RESUMO
Self-injury has become a significant public health problem, especially happens in adolescents. Previous studies have suggested that self-injury is related to numerous factors. At present, the occurrence mechanism of self-injury is still unclear, and there is a lack of reliable biological markers in its diagnosis and therapeutic target so far. Previous studies have suggested that self-injury may be related to hypothalamic pituitary adrenal(HPA) axis, β-endorphins, opioids and other hormones. Hypothalamic pituitary thyroid(HPT) axis and hypothalamic pituitary gonadal(HPG) axis are endocrine systems connecting nerves and hormones. Many studies suggested that various hormones in HPT axis and HPG axis of self-injury patients with other mental disorders (such as major depression and bipolar disorder) were abnormal. At present, there are few studies on the relationship between self-injury and HPT axis and HPG axis. There are differences in results even among studies on the same hormones, and some studies involve suicide attempts and even behaviors. Some studies have confirmed that self-injury is related to suicide, expanding the possibility of exploring the correlation between self-injury and hormones. This study will review the relationship between self-injury and hormonal changes.
RESUMO
Este estudio establece una correlación entre la exposición a perclorato de amonio y la presencia clínica de alteraciones en el eje hipotálamo-hipófisis- tiroides, tomando como referencia diferentes dosis de aplicación desde la aceptada como dosis segura hasta un incremento significativo de dicha dosis. El trabajo reviste gran importancia debido a que esta sustancia química es uno de los compuestos de mayor uso como pesticida en el departamento de Boyacá. Mediante ensayos inmunoenzimáticos con microplacas; con los Kit comerciales Kit Accubind Elisa Microwells TSH y Kit Accubind Elisa Microwells T4L y el análisis clínico se pudo establecer la existencia de alteraciones en el eje hormonal, lo que puede ser indicador en el futuro de un alto riesgo por parte de los individuos que manipulen esta sustancia.
This study establishes a correlation between exposure and clinical alterations in the hypothalamic-pituitary-thyroid axis. Different dosages were applied, from the accepted safe dosage up to a significant increase dosage. The study was carried out under the laboratory animal center conditions at Universidad of Boyacá (Colombia). Due that ammonium perchlorate is one of the most used compounds as pesticide in Boyacá department this type of studies are extremely important. Using enzyme immunoassay in micro-plate (Accubind Elisa Microwells TSH and Kit Accubind Elisa Microwells T4L ) and following clinical analysis alterations in the hormonal axis were found which could be be indicative of a possible high risk in the future for individuals who handle this substance.
Assuntos
Humanos , Glândula Tireoide , Hipófise , Imunoglobulinas Estimuladoras da Glândula Tireoide , HipotálamoRESUMO
ObjectiveTo investigate the intervention effects of fluoxetine on hypothalamic-pituitary-thyroid (HPT) axis function changes in post-stroke depression (PSD) patients.MethodsMild to moderate stroke patients were enrolled and blood T3,T4,FT3,FT4 and TSH were measured at day 0,1,7,14,21 and 3 months.At day 7,thyroid hormone releasing hormone (TRH) stimulation test were performed.After evaluated with the anxiety scale screening using the HAMD scale assessment at day 21,the subjects were divided into simple stroke subgroup ( ＜8 points,25 cases) and PSD sub-group ( ≥ 8 points,18 cases),with 16 healthy age and sex matched individuals as control group.In the 2nd stage,TRH stimulation test were performed in PSD patients before and after 7 days of fluoxetine administration.ResultsCompared with control group,stroke patients presented lower FT3 (P ＜0.05 ) and higher serum TSH (P ＜ 0.05) at day 0,1,7,14.Furthermore,PSD patients presented lower FT3,TSH levels and higher FT4 levels than simple stroke patients did(P＜0.05).At day 21 and month 3,T3,T4,FT3,FT4 and TSH levels in stroke patients were not different from those in control group(P ＞ 0.05).TRH test showed that the responses in PSD patients were lower than those in simple stroke patients( (2.65 ±0.42)μIU/ml vs (5.31 ±0.68 ) μIU/ml,P ＜ 0.05 ).Correlation analysis showed HAMD scores correlated with TSH level changes and TSH0 ～30 in PSD subgroup closely( r=0.35,0.25,P＜0.01 ).In the 2nd stage,TRH test showed that PSD patients who took fluoxetine presented a lower TSH level change than PSD patients who did not( (4.61 ± 2.02) μIU/ml vs (7.05 ± 2.12) μIU/ml,P ＜ 0.05 ).ConclusionPSD patients present a long and severe HPT axis function inhibition,which may due to TRH deficiency,and fluoxetine may improve this abnormality.