Effects of tigacycline-based combination therapy onprocalcitonin, high sensitivity C-reactive protein and interleukin-6 in patients with multiple drug-resistant acinetobacterbaumannii post-operative abdominal infection in intensive care unit / 中国医师进修杂志

Objective:To explore the effects of tigacycline-based combination therapy on procalcitonin (PCT), high sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in patients with multiple drug-resistant acinetobacterbaumannii post-operative abdominal infection in intensive care unit (ICU).Methods:Seventy-five patients with multiple drug-resistant acinetobacter baumannii post-operative abdominal infection in ICU admitted to West Central Hospital of Hainan Prorvincefrom October 2015 to October 2018 were selected and divided into the control group (37cases) and the observation group (38 cases) according to random number table method. The control group was treated with cefoperazone-sulbactam on the basis of routine treatment, while the observation group was treated with tegacycline on the basis of the control group. Both groups were treated for 1 week. The clearance of acinetobacterbaumannii and clinical efficacy of the two groups were counted; the levels of serum PCT, hs-CRP and IL-6 and ummune function were compared.Results:The clearance rate of acinetobacterbaumannii in the observation group was significantly higher than that in the control group: 76.32%(29/38) vs. 54.05%(20/37), χ2 = 4.10, P = 0.043. Compared with before treatment, the levels of serum PCT, hs-CRP and IL-6 in the two groups were decreased after 1 week of treatment, and the levels of serum PCT, hs-CRP and IL-6 in the observation group were lower than those in the control group ( P<0.05). Compared with before treatment, the levels of peripheral blood CD 3+, CD 4+, CD 4+/CD 8+ were increased and peripheral blood CD 8+ was decreased in both groups, and the levels of peripheral blood CD 3+, CD 4+, CD 4+/CD 8+ in the observation group were higher than those in the control group ( P<0.05), while the level of peripheral blood CD 8+ in the observation group was lower than that in the control group ( P<0.05). The total effective rate in the observation group was significantly higher than that in the control group: 89.47% (34/38) vs. 67.57% (25/37), χ2 = 4.13, P<0.05. Conclusions:Tigacycline combined with cefoperazone-sulbactam in the treatment of intra-abdominal infection after surgery of acinetobacterbaumannii in ICU could reduce the levels of serum PCT, hs-CRP, IL-6, reduce the body′s inflammatory response and improve the immune function, and improve the treatment efficiency of intra-abdominal infection.

Effect of Salvia Salvianolic Acid on Cardiac Function and Hypersensitive C Reactive Protein in Patients with Acute Myocardial Infarction / 现代医院

Objective To investigate the effect of Salvia miltiorrhiza on cardiac function and hypersensitive C reactive protein in patients with acute myocardial infarction. Methods The clinical data of 80 patients with myocardial infarction admitted to our hospital from October 2016 to December 2017 were randomly selected and analyzed. They were randomly divided into control group (40 cases) and experimental group (40 cases). The control group was treated with standardized treatment. The experimental group was given salvianolic acid on this basis. Cardiac function improvement, hypersensitivity C reactive protein (hs-CRP), serum cardiac troponin I (cTnI), creatine kinase isoenzyme (CKMB) and total effective rate of two groups were compared. Results The treatment group of patients with heart function improved significantly better than the control group, the two groups have statistical significance compared to patients in the treatment group (P＜0. 05); high sensitivity C reactive protein score and serum cardiac troponin I and creatine kinase were significantly better than the control group, with statistically significant differences between data (P＜0. 05). After treatment, the total effective rate of the treatment group was 92. 50％, while that of the control group was 80％. The treatment group was significantly higher than the control group, and the data comparison was statistically significant (P＜0. 05). Conclusion Salvia salvianolic acid salt can significantly improve the cardiac function and hypersensitivity C reaction protein in patients with myocardial infarction.

Value of procalcitonin combined with high-sensitivity C-reactive protein in the diagnosis and treatment of bronchopneumonia in children / 中国综合临床

Objective To research the clinical application of procalcitonin (PCT) combined with high sensitivity C reactive protein ( hs-CRP ) in the diagnosis and treatment of bronchopneumonia in children. Methods From February 2016 to March 2017, seventy-nine cases of 2～6 years old children with bronchial pneumonia in Hainan Maternity and Child Health Care Hospital were selected as the observation group. According to the degree of infection,the patients were divided into the general infection group (46 cases) and the severe infection group (33 cases). At the same time,a total of 43 healthy children of the same age group who underwent physical examination at the physical examination center of the same hospital during the same period were selected as control group. The changes of PCT and hs-CRP levels among different groups were compared. Results Before treatment, the levels of PCT and hs-CRP in the observation group were ( 0. 781 ±0.273) μg/L,(15.21±2.57) g/L,higher than those in the control group ((0.038±0.019)μg/L,(2.83 ±0. 49) g/L),the difference of the two groups was statistically significant (t＝17. 789,31. 224,respectively,P＝0. 000). The PCT and hs-CRP levels of children in the general infection group were (0. 673±0. 186)μg/L, (12. 78±2. 52) g/L,which were significantly lower than those of the severe infection group ((1. 235±0. 287) μg/L,(18. 54±3. 67) g/L),and the differences were statistically significant (t＝10. 557,8. 275,P＝0. 000). After 7 days of treatment,the levels of PCT and hs-CRP in the general infection groups ((0. 112±0. 045)μg/L, (3. 92±0. 73) g/L) were still lower than those in the severe infection group ((0. 171±0. 062)μg/L,(5. 21 ±1. 08) g/L)),and the differences were statistically significant (t＝4. 970,6. 337,P＝0. 000). The levels of PCT and hs-CRP in general infection group and severe infection group were significantly lower than those before treatment ( t＝19. 882,22. 904,20. 816,20. 016,P＝0. 000). Before the treatment,the PCT and hs-CRP positive rates in general infection group and severe infection group were 67. 39%,60. 87% and 90. 91%,87. 88%. After treatment,the PCT,hs-CRP positive rates of general infection group and severe infection group were 10. 87%, 23. 91%,30. 03% and 48. 48%. The positive rates of PCT and hs-CRP in the two groups after treatment were significantly lower than those before treatment,the differences were statistically significant (t ＝30. 849,12. 863, 25. 384,11. 803,P＝ 0. 000,0. 000,0. 000,0. 001) . The positive rates of PCT and hs-CRP in the general infection group before and after treatment were all significantly lower than those in the severe infection group,the differences were statistically significant(χ2＝6. 040,6. 976,4. 717,5. 157,P ＝0. 014,0. 008,0. 029,0. 023). Conclusion The levels of PCT and hs-CRP in children with bronchial pneumonia were significantly higher than those in healthy children of the same age. During the period of diagnosis and treatment,the changes of PCT and hs-CRP levels can be observed,so that the attending doctors can control their changes in time and play a guiding role in clinical treatment.

Analysis of the effect of amiodarone combined with psychological intervention on arrhythmia and its effects on serum high sensitive C reactive protein / 中国生化药物杂志

Objective To investigate the clinical effect of amiodarone combined with psychological intervention on the treatment of the patients with arrhythmia and its influence on the serum high sensitive C reactive protein. Methods The control group were treated with amiodarone on the basis of routine treatment, the study group was given amiodarone combined with psychological intervention on the basis of routine treatment. The effect in the two groups before and after treatment and the hs-CRP level changes in the two groups were recorded. Results The total efficiency in the study group was 89.13%, which was higher than 71.74% in the control group(P<0.05). There was no significant difference in the level of hs-CRP between the two groups before treatment. After treatment, the hs-CRP in study group was better than that in control group (P<0.05). Conclusion On the basis of routine treatment, amiodarone combined with psychological intervention can significantly improve the clinical efficacy of arrhythmia patients, and significantly reduce the level of hs-CRP.

Analysis of the effect of amiodarone combined with psychological intervention on arrhythmia and its effects on serum high sensitive C reactive protein / 中国生化药物杂志

Objective To investigate the clinical effect of amiodarone combined with psychological intervention on the treatment of the patients with arrhythmia and its influence on the serum high sensitive C reactive protein. Methods The control group were treated with amiodarone on the basis of routine treatment, the study group was given amiodarone combined with psychological intervention on the basis of routine treatment. The effect in the two groups before and after treatment and the hs-CRP level changes in the two groups were recorded. Results The total efficiency in the study group was 89.13%, which was higher than 71.74% in the control group(P<0.05). There was no significant difference in the level of hs-CRP between the two groups before treatment. After treatment, the hs-CRP in study group was better than that in control group (P<0.05). Conclusion On the basis of routine treatment, amiodarone combined with psychological intervention can significantly improve the clinical efficacy of arrhythmia patients, and significantly reduce the level of hs-CRP.

Test study on changes of serum cortisol and hypersensitivity C-reactive protein in elderly patients with neurasthenia / 国际检验医学杂志

Objective To investigate the significance of serum cortisol and high‐sensitivity C‐reactive protein (hs‐CRP) test in elderly patients with neurasthenia .Methods A total of 160 elderly patients with neurasthenia in our hospital from January 2012 to June 2015 were selected as the research subjects (observation group) and 160 individuals undergoing the physical examination as the control group .The differences of serum BDNF ,CORT and hs‐CRP levels were compared between the two groups .The patients were divided into the obvious anxiety group and anxiety group according to the Hamilton Anxiety Scale (HAMD) .The differences of serum BDNF ,CORT and hs‐CRP levels were compared between these two groups ;meanwhile serum BDNF ,CORT and hs‐CRP levels after treatment in the patients with ideal curative effect were detected and the detection results were statistically compared with those before treatment .Results The BDNF and CORT levels in the observation group were significantly lower than those in the control group ,while the hs‐CRP level was significantly higher than that in the control group ;the BDNF and CORT levels in the obvious anxiety group were significantly lower than those in the anxiety group ,while the hs‐CRP level was significantly higher than that in the anxiety group ;the treatment outcome also showed that the BDNF and CORT levels after treatment in the patients obtai‐ning the ideal effect were significantly increased compared with the pre‐treatment levels ;while the hs‐CRP level was significantly decreased .Conclusion BDNF ,CORT and hs‐CRP are significantly correlated with neurasthenia occurrence and its severity ,which deserves to pay attention to in clinical practice .

Clinical studies of hs-CRP,Hcy,D-D,Fib,SF joint detection to predict progressive cerebral infarction / 国际检验医学杂志

Objective To discuss the value of joint detection in patients with progressive cerebral infarction (PCI) on high sensi‐tivity c‐reactive protein(hs‐CRP) ,and homocysteine(Hcy) ,D‐Dimer ,Fibrinogen(Fib) ,ferritin(SF) .Methods According to the de‐velopment and evolution of the 156 patients with acute cerebral infarction were divided into progressive cerebral infarction group and non‐progressive cerebral infarction group ,to determine the level of serum hs‐CRP ,Hcy ,one or two D‐Dimer ,Fib ,SF .Results hs‐CRP ,Hcy ,D‐D ,Fib ,SF in the PCI group were higher than those in the control group ,the difference was statistically significant (P<0 .05) .Conclusion Between the development of the PCI with hs‐CRP ,Hcy ,D‐D ,Fib and SF ,there is a close relationship ,to detect the level has a certain significance to the prediction of progressive ischemic stroke .