RESUMO
Objective To investigate the relationship between pulmonary function,serum inflammatory factors and coronary artery disease in elderly patients with hypertension.Metbods One hundred and fifty-two patients with hypertensive disease were involved.According to whether the patients had coronary artery disease,the patients were divided into hypertension with coronary artery disease group included 84 patients and non-combined coronary artery disease group included 68 patients.Results Age (75.23-± 7.49years vs 71.42 ± 8.21years),triglyceride (1.59 ± 0.41mmol/L vs 1.41 ± 0.63mmol/L) serum creatinine (82.42 ± 39.27μmol/L vs 70.39 ±25.76μmol/L),blood urea nitrogen (7.85 ± 4.31mmol/L vs 6.12 ± 2.49mmol/L),IL-2 (567.32 ± 191.53pg/d1 vs 501.26 ±214.74pg/dl),IL-6 (3.95 ± 2.92pg/dl vs 3.04 ± 2.61pg/dl) and CRP (1.75 ± 1.84mg/dl vs 1.04 ± 2.01 mg/dl) of hypertension with coronary artery disease group were higher than hypertension non-combined coronary artery disease group,however FEV1％ (83.42％ ± 24.57％ vs 92.15％ ± 19.38％) and FEV1/FVC (62.91 ± 13.65 vs 70.24 ± 9.42) were more lower.There was significant difference (P ＜ 0.05).From the multiple linear regression analysis of relevant factors,we found that FEV1 ％ (P =0.005),FEV1/FVC (P =0.003),IL-2 (P =0.012) and CRP (P =0.009) was independently associated with hypertension complicated with coronary artery disease.From the analysis between IL-2,CRP and FEV1％,FEV1/FVC of hypertensive patients with coronary artery disease,we found that IL-2 was significantly negatively correlated with FEV1 ％ (r =-0.391,P =0.000) and FEV1/FVC (r =-0.571,P =0.000),and CRP was also was significantly negatively correlated with FEV1％ (r =-0.437,P =0.000) and FEV1/FVC (r =-0.559,P =0.000).Conclusion We find that pulmonary function and serum inflammatory factors are the risk factors of the coronary artery disease in elderly patients with hypertension.
RESUMO
Objective To investigate the relationship between pulmonary function,serum inflammatory factors and coronary artery disease in elderly patients with hypertension.Metbods One hundred and fifty-two patients with hypertensive disease were involved.According to whether the patients had coronary artery disease,the patients were divided into hypertension with coronary artery disease group included 84 patients and non-combined coronary artery disease group included 68 patients.Results Age (75.23-± 7.49years vs 71.42 ± 8.21years),triglyceride (1.59 ± 0.41mmol/L vs 1.41 ± 0.63mmol/L) serum creatinine (82.42 ± 39.27μmol/L vs 70.39 ±25.76μmol/L),blood urea nitrogen (7.85 ± 4.31mmol/L vs 6.12 ± 2.49mmol/L),IL-2 (567.32 ± 191.53pg/d1 vs 501.26 ±214.74pg/dl),IL-6 (3.95 ± 2.92pg/dl vs 3.04 ± 2.61pg/dl) and CRP (1.75 ± 1.84mg/dl vs 1.04 ± 2.01 mg/dl) of hypertension with coronary artery disease group were higher than hypertension non-combined coronary artery disease group,however FEV1％ (83.42％ ± 24.57％ vs 92.15％ ± 19.38％) and FEV1/FVC (62.91 ± 13.65 vs 70.24 ± 9.42) were more lower.There was significant difference (P ＜ 0.05).From the multiple linear regression analysis of relevant factors,we found that FEV1 ％ (P =0.005),FEV1/FVC (P =0.003),IL-2 (P =0.012) and CRP (P =0.009) was independently associated with hypertension complicated with coronary artery disease.From the analysis between IL-2,CRP and FEV1％,FEV1/FVC of hypertensive patients with coronary artery disease,we found that IL-2 was significantly negatively correlated with FEV1 ％ (r =-0.391,P =0.000) and FEV1/FVC (r =-0.571,P =0.000),and CRP was also was significantly negatively correlated with FEV1％ (r =-0.437,P =0.000) and FEV1/FVC (r =-0.559,P =0.000).Conclusion We find that pulmonary function and serum inflammatory factors are the risk factors of the coronary artery disease in elderly patients with hypertension.