Medication adherence and health-related quality of life amongst HIV patients receiving care at umuebule cottage hospital, etched, Rivers State

HIV treatment is available, free, and accessible for individuals who are infected. The study is aimed at determining the levels of medication adherence and health related quality of life (HRQOL) among HIV patients receiving care at Umuebule Cottage Hospital, Etche, Rivers State.Method: This cross-sectional study recruited 430 adult clients who have been on ART for at least one year using a convenient sampling method. An average of 10 patients visits the facility on clinic days. After explaining the purpose of study and obtaining consent,patients who met the eligibility criteria were recruited on each clinic day for a period of 12 weeks, until the sample size was reached. Data was collected using semi-structured interviewer administered validated questionnaire; Morisky Medication Adherence Questionnaire (MMAS-8) and WHO-Quality of Life-BREF(WHOQOL-BREF), after a pilot study on 30 PLHIV from Okomoko general hospital, Etche. Data was analyzed with IBM-SPSS Version 25. The mean age of respondents was 35.9±10.9 years, 59.3% of the respondents' last viral load was suppressed, 19.1% had low level viremia, while (21.6%) were virally unsuppressed. Medication adherence levels were observed to be good (67.7%), poor (32.3%) respectively, while HRQOL of respondents were found to be poor (56.9%) and good (43.1%).Conclusion:A significant proportion of the respondents adhere to their medication whereas most of them had poor HRQOL. There is need for hospital management to collaborate with social welfare organizations to support PLHIV to set up means of earning to enable them to provide their basic needs for improved HRQOL

Drug use pattern and quality of life in patients with migraine at a tertiary care hospital in India: An observational study

Background: Migraine is a debilitating neurological disorder. As a leading cause of disability worldwide, it affects health-related quality of life (HRQoL). There are limited studies assessing the prescription pattern and improvement in HRQoL post-treatment. Aims and Objectives: This study aims to evaluate the drug use pattern and compare the effects of medications on HRQoL as per Migraine Disability Assessment Score (MIDAS). Materials and Methods: A prospective observational cross-sectional study was conducted on migraine patients attending neurology OPD at a tertiary care hospital. One hundred and seven patients were recruited by periodic sampling over 6 months. Prescription indicators assessed were number of antimigraine drugs per prescription, frequency of prescribed drugs, prescriptions by generic name, etc. Data were analyzed using descriptive statistics. The HRQoL was assessed after 3 months of medications by telephonic questionnaire. The change was analyzed by Wilcoxon matched pair signed-rank test. Results: Majority patients were in the third (40.2%) and fourth decade (32.7%) with a female preponderance (72.9%). Nonsteroidal anti-inflammatory drugs were commonly prescribed for aborting acute attacks with naproxen (24.1%) followed by diclofenac (2.71%). Prophylactically topiramate (27.51%), amitriptyline (18.6%), and propranolol (3.1%) were prescribed. About 36.43% of drugs were prescribed by generic names. Improvement in HRQoL was reflected by a significantly reduced MIDAS (13.95 ± 5.20 to 11.39 ± 5.07 [P < 0.05]). Conclusion: In our study, there was low generic prescribing. Naproxen was most prescribed for acute migraine and topiramate for prophylaxis. The HRQoL significantly improved after 3 months of antimigraine medications causing lesser disease burden.

Effect of lifestyle intervention holistic approach on blood glucose levels, health-related quality of life and medical treatment cost in type 2 diabetes mellitus patients

Type 2 Diabetes Mellitus (T2DM) is a costly, lifestyle-related disorder, its management is very critical and challenging hence lifestyle intervention may a cornerstone in the reversal and management of T2DM. This study designed to assess the impact of lifestyle intervention holistic (LIH) Model on blood glucose levels (BGL), Health-Related Quality of Life (HRQOL), and medical treatment cost in T2DM patients. This prospective, quasi-experimental study was conducted among 224 T2DM patients in Delhi Diabetes Research Center (DDRC), New Delhi. The study participants were allocated into two groups-Lifestyle Intervention Counseling (LIC) group received lifestyle-based counseling through the LIH model while the Usual-care group received only standard treatment. Study outcomes were assessed at baseline, 3rd, 6th, and 12th month and data were analyzed through SPSS. Study results revealed that LIC participants had decreased in fasting blood glucose 0.26 mg dL-1(-4.37 to 4.89), blood glucose postprandial -70.16 mg dL-1(-85.15 to -55.16), HbA1C -2.82% (-5.26 to -0.37), medicine cost (p < 0.004), hospitalization cost (p < 0.011), and cost of surgery (p < 0.0005). A significant improvement also observed in HRQOL and adherence towards a holistic model in LIC group. The study concludes that lifestyle-based counseling and its adherence was cost-effective and significantly improves BGL, HRQoL, and medical treatment in T2DM patients.

Health-Related Quality of Life among University Healthcare Academics

Introduction: Having a good health-related quality of life (HRQoL) is important to ensure good job performance. However, it is subjective and it cannot be measured easily. This study aimed to evaluate HRQoL among universityhealthcare academics in public andprivate universities.Method:In this study,a stratified random sampling approach was employed. The strata were created based on departments in the universities. Arandom sample from each stratum was taken in a number proportional to the stratum's size when compared to the overall target population. A validated questionnaire comprising two sections was administered online to collect the data. Descriptive and inferential statistical analysis (Mann-Whitney U test and Kruskal Wallis H test) were applied using SPSS version 22.Results: Out of all the total 130 respondents, 57 (43.8%) were from a private university and the other 73 (56.2%) were from a public university. There were 61 (46.9%) male respondents and 69 (53.1%) female respondents. HRQoL according to the studied domains of the DUKE health profile was associated with various demographic and socioeconomic variables such as type of institution, department/faculty, age, gender, number of children,and years of experience.Conclusion:The demographic and socioeconomic variables were strongly associated with the HRQoL among university healthcare academics.

Health-related Quality of Life among Community Pharmacists

Introduction:The role of community pharmacists (CPs) has kept on changing. Due to the evolving role of CPs, it is important to know its impact on the health-related quality of life (HRQoL) among CPs. Besides, the literature on the HRQoL of CPs is not being enriched, there is an urge to carry out a study to evaluate the HRQoL among CPs. This study aimed to examine the association between the socio-demographic factors and the HRQoLamongCPs. Methodology: A set of questions related to the HRQoL has been adopted from a pre-validated questionnaire, the Duke Health Profile and contextualized it to measure study outcomes. The target population in this study was the registered CPs that were practicing. The site of the study included all the chain and independent pharmacies. Statistical Package for Social Science (SPSS)version 22.0 was used to analyze the data and the significance level was set at p≤0.05. Variousdomains of the Duke Health Profile (DHP) were calculated using the provided formula Results: A total of 172 respondents were included in this study. Several HRQoL domains were significantly associated with socio-demographic factors. The univariate analysis illustrated that mental and general healthstatehad significant associations with age, practice setting was significantly associated with the mental health state, the salary was significantly associated with self-esteem and mental health was significantly associated with length of service and practice setting. Dysfunction dimensions of anxiety, anxiety-depression, and pain were significantly associated withgender. Conclusion: Gender, age, length of service, salary and practice setting were the risk factors for HRQoL among CPs

Evaluation of differences in health-related quality of life in patients receiving conventional versus newer anti-epileptic drugs

Background: Epilepsy is associated with stigma and bad health-related quality of life (HR-QOL) due to this, and side effects of the drug therapy. Newer anti-epileptics are claimed to be better than the conventional. We evaluated this based on comparison of HR-QOL in patients taking the respective therapy.Methods: An observational, cross-sectional, single point study involved 127 consenting patients from Neurology OPD at V.S. General Hospital. Quality of life in epilepsy-10 (QOLIE-10) questionnaire was used to measure HR-QOL in patients. SPSS software and Graphpad prism were used to analyze the variables.Results: Patients of 20-30 age group were commonly affected (37.80%) with a male predominance (56.69%). 41.73% were unemployed. The difference in HR-QOL between patients and controls in all three domains (epilepsy effects, mental effects, role function domains) of QOLIE-10 was significant (p=0.0002), indicating better HR-QOL in controls. The worst HR-QOL scores were found in Epilepsy effects domain. Metabolic adverse effects (38.58%) were the common ADRs. Sodium valproate was the most effective in controlling seizures (last seizure episode: 15 months). HR-QOL correlation between patients receiving monotherapy and polytherapy was significant (p=0.026) with monotherapy rendering a better HR-QOL. Comparison of HR-QOL between patients taking the conventional and the newer drugs was not significant (p=0.1768).Conclusions: Our study nullifies the claims that newer drugs are better than the conventional since no such benefit was seen in HR-QOL as well as ADRs. Our findings ruled out the belief that cases of epilepsy are better controlled with polytherapy.

Comparative Study to Evaluate Efficacy, Safety and Quality of Life of Metoprolol and Telmisartan versus Metoprolol and Ramipril in Patients of Hypertension

Background: Hypertension(HTN) is a major cardiovascular disease and is a major worldwide clinical problem. The prevalence of hypertension increases in urban and rural areas. The treatment of hypertension began in the 1960s with oral diuretics. The other modalities of treatment of hypertension are beta – blockers, calcium-channel blockers, alphareceptors blockers, ACE inhibitors and ARBs. The better compliance occurs with single-pill combination, and may be even double or even triple pill combination therapy should be used. Also quality of life was improved better with Metoprolol and Telmisartan as compared with Metoprolol and Ramipril. Quality of life was assessed by SF -36 Quiestionnare. Objective: To compare the effect of Metoprolol and Telmisartan versus Metoprolol and Ramipril on BP and quality of life in patients of hypertension. Material and Methods: In this prospective, open, randomized, parallel group, comparative study, 80 patients of hypertension attending the Cardiology Outpatient Department, Govt. Medical College & Rajindra Hospital, Patiala were recruited. This randomized comparative study was done on 80 patients for 4 months. Quality of Life: In my project of Quality of life, I had taken total 80 patients and the patients were divided into two groups and 40 patients each of Metoprolol and Ramipril versus Metoprolol and Telmisartan. To assess quality of life questionnaire SF-36 was administered to the patients. Results: There was a marked decrease in SBP and DBP with the use of Metoprolol and Telmisartan than Metoprolol and Ramipril. There was also no change in demographic parameters. There was significant improvement in the quality of life with Metoprolol and Telmisartan. Conclusion: Metoprolol and Telmisartan was a better choice than Metoprolol and Ramipril in treating hypertension as this combination causes more reduction in BP and little effect on HR.

Assessment of Quality of Life in Asthmatic Patients on Inhaled Corticosteroids: An Observational Study

Introduction: Corticosteroids play a pivotal role in thetreatment of the asthma. They rapidly reduce the numberof eosinophils in the blood and tissues and inhibit theirdegranulation, suggesting that sputum eosinophilia could be agood predictor of response to inhaled corticosteroids. Chronicdiseases like asthma have significant effects on patients'health-related quality of life (HRQoL). HRQoL measuresadditional indices as compared to objective measurements likespirometry. Objective: To assess and compare disease-specificquality of life in asthma patients using St. George's RespiratoryQuestionnaire (SGRQ) receiving inhaled corticosteroids.Material and Methods: Patients were enquired for theirduration of illness, other co morbidities (if present), historyof smoking and familial history of the illness. Pattern ofasthma was duly assessed. For Health-related Quality oflife assessment, Saint George’s Respiratory Questionnaire(SGRQ) was used in the study after obtaining due permissionfrom the concerned authority at St George’s, University ofLondon.Results: Mean age of the study population was found tobe 36.17 ± 18.77 years. Mean duration of illness for theasthmatics was 10.19 ± 11.08 years. Majority i.e. 69% deniedof having any familial history of asthma, while 31% confirmedhaving the same. Smoking status was enquired among thestudy subjects, which revealed that 85% were non-smokers,while 9% were past smokers and 6% were current smokers.Pattern of asthma was found to be seasonal for 65% patientswhile perennial for 35% patients. Baseline symptoms scorewas 61.45± 15.78, which was reduced to 48.19±18.73 after 3months on inhaled corticosteroids therapy. Baseline activityscore was 49.67± 15.34, which was reduced to 41.51±18.52after 3 months on inhaled corticosteroids therapy. Baselineimpact score was 48.79± 16.85, which was reduced to38.69±18.14 after 3 months on inhaled corticosteroids therapy.Conclusion: There was evidence for an early QoLimprovement on inhaled corticosteroids in moderate andsevere persistent asthma.

Health-related quality of life of elderly with chronic obstructive pulmonary disease from selected government institutions

@# Introduction: It is widely recognised that health-related quality of life (HRQOL) is impaired in chronic obstructive pulmonary disease (COPD) patients. Most previous studies were conducted among the younger adult population and there is limited information on the elderly population. This study aimed to determine the COPD assessment test (CAT) score in the elderly with COPD. Methods: This was a crosssectional study involving 140 elderly patients who had been diagnosed with COPD at two selected government institutions. Data on socio-demographic and health status were collected by interviewing patients and reviewing their medical records. The HRQOL was measured using CAT. The independence sample t-test and one-way ANOVA were conducted to compare the CAT scores with socio-demographic and health status. Results: The socio-demographic and health characteristics of the patients were as follows: majority (54%) were aged 60-70 years, male (97%), Malay (59%), married (75%), ex-smokers (72%), had attained primary education (48%), had co-morbidities (54%), no history of hospitalisation or visits to the emergency department due to COPD (57%), and were in moderate stage of airflow obstruction (53%). The mean of CAT score was 21.87±6.85 and the majority of the patients were classified as having worst symptoms of COPD (93%) as they had high CAT score which was ≥ 10. Conclusion: Majority of the patients in this study had high scores of CAT, which indicated poor HRQOL. Ex-smokers had higher scores compared to non-smokers. More attention need to be given to these subgroups in order to increase their quality of life.

Effectiveness of reminiscence therapy on health related quality of life among the old age people residing at a selected old age home, Bengaluru, India

Background and Objectives: The well being of oneself, happiness with one’s situation in life and ability to perform and control the different situation of life is HRQoL. Reminiscence therapy is a way for residents of assistant living facilities to become better acquainted with one another and strengthen the personal value and self esteem. The objective of this study was to assess the HRQoL while application of Reminiscence Therapy among the old age people who are residing at a selected old age home in Bengaluru, India. Materials and Methods: For this study quasi experimental research design was selected and convenient sampling technique was used to collect data from 60 samples staying at old age home by using the SF-36 scale. The samples in experimental group receive 10 sessions of reminiscence therapy each session last for 45 minutes to 1 hour. The experimental group was divided into 6 groups each group having five members for group discussion related to the topics like childhood memories, education pattern, first job and first salary, marriage, first child etc. Post test data was collected after a week of implementation of Reminiscence Therapy. Then the data was analyzed and interpreted. Results: The findings of the study with regard to pretest HRQoL reveals that 86.7% has poor HRQoL, 13.3 % moderate HRQoL and no one was having good HRQoL in experimental group. In control group 56.7% has poor HRQoL, 43.3% moderate HRQoL and no one was having good HRQoL. But in posttest, only in experimental group there was significant improvement in HRQoL as 83.3% has good HRQoL, 13.3% moderate HRQoL and 3% poor HRQoL.  Conclusion: This study concluded that with significant improvement in the SF-36 Scale score after administration of the reminiscence therapy and seen improvement in HRQoL.

Assessment of health-related quality of life (HRQoL) in patients with spasmodic dysphonia

Background: There is paucity of literature regarding health related quality of life in Spasmodic Dysphonia (SD) especially from India. This study assessed HRQoL in it’s global and disease specific aspect by previously validated instruments in patients with SD.Methods: The study was performed in AIIMS, New Delhi. Subjects with SD as well as age and gender matched healthy controls were enrolled from Movement Disorder and botulinum toxin clinic, Department of Neurology, AIIMS, New Delhi. Uneducated patient, those could not read questionnaires & cases who had received botulinum toxin within 6 months were excluded from the study. Each patient filled SF-36, BDI, VoiSS-30 and VPQ questionnaire.Results: 14 pts of Spasmodic Dysphonia (SD) were enrolled. Compared with controls SD patients suffered from statistically significant impaired global health related quality of life (SF36) in areas of role physical (p = 0.007), general health (p = 0.004), social functioning (p = 0.024), role emotion (p = 0.008) and mental health (p=0.039). Patients with SD scored much worse in BDI scale than their control group (12.57±8.0 vs. 4.71±5.0, p=0.005). 65% pt of SD had depression out of whom 14% had moderate depression. SD patient group showed statistically significant impaired scores in disease-specific QOL (VoISS) in 2 out of 3 subscales, impairment (p= <0.001) and emotional (p=<.001) but not in physical (p=0.44). Voice quality of patients with SD was severely affected compared to controls (mean 37± 8.0 vs. 12.9± 1.5).Conclusions: This study clearly demonstrated that patients with SD suffered from significant impairment in HRQoL as compared to controls. Higher proportion of patients with SD suffered from mild to moderate depression compared to their control.

Comparision of Health Behaviors, Diabetes Mellitus(DM) Management and Health-related Quality of Life(HRQoL) between DM Groups with and without Diabetic Education Experience / 農村醫學 地域保健

PURPOSE: This study was to compare health behaviors, DM management and HRQoL among Diabetic patients according to education experience. METHODS: Data were obtained from Community health Survey(CHS) of 2015. The participants were 22,937 diabetic patients who had education experience or not. Data were analyzed on complex sample anaysis using SPSS 24 program. RESULTS: The education experience group showed higher percentages of health behaviors and DM Management and higher HRQoL. The significant negative factors influencing HRQoL were Bed ridden experience, higher subjective stress, depression expereince, age, low education and positive factors were good subjective health status, walking, mod-exercise, drinking, employment, spouse, good subjective happiness. CONCLUSION: These results show that education experience is a way to help diabetic patients' health behavior, DM management, HRQoL.

Health Related Quality of Life, Disability, and Pain in Alpha Mannosidosis: Long-Term Data of Enzyme Replacement Therapy With Velmanase Alfa (Human Recombinant Alpha Mannosidase)

Abstract Alpha-mannosidosis, a rare lysosomal storage disorder caused by deficiency of the lysosomal enzyme alpha-mannosidase, results in accumulation of mannose-rich glycoproteins in the tissues and sequelae leading to intellectual disability, ataxia, impaired hearing and speech, recurrent infections, skeletal abnormalities, muscular pain, and weakness. This study aimed to investigate disability, pain, and overall health using the Childhood Health Assessment Questionnaire (CHAQ) and the EuroQol 5 Dimension-5 Level Questionnaire (EQ-5D-5L) in patients with alpha-mannosidosis participating in rhLAMAN-10, a phase III open-label, clinical trial of velmanase alfa, a recombinanthumanlysosomalalpha-mannosidase. Long-termprognosesformost patients withuntreatedalpha-mannosidosisarepoor due to progressive neuromuscular, skeletal, and intellectual deterioration, leading to increased dependence in mobility and activities of daily living and increased caregiver and health-care burden. Long-term CHAQ and EQ-5D-5L data highlight improvement trends in health-related quality of life and a reduction in disability and pain in patients receiving up to 48 months of velmanase alfa treatment.

Health-related quality of life and disability in patients with acute unilateral peripheral vestibular disorders / Qualidade de vida relacionada à saúde e incapacidade em pacientes com distúrbios vestibulares periféricos unilaterais agudos

Abstract Introduction: Health-related quality of life is used to denote that portion of the quality of life that is influenced by the person's health. Objectives: To compare the health-related quality of life of individuals with vestibular disorders of peripheral origin by analyzing functional, emotional and physical disabilities before and after vestibular treatment. Methods: A prospective, non randomized case-controlled study was conduced in the ENT Department, between January 2015 and December 2015. All patients were submitted to customize a 36 item of health survey on quality of life, short form 36 health survey questionnaire (SF-36) and the Dizziness Handicap Inventory for assessing the disability. Individuals were diagnosed with acute unilateral vestibular peripheral disorders classified in 5 groups: vestibular neuritis, Ménière Disease, Benign Paroxysmal Positional Vertigo, cochlear-vestibular dysfunction (other than Ménière Disease), or other type of acute peripheral vertigo (as vestibular migraine). Results: There was a statistical significant difference for each parameter of Dizziness Handicap Inventory score (the emotional, functional and physical) between the baseline and one month both in men and women, but with any statistical significant difference between 7 days and 14 days. It was found a statistical significant difference for all eight parameters of SF-36 score between the baseline and one month later both in men and women; the exception was the men mental health perception. The correlation between the Dizziness Handicap Inventory and the SF-36 scores according to diagnostics type pointed out that the Spearman's correlation coefficient was moderate correlated with the total scores of these instruments. Conclusion: The Dizziness Handicap Inventory and the SF-36 are useful, proved practical and valid instruments for assessing the impact of dizziness on the quality of life of patients with unilateral peripheral vestibular disorders.

Resumo Introdução: Qualidade de vida relacionada à saúde é usada para designar a parte da qualidade de vida que é influenciada pela saúde do indivíduo. Objetivos: Comparar a qualidade de vida relacionada à saúde de indivíduos com distúrbios vestibulares de origem periférica, analisar incapacidades funcionais, emocionais e físicas antes e após o tratamento vestibular. Método: Um estudo de caso-controle prospectivo, não randomizado, foi conduzido no Departamento de Otorrinolaringologia, entre janeiro de 2015 e dezembro de 2015. Todos os pacientes foram submetidos a uma pesquisa de saúde personalizada de 36 itens sobre qualidade de vida, ao formulário abreviado de avaliação de saúde 36 (SF-36) e ao Dizziness Handicap Inventory para avaliar a incapacidade. Os indivíduos foram diagnosticados com distúrbios vestibulares periféricos unilaterais agudos, classificados em cinco grupos: neurite vestibular, doença de Ménière, vertigem posicional paroxística benigna, disfunção cócleo-vestibular (exceto Doença de Ménière) ou outro tipo de vertigem periférica aguda (como enxaqueca vestibular). Resultados: Houve uma diferença estatisticamente significante para cada parâmetro de escore no Dizziness Handicap Inventory (emocional, funcional e físico) entre a avaliação basal e depois de um mês, tanto em homens quanto em mulheres, mas sem diferença estatística significativa entre sete dias e 14 dias. Foi encontrada uma diferença estatisticamente significante para todos os oito parâmetros do escore no SF-36 entre a avaliação basal e um mês mais tarde, tanto em homens quanto em mulheres; a exceção foi a percepção de saúde mental nos homens. A correlação entre Dizziness Handicap Inventory e o SF-36 de acordo com o tipo de diagnóstico mostrou que o coeficiente de correlação de Spearman foi moderado quando correlacionado com o escore total desses instrumentos. Conclusão: O Dizziness Handicap Inventory e o SF-36 demonstraram ser instrumentos úteis, práticos e válidos para avaliar o impacto da tontura na qualidade de vida de pacientes com distúrbios vestibulares periféricos unilaterais.

Estrés, afrontamiento y calidad de vida relacionada a la salud en mujeres con cáncer de mama

Este estudio examina la contribución que tienen el estrés traumático, el estrés percibido y el afrontamiento sobre los componentes físico y mental de la CVRS de 53 mujeres diagnosticadas con cáncer de mama. Los instrumentos utilizados fueron el cuestionario de salud SF-36, el inventario de estimación del afrontamiento COPE, la escala de estrés percibido EEP y la adaptación peruana de la escala de estrés traumático. Se encontraron niveles promedio y altos de CVRS. La condición de migración, el tipo de tratamiento y el estrés traumático explican el 30% de la variabilidad del componente físico; mientras que, el estrés traumático, el estrés percibido y el estilo orientado a la emoción, explican el 43% de la variabilidad del componente mental.

This study analyzes the contribution that traumatic stress, perceived stress, and coping have on the variability of physical and metal components of the HRQoL of 53 women with breast cancer. The instruments used include the SF36 health survey, the COPE Inventory, the Perceived Stress Scale PSS and the Peruvian adaptation of the traumatic stress scale. The analysis found medium and high levels of global HRQoL. The migration status, type of treatment and traumatic stress account for 30 % of the variability of the physical component of HRQoL, whereas traumatic stress, perceived stress and emotional oriented style account the 43% of the variability of the mental component.

The Association Between The Use Of Complementary And Alternative Medicine (Cam) With Health-Related Quality Of Life (Hrqol) And Anthropometric Indices Among University’s Staff

@#Complementary Alternative Medicine (CAM) is broadly used as an adjunct treatment for patients to treat various kinds of disease, prevent disease and to sustain and enhance quality of life of the users. The study is aimed to investigate the association between CAM uses, Health-Related Quality of Life (HRQoL) and anthropometric indices among workers or staffs in Universiti Sultan Zainal Abidin (UniSZA) Gong Badak Campus, Kuala Terengganu. A total of 300 subjects participated in this study and completed the malay version of modified HRQol (SF-12) questionnaires. Anthropometric measurements among the subjects were done. Independent t-test, One-way ANOVA and Pearson correlation were used to test the association and the hypotheses. The prevalence of CAM users was 37.3%. The results showed that bodily pain score domain was significantly higher among non-CAM users. Overall, male had higher Mental Health Composite Score (MCS) score than female. Physical Health Composite Score (PCS) was only correlated negatively with BMI among non-CAM users but negative correlated with body fat percentage in both CAM and non-CAM users. As conclusion, HRQoL had significant negative correlation with body fat percentage among CAM users. No association was found between CAM use and HRQoL scores.

The evaluation of health-related quality of life for prostate cancer patients receiving androgen deprivation therapy / 中华泌尿外科杂志

Objective To evaluate the health-related quality of life (HRQOL) for prostate cancer patients receiving androgen deprivation therapy (ADT).Methods We studied 200 patients with prostate cancer who were treated with primary ADT in Peking University People's Hospital from June 2014 to June 2015.The patients'average age was 73.9 years.The mean PSA level was 21.57 ng/ml when they were diagnosed with prostate cancer.Of these 200 patients,79％ (158/200) were localized and seclected ADT therapy due to age,body condition,basic diseases or individual will.21％ (42/200) were locally advanced or metastasic,which accord with the indication of ADT therapy.The scales,including the MOS item short from health survey (SF-36),Functional Assessment of Cancer Therapy-General module (FACT-G),Functional Assessment of Cancer Therapy-Prostate instrument (FACT-P),Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) were used to evaluate their HRQOL.Results According to results of SF36,the physical health component score and mental health component score was 67.41 ± 16.39 and 64.81 ± 17.51,respectively.They indicated that the overall quality of life of these patients was at an acceptable level.And the average score of all domains exceeded 60 except general health domain,which the score was only 40.03 ± 21.89.When it comes to FACT-P,the sum score,emotional well-being score and prostate cancer component score were 8.15 ± 3.72,12.30 ± 4.04 and 77.41 ± 9.95,respectively,which were less than half of their respective top score.However the physical well-being score was 20.41 ±4.29,which was a relatively satisfactory value.In addition,61％ (121/200) patient selected not at all in item I am able to have and keep an erection.The score of SDS and SAS was 46.76 ± 8.29 and 43.25 ±9.69,respectively.And there were 23.0％ (46/200) and 21.5％ (43/200) patiens exhibited depression and anxiety,respectively.Conclusion In the present study,the prostate cancer patients receiving ADT showed acceptable HRQOL,but some patients sufferd from depression,anxiety and erectile dysfunction.

The Association Between The Use Of Complementary And Alternative Medicine (Cam) With Health-Related Quality Of Life (Hrqol) And Anthropometric Indices Among University’s Staff

Complementary Alternative Medicine (CAM) is broadly used as an adjunct treatment for patients to treat various kinds of disease, prevent disease and to sustain and enhance quality of life of the users. The study is aimed to investigate the association between CAM uses, Health-Related Quality of Life (HRQoL) and anthropometric indices among workers or staffs in Universiti Sultan Zainal Abidin (UniSZA) Gong Badak Campus, Kuala Terengganu. A total of 300 subjects participated in this study and completed the malay version of modified HRQol (SF-12) questionnaires. Anthropometric measurements among the subjects were done. Independent t-test, One-way ANOVA and Pearson correlation were used to test the association and the hypotheses. The prevalence of CAM users was 37.3%. The results showed that bodily pain score domain was significantly higher among non-CAM users. Overall, male had higher Mental Health Composite Score (MCS) score than female. Physical Health Composite Score (PCS) was only correlated negatively with BMI among non-CAM users but negative correlated with body fat percentage in both CAM and non-CAM users. As conclusion, HRQoL had significant negative correlation with body fat percentage among CAM users. No association was found between CAM use and HRQoL scores.

Validación por modelo de Rasch del Cuestionario de Calidad de Vida (PedsQL 4. 0®) en niños y adolescentes colombianos / Rasch Model in the Validation of the Paediatric Quality of Life Inventory TM 4. 0 (PedsQL 4.0TM) in Colombian Children and Adolescents

Introducción: La escala PedsQL 4.0® se ha probado confiable y sensible a los cambios en el estado de salud, y es de rápida y fácil aplicación. El propósito de este estudio es validar la PedsQL 4.0®a partir de la aplicación del modelo de Rasch en niños y adolescentes colombianos de ambos sexos. Métodos: Se llevó a cabo un estudio observacional de validación de instrumentos de medición. Se realizó un muestreo no probabilístico por conveniencia, conformado por 375 sujetos de 5 a 18 años de edad y 500 cuidadores de menores de 2 a 18 años en cinco ciudades colombianas. Las propiedades psicométricas de la escala se analizaron según el modelo de Rasch, entre ellas el ajuste, la separación y el funcionamiento diferencial del ítem. Resultados: Se encontró un adecuado ajuste de los datos al modelo de Rasch. La dimensión social presentó mayor dificultad que la dimensión de salud física en las dos versiones. Se observó consistencia interna de los ítems, mientras que para las personas, los valores de confiabilidad y separación estuvieron por debajo de lo establecido. El funcionamiento diferencial del ítem ocurrió en unas pocas variables, en especial, al comparar por ciudad. Las curvas características de los ítems presentaron umbrales desordenados. Conclusiones: Los ítems presentaron una consistencia adecuada; el análisis por personas no mostró una separación adecuada; sin embargo, se encontraron umbrales desordenados en las categorías de respuesta. No se presentó funcionamiento diferencial del ítem por sexo o por enfermedad, pero llama la atención que el sí ocurriera entre ciudades.

Introduction: The aim of this study was to validate the PedsQL 4.0TM in Colombian children and adolescents using the Rasch model. The Paediatric Quality of Life Inventory (PedsQL 4.0TM) has demonstrated to be a reliable and sensitive measurement to changes in health status, as well as being quick and easy to use. Methods: Validation study of measurement tools. The PedsQL 4.0TMwas applied to a convenience sample of 375 children and adolescents between 5 and 17 years old and 500 caregivers of children between 2 and 18 years old in five Colombian cities. The psychometric properties were analysed according to the Rasch model, including adjustment, separation, and differential item functioning (DIF). Results: The Rasch model provided adequate fits to data. The social dimension, for both versions, had greater difficulty than the physical health dimension. Internal consistency for the items was observed, while for individuals, the values of reliability and separation were lower than that established. The DIF occurred in very few variables, especially when comparing cities. The characteristic curves for the items presented disordered thresholds. Conclusions: The items had adequate internal consistency. Analysis showed adequate individual separation, but disordered thresholds were found in the response categories. No DIF was observed by sex or disease, but it is noteworthy that the DIF occurred between cities

Quality of Life in Critically Ill Patients: A Systematic Review.

Objective: This paper aims to present a comprehensive literature review of Quality of Life (QOL) in patients who are suffering from serious medical illness as evidenced by receiving treatment in the intensive care setting. By examining the instruments used to measure QOL, as well as the factors that influence it, this review will explore the relevance of QOL to patient care and management. Data Sources: From Medline and other online resources, over 467 articles were identified, of which 73 articles were selected for inclusion in this review by three independent reviewers. The reviewers reached a consensus using pre-defined selection criteria. Study Selection Criteria: Articles had to: 1) be written in English or have an available published English translation, 2) be published in a peer-reviewed journal, 3) study adult humans, 4) focus on serious medical illnesses, such as sepsis and MI (myocardial infarction), rather than focusing exclusively on terminal illnesses (any study design was accepted), and 5) use at least one QOL measure. Data Extraction: The study selection process yielded 73 articles. Research methodology and key findings were derived from the full text and tables of the selected studies. Data Synthesis: QOL is very poor in gravely ill medical patients and continues to decline with further deterioration of medical status. A model that incorporates QOL and the severity of the medical illness, in addition to the patient’s wishes, might have the potential to improve overall QOL for patients and their families and guide end-of-life decisions. Conclusions: A formal assessment of the patient's QOL and final wishes could assist the patient, their loved ones, and the treating physician in making critical decisions about how to improve QOL through comfort/palliative care.