RESUMO
【Objective】 To explore the efficacy of modified prostate tip separation technique combined with laparoscopic radical prostatectomy based on propensity score matching (PSM) in the treatment of prostate cancer. 【Methods】 A total of 74 prostate cancer patients treated during Jan.2019 and Dec.2022 with modified prostate tip separation technique combined with laparoscopic radical prostatectomy were included in the combined group, and another 63 prostate cancer patients treated during the same period with laparoscopic radical prostatectomy were selected as the control group. Altogether 58 pairs of patients were matched with PSM. The perioperative indicators, incidence of complications, urinary control function and sexual function before and one month after surgery between the two groups after matching were compared. 【Results】 There were no statistically significant differences in general data between the two groups (P>0.05). One month after operation, the scores of the International Urinary Incontinence Questionnaire (ICIQ-SF) and International Erectile Function Questionnaire (IIEF-5) in both groups decreased, while the Expanded Prostate Cancer Index Composite (EPIC-UIN) and International Prostate Symptom Score (IPSS) in both groups increased (P<0.05). The scores of ICIQ-SF [(9.02±1.98) vs. (11.38±2.04)] and IPSS [(19.67±4.19) vs. (21.68±4.23)] were lower in the combined group than in the control group (P<0.05), while the scores of EPIC-UIN [(70.49±6.82) vs. (63.34±6.48)] and IIEF-5 [(18.17±1.73) vs. (16.72±1.58)] were higher in the combined group than in the control group (P<0.05). Compared with the control group, the combined group had shorter catheter retention time [(7.38±1.97) d vs. (5.11±1.82) d] and hospital stay [(13.18±2.23) d vs. (11.74±2.09) d], lower incidence of complications (22.41% vs. 6.90%), and higher positive rate of incision margin (8.62% vs. 20.69%) (P<0.05). 【Conclusion】 PSM can balance the differences between groups. The modified prostate tip separation technique combined with laparoscopic radical prostatectomy can improve the urinary control function, have little impact on sexual function, and cause fewer postoperative complications. However, the risk of positive incision margin is high, and further modification is needed to achieve the best therapeutic effects.
RESUMO
Objective: To explore the relationship between margin width in extended lumpectomy for breast cancer with survival rate, local recurrence rate, and cosmetic result. Methods: The clinical data of 42 breast cancer patients who had a 2cm incision margin width (group A) and 37 who had a 3cm incision margin width (group B) were retrospectively analyzed. The 5-year, 10-year survival rates, recurrence rates, and the cosmetic results were compared between the 2 groups. Results: The 5-year and 10-year survival rates in patients of group A were 90.1% and 85.3%, respectively; in patients of group B were 92.3% and 83.6% , respectively(P>0.05). The 5-year and 10-year local recurrence rates in patients of group A were 5.9%, and 11.%, respectively; in patients of group B were 3.4% and 12.9%, respectively(P>0.05). The cosmetic result was significantly better in group A than that in group B(P<0.05). Conclusion: An incision margin width of 2 cm is enough for extended lumpectomy. It is not necessary to further expand the margin width; otherwise, it may influence the cosmetic results after operation.