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Objective • To explore the common clinical features of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-infected local patients in Shanghai and their related influencing factors. Methods • A total of 320 patients admitted to Shanghai Public Health Clinical Center from January to March 2020 and diagnosed as having coronavirus disease 2019(COVID-19) were selected. Clinical data of the patients were collected to analyze their characteristics. Using the statistical operation formula of R language, the correlation analysis of hospitalization days, days of increased hypersensitive C-reactive protein concentration (allergic days), days of lung CT improvement (CT days), and days required for nucleic acid turning negative with the main clinical manifestations and laboratory data was carried out. The correlation factors affecting the above four variables were analyzed. Results • Among the 320 patients, the proportions of mild type, moderate type, serious type and critical type were 6.25%, 83.44%, 6.88% and 3.44%, respectively; 91.25% of them had a history of exposure to Hubei. The proportions of fever, cough, sputum and fatigue were 79.06%, 46.56%, 21.56% and 15.31%, respectively. Spearman correlation analysis showed that the concentrations of lactate dehydrogenase, interleukin-2(IL-2) and IL-6 were positively correlated with the above four variables, respectively (all P<0.05), albumin concentration was negatively correlated with allergic days (P=0.018), and CD4+ cell count was negatively correlated with CT days and days required for nucleic acid turning negative (both P<0.05). Stepwise multiple linear regression analysis showed that procalcitonin (PCT) concentration was negatively correlated with hospitalization days, CT days and allergic days (both P<0.05), and disease type was positively correlated with hospitalization days, allergic days, CT days and days required for nucleic acid turning negative (all P<0.05). Conclusion • Moderate type is common in the local patients in Shanghai; fever, cough and fatigue are common symptoms, and most of the patients are accompanied by lung CT abnormalities. The therapeutic effect and prognosis of these patients are closely related to disease type, concentrations of PCT and IL-6, as well as CD4+ cell count.
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Objective To investigate the influence of postoperative infection on average hospitalization days and medical costs in patients with nervous system tumor.Methods The tumor patients treated in neurosurgery ward from July 1,2015 to June 30,2017 were included in the study.The patients with and without postoperative infections were divided into a case group and a control group,respectively (1:1 ratio),matched by admission time (± 3 months),age (± 5 years) and surgical site.Average hospitalization days and medical costs between the two groups were analyzed.Results The incidence of postoperative infection was 5.66％,the surgical site infection and lower respiratory tract infection accounted for 54.72％ and 31.32％ of the total,respectively.The median of hospitalization days in the case group was 20.5,8.5 days longer than that in the control group (Z=-10.618,P＜0.001).The median of total medical costs in the case group was 91 573.42 yuan,higher than that of the control group by 30 518.17 yuan (Z=-9.988,P＜0.001).The average costs of surgical and lower respiratory tract infection were 84 888.50 yuan and 110 442.64 yuan,respectively.Among them,surgical site infection or lower respiratory tract infection caused the extra cost of 23 627.49 yuan (Z=-6.627,P＜0.001) and 43 631.36 yuan (Z=-4.954,P＜0.001),respectively.Conclusions Postoperative infection greatly increased the patient's financial burden,prolonged the hospitalization duration and resulted in unnecessary use of health resources.It is necessary to pay close attention to postoperative infection.
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Objective To investigate the influence of postoperative infection on average hospitalization days and medical costs in patients with nervous system tumor.Methods The tumor patients treated in neurosurgery ward from July 1,2015 to June 30,2017 were included in the study.The patients with and without postoperative infections were divided into a case group and a control group,respectively (1:1 ratio),matched by admission time (± 3 months),age (± 5 years) and surgical site.Average hospitalization days and medical costs between the two groups were analyzed.Results The incidence of postoperative infection was 5.66％,the surgical site infection and lower respiratory tract infection accounted for 54.72％ and 31.32％ of the total,respectively.The median of hospitalization days in the case group was 20.5,8.5 days longer than that in the control group (Z=-10.618,P＜0.001).The median of total medical costs in the case group was 91 573.42 yuan,higher than that of the control group by 30 518.17 yuan (Z=-9.988,P＜0.001).The average costs of surgical and lower respiratory tract infection were 84 888.50 yuan and 110 442.64 yuan,respectively.Among them,surgical site infection or lower respiratory tract infection caused the extra cost of 23 627.49 yuan (Z=-6.627,P＜0.001) and 43 631.36 yuan (Z=-4.954,P＜0.001),respectively.Conclusions Postoperative infection greatly increased the patient's financial burden,prolonged the hospitalization duration and resulted in unnecessary use of health resources.It is necessary to pay close attention to postoperative infection.