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1.
Annals of Dermatology ; : 250-253, 2014.
Artigo em Inglês | WPRIM | ID: wpr-42010

RESUMO

Congenital self-healing reticulohistiocytosis (CSHRH) is a rare, cutaneous, self-limited form of Langerhans cell histiocytosis. Whereas multiple lesions are common, a solitary lesion is rare. A 14-day-old neonate presented with a solitary, 5-mm, oval, reddish, and eroded papule with crust on the left thigh that had existed since birth. No systemic involvement was found. Histopathology revealed dense infiltration of large histiocytes with scattered eosinophils and lymphocytes in the dermis. Immunohistochemistry showed S-100 and CD1a positivity. Two months later, the skin lesion involuted spontaneously, without evidence of recurrence and extracutaneous involvement. On the basis of the characteristic clinical course and typical histopathological findings, a diagnosis of solitary CSHRH was made.


Assuntos
Humanos , Recém-Nascido , Citocromo P-450 CYP1A1 , Derme , Diagnóstico , Eosinófilos , Histiócitos , Histiocitose , Histiocitose de Células de Langerhans , Imuno-Histoquímica , Linfócitos , Parto , Recidiva , Pele , Coxa da Perna
2.
Int. j. morphol ; 31(3): 1137-1145, set. 2013. ilus
Artigo em Espanhol | LILACS | ID: lil-695013

RESUMO

La Histiocitosis de células de Langerhans (HCL) corresponde a una proliferación anormal de células dendríticas, de tipo clonal, cuyo espectro clínico general incluye compromiso de la piel y las mucosas, las uñas, el hueso, la médula ósea, el hígado, el bazo, linfonodos, el pulmón, el tracto gastrointestinal inferior, el sistema endocrino y el sistema nervioso central. En este trabajo presentamos tres casos de la enfermedad, con manifestaciones orales y craneofaciales, analizadas desde el punto de vista clínico (examen extra e intra oral), imagenológico (tomografías computadas) e histopatológico (expresión de marcador específico CD1a). Dos casos fueron clasificados como HCL de presentación aguda diseminada y uno como presentación crónica. Los pacientes fueron tratados oportunamente con quimioterapia según el protocolo del Programa Infantil Nacional de Drogas Antineoplásicas.


The Langerhans cell histiocytosis (LCH) corresponds to an abnormal proliferation of dendritic cells, clonal type, which usually involves compromise of skin and mucous membranes, nails, bone, bone marrow, liver, spleen, lymph nodes, lung, lower gastrointestinal tract, endocrine system and the central nervous system. We present three cases of the disease, with oral and craniofacial manifestations, analyzed from the clinical perspective (intra and extra oral exam), imaging (CT scans) and histopathological (specific marker CD1a expression). Two cases were classified as acute disseminated LCH presentation and one as a chronic disease. Patients were treated with chemotherapy timely according to the protocol of the National Child Program of Antineoplastic Drugs.


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Doenças Ósseas/patologia , Doenças da Boca/patologia , Histiocitose de Células de Langerhans/patologia , Protocolos Clínicos , Face/patologia , Crânio/patologia , Doenças Ósseas/diagnóstico , Doenças Ósseas/tratamento farmacológico , Doenças da Boca/diagnóstico , Doenças da Boca/tratamento farmacológico , Histiocitose de Células de Langerhans/tratamento farmacológico , Imuno-Histoquímica , Tomografia Computadorizada por Raios X
3.
Indian J Pathol Microbiol ; 2009 Jul-Sept; 52(3): 374-376
Artigo em Inglês | IMSEAR | ID: sea-141485

RESUMO

A two-month-old female child presented with discrete skin-colored papules on the forehead and scalp. She was earlier diagnosed to have neuroblastoma of the adrenal gland which had metastasized to the liver. Histological sections of the skin lesion showed a nodule composed of sheets of cells with abundant eosinophilic cytoplasm and an occasional grooving of the nucleus. These cells were CD 68 positive. Eosinophilic abscesses were seen in between the neoplastic cells.

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