RESUMO
Generalized perforating granuloma annulare is a rare variety of granuloma annulare presenting a distinct clinical pattern. We, herein, report a case of generalized perforating granuloma annulare with diabetes mellitus, which developed on a 73 year-old-female who had pruritic generalized small papular lesions with central umbilication, especially on the back and lower extremities for 1 month. Histopathologic examination showed an epidermal perforation and transepidermal elimination of necrobiotic material. The epidermal perforation was communicated with areas of necrobiotic collagen surrounded by palisading granuloma in the dermis.
Assuntos
Colágeno , Derme , Diabetes Mellitus , Granuloma Anular , Granuloma , Extremidade InferiorRESUMO
Generalized perforating granuloma annulare is a rare atypical type of granuloma annulare. It has typical clinicopathological features. We report a case of generalized perforating granuloma annulare in a 31-year-old woman. In our case, erythematous scaly and umbilicated papules were on the whole body, and histopathological finding showed that the transepidermal elimination and the deposition of degenerated collagen in the dermis with palisading granuloma.
Assuntos
Adulto , Feminino , Humanos , Colágeno , Derme , Granuloma Anular , GranulomaRESUMO
Generalized perforating granuloma annulare is a rare variant of granuloma. annulare, which was first described by Duncan et al 1) in 1973. A 21-year-old female had hundreds of 3 to 5mm papules over the whole body, which were mainly distributed in the extremities and trunk since three months ago. Individual papules developed a central umbilication with a peripheral collarette of scale. Histopathologic examination showed an epidermal perforation and transepidermal elimination of necrobiotic material. The epidermal perforation communicated with areas of necrobiotic collagen surrounded by palisading granulorna in the dermis. We treated her with oral prednisolone and dapsone, but there was no clinical improvement.