A neglected cause of anaemia: hereditary hemorrhagic telangiectasia

Hereditary hemorrhagic telangiectasia (HHT) or Osler-Weber-Rendu syndrome is an inherited disorder characterized by vascular dysplasiasleading to hemorrhages. If affects approximately 1 in10,000 Caucasian people. The most common presentation is chronic and recurrent epistaxis whereas bleeding from other sites can lead to life-threatening complications.

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction. Lipid mediators orchestrate both the initiation and resolution of inflammation. Switching from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation, though drug candidates exhibiting such features are unknown. Starting from a library of Vietnamese medical plant extracts, we identified isomers of the biflavanoid 8-methylsocotrin-4'-ol from

Method for analyzing the signal of hip joint angles during human walking using Hilbert-Huang transform / 医用生物力学

Objective To propose a method for analyzing the hip joint signals during human walking based on Hilbert-Huang transform (HHT) method and verify its feasibility. Methods First, the hip joint angles of one healthy subject were measured by using the hip joint measuring platform composed of acceleration sensors and gyroscopes. Second, all intrinsic mode functions (IMFs) at different scales, which could be further analyzed and combined, were obtained by applying the ensemble empirical mode decomposition (EEMD) to original signals. Finally, the Hilbert spectrum of original signals were plotted and analyzed. Results The signals representing different motion modes as well as gait characteristics indicated by rotating track of the hip joint were obtained. The Hilbert spectrum could show the intra-wave frequency modulation in the main motion mode and the characteristics of walking frequencies. Conclusions This method can be used in rehabilitation and treatment of patients with gait diseases. By using this method, the characteristic signals of the hip joints at different frequency scales can be effectively decomposed, and the post-processing signals can be filtered and centrally corrected, so as to adaptively analyze gait signals of the patients.

Effects of homoharringtonine (HHT) on expression of caspase-3 protein and mRNA in nasopharyrgeal carcinoma cells CNE-2Z / 中国药理学通报

AIM To investigate the effects of homoharringtonine (HHT) on the expression of caspase-3 pro-tein and mRNA in nasopharyngeal carcinoma cells CNE-2Z. METHODS After CNE-2Z cells were treated with HHT [0(control),0.125,0.25,0.5,1 mg?L -1] for 8 h, the expression of pro-caspase-3 protein was analyzed by Western Blot and the expression of caspase-3 mRNA was detected by semi-quantitative RT-PCR. RESULTS As HHT-concentration increased, the expression of pro-caspase-3 protein decreased significantly (P

Effects of homoharringtonine on inhibition of proliferation and induction of apoptosis of nasopharyngeal carcinoma cells CNE-2Z / 中国药理学通报

AIM To study the effects of homoharringtonine(HHT) on inhibition of proliferation and induction of apoptosis of nasopharyngeal carcinoma cells CNE 2Z. METHODS The inhibitory rates of the proliferation and IC 50 were detected by MTT method. The apoptosis was analyzed by flow cytometry (FCM), agarose gel electrophoresis and Hoechst 33258/PI fluorescence staining. RESULTS After cells were treated with HHT of different concentrations for 24, 48 and 72 h,respectively,the inhibitory rates of the proliferation rised with concentration and time. The IC 50 values of 24, 48 and 72 h were (0 629?0 039), (0 483?0 011) and (0 389?0 027) mg?L -1 , respectively. The difference among IC 50 values was obvious ( P