A COMPARATIVE ANALYSIS ON FINANCIAL PERFORMANCE OF INFOSYS LTD. USING RATIO ANALYSIS AND TREND ANALYSIS: AN EMPIRICAL STUDY

The main focus of this research paper is to make a comparative analysis of one of the leading IT Company by market capitalization named Infosys Ltd. The nancial status of this company has been analyzed by leveraging out various nancial ratios such as liquidity, protability, solvency and activity ratios. For the purpose of conducting our research, the data has been collected from secondary sources such as company's annual reports, journals, etc. The study covers a time period from FY18 to FY22. Sampling technique adopted for the purpose of carrying out this research is purposive sampling method. We also used trend analysis to forecast the future growth in sales and protability of the business. This research also uses simple correlation technique to compute the relationship between liquidity and protability of the company. More interestingly, this paper also considers the outputs of regression analysis so as to nd the cause - and - effect relationship among variables.

Health Technology Use in Noncommunicable Disorders: Challenges and Opportunities in India

Health care in India is undergoing a rapid change from its historical focus on acute disease management to a focus more on chronic and continuous care-based model for noncommunicable disorders. Health technology could be a game changer as it has a potential to optimize costs and effectively manage such operations. IT solutions are likely to become an integral part of process management, patient care and the hospital management information system in future. This brief communication describes the key enablers and limitations of using health technology in chronic diseases in developing countries like India.

Formulation and evaluation of Buccal mucoadhesive tablets of diclofenac sodium using 23 factorial designs

Buccal tablets

Diclofenac sodium

Drug release

Mucoadhesion

Mucoadhesive tablets

Release kinetics

Predictive values of the Status Epilepticus in Pediatric Patients Severity Score and END-IT score for short-term prognosis of children with status epilepticus / 中华实用儿科临床杂志

Objective:To evaluate the predictive values of the Status Epilepticus in Pediatric Patients Severity Score (STEPSS) and END-IT score in the short-term prognosis of children with status epilepticus (SE).Methods:It was a retrospective study involving 103 children with SE who were admitted to the Qingdao Women and Children′s Hospital Affiliated to Qingdao University from January 1, 2012 to January 1, 2022.Glasgow Outcome Scale was used to evaluate the prognosis at discharge, and the children were divided into good prognosis group ( n=78) and poor prognosis group ( n=25). Risk factors for poor prognosis of SE in children were analyzed by Logistic regression.Receiver operating characteristic (ROC) curve was used to evaluate the prognostic values of STEPSS and END-IT score in children with SE. Results:Compared with those of the good prognosis group, significantly younger age [16 (9, 58) months vs.56 (21, 84) months, Z=-3.068, P=0.002], higher blood lactic acid levels [3.16 (2.43, 4.01) mmol/L vs.1.67 (1.32, 2.10) mmol/L, Z=-6.085, P<0.001], STEPSS scores [3.0(3.0, 4.0) points vs.1.0(1.0, 2.0) points, Z=-6.956, P<0.001], END-IT scores [3.0(1.5, 4.0) points vs.1.0(0, 1.0) points, Z=-5.502, P<0.001], proportion of developmental delay ( χ2=16.756, P<0.001), abnormal brain magnetic resonance imagine examination ( χ2=5.860, P=0.015), use of ventilator and multiple drugs (all P<0.001), and longer duration of anti-SE therapy time( Z=1.488, P=0.024) were detected in the poor prognosis group. Logistic regression analysis indicated that increased blood lactic acid ( OR=7.975, 95% CI: 2.705-23.518), increased drug types ( OR=14.562, 95% CI: 2.035-104.173), STEPSS scores( OR=8.914, 95% CI: 2.824-28.140) and END-IT scores ( OR=2.209, 95% CI: 1.046-4.667) were risk factors for the poor prognosis of SE in children.The area under the curve (AUC) of STEPSS in predicting the poor prognosis of SE in children was 0.939, with the cut-off value, sensitivity, specificity and Youden index of 2.5 points, 96.0%, 85.9% and 0.82, respectively.AUC of END-IT scores in predicting the poor prognosis of SE in children was 0.853, with the cut-off value, sensitivity, specificity and Youden index of 1.5 points, 76.0%, 75.6% and 0.52, respectively.AUC of STEPSS in predicting the poor prognosis of SE in children was significantly higher than that of END-IT scores ( U=36.91, P<0.05). The predictive value of STEPSS combined with END-IT was higher, and the sensitivity and negative predictive value of parallel test were 100.0%, while the specificity and positive predictive value of series test were 94.9% and 81.8%, respectively. Conclusions:STEPSS and END-IT scores may be used as predictors for the poor prognosis of SE in children.Their combination provides a better prediction.

Structure identification and content analysis of active components in Xiaoyao pills / 药学学报

Xiaoyao pills are a famous traditional Chinese medicine collected in Welfare Pharmacy, which is a classic prescription for treating liver depression and spleen deficiency. However, its composition is complex. In order to better control the quality of Xiaoyao pills, in this study, HPLC-ion-trap time-of-flight mass spectrometry (LC-IT-TOF/MS) was used to identify the main ingredients of Xiaoyao pills, paeoniflorin, albiflorin, glycyrrhizic acid, saikosaponin A and saikosaponin B2. Then a liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed for simultaneous determination and quantification of the main compounds. Fragmentation pathways of five active components were obtained. The method was validated. Five active ingredients in Xiaoyao pills had a good linear relationship, and the values of RSD (%) of repeatability were all less than 5%, the recovery ranges were between 90% and 115%, and the values of RSD (%) of each substance were less than 10% after the sample solution is placed for 24 hours. Three batches of Xiaoyao pills (concentrated pellets) and two batches of Xiaoyao pills (water pellets) were determined, the contents of paeoniflorin in concentrated pills were more than 4.0 mg·g-1, and those in water pills were more than 2.5 mg·g-1, which was accordance with Chinese Pharmacopoeia. However, other compounds behave differently. This method has high sensitivity and reliable measurement results, which provides basis for quality control of Xiaoyao pills and material basis for pharmacology research.

The role of IT capabilities, IT reconfiguration capability and innovativeness on organizational performance: evidence from the Brazilian public sector / Papel de las capacidades de TI, capacidad de reconfiguración de TI e innovación en el desempeño organizacional: evidencia del sector público brasileño / O papel das capacidades de TI, capacidade de reconfiguração de TI e inovatividade no desempenho organizacional: evidências do setor público brasileiro

Abstract The growing investments in information technology (IT) each year pushes public sector organizations to develop the ability to gather, integrate, and implement these resources to improve organizational processes. Public sector organizations have to be agile and flexible to meet society's dynamic demands. In this sense, IT management and creating an organizational environment facilitating innovation are crucial measures. These organizations must learn to cultivate IT capabilities and innovativeness to improve their performance and create public value. Thus, this study aims to identify the existing relationships between innovativeness, IT capabilities, IT reconfiguration capability, and organizational performance in the public sector. The research analyzed data from 254 Brazilian public organizations of the most diverse sizes and sectors using structural equation modeling (SEM). The results indicated that the ability to reconfigure IT must be listed among the organizations' IT capabilities. Also, the findings suggest that IT capabilities foster organizations' innovativeness, and IT capabilities and innovativeness positively impact the organizations' performance. The study contributes to knowledge of innovation and IT capabilities by testing theoretical propositions identified in the context of the private sector but insufficiently assessed in the public sector. Finally, the study points out ways for public managers to better prepare their institutions to face constantly changing environments.

Resumen En vista del creciente volumen de recursos invertidos anualmente en tecnología de la información, las organizaciones del sector público deben tener cada vez más la capacidad de reunir, integrar e implementar recursos de TI para satisfacer las necesidades de los procesos organizacionales. Además, a las organizaciones públicas se les exige cada vez más ser más ágiles y flexibles para poder atender las demandas dinámicas de las sociedades. En este sentido, las organizaciones públicas deben ser capaces de gestionar y aplicar adecuadamente los recursos informáticos de los que disponen, así como crear entornos organizativos que permitan y favorezcan el florecimiento de la innovación. Es decir, deben aprender a cultivar las capacidades de TI y la innovación, con el objetivo de cumplir mejor su misión y crear valor público. Así, el objetivo de este estudio es identificar las relaciones existentes entre la innovación, las capacidades de TI, la capacidad de reconfiguración de TI y el desempeño organizacional, en el contexto del sector público. Para ello, se analizaron datos de 254 organizaciones públicas brasileñas de los más diversos tamaños y sectores, utilizando un enfoque de ecuaciones estructurales (SEM). Los resultados indicaron que la capacidad de reconfigurar la TI debe figurar entre las capacidades de TI de las organizaciones públicas, así como que las capacidades de TI desempeñan un papel en el fomento de la innovación de las organizaciones y que ambas (capacidades de TI e innovación) tienen un impacto positivo en el desempeño de las organizaciones. Al contrastar proposiciones teóricas identificadas en el contexto del sector privado, pero insuficientemente evaluadas en el sector público, el estudio agrega un bloque en la construcción de conocimiento sobre la capacidad de innovación y las capacidades de TI, además de señalar caminos para los gestores públicos sobre cómo pueden hacer que sus instituciones estén mejor preparadas para enfrentar entornos en constante cambio.

Resumo Tendo em vista o crescente volume de recursos investidos em tecnologia da informação a cada ano, as organizações do setor público devem cada vez mais ter a capacidade de reunir, integrar e implementar recursos de TI, a fim de atender às necessidades dos processos organizacionais. Além disso, as organizações públicas são cada vez mais exigidas a serem mais ágeis e flexíveis para atender às demandas dinâmicas das sociedades. Nesse sentido, as organizações públicas devem ser capazes de administrar e aplicar adequadamente os recursos de TI de que dispõem, bem como criar ambientes organizacionais que permitam e estimulem o florescimento da inovação. Ou seja, devem aprender a cultivar as capacidades de TI e a inovação, com o objetivo de melhor cumprir sua missão e criar valor público. Assim, o objetivo deste estudo é identificar as relações existentes entre inovatividade, capacidades de TI, capacidade de reconfiguração de TI e desempenho organizacional, no contexto do setor público. Para tanto, dados de 254 organizações públicas brasileiras, dos mais diversos portes e setores, foram analisados por meio de uma abordagem de equações estruturais (SEM). Os resultados indicaram que a capacidade de reconfigurar TI deve ser listada entre as capacidades de TI das organizações públicas, bem como que as capacidades de TI desempenham um papel no fomento da inovação das organizações e que ambas (as capacidades de TI e a inovatividade) têm um impacto positivo no desempenho das organizações. Ao testar proposições teóricas identificadas no contexto do setor privado, mas insuficientemente avaliadas no setor público, o estudo acrescenta um bloqueio na construção do conhecimento sobre capacidade de inovação e capacidades de TI, além de apontar caminhos para gestores públicos sobre como eles podem tornar suas instituições mais bem preparadas para enfrentar ambientes em constante mudança.

A Study on Depression Experienced by Information Technology Professionalsin a Private Company at Chennai, Tamil Nadu, India

Introduction :In the past 30 years, there had been more than 916 Information Technology (IT)providers registered with National Association of Software and Service companies. Career in the IT field warrants struggles with deadlines, working at odd and long hours and poor inter-personal relationships all affecting the mental wellbeing of workers. To assess the levels of depression and its associatedObjective: factors among IT Professionals. A cross sectional study, among 170 IT professionals in Chennai.Method: Interview was conducted collecting socio demographic details and Patient Health Questionnaire (PHQ - 9) was used to assess the depression levels. Descriptive statistics were computed for background variables. Association between various factors and levels of depression were analyzed using chi square test. Multiple logistic regression was performed to identify independent risk factors. Among the participants,Results: majority 83 (48.8%) were between 21 – 30 years and 95 (55.9%) had work experience > 5 years. Most of them worked on day shifts 105(61.8%). A total of 60 (35.3%) participants had mild and 46 (27%) participants had moderate depression level. These risk factors when compared with depression, it was found that age, gender and working years were found to be significant. (p<0.05). In presentConclusion: study, 2/3 of the participants had mild to moderate depression levels. It is necessary to increase the activerd depression management counseling services.

A Cross Sectional Study Among Information Technology Professionals of Vishakhapattanam City to Study the Prevalence of Musculoskeletal Work Related Disorders

Background: The Information technology has revolu?onized many changes throughout the society, and also in bringing up the economic growth of the country.IT professionals are prone to various job-related complaints and symptoms which can be reduced or eliminated by using proper ergonomics. The present study was carried out to study the prevalence of Musculoskeletal disorders among the Informa?on technology (IT) professionals and to determine the factors associated with musculoskeletal problems. Objec?ves:1.To study the prevalence of Musculoskeletal disorders among the Informa?on Technology (IT) professionals. 2. To determine the factors associated with Musculoskeletal disorders among IT Professionals. Methodology: A cross-sec?onal study was done among 400 Informa?on technology professionals of selected IT companies of Visakhapatnam city using mul?stage sampling technique. Structured Interview schedule was taken to collect socio-demographic, personal and working details of employees. Standardised Nordic Musculoskeletal ques?onnaire was used to assess the work-related musculoskeletal symptoms in rela?on to various body regions during last 12 months and last 1 week. Results:The overall musculoskeletal disorders among IT professionals was 74% of which lower back (56.7%) is the most common body region affected in the last 12 months followed by neck (43%), shoulder (28.2%), wrist/hand (8.5%), elbow (5.7%), knee (4%) and ankle (3.7%). Conclusions: The study concludes that, prevalence of work-related health problems among IT professionals are of concern. Work related musculoskeletal problems were widely reported and it was observed that, individuals who have regular physical ac?vity are less prone to Musculoskeletal disorders (MSD).

COVID 19 INFECTION IN A PATIENT NEWLY DIAGNOSED WITH HIV/TB COINFECTION – A CASE REPORT

HIV/TB coinfection, COVID 19 with HIV/TB, immune reconstitution inflammatory syndrome (IRIS), TB lymphadenopathy

Telemedicine Acceptance and User Experience: A Gap to Be Addressed?

Introduction: Telemedicine is a constantly evolving science. Telemedicine is transfer of, medical information over phone or net with the aim of consultation. Advancement and drop in the cost of information & communication technologies, has booned the interest in the application of telemedicine. During the pandemic, in India where doctor population relationship is low, telemedicine was considered as solution. Objective: This study was done with the aim to estimate the rate of acceptance, convenience and experience on telemedicine usage among IT professionals. Materials and Methods: This cross sectional study was carried out among 162 IT professionals working in six IT companies which was choosed randomly from the IT companies in Chengalpattu division. Employee who have used telemedicine service were listed from all the six companies and were included in the study. From the list 162 employees were selected through simple random sampling. Selected employees were given a semi-structured questionnaire consisting of four sections to assess their acceptance, convenience and experience on telemedicine usage. The collected information was analyzed using SPSS software version 21.0. Qualitative variables will be expressed in proportions and Quantitative variables in Mean(SD) / Median (IQR). Chi-square test was applied. Results: 83(51.2%) male and 79(48.8%) female employees took part in the study. 56 participants (35%) of 162 participants accepted using telemedicine for medical consultation. 78 participants (48.1%) found it convenient to use the telemedicine applications, depicting that the applications are not user friendly. Only 34 participants (21%) were satisfied with their experience with telemedicine usage. Conclusion: Telemedicine was the saviour for those who were in need of medical service but was restricted due to pandemic/disease. But non-availability of user-friendly applications was found to barrier in accepting telemedicine service. In addition to it there are several other barriers that has to be found and addressed for successful telemedicine service across our country. Proper promotion is also needed to improve acceptance.

Clinical significance of MAPT-IT1 in breast cancer and its mechanism of biological effect in vitro / 中华内分泌外科杂志

Objective:To investigate the clinical significance of MAPT-IT1 in breast cancer and its biological effect in vitro.Methods:The expression of MAPT-IT1 in breast cancer was analyzed by TCGA database. 64 cases of breast cancer and normal adjacent tissues were collected. Human breast cancer MDA-MB-231 and MCF-7 cells were cultured and overexpressed MAPT-IT1 or rescue miR-181a-5p by cell transfection. MDA-MB-231 cells were divided into blank group A, overexpression group A and recovery group A; MCF-7 cells were divided into blank group B, overexpression group B and recovery group B. Real time quantitative PCR (RT-qPCR) was used to detect the expression of MAPT-IT1, miR-181a-5p and MAPT mRNA. Western blot was used to detect the expression of MAPT protein. CCK-8 assay was used to detect cell proliferation, and Transwell invasion assay was used to detect cell invasion.Results:The expression of MAPT-IT1 in normal paracancerous tissues and breast cancer tissues was 0.011±0.002 and 0.028±0.003 respectively. The expressions of MAPT-IT1 in breast cancer tissues were significantly higher than those in adjacent normal tissues, and high expression of MAPT-IT1 was correlated with early tumor progression, ER positive and prolonged prognosis ( P<0.05) . In blank group A, overexpression group A and recovery group A, the expressions of MAPT-IT1 were 1.000±0.078, 8.597±0.320 and 8.540±0.177, miR-181a-5p were 1.000±0.027, 0.263±0.024, 4.433±0.239, MAPT were 1.000±0.071, 3.297±0.243, 0.497±0.029. In blank group B, overexpression group B and recovery group B, the expressions of MAPT-IT1 were 1.000± 0.081, 5.716±0.309, 5.288±0.176, miR-181a-5p were 1.000±0.024, 0.291±0.022, 3.648±0.073, and MAPT were 1.000±0.054, 3.309±0.177, 0.883±0.075. After overexpression of MAPT-IT1, the expression of miR-181a-5p was down-regulated, while the expression of MAPT was significantly increased ( P<0.001) , and the proliferation and invasion ability of MDA-MB-231 and MCF-7 cells were significantly decreased ( P<0.05) . Re-expression of miR-181a-5p down-regulated MAPT and promoted cell proliferation and invasion ( P<0.05) . Conclusion:Overexpression of MAPT-IT1 can significantly down-regulate the expression of miR-181a-5p and enhance MAPT and inhibit the malignant phenotype of breast cancer cells in vitro.

Profissionais de TI: Um estudo sobre as forças pessoais/de caráter / IT Professionals: A study of character strengths

RESUMO As forças pessoais/de caráter são as características psicológicas positivas que se refletem nos pensamentos, sentimentos e comportamentos. Esse artigo objetivou descrever as forças pessoais/de caráter mais prevalentes em 60 profissionais de Tecnologia da Informação e comparar quatro grupos distintos nos cargos de Atendimento e Suporte Técnico, Desenvolvedor de Software, Gestor e Líder Técnico em um Parque Tecnológico do Sul do Brasil. Estudo com delineamento quantitativo, descritivo, comparativo e transversal com aplicação online de um Questionário Sócio Demográfico e Laboral e da Escala das Forças de Caráter. As forças mais prevalentes são a imparcialidade, a curiosidade, a bondade, o pensamento crítico e o amor ao aprendizado. As forças com menor prevalência são a apreciação do belo, a espiritualidade, o perdão, a inteligência social e a sensatez. As implicações práticas sugerem que as características psicológicas positivas sejam fortalecidas em processos de desenvolvimento pessoal e profissional dos trabalhadores de TI no âmbito organizacional.

ABSTRACT Character strengths are the positive psychological characteristics that are reflected in thoughts, feelings and behaviors. This article aimed to describe the most prevalent character strengths in 60 Information Technology (IT) professionals and compare four distinct groups in the positions of Service and Technical Support, Software Developer, Manager and Technical Leader in a Technology Park in the Southern Brazil. Study with quantitative, descriptive, comparative and cross-sectional design with online application of a Socio-Demographic and Labor Questionnaire and the Scale of Character Strengths. The most prevalent strengths are impartiality, curiosity, kindness, critical thinking and love of learning. The least prevalent character strengths are appreciation of beauty, spirituality, forgiveness, social intelligence and wisdom. Practical implications suggest that positive psychological characteristics should be strengthened in the personal and professional development of IT workers at organizations.

Effects of long non-coding RNA ALMS1-IT1 on the proliferation and migration of colorectal cancer cells via regulating the expressions of miRNA-889-3p and ATAD2 / 肿瘤研究与临床

Objective:To investigate the expression of long non-coding RNA (lncRNA) ALMS1-IT1 in colorectal cancer tissues and the molecular mechanism of its effect on the proliferation and migration of colorectal cancer HT-29 cells in vitro.Methods:The cancer tissue specimens and paracancerous tissue (>5 cm from the edge of the tumor) specimens were collected from 40 colorectal cancer patients who were diagnosed by pathological examination after surgical resection in Hubei 672 Orthopedic Hospital of Integrated Traditional Chinese and Western Medicine from July 2018 to November 2020. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the expression level of ALMS1-IT1 in colorectal cancer tissues and paracancerous tissues, when the relative expression of ALMS1-IT1 was higher than or equal to its median relative expression, ALMS1-IT1 was highly expressed, and the correlation of ALMS1-IT1 expression with the clinicopathological characteristics of patients was analyzed. HT-29 cells were infected with the empty lentivirus and the lentivirus carrying the ALMS1-IT1 silence sequence, and named control group and si-ALMS1-IT1 group. qRT-PCR was used to detect the expression of ALMS1-IT1 in the two groups of HT-29 cells. CCK-8 method and Transwell experiment were used to detect the proliferation and migration ability of the two groups of HT-29 cells. The starBase v2.0 online database was used to predict ALMS1-IT1 interacting molecules, and qRT-PCR and Western blot were used to detect the expression of these molecules.Results:The relative expression of ALMS1-IT1 in colorectal cancer tissues was higher than that in paracancerous tissues (4.54±0.61 vs. 1.19±0.31, t = 34.89, P < 0.01). The median relative expression of ALMS1-IT1 in cancer tissues of 40 patients was 2.93, and the high expression rate of ALMS1-IT1 was 50.0% (20/40). The high expression rate of ALMS1-IT1 in cancer tissues of TNM stage Ⅲ patients was higher than that in TNM stage Ⅰ-Ⅱ patients, the high expression rate of ALMS1-IT1 in poorly-differentiated patients was higher than that in well- and moderately-differentiated patients, and the high expression rate of ALMS1-IT1 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis (all P < 0.01). The cell proliferation capacity (absorbance value) of HT-29 cells in the si-ALMS1-IT1 group after cultured for 2, 3, 4, and 5 days was lower than that in the control group (all P < 0.05). The number of cell migration at 24 h in HT-29 cells of the si-ALMS1-IT1 group was less than that of the control group (45±7 vs. 112±18, t = 3.45, P < 0.05). Using starBase v2.0 online database to predict that the target gene of ALMS1-IT1 may be miRNA-889-3p (miR-889-3p), and the target gene of miR-889-3p may be ATAD2. Compared with the control group, the relative expression of miR-889-3p in HT-29 cells of the si-ALMS1-IT1 group increased (4.24±0.46 vs. 1.01±0.11, t = 6.81, P < 0.01). Compared with the control group, ATAD2 mRNA ( P < 0.01) and protein expression levels in the si-ALMS1-IT1 group were reduced. Conclusions:ALMS1-IT1 is highly expressed in colorectal cancer tissues, and the ALMS1-IT1 expression is related to the TNM stage, degree of tumor differentiation and lymph node metastasis of patients. Down-regulation of ALMS1-IT1 in vitro may inhibit the proliferation and migration of colorectal cancer HT-29 cells by regulating the miR-889-3p-ATAD2 axis. ALMS1-IT1 may be a therapeutic target for colorectal cancer.

Research on in vivo metabolites of Longxue Tongluo Capsules by liquid chromatography coupled with hybrid ion trap/time-of-flight mass spectrometry / 中国中药杂志

Longxue Tongluo Capsules(LTC) has good efficacy against blood stasis syndrome during the recovery period of ischemic stroke. Its main active ingredient is the phenolic extract of Chinese dragon's blood. In our previous study, the primary mass fragmentation pathways of phenolic derivatives from LTC were clarified. Herein, the metabolites in rat plasma were characterized following the oral administration of loureirin A and loureirin C using liquid chromatography coupled with hybrid ion trap/time-of-flight mass spectro-metry(LC-IT-TOF-MS), with 18 and 55 metabolites identified, respectively. On this basis, with the help of the obtained accurate molecular weight, characteristic fragment ions, reference comparison, combined with LTC database and natural products database self-created in our group, 18 prototypes and 106 metabolites were tentatively identified in rat plasma after oral gavage of LTC at a dose of 500 mg·kg~(-1). Glucuronidation, sulfonation, and methylation were major biotransformation pathways of LTC. This study preliminarily clarified the LTC constituents absorbed into blood and laid the foundation for clarifying the effective substances of LTC.

Sisprad: software for radiological protection management in a hospital environment / Sisprad: software para gestión de protección radiológica en entorno hospitalario / Sisprad: software para gestão da proteção radiológica em ambiente hospitalar

ABSTRACT Objective: to describe the software for the management of radiological protection, SisPRad, and its construction process, as well as to analyze its implementation and use in a radiodiagnosis service. Method: a methodological and quasi-experimental research study carried out between November 2016 and October 2019. The study population consisted of the professionals who make up the Radiological Protection Committee of the service. The model chosen for software engineering was the cascade model. In the implementation phase, an evaluation and analysis of the usability of the software was carried out. Results: the software for radiological protection management presents the structure of the technology and its functionalities. The usability evaluation showed that SisPRad is a tool that will assist the multi-professional and interdisciplinary team of the hospital radiology service in the management of radiological protection. The computerization of the systems and the integration of the sectors that need shared data in the work routines enhance the management of hospital radiological protection for the multi-professional team. The technology was positively evaluated by the multi-professional team working in the hospital radiodiagnosis service. SisPRad generated registration n.. 512019002125-8 by the National Institute of Industrial Property. Conclusion: this tool was developed aiming at the safety of the professionals working in the radiodiagnosis service and of its users, in addition to enabling the constant improvement of the tool, and it can be adapted in other institutions.

RESUMEN Objetivo: describir el software para la gestión de protección radiológica, SisPRad, su proceso de construcción y analizar su implementación y uso en un servicio de radiodiagnóstico. Método: investigación metodológica y cuasiexperimental realizada entre noviembre de 2016 y octubre de 2019. La población de estudio estuvo constituida por los profesionales que integran el Comité de Protección Radiológica del servicio. Para la ingeniería de software, se eligió el modelo en cascada. En la etapa de implementación se realizó la evaluación y el análisis de usabilidad del software. Resultados: el software de gestión de protección radiológica presenta la estructura de la tecnología y sus funcionalidades. La evaluación de usabilidad mostró que SisPRad es una herramienta que ayudará al equipo multidisciplinario e interdisciplinario del servicio de radiología del hospital en la gestión de la protección radiológica. La informatización de sistemas y la integración de sectores que requieren datos en común en las rutinas de trabajo potencian la gestión de la protección radiológica hospitalaria del equipo multidisciplinario. La tecnología fue valorada positivamente por el equipo multiprofesional que cumple sus funciones en el servicio de radiodiagnóstico del hospital. SisPRad generó el registro 512019002125-8 en el Instituto Nacional de Propiedad Industrial. Conclusión: esta herramienta fue desarrollada con el objetivo de promover la seguridad de los profesionales que trabajan en el servicio de radiodiagnóstico y de sus usuarios, además de permitir la mejora constante de la herramienta, que puede ser adaptada a otras instituciones.

RESUMO Objetivo: descrever o software para gestão da proteção radiológica, SisPRad, seu processo de construção e analisar sua implantação e utilização em um serviço de radiodiagnóstico. Método: pesquisa metodológica e quase-experimental realizada entre novembro de 2016 e outubro de 2019. A população do estudo foi constituída pelos profissionais que compõem o Comitê de Proteção Radiológica do serviço. O modelo escolhido para a engenharia do software foi o modelo em cascata. Na fase de implantação foi realizada avaliação e análise da usabilidade do software. Resultados: o software de gestão para proteção radiológica apresenta a estrutura da tecnologia e suas funcionalidades. A avaliação da usabilidade evidenciou que o SisPRad é uma ferramenta que irá auxiliar a equipe multiprofissional e interdisciplinar do serviço de radiologia hospitalar na gestão da proteção radiológica. A informatização dos sistemas e a integração dos setores que necessitam de dados em comum nas rotinas de trabalho potencializam a gestão da proteção radiológica hospitalar para a equipe multiprofissional. A tecnologia foi avaliada positivamente pela equipe multiprofissional atuante no serviço de radiodiagnóstico hospitalar. O SisPRad gerou o registro 512019002125-8 pelo Instituto Nacional de Propriedade Industrial. Conclusão: essa ferramenta foi desenvolvida visando a segurança dos profissionais atuantes no serviço de radiodiagnóstico e seus usuários, além de possibilitar a melhora da ferramenta constantemente, podendo ser adaptada em outras instituições.

Is mean platelet volume the earliest diagnostic marker of neonatal sepsis: a prospective case control study

Background: Neonatal sepsis is the third leading cause of neonatal mortality after prematurity and intrapartum related complications worldwide. The literature regarding the use of Mean platelet volume as a diagnostic tool in neonatal sepsis is scanty.Methods: Prospective case control study in a district hospital. Neonates > 30 weeks gestation admitted to NICU during the study period were included. Neonates who did not have any risk factors for sepsis and did not have a positive blood culture or elevated CRP were categorized as group 1. Neonates who were admitted with risk factors of sepsis but did not have a positive CRP or blood culture positivity were categorized as group 2. Neonates who were admitted as probable sepsis and subsequently developed blood culture or CRP positivity were categorized as group 3.Septic workup was done for all the subjects at admission and at 72 hours after admission. Newborn with congenital anomalies and who were already on antibiotics prior to admission were excluded from the study. Statistical analysis was done using Statistical Package of Social Sciences (SPSS) version 20.0.Results: Total 240 Neonates were included in the study. Elevation of MPV in neonates with sepsis was seen as early as the first sample whereas CRP elevation was seen only on Day 3. Cut off value for Mean Platelet Volume (MPV) was found to be 10.15fl with sensitivity of 84% and specificity of 74%.Conclusions: MPV can be used as a earliest diagnostic marker for prediction of neonatal sepsis and mortality. It can facilitate early initiation of treatment without any additional exposure.

Diaphragmatic fenestration an effective treatment for refractory postoperative chylothorax: a case report

Postoperative chylothorax remains a clinical challenge to the surgeon with substantial morbidity and risk of mortality. Though an uncommon complication, it is known to complicate cardiac and non-cardiac thoracic surgeries. Conservative measures are first employed in managing this. Surgical options are adopted when the effusion is protracted, most recent of which includes diaphragmatic fenestration. A 9-year-old girl is presented who developed recurrent right chylothorax following thoracoscopic excision of a cystic lymphangioma. Following failed conservative therapy, she had thoracic duct ligation and right diaphragmatic fenestration (using fenestrated polytetrafluoroethylene patch) with satisfactory outcome. Aetio-pathologic mechanisms implicated in postoperative chylothorax have been classified into traumatic (iatrogenic injury to the thoracic duct or its branches) and non-traumatic. With initial conservative measures (repeated pleural aspirations and intercostal drainage, medium chain triglyceride/ low fat feeds or alternatively, fasting and total parenteral nutrition) spontaneous closure remains unpredictable. Diaphragmatic fenestration when employed resulted in faster resolution of effusion and earlier commencement of enteral feeding with no significant complication. Diaphragmatic fenestration is effective and safe for treating refractory post-operative chylothorax.

Contribuições técnicas e socioculturais da prevenção quaternária para a atenção primária à saúde: caminhos e desafios / Technical and socio-cultural contributions of quaternary prevention for primary health care: paths and challenges / Contribuciones técnicas y socioculturales de prevención cuaternaria para la atención primaria de salud: caminos y desafíos

Introdução: No contexto do Sistema Único de Saúde, o conceito da prevenção quaternária adentra timidamente os níveis de atenção à saúde, no entanto, sofre expansão significativa no âmbito da atenção primária à saúde. Objetivo: Identificar por meio da sistematização de evidências científicas, as contribuições técnicas e socioculturais da prevenção quaternária no âmbito da atenção primária à saúde no Brasil. Métodos: Trata-se de uma revisão integrativa de estudos presentes nas bases de dados científicas da Scientific Electronic Library Online, Biblioteca Virtual em Saúde, biblioteca virtual da Comissão de Aperfeiçoamento de Pessoal do Nível Superior e MEDLINE via PubMed com a utilização dos descritores "prevenção quaternária" e "atenção primária à saúde", em inglês e português. Resultados: O corpus de análise foi composto por 22 artigos, sendo que a produção científica sobre o tema se deu de forma mais intensa a partir do ano de 2015 e, em sua maioria, possuíam como abordagem metodológica ensaios teóricos. Dentre as contribuições técnicas destacaram-se a introdução do ensino da prevenção quaternária de modo continuado aos graduandos e profissionais; a construção de protocolos e documentos de amparo profissional; a utilização de modelos explicativos dinâmicos na socialização do quadro clínico; a conduta profissional com os usuários e as contribuições socioculturais envolvendo mudanças na percepção profissional e comunitária sobre o fenômeno saúde-doença, assim como o incentivo a práticas de desmedicalização sociocultural em relação à dor, incapacidade, desconforto, envelhecimento, nascimento e morte. Conclusão: Apesar do reconhecimento das potencialidades da prevenção quaternária, faz-se necessário fortalecer estratégias que possibilitem o desenvolvimento de políticas públicas para fomentar e gerenciar alianças estratégicas com tomadores de decisão, profissionais de saúde e cidadãos, para fomentar a redução de diagnósticos e tratamentos excessivos, contribuindo com a qualidade do cuidado.

Introduction: In the context of the Unified Health System, the concept of quaternary prevention shyly enters the levels of health care, however, undergoes significant expansion in the scope of primary health care. Objective: To identify, through the systematization of scientific evidence, the technical and socio-cultural contributions of quaternary prevention within the scope of primary health care in Brazil. Methods: This is an integrative review of studies present in the scientific databases of the Scientific Electronic Library Online, Regional Portal of the Virtual Health Library of the Latin American and Caribbean Center on Health Sciences Information of the Pan American Health Organization, virtual library of the Higher Education Personnel Improvement Commission, and MEDLINE through PubMed using the descriptors "quaternary prevention" and "primary health care", in English and Portuguese. Results: The corpus of analysis consisted of 22 articles, and the scientific production on the topic took place more intensively from the year 2015 and, for the most part, had theoretical essays as methodological approach. Among the technical contributions, we highlight the introduction of teaching on quaternary prevention in a continuous way to undergraduates and professionals; the construction of protocols and documents of professional support; the use of dynamic explanatory models in the socialization of the clinical picture and professional conduct with users and socio-cultural contributions involve changes in the professional and community perception about the phenomenon of illness and health conception, as well as the incentive to practices of socio-cultural demedicalization in relation to pain, disability, discomfort, aging, birth, and death. Conclusion: Despite the recognition of the potential of quaternary prevention, it is necessary to strengthen strategies that enable the development of public policies to foster and manage strategic alliances with decision makers, health professionals and citizens, to promote the reduction of excessive diagnoses and treatments, contributing to the quality of care.

Introducción: En el contexto del Sistema Único de Salud, el concepto de prevención cuaternaria entra tímidamente en los niveles de atención de salud, sin embargo, experimenta una expansión significativa en el alcance de la Atención Primaria de Salud. Objetivo: Identificar, a través de la sistematización de evidencia científica, las contribuciones técnicas y socioculturales de la prevención cuaternaria en el ámbito de la Atención Primaria de Salud en Brasil. Métodos: Esta es una revisión integradora de estudios presentes en las bases de datos científicas de la Biblioteca Electrónica Científica en línea, Portal Regional de la Biblioteca Virtual en Salud del Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud de la Organización Panamericana de la Salud, biblioteca virtual de la Comisión de Mejoramiento del Personal de Educación Superior y MEDLINE a través de PubMed utilizando los descriptores de prevención cuaternaria y atención primaria de salud, en inglés y portugués. Resultados: El corpus de análisis estuvo conformado por 22 artículos, siendo la producción científica sobre el tema más intensiva desde 2015 y, en su mayor parte, tuvo ensayos teóricos como abordaje metodológico. Entre los aportes técnicos, destacamos la implantación de la docencia en prevención cuaternaria de forma continua a estudiantes de pregrado y profesionales; construcción de protocolos y documentos de apoyo profesional, uso de modelos explicativos dinámicos en la socialización del cuadro clínico y conducta profesional con los usuarios y los aportes socioculturales implican cambios en la percepción profesional y comunitaria sobre el fenómeno de la enfermedad y la concepción de la salud, así como el incentivo a prácticas de desmedicalización sociocultural en relación al dolor, discapacidad, malestar, envejecimiento, nacimiento y muerte. Conclusión: A pesar del reconocimiento del potencial de la prevención cuaternaria, es necesario fortalecer estrategias que permitan el desarrollo de políticas públicas para fomentar y gestionar alianzas estratégicas con los tomadores de decisiones, profesionales de la salud y ciudadanos, para promover la reducción de diagnósticos y tratamientos excesivos, contribuyendo a la calidad de la atención.

LCMS-IT-TOF Analysis of Retention Behavior of Sanguisorbae Radix Components on D101 Macroporous Resin and Polyamide Resin / 中国实验方剂学杂志

Objective:To study on the material basis of Sanguisorbae Radix by column chromatography and liquid chromatography-ion trap-time-of-flight mass spectrometry (LCMS-IT-TOF), and analyze the distribution of different components in Sanguisorbae Radix water extract on D101 macroporous resin and polyamide resin. Method:Sanguisorbae Radix water extract was separated by D101 macroporous resin and polyamide resin, and LCMS-IT-TOF was used for detection, chromatography separation was achieved on an ACQUITY UPLC HSS T3 column (2.1 mm×100 mm, 1.8 μm) with the mobile phase consisted of water (A) and acetonitrile (B) for gradient elution (0-10 min, 5%-20%B; 10-18 min, 20%-35%B; 18-23 min, 35%-50%B; 23-28 min, 50%-90%B; 28-30 min, 90%B; 30-33 min, 90%-5%B; 33-35 min, 5%B), the flow rate was 0.3 mL·min-1, the column temperature was 30 ℃. Data acquisition was carried out in electrospray ionization (ESI) under the positive and negative ion modes, the scanning range was m/z 100-1 200. According to mass spectrometry data such as accurate molecular mass and fragment information, combined with literature, different chemical components in loading effluents and ethanol eluents of Sanguisorbae Radix water extract were identified. A heat map of the distribution of components in each fraction was drawn by extracting mass spectrum peak intensity data of each sample. The elution rules of various components were compared visually. Result:The enrichment and separation of D101 macroporous resin and polyamide resin were obvious. Tannins in Sanguisorbae Radix water extract was mainly concentrated in loading effluent of macroporous resin and its water eluent, triterpenoids were mainly distributed in the 90% ethanol eluent of macroporous resin. In the above effluents and eluents, a total of 63 compounds (including isomers) were identified. Among them, 6 compounds, ellagic acid-4-pyranoarabinoside or its isomer, 6-O-galloylnorbergerin, 3-O-galloylnorbergerin, (6-acetyloxy-5,7-dihydroxy-8-methoxy-4-oxochromen-2-yl) acetate, ethyl 2-methyl-5,6-bis (sulfooxy) benzofuran-3- carboxylate were first discovered in Sanguisorbae Radix. Conclusion:The method can quickly and accurately identify the distribution of components in aqueous extract of Sanguisorbae Radix after column chromatography, providing experimental basis for exploring the pharmacodynamic components and mechanism of Sanguisorbae Radix.

Identification and Content Determination of Main Unknown Impurity in Oxiracetam Capsule / 中国药房

OBJECTIVE：To identify the main unknow impurity of Oxiracetam capsule and determine its content ，so as to improve the standard of quality control. METHODS ：Two-dimensional UPLC -IT-TOF-MS was adopted to qualitatively analyze the unknown impurity. One-dimensional liquid chromatogram analysis was performed on ST PAK C 18 ES column with mobile phase consisted of 0.02 mol/L sodium dihydrogen phosphate solution at the flow rate of 0.5 mL/min. The column temperature was set at 30 ℃，sample size was 20 μL. The detection wavelength was set at 210 nm. Two-dimensional liquid chromatogram analysis was performed on Techmate C 18-STⅡ column with mobile phase consisted of 0.02 mol/L ammonium acetate solution at the flow rate of 0.5 mL/min. The column temperature was 30 ℃. Mass spectrometry was adopted （electropray ionization source ，MS+ and MS － mode data acquisition ）. After the target impurity was located by one-dimensional liquid chromatography ，it was transferred to two-dimensional liquid chromatography-mass spectrometry system for qualitative analysis. The unknown impurity structure was inferred by means of molecular formula prediction module “Accurate Mass Calculator ”in LCMS Solution ，and the refined impurity products by preparation and purification were standardized and confirmed . The impurity content was determined by HPLC （with the same condition of one-dimensional liquid chromatography for qualitative analysis ）. RESULTS ：The main unknown impurity in Oxiracetam capsules is oxiracetam acid. The content of the refined product was 99.5％ after preparation and purification. The contents of oxiracetam acid in 9 batches of Oxiracetam capsules were 0.05％ -0.14％ . CONCLUSIONS ：The established two-dementional UPLC-IT-TOF-MS method can accurately locate the peak position of the impurity oxiracetam acid ，and analyze its structure，while the corresponding content determination method can better separate the impurity from the main drug and other components，with good sensitivity ，precision，repeatability，stability and accuracy. The quality of the finished product of Oxiracetam capsules can be well controlled by using above method .