta tem papel potencial na geração de radicais livres que podem ter efeitos prejudiciais em algumas funções biológicas. Portanto, sempre se questionou se existe uma maneira eficiente e econômica de prevenir ou pelo menos reduzir os efeitos nocivos do uso repetido de óleo comestível para fritar. Como o hibisco tem ampla variedade de efeitos terapêuticos, foi importante investigar suas propriedades como agente antioxidante contra os efeitos nocivos dos radicais livres. O presente estudo pretende descobrir se o pó irradiado de hibisco tem papel protetor contra os efeitos adversos do uso repetido de óleo comestível para fritar. Trinta e cinco ratos albinos machos adultos foram divididos igualmente em cinco grupos. O primeiro grupo "G1" foi alimentado com dieta normal como grupo controle, enquanto o grupo "G2" dieta misturada com óleo fresco, dieta "G3" misturada com óleo de fritura repetida, dieta "G4" misturada com óleo de fritura tratada com hibisco e dieta "G5" misturada com óleo de fritura tratada com hibisco irradiado. A duração da alimentação foi de seis semanas. Foram determinadas as análises de ácidos graxos de óleo, bem como os valores de peróxidos. Amostras de sangue e fígado foram coletadas para análises bioquímicas e estudo histológico. O óleo cozido repetidamente aquecido tem aumentos significativos no valor de peróxido, valor de ácido, ácido graxo livre e dieno e trieno conjugados em comparação com óleo de fritura repetidamente tratado com hibisco. Também há aumentos significativos no colesterol e triglicérides e comprometimento das funções hepáticas no "G3" em comparação com outros. Além disso, em relação aos grupos de hibiscos, há uma redução substancial no consumo de oxigênio no "G3". Tanto o hibisco como o hibisco irradiado chamam atenção por desempenhar papel vital e econômico contra os efeitos nocivos do uso frequente de óleo comestível para fritar em algumas funções biológicas, mas o hibisco irradiado foi mais eficaz.

The bioprotective role of irradiated hibiscus against harmful effects of using repeatedly frying edible oil

Abstract Repeatedly frying process of dietary edible oil has a potential role in the generation of free radicals. Therefore, questions have always been raised as to whether, there is an efficient and economical method to reduce the harmful effects of repeated use of frying edible oil. Since hibiscus has been stated to have a wide variety of therapeutic effects, it was important to investigate its properties against harmful effects of free radicals. The current study aspires to find out whether irradiated powder of hibiscus has a protective role against adverse effects of repeated use of frying edible oil. Thirty-five adult male albino rats were equally assigned into five groups. First groupG1 was fed with normal diet as control group, meanwhile, groupG2 the diet mixed with fresh oil, G3 diet mixed with repeatedly frying oil only, G4 diet mixed with frying oil treated with hibiscus and G5 diet mixed with frying oil treated with irradiated hibiscus. Feeding duration was six weeks. Fatty acid analyses of oil as well as peroxide values were determined. Blood and liver samples were collected for biochemical analyses as well as histological study. Repeatedly heated cooked oil has significant increases in peroxide value, acid value, free fatty acid and both conjugated diene and triene compared with repeatedly frying oil treated with hibiscus. Also there are significant increases in cholesterol and triglyceride and impaired in liver functions in G3compared with others. In addition, relative to the hibiscus groups, there is a substantial reduction in oxygen consumption in G3. Both hibiscus as well as irradiated hibiscus attract attention in order to play a vital and economical role against harmful effects of frequent use of frying edible oil on some biological functions but, irradiated hibiscus was more effective.

Resumo O processo de fritura repetida de óleo comestível da dieta tem papel potencial na geração de radicais livres que podem ter efeitos prejudiciais em algumas funções biológicas. Portanto, sempre se questionou se existe uma maneira eficiente e econômica de prevenir ou pelo menos reduzir os efeitos nocivos do uso repetido de óleo comestível para fritar. Como o hibisco tem ampla variedade de efeitos terapêuticos, foi importante investigar suas propriedades como agente antioxidante contra os efeitos nocivos dos radicais livres. O presente estudo pretende descobrir se o pó irradiado de hibisco tem papel protetor contra os efeitos adversos do uso repetido de óleo comestível para fritar. Trinta e cinco ratos albinos machos adultos foram divididos igualmente em cinco grupos. O primeiro grupo G1 foi alimentado com dieta normal como grupo controle, enquanto o grupo G2 dieta misturada com óleo fresco, dieta G3 misturada com óleo de fritura repetida, dieta G4 misturada com óleo de fritura tratada com hibisco e dieta G5 misturada com óleo de fritura tratada com hibisco irradiado. A duração da alimentação foi de seis semanas. Foram determinadas as análises de ácidos graxos de óleo, bem como os valores de peróxidos. Amostras de sangue e fígado foram coletadas para análises bioquímicas e estudo histológico. O óleo cozido repetidamente aquecido tem aumentos significativos no valor de peróxido, valor de ácido, ácido graxo livre e dieno e trieno conjugados em comparação com óleo de fritura repetidamente tratado com hibisco. Também há aumentos significativos no colesterol e triglicérides e comprometimento das funções hepáticas no G3 em comparação com outros. Além disso, em relação aos grupos de hibiscos, há uma redução substancial no consumo de oxigênio no G3. Tanto o hibisco como o hibisco irradiado chamam atenção por desempenhar papel vital e econômico contra os efeitos nocivos do uso frequente de óleo comestível para fritar em algumas funções biológicas, mas o hibisco irradiado foi mais eficaz.

A Delphi survey-based development and validation of cognitive-communication assessment tool for Indian preschoolers

ABSTRACT Purpose To address the need for a standardized assessment tool for assessing cognitive-communication abilities among Indian preschoolers, the current study aimed at describing a Delphi based development and validation process for developing one such tool. The objectives of the research were to conceptualize and construct the tool, validate its content, and assess its feasibility through pilot testing. Methods The study followed a Delphi approach to develop and validate the tool across four phases i.e. conceptualization; construction; content validation; and pilot testing. The first three phases were performed with a panel of six experts including speech-language pathologists and preschool teachers while the pilot testing was done with 20 typically developing preschoolers. A literature review was also conducted with the Delphi rounds to support the developmental process. Results The first two rounds of the Delphi aided in the construction of a culturally and linguistically suitable story-based cognitive-communication assessment tool with the memory (free recall, recognition, and literary recall) and executive function (reasoning, inhibition, and switching) related tasks relevant for preschoolers. The content validation of the tool was continued with the experts till the revisions were satisfactory and yielded an optimum Content Validity Index. The pilot test of the finalized version confirmed its feasibility and appropriateness to assess developmental changes in the cognitive-communication abilities of preschoolers. Conclusion The study describes the Delphi-based conceptualization, construction, content validation, and feasibility check of a tool to assess cognitive-communication skills in preschool children.

Continuous erector spinae plane block for analgesia and better pulmonary functions in patients with multiple rib fractures: a prospective descriptive study

Abstract Background: The present study explored the role of continuous erector spinae plane (ESP) block for analgesia as well as its impact on pulmonary functions in patients with multiple rib fractures. Methods: Ten patients with multiple rib fractures were enrolled after getting informed and written consent. Ultrasound-guided ESP block was performed at the level midway between the fractured ribs followed by the insertion of the catheter. Pre- and post-block VAS score, hemodynamics, respiratory rate (RR), peripheral oxygen saturation (SpO2), inspiratory capacity (IC), blood gases (PaO2 and PCO2), and complications were compared. Results: Pain scores at rest as well as on movement showed a significant reduction from 5.9 and 7.5 pre block to 1.6 and 2.5 respectively at 96 hours (p < 0.0001). Similarly, RR, SpO2, IC, and PaO2 were significantly better after the block placement (p < 0.001). Conclusion: Continuous ESP block provide adequate analgesia with better respiratory functions in patients with multiple rib fractures.

Executive and attentional functions in patients with migraine / Funções executivas e atencionais em pacientes com enxaqueca

INTRODUCTION: Migraine is a disease that affects the overall performance of the patient, especially attention and executive functions (EF), with a direct impact on the person's functionality, highlighting the importance of studies in order to minimize its damage. OBJECTIVE: The objective of this study was to evaluate if there is a link between migraine and executive and attentional functions. METHODOLOGY: Observational study (44 subjects; 29 migraineurs and 15 non-migraineurs) on attentional and executive functioning changes in migraine. Subjects over 18 years of age were included in the study, regardless of gender, recruited for convenience at CAM FAME, FAME and Centro AMA, primary recruitment centers, following the criteria of the International Classification of Headache Disorders (ICHD-3). The participants underwent neuropsychological tests that estimated executive and attentional functioning. For attention, the Psychological Attention the Assessment Battery (AAB) was used, and for EF, the Five-Digit Test (FDT) was used. Student's t test, ANOVA, Mann-Whitney and/or Kruskal-Wallis U test were used, whose analyzes fixed the type I error at 0.05. RESULTS: All AAB subtests pointed to a reduction in the attentional potential in migraineurs when compared to the control group. The FDT showed lowering in the migraineurs group subjects, when compared with the non- migraineurs group. Multivariate analysis identified a relationship between EF, Attention and migraine (p<0.05). CONCLUSION: migraineurs present a decrease in executive functioning and attentional skills and an increase in execution time when compared to non-migraineurs individuals

INTRODUÇÃO: A enxaqueca é uma doença que afeta o desempenho global do paciente, principalmente a atenção e as funções executivas (FE), com impacto direto na funcionalidade da pessoa, destacando a importância de estudos a fim de minimizar seus danos. OBJETIVO: O objetivo deste estudo foi avaliar se existe ligação entre enxaqueca e funções executivas e atencionais. METODOLOGIA: Estudo observacional (44 indivíduos; 29 com enxaqueca e 15 sem enxaqueca) sobre alterações de atenção e funcionamento executivo na enxaqueca. Foram incluídos no estudo indivíduos maiores de 18 anos, independente do sexo, recrutados por conveniência no CAM FAME, FAME e Centro AMA, centros primários de recrutamento, seguindo os critérios da Classificação Internacional de Cefaleias (ICHD-3). Os participantes foram submetidos a testes neuropsicológicos que estimaram o funcionamento executivo e atencional. Para atenção foi utilizada a Bateria de Avaliação da Atenção Psicológica (AAB) e para FE foi utilizado o Teste de Cinco Dígitos (FDT). Foram utilizados teste t de Student, ANOVA, Mann-Whitney e/ou teste U de Kruskal-Wallis, cujas análises fixaram o erro tipo I em 0,05. RESULTADOS: Todos os subtestes da AAB apontaram redução do potencial atencional em enxaquecosos quando comparados ao grupo controle. O FDT apresentou redução nos indivíduos do grupo com enxaqueca, quando comparado com o grupo sem enxaqueca. A análise multivariada identificou relação entre FE, Atenção e enxaqueca (p<0,05). CONCLUSÃO: enxaquecosos apresentam diminuição do funcionamento executivo e das habilidades de atenção e aumento no tempo de execução quando comparados a indivíduos não enxaquecosos

La Figura del Intérprete en Lengua de Señas Chilena: Estado Actual y Desafíos en el Contexto Escolar / The Figure of the Interpreter in Chilean Sign Language: Current State and Challenges in the School Context

RESUMEN: Los intérpretes en Lengua de Señas Chilena (ILSCh) constituyen un recurso para la inclusión, eliminando barreras de estudiantes sordos que manejan la modalidad visual-gestual para comunicarse. Chile tiene normativa que favorece la participación del ILSCh en distintos ámbitos, y este estudio se centró en los intérpretes en contexto escolar, considerando que existe un desconocimiento de los procesos, implementación, resultados, logros y situación laboral. Las interrogantes del estudio fueron: ¿cuál es el estado actual del ILSCh, las trayectorias formativas, el rol y los desafíos de su quehacer? El objetivo general fue describir la figura del ILSCh y los desafíos que enfrenta en su desempeño laboral en contexto escolar, situados en las regiones Metropolitana y Valparaíso, Chile. El enfoque fue cualitativo, interpretativo, diseño fenomenográfico, descriptivo y transeccional, la muestra intencionada por criterios de 24 intérpretes de nivel escolar. Las técnicas de recogida de información fueron: formulario de identificación, entrevista y grupo focal. Se analizaron las transcripciones con el software Atlas TI. Los resultados muestran la diversidad en la formación, centrada en el vocabulario de la lengua, con mínimas líneas del contexto educativo, desconocimiento del rol, solicitudes de tareas fuera de sus funciones y situaciones laborares sin regulación y diversidad de jefaturas.

ABSTRACT: The interpreters in Chilean Sign Language (ILSCh) constitute a resource for inclusion, eliminating the barriers of deaf students who use the visual-gestural modality to communicate. Chile has regulations that favor the participation of the ILSCh in different áreas, and this study focused on interpreters in the school context, considering that there is a lack of knowledge of the processes, implementation, results, achievements and employment situation. The questions of the study were: What is the current state of the ILSCh, its formative trajectories, its role and the challenges of its work? The general objective was to describe the figure of the ILSCh and the challenges it faces in its work performance in the school context, located in the Metropolitan and Valparaíso regions, Chile. The approach was qualitative, interpretative, phenomenographic, descriptive and transactional design, the sample intentional by criteria of 24 school level interpreters. The information collection techniques were: identification form, interview and focus group. The transcripts were analyzed with the Atlas TI software. The results show the diversity in the training, focused on the vocabulary of the language, with minimal lines of the educational context, lack of knowlegde of the role, requests for tasks outside their functions and work situations without regulation and diversity of leadership.

Terapia de remediación cognitiva en bulimia nerviosa: Un estudio de caso / Cognitive remediation therapy in bulimia nervosa: A case study

Resumen El objetivo de este estudio fue realizar una evaluación preliminar de la terapia de remediación cognitiva (TRE) en una paciente con bulimia nerviosa (BN). Bajo un diseño pre-post-tratamiento, la paciente (20 años de edad e índice de masa corporal [IMC] de 22.41) completó cuatro pruebas neuropsicológicas, tres medidas de síntomas de BN y dos de sintomatología psiquiátrica (depresión y ansiedad). Con base a las puntuaciones pre y post TRE fue calculado el cambio clínico objetivo (CCO). Los principales efectos neuropsicológicos se registraron en: flexibilidad de pensamiento, proceso visocontructivo, coherencia central y planificación (CCO = 0.39-0.99). También se identificaron cambios relevantes en las medidas de sintomatología psiquiátrica y de BN (CCO = 0.53-0.88), no así en el IMC. Este estudio suma evidencias respecto a la utilidad de la CRT en el tratamiento multidisciplinario, ya no solo de la anorexia nerviosa, sino que extiende su aplicabilidad a la BN.

Abstract The aim of this study was to perform a preliminary evaluation of cognitive remediation therapy (CRT) in a patient with bulimia nervosa (BN). The participant was 20 years old with a 22.41kg/m2 body mass index (BMI). Under a pre-post treatment design, the patient was administered four neuropsychological tests, three measures of BN symptoms and two of psychiatric symptomatology (depression and anxiety). Based on the pre and post CRT scores, the objective clinical change (OCC) was calculated. The main neuropsychological effects were observed in cognitive flexibility, visoconstructive processing (memory and central coherence) and working memory (OCC = 0,39-0,99). Relevant changes were also identified in the measures of psychiatric symptomatology and BN (OCC = 0,53-0,88), with no change in BMI. This study adds evidence regarding the usefulness of CRT in the multidisciplinary treatment not only of anorexia nervosa, but also extends its applicability to another eating disorder, BN.

Construcción y validación de un instrumento para evaluar el desempeño pedagógico del tutor de Medicina General Integral

Introducción: Para evaluar resulta imprescindible la construcción de herramientas en función de establecer resultados medibles. Objetivo: Construir y validar un instrumento para evaluar el desempeño profesional pedagógico del tutor de la especialidad de Medicina General Integral. Materiales y métodos: Enfoque mixto, diseño transversal analítico. Métodos: teóricos: análisis y síntesis, inducción-deducción, enfoque sistémico; empíricos: análisis documental, encuesta a tutores y residentes, observación y criterio de expertos; estadísticos: estadística descriptiva (valores absolutos y porcentuales), coeficiente alfa de Cronbach, coeficiente W de Kendall. Procedimientos: parametrización y triangulación metodológica. Fases: revisión bibliográfica, parametrización, análisis de validez de contenido, confiabilidad y aplicabilidad. Resultados: Se elaboró un instrumento con tres dimensiones (cognoscitiva, procedimental y comportamental) y 19 indicadores. Se seleccionaron 15 expertos. Más del 70 % evaluaron los ítems según los criterios de Moriyama en la categoría Mucho. El cálculo del coeficiente W de Kendall sugirió una alta concordancia entre los jueces. El instrumento final contó con 18 ítems. El coeficiente alfa de Cronbach resultó en 0,83 (alta confiabilidad). Con su aplicación se identificaron siete problemas y seis potencialidades, lo cual demostró su validez en la práctica para el diagnóstico. Conclusiones: El instrumento construido evidenció buenas condiciones de validez teórica y práctica, lo cual permitirá direccionar las acciones de superación para los tutores de la especialidad de Medicina General Integral. También puede complementar la evaluación profesoral, al particularizar en el cumplimiento de las funciones del tutor.

Introduction: To evaluate, the construction of tools able to establish measurable results is essential. Objective: To build and validate an instrument to evaluate the professional pedagogical performance of the tutor of the Comprehensive General Medicine specialist. Materials and methods: Mixed approach, cross-sectional, analytical design. Theoretical methods: analysis and synthesis; induction-deduction; systemic approach. Empirical methods: documentary analysis; survey to tutors and residents; observation, and experts' judgment. Statistical methods: descriptive statistics (absolute and percentage value), Cronbach Alpha coefficient; Kendall's W coefficient. Procedures: parametrization and methodological triangulation. Phases: bibliographic review; parametrization; analysis of content validity; reliability, and applicability. Results: An instrument was developed with three dimensions (cognitive, procedural and behavioral) and 19 indicators. 15 experts were chosen. More than 70% evaluated the items according to Moriyama criteria in the category A lot. The calculation of the Kendall's W coefficient suggested a high concordance between judges. The final instrument had 18 items. Cronbach Alpha coefficient resulted in 0.83 (high reliability). With its application, seven problems and six potentialities were identified, which demonstrated its validity in practice for diagnostic. Conclusions: The built document showed good conditions of theoretical and practical validity, which will allow directing the training actions for the tutors in the specialty of Comprehensive General Medicine. It can also complement the professorial evaluation, by particularizing in the fulfillment of the tutor's functions.

Las funciones ejecutivas: su significado y aplicación clínica / Executive functions: meaning and clinical application

Las funciones ejecutivas generalmente se conceptualizan como un conjunto de procesos generales de control de orden superior que trabajan juntos para dirigir y gestionar las funciones cognitivas, emocionales y conductuales, especialmente durante la resolución activa de problemas. Su disfunción es frecuente de ser detectada como comorbilidad de otros trastornos del neurodesarrollo, causa o efecto? La detección precoz de la disfunción ejecutiva y su abordaje terapéutico temprano, mejora el pronóstico global madurativo en el periodo infantojuvenil. Esta sucinta revisión de las funciones ejecutivas intenta resaltar su importancia para el pediatra y su mirada de los trastornos del neurodesarrollo (AU)

Executive functions are typically understood as a set of general higher-order control processes that collectively direct and manage cognitive, emotional, and behavioral functions, especially during active problem solving. Their dysfunction is often detected as a comorbidity of other neurodevelopmental disorders; cause or effect? Early detection of executive dysfunction and a prompt therapeutic approach improves the overall developmental prognosis in childhood and adolescence. This brief review of executive functions aims to highlight their importance for the pediatrician and his/her view of neurodevelopmental disorder (AU)

Perfil Neurocognitivo de una cohorte de menores de edad con vivencias de maltrato infantil / Neuropsychological profile of a cohort of children victims of child abuse

El maltrato infantil (MI) es un problema multidimensional. El estrés crónico producido por dicho fenómeno afecta el desarrollo cerebral de niños, niñas y adolescentes (NNA), incidiendo negativamente en la evolución de diversos aspectos del desarrollo, condicionando su vida futura. El objetivo de este estudio es analizar el desempeño sociocognitivo de NNA que han vivenciado MI, mediante el análisis de las funciones del neurodesarrollo, evaluado con subpruebas de la NEPSY II. Se analizan funciones ejecutivas y percepción social, bases del razonamiento y adaptación social. Se estudia el desempeño de 14 de NNA pertenecientes a un Programa de la Fundación Súmate, cuya Misión es la recuperación de la escolaridad NNA que han visto alterado el curso de su desarrollo por MI. Los resultados dan cuenta de alteraciones cerebrales asociadas al MI, las que se evidencian en un deficitario desarrollo funcional de las variables estudiadas. Existe grave descenso en los procesos y subprocesos del funcionamiento ejecutivo. En relación con la percepción social, la muestra estudiada presenta un mejor desarrollo, el que desciende a medida que aumenta la edad. Las funciones estudiadas tienen directa relación con el razonamiento cognitivo y desarrollo socio adaptativo, bases sobre las que se estructura el desarrollo académico. Los hallazgos, refuerzan la urgencia de abordar esta sensible realidad desde la práctica médica en la atención primaria y especializada. Los resultados también son de utilidad para orientar el desarrollo de políticas públicas que efectivamente contribuyan al progreso de nuestro país.

Abstract. Child maltreatment (MI) is a multidimensional problem. The chronic stress produced by this phenomenon affects the brain development of children and adolescents (NNA), negatively affecting the evolution of various aspects of development, conditioning their future life. The objective of this study is to analyze the sociocognitive performance of children and adolescents who have experienced IM, through the analysis of the performance of neurodevelopmental functions, evaluated through subtests of the NEPSY II. Executive functions and social perception, reasoning bases and social adaptation are studied. The performance of 14 NNA belonging to a Fundación Súmate Program is studied, whose mission is the recovery of NNA schooling that has seen the course of their development altered by IM. The results show brain alterations associated with MI, evidenced in a deficient functional development of the variables studied. There is a serious decline in the processes and threads of executive functioning. In relation to social perception, the studied sample presents a better development, which decreases as age increases. The functions studied are directly related to cognitive reasoning and socio-adaptive development, based on which academic development is structured. The findings reinforce the urgency of addressing this sensitive reality from medical practice in primary and specialized care. The results are also useful to guide the development of public policies that effectively contribute to the progress of our country.

Parental Skills and Academic Competences in School Children: The Mediator Role of Executive Functions

Abstract The role of parenting in the development of children's learning constitutes, at present, part of the discussion in the psychoeducational field. Although parental competences (PC) and executive functions (EF) have been investigated by psychology and neuropsychology, their relationship with academic competences remains to be fully studied. The aim of this investigation was to analyze the effect of PC perceived by parents on behavioral EF and performance-based measures of reading and mathematical competences in children. We worked with 131 school children of both sexes, between 9 and 11 years old, and their respective parents. Multivariate Analysis of Variance (MANOVA) and structural equation model (SEM) were used. The results indicate that parental skills from the parents' perspective have a significant effect on EF, reading, and mathematical skills. However, the best fit model indicates that EFs mediate the relationship between parenting skills and reading and math skills.

Resumen El rol parental en el desarrollo del aprendizaje de los niños constituye, en el presente, una parte de la discusión en el campo psicoeducativo. Aunque las competencias parentales (PC) y las funciones ejecutivas (EF) han sido investigadas por la psicología y la neuropsicología, su relación con las competencias académicas permanece abierta para ser estudiada a profundidad. El objetivo de esta investigación es analizar el efecto de los PC percibidos por los padres en EF comportamentales y las mediciones basadas en el desempeño de las competencias lectoras y matemáticas en niños. Trabajamos con 131 niños y niñas de colegio, entre 9 y 11 años, y sus padres. Se hizo uso del Análisis Multivarial de Variación (MANOVA) y el modelo de ecuación estructural (SEM). Los resultados indican que las habilidades parentales desde la perspectiva de los padres poseen un efecto significativo en las EF, la lectura y las habilidades matemáticas. De forma que los modelos mejor ajustados indican que las EFs median la relación entre las habilidades parentales, lectoras y matemáticas.

Funciones ejecutivas y comprensión lectora en estudiantes de educación primaria en Lima - Perú

Las funciones ejecutivas y la comprensión de lectura son temas poco estudiados desde sus elementos asociativos. En particular, la primera variable, desde la educación primaria, no es tema que haya requerido un nivel amplio de profundización. De esta forma, los estudiantes de educación primaria van adquiriendo diversas estrategias a lo largo de su formación por lo que se espera que en el IV ciclo de EBR puedan emplearlas para el desarrollo de diversas capacidades como las de comprender textos. Esta situación ha determinado que se describa la relación entre dos variables de investigación para tomar acción educativa en este grupo de estudio en particular. El alcance correlacional, dentro de lo cuantitativo. Se aplicaron dos instrumentos: una Escala EFECO y una Evaluación de comprensión lectora ACL-4 aplicados a 110 estudiantes de 4to grado de educación primaria. Se concluyó que no existe relación (p ≥ 0,05) entre estas. Esto es estadísticamente significativo con un p-valor = -0,077. En tal sentido, los estudiantes, si bien reciben el aprendizaje de las estrategias de las funciones ejecutivas como parte del desarrollo de las sesiones del docente, estas no tienen relación con el desarrollo de su competencia lectora debido al poco estímulo que reciben.

Executive functions and reading comprehension correspond to topics little studied from their associative elements. In particular, the first variable, from primary education, is not a subject that has required a broad level of deepening. In this way, primary education students acquire various strategies throughout their training, so it is expected that in the IV cycle of EBR they will be able to use them for the development of various capacities such as understanding texts. This situation has determined that the relationship between two research variables be described in order to take educational action in this particular study group. The correlational scope, within the quantitative, has served so that, with the application of two instruments: an EFECO Scale and an ACL-4 Reading Comprehension Assessment applied to 110 students of 4th grade of primary education. It was concluded that there is no relationship (p ≥ 0.05) between them. This is statistically significant with a p-value = -0.077. In this sense, the students, although they receive the learning of the strategies of the executive functions as part of the development of the teacher's sessions, these are not related to the development of their reading competence due to the little encouragement they receive.

As funções executivas e a compreensão leitora correspondem a temas pouco estudados a partir de seus elementos associativos. Em particular, a primeira variável, desde o ensino primário, não é um tema que tenha exigido um nível de aprofundamento alargado. Desta forma, os alunos do ensino básico adquirem várias estratégias ao longo da sua formação, pelo que se espera que no IV ciclo da EBR consigam utilizá-las para o desenvolvimento de várias capacidades como a compreensão de textos. Essa situação determinou que a relação entre duas variáveis de pesquisa fosse descrita para a realização de ações educativas nesse grupo específico de estudo. O escopo correlacional, dentro do quantitativo, serviu para que, com a aplicação de dois instrumentos: uma Escala EFECO e uma Avaliação da Compreensão de Leitura ACL-4 aplicada a 110 alunos da 4ª série do ensino fundamental. Concluiu-se que não há relação (p ≥ 0,05) entre eles. Isso é estatisticamente significativo com um valor p = -0,077. Nesse sentido, os alunos, embora recebam o aprendizado das estratégias das funções executivas como parte do desenvolvimento das sessões do professor, estas não estão relacionadas ao desenvolvimento de sua competência leitora devido ao pouco incentivo que recebem.

Estandarización de la batería neuropsicológica de funciones ejecutivas y lóbulos frontales BaNFE-2 en muestra paraguaya con esclerosis múltiple tipo recaída remisión

Introducción: la esclerosis múltiple (EM), enfermedad crónica del sistema nervioso (SNC), compromete significativamente la cognición. Su prevalencia en Paraguay es 9,2/100.000 habitantes, 72% con recaída remisión (EMRR) e incidencia de 2-3mujeres/hombre, afecta más a personas en edad productiva, con altos costos económicos y afectivos. Objetivos: caracterizar al paciente con EMRR, evaluar sus funciones ejecutivas (FEs) con BaNFE-2; establecer valores de corte ajustados al país. Metodología: con fundamento en teoría de la neurociencia cognitiva, diseño no experimental, cuantitativo, descriptivo, empírico, retrospectivo y transversal; técnica psicométrica y entrevista neuropsicológica en una muestra por conveniencia de 40 pacientes, 82,5% mujeres y edad 25-55 años (37,78±7,89). Resultados: se reportaron datos demográficos y clínicos, se caracterizaron las escalas de BaNFE-2 cuya consistencia interna resultó significativa. Se obtuvo 52,5% de alteración en la escala prefrontal y 42,5% en FEs; relaciones significativas con escolaridad, discapacidad física (DF), cantidad de brotes y deterioro cognitivo (DC); diferencias significativas por sexo, escolaridad, DF y DC. Se calcularon puntuaciones tipificadas por escolaridad, z<-1 establece el corte entre normalidad y alteración. Conclusión: las pruebas de BaNFE-2 perfilan la afectación del tiempo de ejecución, atención, memoria de trabajo y FEs. Este estudio aporta baremos ajustados al país y abre una novedosa línea de investigación aplicando BaNFE-2 en EM.

Introduction: Multiple sclerosis (MS) is a chronic, neurodegenerative, inflammatory disease of the central nervous system (CNS) that significantly compromises cognitive functions. In Paraguay, it occurs with a prevalence of 9.2/100,000 inhabitants, 72% in the clinical form of relapsing remission (RRMS) and an incidence of 2 to 3 women/men, affecting more people of productive age with high economic and emotional costs. Objectives: To characterize the Paraguayan patient with RRMS, to assess the state of their executive functions (EFs) with the BaNFE-2 battery, and to establish cut-off values adjusted to the country. Methods: Research based on the theory of cognitive neuroscience of non-experimental, quantitative and descriptive design for analytical purposes. It is empirical, retrospective and cross-sectional. The psychometric technique and neuropsychological interview were used in a convenience sample of 40 patients aged 25 to 55 (37.78 ± 7.89) and 82.5% women. Results: Demographic and clinical data of the participants were reported. The BaNFE-2 coded and normalized scales were statistically characterized, the internal consistency of which was significant. 52.5% of the alteration was obtained in the anterior prefrontal scale and 42.5% in FEs; there are significant relationships with schooling, physical disability (PD), number of outbreaks and cognitive impairment (CI); there were also significant differences by sex, education, PD and CI. Standardized scores adjusted for schooling were calculated such that z<-1 establishes the cutoff between normality and abnormality. Conclusion: BaNFE-2 battery tests profile the affectation of execution time, attention, working memory, and FEs. This study provides the adjusted scales for the country and opens a new line of research applying the BaNFE-2 battery in people with MS.

Comentario del caso clínico "Un barril sin fondo" / Clinical case comment "A bottomless barrel" / Commentaire de cas clinique "Un tonneau sans fond" / Comentário de caso clínico "Um barril sem fundo"

Niño de 10 años por el que consultan a causa de mentiras, "actitudes manipuladoras" y trastornos alimenticios, manifestaciones vivenciadas como "inmanejables" por su entorno familiar, a su vez caracterizado por confusión de roles, escasa posibilidad de regulación de lo pulsional y modos de vinculación violentos e ineficaces en cuanto a la puesta de límites. Concebido desde la fantasmática materna para empoderarla frente a su propia madre, él mismo, identificado con lo demoníaco, manifiesta desear que "le cambien las cosas que hace mal". Fue un tratamiento llevado a cabo en el contexto del primer año de pandemia (ASPO) en el que la analista, ofertó un espacio de virtualidad que posibilitó un vínculo transferencial en el cual el niño armó juego, y le fue posible ir abandonando las identificaciones que lo enlazaban a lo demoníaco, para poder comenzar a vivir con deseos propios AU

A 10-year old boy is being consultedfor his lying, "manipulative behaviors," and eating disorders, which are experienced as "unmanageable" by his family environment. His family is characterized by role confusion, a lack of ability to regulate impulses, and violent and ineffective modes ofsetting limits.The boy was conceived from his mother's fantasy to empower her against her own mother. He himself, identified with the demonic, expresses a desire to "change the things he does wrong."The treatment was carried out during the first year of the pandemic (ASPO), in which the analyst offered a virtual space that enabled a transference relationship in which the boy played games and was able to gradually abandon the identifications that linked him to the demonic, in order to begin to live with hisown desires AU

Je reÒ«ois en consultation un enfant de dix ans à cause de ses mensonges, ses "attitudes manipulatrices" et ses troubles alimentaires, des manifestations vécues comme "ingérables" par son entourage, qui se caractérise à la fois par une confusion des rôles, une faible possibilité de régulation de la force pulsionnelle, et des modes violents pour établir des liens et inefficaces pour mettre des límites.ConÒ«u dans la perspective fanstasmatique maternelle pour devenir puissante face à sa propre mère, l'enfant, identifié à ce qui est démoniaque, exprime lui-même son désir qu'"on lui changeles choses qu'il fait mal".Ce traitement a été réalisé dans le contexte de la première année de la pandémie (ASPOI/Isolement social préventif obligatoire), où l'analyste a proposé un espace de virtualité rendant possible un lien tranférentiel, dans lequel l'enfant s'est livré au jeu et a pu abandonner peu à peu les identifications qui le reliaient aux idées démoniaques, pour pouvoir commencer à vivre avec ses désirs à lui AU

Criança de 10 años que é levada à consulta devido a mentiras, "atitudes manipuladoras" e distúrbios alimentares, manifestações vivenciadas como "incontroláveis" por seu ambiente familiar, por sua vez caracterizado por confusão de papéis, escassa possibilidade de regulação do pulsional e modos de vinculação violentos e ineficazes quanto à imposição de límites. Concebido a partir da fantasmática materna para empoderá-la diante de sua própria mãe, ele próprio, identificado com o demoníaco, manifesta desejar que "as coisas que faz mal sejam mudadas". Foi um tratamento realizado no contexto do primeiro ano de pandemia (ASPO) no qual a analista ofereceu um espaço virtual que possibilitou um vínculo transferencial no qual a criança montou um jogo e lhe foi possível ir abandonando as identificações que o ligavam ao demoníaco, para poder começar a viver com desejos próprios AU

THE IMMEDIATE EFFECT OF TRATAKA ON EXECUTIVE FUNCTIONS AMONG ADULTS

Background: There is evidence to suggest that lack of physical activity, a common experience among adults, can negatively impact executive functions such as attention, memory, and decision making. Trataka can improve eye deformity, executive ability, willpower, and relaxation. Trataka may also have a protective effect on the brain, reducing inflammation and the risk of neurodegenerative diseases. The immediate effect of Trataka on executive Aim of the study: Material & methods: function among adults. Forthy healthy Adults to observe the immediate effects of thirty minute trataka regimen for one day. Participants were recruited through convenient sampling and were between the ages of 18-40. The study used a single group pre-post design. After single trataka session Results: showed that 11.59% significant increase (P< 0.05) in total attempted score on DLST. Similarly, there was 11.48% significant increase (P = 0.05). and there was 16.6% increase in (P> 0.05) in wrong attempt scores. After single trataka session it showed that 22.48% significant increase (P< 0.01) in total attempted score on SLCT. Similarly, there was 22.71% significant increase (P = 0.01) in NS. However, there was 70.58% reduction in wrong attempt score which was highly significant (P = 0.001). the available evi Conclusion: dence suggests that the practice of single session trataka has a positive on executive function among adults.