RESUMO
The basic pathological change of diabetic macroangiopathy is atherosclerosis， and the metabolism legacy effect of hyperglycemia will cause continuous damage to the large vessels. Oxidative stress is a common mechanism for diabetes and its chronic complications and it is also the basis of the metabolism legacy effect which keeps damaging the large vessels. Anti-oxidant therapy can delay the course of diabetic macroangiopathy. According to the theory of traditional Chinese medicine （TCM）， the pathogenicity of hidden pathogen is concealing， lingering， and refractory. On the basis of the syndrome and treatment of collateral diseases， vessel-collateral theory， and hidden pathogen theory of TCM， the pathological changes of diabetic macroangiopathy are summarized as pathogen concealment-accumulation of sugar and lipids leading to phlegm and blood stasis-accumulation of toxins-damage to vessels and collaterals-hardening vessels. The core pathogenesis is the hidden pathogen damaging the collaterals， and the basic pathological change is vessel hardening. The toxins of sugar， lipid， phlegm， and stasis are the pathological products and the key to be treated. According to this theory， the medicinal materials with the functions of activating blood to dredging collaterals， resolving phlegm to clearing collaterals， Promoting qi to unblocking collaterals and removing toxins to shunting collaterals can be selected for prescription. These medicinal materials can inhibit the generation of reactive oxygen species， affect the oxidase activity， and enhance the antioxidant capacity， thereby regulating the oxidative stress response， protecting the vascular endothelial function， reducing the damage of the large blood vessels， and slowing down the progression of the disease. Such therapy is of great significance in clinical practice and research， providing a new idea for the prevention and treatment of diabetic macroangiopathy.
RESUMO
Tic disorder (TD) is a common neuro-developmental disorders in children during school age. The cause is complex and it can be induced or aggravated by varies of factors such as genetics, exogenous pathogens, and emotions. TD affects children's self-cognition, academic level, and social function, and causes parents to have unhealthy psychological states such as anxiety and depression, and affects family harmony. Therefore, clinical attention should not only be paid to the treatment of this disease, but also to prevention and nursing care. Incubative evil theory is one of the important theories of Traditional Chinese Medicine. This theory can help to treat and prevent diseases. Incubative evil is characterized by no symptoms with spontaneous attack by latent pathogen, but symptoms appearance induced by the pathogen. The pathological process of TD is similar to incubative evil characteristics. This paper discusses the prevention and nursing care of children's tic disorder based on the theory of incubative evil.
RESUMO
Hidden-pathogen theory is always a leading theory of febrile disease etiology from the proposal until the Ming Dynasty and it plays a critical guiding role on development and maturity of febrile disease theory. However, along with the change of times and drift of disease spectrum, this theory is facing unprecedented challenges. The gradually in-creased clinical experiences and facts have been difficult to be explained and induced using the already existed hidden-pathogen theory. Since hidden-pathogen theory has its own theoretical status and value, which cannot be lightly given up, the question of how to develop this theory in order to better reveal the pathogenesis in the guidance of diagnosis and treatment has become the focus of attention. This paper tried to proposeemotional hidden-pathogenas an example to provide a possible paradigm to develop hidden-pathogen theory and systematically expound main ideas and reasoning processes of emotional hidden-pathogen doctrine and to explore its theoretical significance and application value.