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Objective To analyze the clinical characteristics of collagenous gastritis (CG) and provide evidence for the precise diagnosis and treatment of CG.Methods Published case reports and case series were collected from PubMed,CNKI,and Wanfang Med Online with the key words of collagenous gastritis,collagenous gastroduodenitis,collagenous gastrointestinal diseases,and gastric mucosal nodules.The demographic and clinical information of each case was collected.Results According to the extent of collagen deposition in the digestive tract,94 CG cases included in this study were assigned into upper digestive tract (UDT)-CG,total digestive tract (TDT)-CG and other groups.The UDT-CG group included 52 cases (57.69% females and 42.31% males) with a median age of 14.50 (11.00,25.75) years old.There were 17 cases in the TDT-CG group,including 70.59% females and 29.41% males,with a median age of 15.00 (9.50,48.50) years old.The other group contained 25 cases,(64.00% females and 36.00% males) with a median age of 25.00 (15.50,59.50) years old.The main clinical manifestations in the UDT-CG group were anemia (59.62%) and diarrhea (17.31%),and those in the TDT-CG group were anemia (29.41%) and diarrhea (94.12%).The nodular appearance of gastric mucosa was observed in 75.00% cases in the UDT-CG group and 35.29% cases in the TDT-CG group.In the initial treatment,symptomatic therapy and hormonal therapy respectively relieved the symptoms in 75.00% (30/40) and 100% (3/3) cases in the UDT-CG group and 57.14% (4/7) and 83.33% (5/6) cases in the TDT-CG group.In the retreatment,symptomatic therapy and hormone therapy respectively achieved the remission rates of 100.00% (3/3) and 88.89% (8/9) in the UDT-CG group and 80.00% (4/5) and 66.67% (2/3) in the TDT-CG group.Conclusions CG,a rare disease of gastric collagen deposition,mainly occurs in young patients,and females are more susceptible than males.The clinical manifestations of CG are nonspecific,and anemia,abdominal pain,diarrhea,weight loss,and gastrointestinal bleeding are the common symptoms of CG.Nodular appearance of gastric mucosa is a relatively specific endoscopic feature of CG.There is no standardized treatment for CG.Symptomatic treatment is commonly adopted to improve the quality of life of the patients,and hormones can be added when necessary.
Assuntos
Masculino , Feminino , Humanos , Qualidade de Vida , Gastrite/diagnóstico , Mucosa Gástrica , Colágeno , Anemia/etiologia , Diarreia/complicaçõesRESUMO
Introducción: El dolor abdominal crónico se presenta en forma frecuente e interfiere en la calidad de vida del niño; conocer su verdadera prevalencia en la consulta, contribuye a mejorar el abordaje diagnóstico y esclarecer la causa orgánica o funcional para indicar tratamiento específico. Objetivo: determinar la prevalencia de dolor abdominal crónico orgánico y funcional en la consulta de gastroenterología. Pacientes y Método: estudio descriptivo, retrospectivo y longitudinal (enero 2014-marzo 2015). Definición de dolor crónico, orgánico y funcional. Criterios de Roma III. Variables: edad, sexo, clínica, laboratorio, ecografía y endoscopia. Resultados: 137 niños con dolor abdominal crónico de un total de 1194 pacientes evaluados, para una prevalencia general en la consulta de 11,45% (IC 99%: 9,10-13,85). Edad promedio 9,8 años (rango 4-19), femenino 56,20% y masculino 43,8%; el grupo más afectado entre 10-15 años. En la identificación de la causa se realizó videogastroscopia al 64,96%, hallazgos anormales en ultrasonido abdominal en 11,67%. El dolor abdominal de origen orgánico se encontró en 92/137(67,15%) para una prevalencia real de 7,71% (IC 99%: 5,72-9,69), las causas: Gastroduodenitis con o sin infección Helicobacter pylori 71/92(77,17%), Enteropatía alérgica 12/92(13,04%), Parasitosis 5/92(5,43%), otras causas 4/92 (4,36%). Origen funcional 45/137(32,85%) con una prevalencia 3,77% (IC99%: 2,32-5,19), siendo el estreñimiento lo más frecuente, 30/45(66,66%), dispepsia 8/45(17,78%) y Síndrome de intestino irritable 7/45(15,56%). Conclusiones: el dolor abdominal crónico tiene una prevalencia importante en la consulta, la causa orgánica fue más frecuente que la funcional, y la utilización de definiciones claras permitió una mejor evaluación del paciente, identificar la causa e indicar el tratamiento específico.
Introduction: Chronic abdominal pain occurs on a frequent basis and interferes with the quality of life of the child; know its true prevalence in the consultation helps to improve the diagnostic approach and clarify the organic or functional cause to indicate specific treatment. Objective: determine the prevalence of organic and functional chronic abdominal pain in gastroenterology consultation. Patients and methods: A descriptive, retrospective and longitudinal study (January 2014-March 2015). Defintion of chronic abdominal pain, organic and functional. Rome III criteria. Variables: age, sex, clinical features, laboratory, ultrasound and upper endoscopy. Results: 137 children with chronic abdominal pain of a total of 1194 patients evaluated, for an overall prevalence in the consultation of 11.45% (99% CI: 9.10 to 13.85). Average age 9.8 years (range 4-19), 56.20% female and 43.8% male; the most affected age group 10-15. Upper endoscopy was performed at 64.96%, an abdominal ultrasound was altered in 11.67%. Abdominal pain of organic origin was found in 92/137 (67.15%) for a real prevalence of 7.71% (99% CI: 5.72 to 9.69), causes: gastroduodenitis with or without Helicobacter pylori infection 71/92 (77.17%), allergic enteropathyn 12/92 (13.04%), parasitosis 5/92 (5.43%), other causes 4/92 (4.36%). Functional abdominal pain 45/137 (32.85%) with a prevalence 3.77% (IC99%: 2.32 to 5.19), the most frequent was constipation, 30/45 (66.66%), dyspepsia 8/45 (17.78%) and irritable bowel syndrome 7/45 (15.56%). Conclusions: chronic abdominal pain is a significant prevalence in the consultation, the organic cause was more common than functional, and use of clear definitions allowed for better patient assessment, identify the cause and indicate the specific treatment.
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Nhi Nhan Hoa Vi is a new formula which established by combining modern medicine and traditional Vietnam’s medicine to treat gastric inflammation and gastro-duodenal ulcer. Pharmacology and biochemistry in mice showed no statistical significance difference in the volume of gastric such in 2 experimental samples and the control.There was a non significant trend of decrease of free acidity and total acidity. The injury and the ulcer decreased considerably. At the dose of hundredfold highher than the therapeutic dose, no toxicity was notified as theoretically. The remedy was safe clinically