Warm Autoimmune Haemolytic Anaemia due to IgA and IgG � A Rare Clinical Scenario

Autoimmune Haemolytic Anaemia (AIHA) is a decompensated acquired haemolysis caused by the host immune system producing autoantibodies that bind to the antigens on the surface of circulating erythrocytes, leading to haemolysis and decreased red cell survival. It requires efficient and advanced immunohaematological and transfusion support. Despite advances in medical field, simple test like Direct Antiglobulin Test (DAT) still remains the diagnostic hallmark. The sensitive column gel technology further helps to characterise these antibodies according to class, subclass and titre of antibodies. It is very important to characterize these autoantibodies as there is a relation between strength of DAT and in vivo haemolysis. Serologically, cases are divided into warm (mainly due to IgG), cold (mainly due to IgM) or mixed depending upon the thermal amplitude of the antibody. IgA and IgG antibodies causing warm type of AIHA are rare as monospecific gel cards are not available in all centres. We here report rare case series of warm AIHA caused by dual antibodies IgA and IgG.

Associations between human plasma anti-gliadin antibodies and occurrence of schizophrenia in patients with different ages / 吉林大学学报(医学版)

Objective; To investigate the associations between the levels of human plasma anti-gliadin antibodies and occurrence of schizophrenia in the patients with different ages in Chinese Han population, and to clarify the effects of human plasma anti-gliadin antibodies in the occurrence of schizophrenia. Methods; The plasma samples were collected from 313 schizophrenia patients (schizophrenia group) and 408 healthy controls (healthy control group) in Chinese Han population. The levels of human anti-gliadin IgA and IgG antibodies of the subjects in various groups were detected by enzyme-linked immnosorbent assay (ELISA) method. The levels of human plasma anti-gliadin IgA and IgG antibodies in the subjects in schizophrenia group and healthy control group were analyzed by Pearson's correlation analysis and compared by Mann-Whitney U test; receiver operating characteristic (ROC) curve analysis was performed. Results; The level of plasma anti-gliadin IgA antibody showed a significantly positive correlation with the age and age ranges of the subjects (r= 0. 177, P0. 05). The ROC curve analysis results showed that the area under ROC curve (AUC) of anti-gliadin IgA and IgG antibodies were 0.573 (SE = 0. 022, 95% Cl: 0.53-0.62) and 0. 520 (SE=0. 022, 95%CI; 0. 48-0. 56). The sensitivities of anti-gliadin IgA and IgG antibodies were 13. 7% and 12. 8% when the specificity was 92. 2%. Conclusion; The increasing of plasma anti-gliadin antibodies level is associated with the occurrence of schizophrenia in the patients with different age ranges in Chinese Han population, and the human plasma anti-gliadin antibodies maybe play an important role in the young schizophrenia patients.

The statistical analysis of association between serum level of chlamydia pneumonia immunoglobulin A antibody and the attack of ischemic stroke / 中国实用内科杂志

0.05),the odds ratio(OR)being 0.873,[95% confidential interval(CI):0.428～1.782].(3)The relationship between ischemic stroke and the risk factors was illuminated by the Logistic Regression analysis.The results showed that there was no significant difference of the positive rate of IgA antibody between the case group and control group.Conclusion There may be not relationship between CP IgA antibody and ischemic stroke.There is no relationship between IgA CP antibody and the other risk factors of ischemic stroke.