Diagnóstico e tratamento de granuloma periférico de células gigantes em mandíbula - relato de caso / Diagnosis and treatment of peripheral granuloma of giant cell in the jaw - case report

O granuloma periférico de células gigantes (GPCG) é uma lesão hiperplásica benigna causada por trauma local ou trauma crônico. Origina-se do ligamento periodontal ou mucoperiósteo. O objetivo deste trabalho é apresentar um caso de GPCG em mandíbula tratada com sucesso através de excisão cirúrgica, curetagem e ostectomia periférica.

Peripheral giant cell granuloma (PGCG) is a benign hyperplastic lesion caused by local trauma or chronic trauma. It originates from the periodontal ligament or mucoperiosteum. The objective of this work is to present a case of PGCG in the mandible successfully treated through surgical excision, curettage and peripheral ostectomy.

Granuloma actínico: reporte de un caso / Actinic granuloma: a case report

Resumen El granuloma actínico es una dermatosis granulomatosa poco frecuente, que se observa en adultos de mediana edad con antecedentes de fotoexposición. Su patogénesis no es clara; siendo la teoría más aceptada la radiación solar como factor disparador. Se caracteriza por placas anulares con atrofia central y bordes eritematosos elevados que son similares a los observados en el granuloma anular. Se presenta el caso clínico de una paciente de 71 años, con placas anulares en antebrazos compatibles con granuloma actínico. Se comunica el caso por lo infrecuente de esta entidad y se realiza una revisión bibliográfica.

Abstract Actinic granuloma is a rare granulomatous dermatosis, seen in middle-aged adults with a history of photoexposure. Its pathogenesis is not clear; the most accepted theory being solar radiation as a triggering factor. It is characterized by annular plaques with central atrophy and raised erythematous borders that are similar to those seen in granuloma annulare. The clinical case of a 71-year-old patient with annular plaques on the forearms compatible with actinic granuloma is presented. The case is reported due to the infrequent nature of this entity and a bibliographical review is carried out.

Aggressive Central Giant Cell Granuloma in a Child: A Case Report and Review

Introduction: An aggressive variant of central giant cell granuloma in a paediatric patient is a localized benign osteolytic prolif- eration. The lesion consist of fibrous tissue with haemorrhage, hemosiderin deposits and presence of osteoclast-like giant cells with reactive bone formation. Clinically shown with rapid growth, resorption of roots, displacement of teeth and thinning or perforation of cortical bone, and marked recurrence. Case presentation: A 9-year-old boy reported with a 3 days history of asymptomatic soft tissue swelling in left mandibular pos- terior region which was diagnosed as central giant cell granuloma based on clinical, radiological and histopathological features. Management and Prognosis: Surgical resection was performed without any signs of recurrence on 9 months follow up. Conclusion: Prompt diagnosis and treatment of Central giant cell granuloma can significantly improve morbidity and long- term outcomes.

Aggressive central giant cell granuloma of the mandible: A case report and review of literature

Mandibular aggressive central giant cell granuloma is a rare non-neoplastic giant cell tumour characterised by pain, bone destruction, tooth root resorption, jawbone cortical perforation, and high recurrence rate. This is a case of a 10-year-old boy who presented to the Dental Surgical outpatient clinic of University of Uyo Teaching Hospital with a three-year history of left jaw swelling. The clinical diagnosis was fibrous dysplasia of the left hemi-mandible. Consequently, left hemi-mandibulectomy was performed, and subsequent histopathological diagnosis was aggressive central giant cell granuloma of the mandible. This article presents this rare diagnosis and explores its classification, aetiopathogenesis, clinico-pathological features and management.

Granuloma gigantocelular central: presentación de un caso / Central giant cell granuloma: report of a case

Objetivo: el objetivo de este estudio es describir y presentar el tratamiento para los granulomas gigantocelulares centrales con múltiples recidivas. Caso clínico: paciente femenina de 14 años que presenta granuloma gigantocelular central en maxilar inferior izquierdo, con múltiples recidivas luego del curetaje del mismo. Clínicamente se observa aumento de tamaño, desplazamiento dentario y, radiográficamente, una gran zona radiolúcida compatible con pérdida ósea. Se realizó la resección de la lesión en bloque con margen de seguridad, conservando la basal mandibular con colocación de placa de osteosíntesis de carga soportada. Conclusiones: el granuloma gigantocelular central es una lesión osteolítica, generalmente de crecimiento lento, asintomático y no agresivo. El tratamiento quirúrgico de resección con márgenes de seguridad es fundamental debido a su gran potencial de recidiva (AU)

Granuloma piógeno oral recurrente con pérdida ósea alveolar y movilidad dentaria: Reporte de un caso inusual / Granuloma piogênico oral recorrente com perda óssea alveolar e mobilidade dental: Relato de um caso incomum / Recurrent oral pyogenic granuloma with alveolar bone loss and tooth mobility: report of an unusual case

Resumen El granuloma piógeno oral es una lesión benigna multifactorial, caracterizada por presentarse como un agrandamiento gingival muy vascularizado. Se puede localizar en cualquier área de la cavidad oral, con más frecuencia en la encía marginal vestibular. Se presenta con mayor incidencia en mujeres adultas y en niños varones. No suele comprometer tejido óseo ni dientes y su tratamiento más seguro es la exéresis quirúrgica, siendo el riesgo de recurrencia alto. El objetivo del presente estudio es reportar el caso de una paciente de 9 años de edad, que fue sometida a la exéresis de un granuloma piogénico oral en el hueso maxilar y al año siguiente presentó una recurrencia de la lesión con pérdida ósea alveolar y movilidad de un diente adyacente. Se le realizó una biopsia y un curetaje minucioso, confirmándose el diagnostico de granuloma piogénico oral.

Resumo O granuloma piogênico oral é uma lesão multifatorial benigna, caracterizada por apresentarse como um aumento gengival altamente vascularizado. Pode estar localizado em qualquer área da cavidade oral, mais frequentemente na gengiva marginal vestibular. Ocorre com maior incidência em mulheres adultas e em crianças do sexo masculino. Geralmente não compromete o tecido ósseo ou os dentes e seu tratamento mais seguro é a escisão cirúrgica, sendo alto o risco de recorrência. O objetivo do presente estudo é relatar o caso de uma paciente de 9 anos de idade, submetida a escisão de granuloma piogênico oral no maxilar e no ano seguinte apresentou uma recorrência da lesão com perda óssea alveolar e a mobilidade de umo de seus dentes adjacentes. Uma biópsia e uma curetagem completa foram realizadas, confirmando o diagnóstico de granuloma piogênico oral.

Abstract Oral pyogenic granuloma is a benign multifactorial lesion that appears as a highly vascular gingival enlargement. It can be located anywhere in the oral cavity, most often in the vestibular marginal gingiva. It occurs most frequently in adult women and male children. It does not usually compromise bone tissue or teeth; its safest treatment is surgical excision, with a high recurrence risk. This study aims to report the case of a 9-year-old female patient who underwent oral pyogenic granuloma excision in the maxilla. The following year, she presented a possible lesion recurrence with alveolar bone loss and the mobility of an adjacent tooth. A biopsy and thorough curettage were performed, confirming the diagnosis of oral pyogenic granuloma.

Granuloma periférico de células gigantes asociado a un implante: informe de un caso clínico con seguimiento a 5 años / Implant-associated peripheral giant cell granuloma: a case report with 5-year follow-up

Objetivo: Presentar la respuesta clínica a largo plazo del tratamiento de un granuloma periférico de células gigantes en un implante oseointegrado en el maxilar inferior. Caso clínico: Un paciente de 60 años, de sexo masculino, sin antecedentes sistémicos, concurrió por una lesión con márgenes definidos, de color rojizo morado y consistencia blanda sobre los tejidos blandos en la cara vestibular de un implante colocado en zona de 46. Se realizó la escisión quirúrgica de la lesión, se procesó el tejido extirpado y se envió al laboratorio. El estudio anatomopatológico confirmó el diagnóstico de granuloma periférico de células gigantes. La lesión recidivó dos veces. En la tercera extirpación se realizó la implantoplastía de la superficie del implante. La cicatrización no presentó inconvenientes. Hasta el último control, a los 5 años, no volvió a haber recidiva. Conclusión: En este caso clínico, se logró mantener la salud periimplantaria durante 5 años luego de la eliminación de un granuloma periférico de células gigantes. No obstante, este tuvo que ser removido en tres oportunidades debido a la alta recidiva (AU)

Aim: To evaluate the long-term clinical response to the treatment of a peripheral giant cell granuloma in an osseointegrated implant in the lower jaw. Clinical case: A 60-year-old male patient, with no systemic medical problems, presented a soft tissue lesion located at the buccal aspect of an implant placed in the 46 area. The lesion had defined reddish-purple margins and soft consistency. Surgical excision of the lesion was performed, processed and sent to the laboratory. The histopathology confirmed the diagnosis of peripheral giant cell granuloma. The lesion recurred twice. During the third surgical removal an mplantoplasty of the implant surface was performed. The healing was uneventful and there was no recurrence until the last control at 5 years. Conclusion: In this clinical case, perimplantar gingival health was maintained for 5 years after the surgical removal of a giant cell peripheral granuloma. However, it had to be removed three times, demonstrating a high recurrence (AU)

Incidence of reactive hyperplastic lesions in the oral cavity: a 10 year retrospective study in Santa Catarina, Brazil / Incidência de lesões hiperplásicas reativas na cavidade bucal: estudo retrospectivo de 10 anos em Santa Catarina, Brasil

Abstract Introduction Reactive hyperplastic lesions develop in response to a chronic injury simulating an exuberant tissue repair response. They represent some of the most common oral lesions including inflammatory fibrous hyperplasia, oral pyogenic granuloma, giant cell fibroma, peripheral ossifying fibroma, and peripheral giant cell lesions. Objective The incidence of those lesions was investigated in an oral pathology service, and the clinical characteristics, associated etiological factors, concordance between the clinical and histopathological diagnostic was determined. Methods A total of 2400 patient records were screened from 2006 to 2016. Clinical features were recorded from biopsy reports and patients' files. Results A total of 534 cases of reactive hyperplastic lesions were retrieved and retrospectively studied, representing 22.25% of all diagnoses. The most frequent lesion was inflammatory fibrous hyperplasia (72.09%), followed by oral pyogenic granuloma (11.79%), giant cell fibroma (7.30%), peripheral ossifying fibroma (5.24%), and peripheral giant cell lesions (3.55%). Females were predominantly affected (74.19%), the gingiva and alveolar ridge were the predominant anatomical site (32.89%), and chronic traumatism was presented as the main etiological factor. The age widely ranges from the 1st decade of life to the 7th. Clinically, the reactive hyperplastic lesions consisted of small lesions (0.5-2 cm) and shared a strong likeness in color to the oral mucosa. The concordance between the clinical and histopathological diagnostic was high (82.5%). Conclusion Reactive hyperplastic lesions had a high incidence among oral pathologies. The understanding of their clinical features helps to achieve a clearer clinical and etiological diagnosis, and the knowledge of factors related to their development. This may contribute to adequate treatment and positive prognosis.

Resumo Introdução As lesões hiperplásicas reativas se desenvolvem em resposta a uma lesão crônica que estimula uma resposta acentuada de reparo tecidual. Elas representam uma das lesões orais mais comuns, inclusive hiperplasia fibrosa inflamatória, granuloma piogênico oral, fibroma de células gigantes, fibroma periférico ossificante e lesão periférica de células gigantes. Objetivo A incidência dessas lesões foi investigada em um serviço de patologia bucal e as características clínicas, os fatores etiológicos associados e a concordância entre os diagnósticos clínico e histopatológico foram determinados. Método Foram selecionados 2.400 registros de pacientes entre 2006 e 2016. As características clínicas foram registradas a partir de laudos de biópsia e dos prontuários dos pacientes. Resultados Um total de 534 casos de lesões hiperplásicas reativas foram recuperados e retrospectivamente estudados, representando 22,25% de todos os diagnósticos. A lesão mais frequente foi hiperplasia fibrosa inflamatória (72,09%), seguida por granuloma piogênico oral (11,79%), fibroma de células gigantes, (7,30%), fibroma periférico ossificante (5,24%) e lesão periférica de células gigantes (3,55%). O sexo feminino foi predominante (74,19%), a gengiva e a crista alveolar foram o local anatômico predominante (32,89%) e o traumatismo crônico foi demonstrado como o principal fator etiológico. A idade variou desde a 1ª década de vida até a 7ª. Clinicamente, as LHR consistiram em pequenas lesões (0,5 a 2 cm) que apresentaram uma forte semelhança de cor com a mucosa oral. A concordância entre o diagnóstico clínico e histopatológico foi alta (82,5%). Conclusão As lesões hiperplásicas reativas apresentaram alta incidência entre as patologias bucais. A compreensão das características clínicas ajuda na realização de um diagnóstico clínico e etiológico mais claro, bem como determinar os fatores relacionados ao seu desenvolvimento. Dessa forma contribui para um tratamento adequado e um prognóstico positivo.

Granuloma Piógeno: Reporte de un caso de lesión hiperplásica reactiva con aspecto tumoral / Pyogenic Granuloma: Case report of a reactive hyperplastic lesion with tumor appearance

El granuloma piógeno es una lesión reactiva en respuesta a diferentes factores locales, su etiología es por traumatismo, caries dental, desequilibrio hormonal, higiene oral deficiente, etc. que produce una proliferación inflamatoria del tejido conectivo, localizada frecuentemente en cavidad oral (encías, lengua, paladar duro, labios y piso de boca) y piel. Clínicamente se presenta como una lesión hiperplásica vascularizada con base pediculada o sésil de tamaño variable y crecimiento lento. Histológicamente presenta proliferación de tejido endotelial a una red vascular con signos de inflamación crónica y tejido de granulación. El presente caso clínico tiene como objetivo identificar las características clínicas, imagenológicas e histopatológicas de Granuloma Piógeno con aspecto tumoral en la cavidad oral en un paciente adulto de la Clínica Dental Docente Cayetano Heredia en el año 2017. Las características clínicas e histopatológicas de granuloma permiten un diagnóstico concreto, dado que su diagnóstico diferencial es similar. Como opciones de tratamiento además de exéresis, tenemos el pulsed-dye laser, inyección intralesional de etanol o corticoides, escleroterapia con tetradecil sulfato de sodio y criocirugía. Las hiperplasias reactivas pueden presentar aspecto tumoral que se descarta con el estudio anatomopatológico. El abordaje y tratamiento requiere un diagnóstico clínico e histopatológico adecuado.

Pyogenic granuloma is a reactive lesion in response to different local factors, including traumatism, caries dental, hormonal imbalance or poor oral hygiene, which produces an inflammatory proliferation of connective tissue. Pyogenic granuloma is frequently located in oral cavity (gums, tongue, hard palate, lips, and floor of mouth) and skin. Clinically, it presents as a vascularized hyperplastic lesion with a slow-growing pedicled or sessile base of variable size and slow growth. Histologically, shows proliferation of endothelial tissue to a vascular network with signs of chronic inflammation and granulation tissue. This case report aims to identify the clinical, imaging and histopathological characteristics of Pyogenic Granuloma with tumor appearance in the oral cavity in an adult patient of the Clínica Dental Docente Cayetano Heredia in 2017. Clinical and histopathological characteristics of granuloma allow a specific diagnosis, given that their differential diagnoses are similar. The treatment options for pyogenic granuloma include excision, laser pulsed-dye, intralesional injection of ethanol or corticosteroids, sclerotherapy with sodium tetradecyl sulfate, and cryosurgery. Reactive hyperplasia may present a tumor appearance that is ruled out by anatomopathological study. Choosing the correct approach and treatment requires a proper clinical and histopathological diagnosis.

Assessment of Efficacy of Oral Calcium Carbonate and Intralesional Triamcinolone Injections in the Management of Central Giant Cell Granuloma of Mandible

The common treatment of Central giant cell granuloma is surgery. Recently non-surgical treatments have been described and their benefits may be worthy of consideration. Hence; we assessed the efficacy of oral calcium carbonate and intralesional triamcinolone injections as a viable treatment option in the management of Central giant cell granuloma (CGCG) of mandible. Methods: A total of 20 patients with CGCG were included in the present study. Complete oral intra-oral and extra-oral examination was carried out in all the patients. Radiograph investigation was carried out in all the patients. In all the patients, intralesional infiltration of triamcinolone was done.Approximately eight to ten injections were given in all the patients over a period of two weeks. Assessment of lesion both clinically and radiographically was done at successive follow-ups upto two years. All the results were recorded in Microsoft excel sheet and were analysed by SPSS software. Results: Radiographic resolution of the lesion at 2 year follow-up was seen in 18 patents while clinical resolution of the lesion was seen in 19 patients. Clinical success of the treatment was seen in 95 percent of the cases while radiographic success of the treatment was seen in 90 percent of the cases. Conclusion: Although treatment of CGCG is still controversial, intralesional steroid injections are safer and effective line of treatment of CGCG.

Granuloma gigantocelular de mandíbula en un niño de 6 años de edad: Reporte de un caso / Giant cell granuloma in the jaw in a 6-year-old child: A case report

El granuloma gigantocelular representa un tumor no odontogénico que se localiza por dentro del endostio de los maxilares (central) o en el periostio (periférico). Corresponde al 3-5 % de todas las lesiones benignas de los maxilares. Es más frecuente en niños y adultos jóvenes. Se presenta como un tumor de crecimiento lento y asintomático. Preferentemente, se ubica en la mandíbula, en la región de los incisivos, caninos y premolares. Se informa sobre un paciente de 6 años de edad que, conjuntamente con la extracción del premolar temporario inferior, presentó un tejido granulomatoso de crecimiento lento en la región premolar izquierda. La toma de la biopsia fue demostrativa para granuloma gigantocelular. Se realizó el tratamiento quirúrgico, con buena evolución, sin evidencia de recidiva hasta la actualidad. Es importante el diagnóstico temprano de esta lesión por el alto poder destructivo local que presenta y la derivación oportuna para el tratamiento quirúrgico.

Giant cell granuloma represents a non-odontogenic tumor. It is located inside the endosteum of the jaws (central) or in the periosteum (peripheral). Although it is a benign disease process, it can also be locally destructive. This condition is a slow-growing, asymptomatic lesion that usually affects children and young adults, predominantly females in its peripheral presentation and males in its central presentation. The mandible, the region of the incisors, canines and premolars are more affected. The etiology of the giant cell granuloma still remains to be defined. It has been reported that the origin of this lesion could be triggered by trauma or inflammation and hormonal factors. A 6-year-old patient presents a slow-growing lesion in the tooth extraction's region, two months ago. The treatment is surgical. It is important to have an early diagnosis because of the high local destructive behavior and timely referral because the treatment is surgical.

Constellation of Oral Inflammatory Hyperplastic Lesions: Case Series with Review of Literature

Oral cavity, when subjected to various forms of chronic insults or microtrauma, often results in a hyperplastic lesion, commonly referred to as inflammatory reactive hyperplasia. This category includes various lesions such as peripheral fibroma, peripheral ossifying/cementifying fibroma, pyogenic granuloma, and peripheral giant cell granuloma. They are primarily seen to develop in close proximity to the source of chronic irritant and have a close resemblance in terms of biological behavior and clinical presentation. Histopathologically, they display a common feature of hyperplastic fibrous tissue, but also have some variations like the presence of giant cells or aggregate of calcified mass depending on the histogenesis of the lesion. They were the most common tumor-like lesions to be seen in the oral cavity, familiarity with these lesions are of utmost importance. The present article portrays a series of 5 cases of different clinical forms of reactive hyperplasia with a brief literature review. The current manuscript is presented with an aim to enhance the knowledge about hyperplastic lesions.

Central giant cell granuloma – A case report

Central giant cell granuloma (CGCG) of the jaws is a benign, intraosseous, osteolytic lesion of debatable etiology. CGCG lacks in clinical and radiographical pathognomonic features to distinguish from common lesions occurring in this region. Histopathology still remains the predominant diagnostic modality to identify the disorder. Clinically aggressive lesions and atypical lesions can lead to early damage and may necessitate aggressive therapy to prevent recurrences. A case of an aggressive type of CGCG of the maxilla in a young adult male patient with diagnostic and treatment challenge is presented.

A Case of an Isolated Peripheral Giant Cell Granuloma in the Parotid Gland / 대한두경부종양학회지

Peripheral giant cell granuloma (PGCG) is an benign non-neoplastic lesion most commonly occurring in oral cavity but extraoral PGCG is extremely rare. Recently, we experienced a case of an isolated PGCG in the parotid gland in 59-year-old man. FNAB findings and radiologic findings including CT and US were suggestive of Warthin's tumor. Partial parotidectomy was performed. Pathologic findings showed fibrillar connective tissue stroma with spindled, ovoid, and round histiocytes-like cells mixed with uneven multinuclear giant cells, small capillaries, hemorrhage, hemosiderin-laden macrophages, and necrosis which were consistent with giant cell granuloma. We report a case of an PGCG in parotid with a review of literature.

Granuloma central de células gigantes: caso clínico y tratamiento quirúrgico / Central giant cell granuloma: a clinical case and surgical treatment

Objetivo: Describir y diagnosticar el granuloma central de células gigantes para poder seleccionar el tratamiento indicado, la enucleación, el curetaje o la resección en bloque de la lesión. Caso clínico: El paciente presentaba un granuloma central de células gigantes en el maxilar inferior derecho. Clínicamente, se observaba un aumento de tamaño y desplazamiento dentario, y radiográficamente, una gran zona radiolúcida compatible con pérdida ósea y piezas dentarias incluidas en el tumor. Se realizó la resección de la lesión en bloque con margen de seguridad, conservando la basal mandibular. Conclusión: El granuloma central de células gigantes requiere de un diagnóstico preciso, a fin de llevar a cabo el tratamiento adecuado. Consideramos que el tratamiento quirúrgico es la mejor opción, ya que minimiza el riesgo de recidiva (AU)

Aim: To describe and diagnose the central giant cell granuloma in order to select the indicated treatment, enucleation, curettage or block lesion resection. Case report: The patient presented a central giant cell granuloma in the lower jaw right side. An increase in size and dental displacement and a large radiolucent zone compatible with bone loss and dental pieces included in the tumor were clinically and radiographically detected. Resection of the lesion was performed in a block with safety margin preserving the mandibular basal bone. Conclusion: Central giant-cell granuloma requires an accurate diagnosis in order to perform the appropriate treatment. We consider surgical treatment as the best valid option, minimizing the risk of relapse (AU)

Peripheral giant cell granuloma manifestation in pregnancy

The peripheral giant cell granuloma (PGCG) is a benign oral lesion occurring on the gingiva and alveolar ridge. It is the most common oral lesion and occurs at an average age of 30 years. The upsurge in the levels of estrogen and progesterone in pregnancy leads to a plethora of changes in various parts of human body, including the oral cavity. In the oral cavity, changes are commonly seen on the gingiva. These include pyogenic granuloma, PGCG and also peripheral ossifying fibroma, etc., The etiology of PGCG in our case might be related to hormonal alterations during the gestation period.

Evaluation of the osteopontin in oral peripheral and central giant cell granuloma

Aim: Peripheral giant cell granuloma (PGCG) and central giant cell granuloma (CGCG) of the jaws are benign proliferations of spindle-shaped mesenchymal cells and multinucleated giant cells. Despite the histopathologic similarities, they have markedly different clinical behavior. PGCG shows low recurrence rate whereas CGCG shows a variable clinical behavior ranging from nonaggressive lesions to aggressive lesions characterizing by pain, rapid growth, and high recurrence rate. Therefore, the aim of the study was to compare CGCG with PGCG by immunohistochemistry using Ki-67, osteopontin (OPN), and integrin ?vantibodies. Subjects and Methods: Twenty PGCG and 20 CGCG were selected for immunohistochemical evaluation of OPN, integrin ?v, and Ki-67 in multinucleated giant cells and mononucleated cells of PGCG and CGCG. Results: PGCG showed higher Ki-67 immunoreactivity in mononucleated cells compared to CGCG (P < 0.05). There was no reactivity with Ki-67 in multinucleated giant cells of both groups. Mononucleated cells in CGCGs demonstrated increased OPN and integrin ?vexpressions in comparison with PGCGs (P < 0.05). Conclusions: The clinic behavior of CGCG being more aggressive than PGCG might be explained by the high expression of OPN and integrin ?v. Further studies are necessary to evaluate the other OPN receptors and their role on the biologic behavior of these lesions.

Reactive hyperplastic lesions of the oral cavity: A retrospective survey study and literature review

The reactive lesions are relatively common in the oral cavity because of the frequency with which the tissues are injured. They often result from a known stimulus or injury such as dental plaque, calculus, or foreign material. Aims: The aim of this study was to review the clinicopathologic features of reactive hyperplastic lesions (RHLs) of the oral cavity at MIDSR, Dental College and Hospital, Latur, Maharashtra, and to compare these data with those of previously reported studies. Settings and Design: The patient case files from the Department of Oral and Maxillofacial Pathology from June 2010 to May 2016 were reviewed for cases of RHLs of the oral cavity. Subjects and Methods: Both clinical and histopathological diagnosis of reactive lesions was selected for the study. Data including the type of the lesion, age, gender, and the site involved were collected. Statistical Analysis Used: Descriptive statistics was applied to the data and differences in frequencies among groups were evaluated using SPSS (IBM Corporation) software. Results: A total of 155 histologically diagnosed cases of RHLs were obtained with a prevalence of 11.7%. The data consist of 56 (36.1%) males and 99 (63.9%) females. The most common lesion clinically was traumatic fibroma (36.5%) and histologically fibrous hyperplasia (37.4%). The reactive lesions clinically presented as either sessile (51%) or pedunculated (49%) lesions. Conclusions: The clinical features of reactive hyperplasia among our patients were similar to those reported previously with divergence in some analyzed data. The novelty in our study was the correlation between histopathology and clinical features which were not reported in literature till date.

ЭЛАСТОЛИТИК АВАРГА ЭСТ ЦАГИРАГАН ГРАНУЛЁМ / Шинэ санаа Шинэ нээлт

@#BACKGROUND. Annular elastolytic giant cell granuloma (AEGCG) is a rare skin disease, characterized by loss of elastic tissue due to elastophagocytosis by multinucleated giant cells in the upper part of dermis, which clinically presents as multiple annular plaques with raised erythematous border and central atrophy. We report a first case of AEGCG in dermatology practice in Mongolia. Its clinical and histological features, differential diagnosis and treatment modalities are described and discussed in detail.

Radiation-Induced Giant Cell Granuloma Mimicking Relapsed Hodgkin Lymphoma at FDG-PET/CT / 대한핵의학회잡지

A 22-year-old woman was diagnosed with intermediate risk stage II Hodgkin lymphoma and treated with three cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by involved-field radiation therapy. A complete metabolic remission was achieved after two cycles of ABVD, which was maintained until three years after completion of treatment. Follow-up FDG-PET/CT four years after completion of treatment, however, showed a new FDG-avid (Deauville score of 4) lesion in the right scapula, suggesting relapsed disease. Computer tomography (CT)-guided biopsy of this lesion was performed and subsequent histological examination revealed a radiation-induced giant cell granuloma.