Unusual Histology of Eosinophilic Myenteric Ganglionitis: A Case Report

Eosinophilic myenteric ganglionitis is a disorder characterized by infiltration of the Auerbach myenteric plexus by eosinophils. As a cause of chronic intestinal pseudo-obstruction (CIPO), eosinophilic myenteric ganglionitis has been rarely reported and the majority of the reported cases in the literature were children. We experienced a case of eosinophilic myenteric ganglionitis associated with CIPO in a 53-year-old female patient. Histologic examination of the resected descending colon showed moderate eosinophilic infiltrates with hypogangliosis in the myenteric plexus. Immunohistochemical study revealed increased number of CD4-positive lymphocytes and stronger but scantier glial fibillary acid protein expression in the inflamed myenteric plexus.

Gabapentin Therapy for Acute Sensory Neuronopathy: A case report

Sensory neuronopathy (sensory ganglionitis), believed to be caused by an autoimmune attack against the dorsal root ganglia, has been recently linked with antiganglioside antibodies (anti-GD 1b). We present a case of idiopathic sensory neuronopathy with a positive anti-GD 1b IgG. The patient showed functional improvement with the use of gabapentin and immediately showed a resumption of symptoms when its use was stopped. Currently there is no proven therapy for sensory neuronopathy and the effect of immunosuppressive and intra venous immunoglobulin has been reported with mixed results. Also, there has been no research yet on the use and effect of gabapentin in sensory neuronopathy. This case shows that gabapentin alleviated neuropathic pain and tingling sensation in sensory neuronopathy. The authors believe that gabapentin modulated the voltage dependent calcium channels in the dorsal root ganglion and that this led to overall clinical and functional improvement. The curative or relieving effect of gabapentin in sensory neuronopathy still needs more research in the future.

One Case of Subacute Sensory Ataxic Neuropathy Associated with Primary Sj gren's Syndrome: A case report

Sjogren's syndrome is an important but poorly recognized cause of peripheral neuropathy. Several forms of peripheral nerve dysfunction occur in Sjogren's syndrome, including trigeminal sensory neuropathy, mononeuropathy multiplex, distal sensorimotor polyneuropathy and pure sensory neuropathy. Rarely, chronic relapsing inflammatory polyneuropathy and multiple cranial neuropathies appear. This report described a patient with primary subacute pure sensory ataxic neuropathy associated with primary Sjogren's syndrome, who presented with ataxia and sensory loss of extremities. The possibility of subacute pure sensory ataxic neuropathy associated with Sjogren's syndrome should be considered in patient, especially middle aged women, who develop sensory neuropathy with ataxia and kinesthetic loss.