Advances in application of induced pluripotent stem cells in childhood genetic diseases / 中国生物制品学杂志

@#Somatic cell reprogramming has developed rapidly in the field of modern biology. Induced pluripotent stem cells(iPSCs)obtained through somatic cell reprogramming are not only capable of self-renewal,but also have multidirectional differentiation potential,which plays an important role in disease modeling and regenerative medicine. This paper reviewed the gene reprogramming technology,the disease models of iPSCs and the application prospects of iPSCs in childhood genetic diseases,so as to provide a reference for the application of iPSCs in the research of mechanism and treatment of various genetic diseases.