A meta-analysis of effects ofLanqin oral liquid and ribavirin on in fantile hand-foot- mouth disease / 国际中医中药杂志

Objective To systematically evaluate the clinical efficacy of Lanqin Oral Liquid(LOL)and ribavirin on infantile hand-foot-mouth disease(HFMD).Methods The randomized controlled trials(RCT)of LOL and ribavirincombined for treating HFMD were retrieved from EMbase, PubMed, CNKI, CBM and VIP(from establish to Oct 2014), the methodological quality of included literature was evaluated, and data analyses were performed with RevMan 5.2 software.Results Fifteen studies involving 2 016 patients were ultimately identified.The meta-analysis results showed that the effective rate of LOL group was superior to that of the control,OR(95%CI)was 5.80 (3.94, 8.52), and there were significant differences in the antifebrile time, erythra regression time, herpes regression time and oral ulcer regression time between the groups,MD (95%CI): -1.29 (-1.45,-1.13), -1.88 (-2.44,-1.33), -1.57 (-2.36,-0.78), -1.57 (-2.07,-1.08), respectively. Conclusion Based on the present clinical evidence, the meta-analysis results indicate that LOL and ribavirin treating HFMD is effective and safe. However, due to the uneven quality of these included studies, this conclusion need more large sample size and high-quality clinical RCTs to be confirmed.

Clinic observation on retention enema of Shuanghuanglian Injection in treating 162 Cases of infant hand-foot-mouth disease / 国际中医中药杂志

Objective To observe the effects of retention enema of Shuanghuanglian injection in treating infantile hand-foot-and-mouth disease. Methods A total of 162 patients of hand-foot-mouth disease were recruited into a control group and treatment group randomly, with 81 cases in each group. The treatment group was treated with retention enema of Shuanghuanglian injection, and the control group was treated with ribavirin granules. Clinical effects were observed in both groups. Results The total effective rate of the treatment group and the control group was 97.53% and 88.89% respectively, showing statistical significance(P<0.05). The time of clinical symptom relief and course of treatment were shorter in the treatment group than those in the control group (P<0.05). Conclusion Retention enema of Shuanghuanglian injection is effective in treating infantile hand-foot-mouth disease.