The hippocampal proteomics mechanism of thalidomide in Alzheimer's disease model mice induced by Aβ / 中国药理学通报

Aim To observe the effect of thalidomide on the learning and memory ability and hippocampal tissue proteome of Alzheimer's disease(AD)mice,to screen the differential proteins of thalidomide in preventing and treating AD,the pathways involved in regulation,and to explore its possible mechanism. Methods The experimental mice were randomly divided into blank control group,model group,and thalidomide high and low dose groups. The drugs were administered by gavage every day for 21 days. After the administration,Morris water maze test was used to evaluate the learning and memory abilities of the mice,HE staining and Nissl staining were used to observe the pathological tissue morphology of the mouse hippocampus,ELISA was employed to detect the mitochondrial respiratory chain enzyme complex in mouse brain,and the Label-free proteomics method was used to screen different groups of hippocampal proteome proteins. Results The results of the Morris water maze showed that compared with the model group,the escape latency time of the drug group was significantly reduced,and the number of crossing the platform significantly increased(P<0.05). Thalidomide administration could improve the morphological structure of neurons in hippocampus,and could increase the activity of the mitochondrial respiratory chain complex ,Ⅱ, and of the brain tissues of AD mice(P<0.05). A total of 4 378 differential proteins were identified,which had a significant regulatory effect on the expression of 580 proteins in hippocampus of AD mice(P<0.05). Energy metabolism may jointly participate in the regulation of neurodegeneration pathways-changes in pathways such as various diseases and Alzheimer's disease. Conclusions Thalidomide can significantly improve the learning and memory function of AD model mice induced by Aβ

Reflection on the construction of pharmacy and traditional Chinese pharmacy disciplines based on patent information analysis: taking “double first-class” universities as an example / 中国药科大学学报

@#Among the second round of “double first-class” construction universities, 12 universities are in the process of building first-class pharmaceutical and traditional Chinese medicine disciplines.The aim is to explore the innovative development trend of these 12 universities, based on their information related to pharmacy and traditional Chinese medicine in the past five years.The study used the PatSnap global patent database to search for pharmaceutical related patents applied by 12 universities from 2018 to 2022, and analyzed the information from perspectives such as application and authorization volume, technical themes, transfer and licensing status, and international patent situation.The results reveal that comprehensive universities and China Pharmaceutical University are superior to other pharmaceutical universities in terms of patent application volume and licensing rate.From the perspective of patent classification, most of the relevant patents involve the effective ingredients of drugs.Comprehensive universities and China Pharmaceutical University pay more attention to the research of anti-tumor drugs.Among all authorized patents, the quantity is insufficient, and most of them are exclusive licenses.The transfer of relevant rights mostly occurs between universities and enterprises.In terms of international patent applications, comprehensive universities dominate in terms of quantity, but the total amount is still insufficient.In the future innovation and development process of “double first-class” universities, it is necessary to improve the awareness of patent protection and layout, attract relevant talents, give full play to the advantages of university intellectual property information service centers, and promote the transformation of university achievements.

Análisis de la producción científica de la Universidad de Ciencias Médicas de Granma en Scopus

Introducción: la evaluación científica y los estudios bibliométricos han devenido en procesos de gran interés e importancia debido a que la investigación científica es un indicador de calidad para las instituciones científicas y académicas. La Universidad de Ciencias Médicas de Granma es una institución de Educación Médica Superior cuya finalidad es la formación y desarrollo de las Ciencias Médicas en la región basada en la integración docencia-asistencia-investigación. Es por esto que se hace necesario comprender el impacto y el comportamiento de su producción científica desde una perspectiva internacional. Objetivo: analizar la producción científica de la Universidad de Ciencias Médicas de Granma en la base de datos bibliográfica Scopus. Métodos: se realizó un estudio bibliométrico retrospectivo y de carácter descriptivo de toda la producción científica de la Universidad de Ciencias Médicas de Granma, usando como fuente de información la base de datos Scopus. Resultados: se identificó una alta concentración de trabajos en idioma español y en revistas cubanas de Q4 aunque predominaron las investigaciones originales. La colaboración internacional se comportó favorable. Por último, el posicionamiento internacional de la universidad es todavía insustancial. Conclusiones: la producción científica de la UCMG presenta valores moderados en cuanto a los indicadores de productividad, visibilidad e impacto. Este comportamiento presenta una marcada tendencia al aumento para los últimos años y se prevé un mejoramiento de estos patrones en años futuros.

Introduction: scientific evaluation and bibliometric studies have become processes of great interest and importance because scientific research is a quality indicator for scientific and academic institutions. The University of Medical Sciences of Granma is an institution of Higher Medical Education whose purpose is the training and development of Medical Sciences in the region based on teaching-assistance-research integration. This is why it is necessary to understand the impact and behavior of its scientific production from an international perspective. Objective: to analyze the scientific production of the Granma University of Medical Sciences in the Scopus bibliographic database. Methods: a retrospective and descriptive bibliometric study of all the scientific production of the University of Medical Sciences of Granma was carried out, using the Scopus database as a source of information. Results: a high concentration of works in the Spanish language and in Cuban Q4 journals was identified, although original research predominated. International collaboration behaved favourably. Finally, the international positioning of the university is still insubstantial. Conclusions: the scientific production of the UCMG presents moderate values ​​in terms of indicators of productivity, visibility and impact. This behavior shows a marked upward trend in recent years and an improvement in these patterns is expected in future years.

Introdução: a avaliação científica e os estudos bibliométricos tornaram-se processos de grande interesse e importância, pois a pesquisa científica é um indicador de qualidade para as instituições científicas e acadêmicas. A Universidade de Ciências Médicas do Granma é uma instituição de Ensino Superior Médico cuja finalidade é a formação e o desenvolvimento das Ciências Médicas na região com base na integração ensino-assistência-pesquisa. Por isso, é necessário compreender o impacto e o comportamento de sua produção científica a partir de uma perspectiva internacional. Objetivo: analisar a produção científica da Universidade de Ciências Médicas do Granma na base de dados bibliográfica Scopus. Resultados: identificou-se alta concentração de artigos em periódicos Q4 espanhóis e cubanos, emboratenha predominado pesquisas originais. A colaboração internacional foi favorável. Por fim, o posicionamento internacional da universidade aindaé insubstancial. Conclusões: a produção científica da UCMG apresenta valores moderados em termos de indicadores de produtividade, visibilidade e impacto. Esse comportamento mostra uma acentuada tendência de aumento nos últimos anos e espera-se uma melhora nesses padrões nos próximos anos.

Análisis bibliométrico de los artículos científicos publicados en Medicina Veterinaria y Zootecnia en Colombia 2010-2019

RESUMEN Objetivo. Analizar la producción científica en Medicina Veterinaria y Zootecnia en Colombia en el período 2010-2019. Materiales y métodos. Se realizó un estudio descriptivo transversal retrospectivo, mediante el análisis bibliométrico de los artículos publicados en nueve revistas del área de la Medicina Veterinaria y Zootecnia en Colombia. La información se obtuvo mediante la búsqueda en internet de la página web de cada revista. Los artículos incluidos fueron artículos originales, revisiones de literatura, comunicaciones breves, casos clínicos y editoriales. Resultados. El total de artículos fue 3.000; 2.250 (75%) publicados en español, 673 (22.4%) en inglés y 77 (2.6%) en portugués. 2.282 (76.1%) fueron originales, 224 (7.5%) revisiones de literatura, 165 (5.5%) casos clínicos, 105 (3.5%) comunicaciones breves, 204 (6.8%) editoriales y 21 (0.6%) otros. Hubo 10.296 autores; 7.109 (69%), nacionales y 3.187 (31%) extranjeros. Del total de autores, 6.659 (64.7%) fueron hombres; 3.199 (31%) mujeres y 438 (4.3%) sin identificación; con un promedio de 3.38 autores/artículo. Las entidades públicas aportaron el 77.9% de la producción científica y las privadas el 22.1%. Las áreas con mayor número de publicaciones fueron zootecnia, salud animal, agricultura y fauna silvestre. El top 5 de las filiaciones de los autores correspondió a universidades públicas. Conclusiones. Las revistas que publican en inglés consiguen un mejor posicionamiento internacional y en ellas publican el mayor número de autores extranjeros. Los artículos más publicados fueron los originales. El top 10 de los artículos más citados arrojó un total de 810 citas que contribuyen con la internacionalización de las revistas colombianas y de Colombia.

ABSTRACT Objective. Analyze the scientific production in Veterinary Medicine and Animal Husbandry in Colombia in the period 2010-2019. Materials and methods. A retrospective cross-sectional descriptive study was carried out, through the bibliometric analysis of articles published in nine journals in the area of Veterinary Medicine and Animal Husbandry in Colombia. The information was obtained by searching theinternet for each journal's website. The articles included were original articles, literature reviews, brief communications, clinical cases and editorials. Results. The total number of articles was 3.000; 2.250 (75%) published in Spanish, 673 (22.4%) in English and 77 (2.6%) in Portuguese. 2.282 (76.1%) were original, 224 (7.5%) literature reviews, 165 (5.5%) clinical cases, 105 (3.5%) brief communications, 204 (6.8%) editorials and 21 (0.6%) others. There were 10,296 authors; 7.109 (69%), nationals and 3.187 (31%) foreigners. Of the total Authors, 6.659 (64.7%) were men; 3.199 (31%) women and 438 (4.3%) without identification, with an average of 3.38 authors/article. Public entities contributed 77.9% of scientific production and private entities 22.1%. The areas with the highest number of publications were zootechnics, animal health, agriculture and wildlife. The top 5 of affiliations of the authors corresponded to public universities. Conclusions. The journal that publish in English achieve a better international positioning and in them the largest number of foreign authors publishes. The most published articles were the original ones. The top 10 of the most cited articles yielded a total of 810 citations that contribute to the internationalization of Colombia and Colombian journals.

Design of course evaluation system based on formative evaluation: a case study of Medical Infor-mation Analysis / 中华医学教育探索杂志

Based on formative evaluation, we constructed the evaluation system of Medical Infor-mation Analysis according to the literatures and theories of learning evaluation and teaching practice. In the present evaluation system, teachers and students evaluate each other. It focuses on the evaluation and feed-back of student learning. The frame of the system includes three primary indicators — learning attitude, interactive participation and behavioral results , and six corresponding secondary indicators for student learning evaluation. It is significant to introduce formative evaluation into course evaluation and to combine process evaluation with summative evaluation in evaluating those courses with many contents and limited time .It could improve teaching quality, promote student learning, and effectively achieve the curriculum objectives at last. The present evaluation system could be reference for other related curriculum evaluation.

Steps and tools for drug repositioning by text mining / 中华医学图书情报杂志

Text mining provides a new approach for drug repositioning, and the emerging databases and their corresponding tools provide more and more convenience for drug repositioning by text mining.The methods and tools for studying drug repositioning by text mining and their successful application examples were thus described in this paper in order to provide reference for the researchers interested in this field.

Expression of miR-665 and Bioinformatic Analysis on Its Target Genes of Kai-Xin Jie-Yu Decoction Based on Depression Model Rats / 世界科学技术-中医药现代化

This study was aimed to detect the expression of miR-665 in the hippocampal of depression rat model treated with Kai-Xin Jie-Yu (KXJY) decoction and bioinformatic analysis of target genes of miR-665,in order to investigate the role of miR-665 in the pathogenesis of depression and the antidepressant mechanism of KXJY decoction.The rat model of chronic stress depression was established and then treated with KXJY decoction for 42 days.The total RNA from hippocampus tissues was extracted.And the relative expression of miR-665 in hippocampus of rats in each group was detected by RT-qPCR.TargetScan and microRNAorg databases were used to predict target genes for miR-665.DAVID database was used to classify GO function and to analyze KEGG signaling pathway of target genes.The results showed that compared with the normal group,the expression level of miR-665 in hippocampus of the model group was significantly higher with significant difference (P ＜ 0.01).Compared with the model group,the expression level of miR-665 in hippocampus of Chinese medicine group and western medicine group decreased significantly with significant difference (P ＜ 0.01).The biological functions of miR-665 target genes were mainly concentrated in the response to organic substance.The signal pathway was mainly concentrated in N-Glycan biosynthesis.It was concluded that miR-665 may be involved in the pathological process of depression,by correcting the abnormal expression of miR-665,which may be one of the antidepressant mechanisms of KXJY decoction.Through the analysis and prediction of the target genes,it provided a certain direction and theoretical basis for further study on the specific mechanism of KXJY decoction intervention on miR-665.

The information analysis of Ebola research by foPubMed / 中华医学科研管理杂志

Objective To probe into the status and development trend of ebola,so as to provide reference for further research.Methods This paper took the ebola literature as the object of study,took GoPubMed as the retrieval and statistical tool,and conducted information analysis of the subjects,time,sources,distribution,authors and literature development trends of ebola research.Results The main subjects of ebola literature involved ebola virus and hemorrhagic fever,ebola.There has been a sharp increase on the literature number of ebola in the recent two years,particularly in 2014.The majority of literature came from the United States,and Britain ranked the second.The sources of ebola literature were mainly the SCI journals published in the United States and British.Conclusions GoPubMed can provide a vivid picture of the current situation and development trend of ebola research.Further improvements are needed both in the quality and quantity of ebola research in China.

Ebola virus-related papers published in China and foreign countries:A comparative analysis / 中华医学图书情报杂志

Ebola virus-related papers covered in PubMed and CNKI were analyzed by co-occurrence and cluster analysis, respectively. The current situation in research of Ebola virus in China and foreign countries was com-pared. Some suggestions were proposed for research of Ebola virus in China, such as attaching importance to re-search of Ebola virus, enforcing research of its vaccine,and strengthening cooperation between domestic and foreign scholars.

The Information Analysis of Eastern Equine Encephalitis Based on a Variety of Visualization Softwares / 医学信息学杂志

〔Abstract〕 Based on various visual softwares, the paper mines the data of SCI papers and published patents on Eastern Equine En-cephalitis ( EEE) during 1995-2015.2, analyzes the overall development, patent technology life circle, research area, cooperation and competition among countries/districts, basic information of institutes or outstanding individuals.The characteristics of various visual soft-wares are showed, the libraries should master data mining and information visualization technology, so as to provide consulting service to satisfy the deep level and personalized demands of users.

Comparison of different literature information analysis tools / 中华医学图书情报杂志

The advantages and disadvantages of 13 representative literature information analysis tools were com-pared in aspects of their support data formats, data preprocessing, constructed relationship matrixes, standard pro-cessing, analysis methods and results visualization, with certain suggestions put forward for the users in selecting proper literature information analysis tools.

Construction of information platform for research and development institutions of foreign miliat ry medical equipments / 中华医学图书情报杂志

The information was obtained through the open access channels and organized with free markers.The relations in research and development institutions of foreign military medical equipments were determined by analy-zing thecompetitive opponents .The information platform for research and development institutions of foreign mili-tarymedical equipments was constructed using the MVC design model in combination with Web2.0 technology and community concept of resources according to the B/S structure forthe collection, storage, organization, analysis, sharing and evaluation of military medical information resources .

The Information Analysis of Avian Influenza Research by Gopubmed / 中华医学科研管理杂志

Objective To probe into the status and development trend of avian influenza,so as to provide reference for further research.Methods The article took the avian influenza literature as the object of study,took Gopubmed as the retrieval and statistical tool,made information analysis of the subjects,time,sources,distribution,authors and literature development trends of avian influenza research.Results The main subjects of avian influenza literature involved influenza in birds and influenza,human.There has been a sharp increase on the literature number of avian influenza in the recent decade with the most in 2006.The United States accounted for the most literature and China ranked the second place.The sources of avian influenza literature were mainly the SCI journals from the United States and European countries.Conclusions Gopubmed can show a vivid picture of the current situation and development trend of avian influenza research.Further improvements are needed both in the quality and quantity of avian influenza research in China

Military medical literature collection:construction and analysis / 军事医学

Objective To explore the way to compile a global military medical literature collection and perspectives for its research.Methods The names of military medical research institutions and their trends of development were summa-rized via semantic analysis.The collection of retrieval words for military medical research institutions( then the collection) was constructed based on expert consultation.The names of military medical research institutions were collect-ed with manual screening after retrieval withthe collection.The literature collection of military medical research institu-tions was completed with coordinated retrieved of their papers and other publications.Results According to different needs of information analysis, the literature collection of military medical research institutions could be analyzed in terms of their size, types of development, and academic authority.Conclusion Based onthe collection, the military medical research institutions collected in this article included institutions that used to be neglected during the course of information tracking of military medicine.Three kinds of institutions should be paid more attention to.The institutions were the ones with a large number of papers and citations, the ones whose papers increased or decreased dramatically, as well as the ones whose research directions were the priority fields of Chinese PLA.

Studies on Internet public opinions in domestic library and information field from 2004 to 2013:A review / 中华医学图书情报杂志

The studies on Internet public opinions in domestic library and information field from 2004 to 2013 were analyzed by subject analysis,which showed that studies on the hot spots of Internet public opinions using bibliometrics and knowledge map were rather mature while studies on how library and information science provides the theoretical support for Internet public opinions in its service were immature. The problems in studies on Internet public opinions in library and information field should be further studied, including their objectives, theoretical support, techniques and application.

El análisis de información y las investigaciones cuantitativa y cualitativa / The information analysis and the qualitative and quantitative research

En el estudio se brindan algunos conceptos sobre el análisis de información. También se ofrecen algunas características de los especialistas que laboran en esta área. Se abordan los métodos de investigación cuantitativa y cualitativa, como aristas de la Metodología de la Investigación y se exponen los conceptos y componentes de ambos métodos. Por otro lado, se hace una valoración de las ventajas y desventajas de cada uno de estos métodos para su utilización en el análisis de información.

The study provides some concepts on the information analysis and also some characteristics of the specialists working in this sphere. The quantitative and qualitative research methods, as lines of the Research Methodology, as well as the concepts and components of both methods were described. On the other hand, an assessment was made on the advantages and disadvantages of each of these methods with a view to using them in the information analysis.

A moden sdudy of training students' information search ability / 中华医学教育探索杂志

The article discusses reforming information search course, integrating the education of users training and information search course for training the persons with ability of innovation or scientific research in new century, strengthening the combination of theory and practice, reforming the way of exams, emboding the individuation in teaching amd strengthening the ability of information analysis and catch .

To Strengthen Information Analysis and Evaluation Competency——On the Education of Information Literacy of Medical Students / 中华医学教育探索杂志

As society develops,it has become one of the important goals of higher medical personnel training to cultivate medical students' information literacy.After explaining the definition of information literacy,this paper discussed the importance of information analysis and evaluation in information literacy education.

A study of information analysis ability training in medical graduate students / 中华医学教育探索杂志

Objective To solve the problem about abundance information but poverty of knowledge by training the information analysis ability of users.Objects Medical graduate students who have the basic knowledge of literature retrieval.Curriculum Bibliometric parameters,reference management software,literature analysis software,Excel and the analysis function of bibliographic database were explained in 18 class hours.Results Satisfactory results have been got.Discussion Users can analyze retrieval results effectively after short time learning with no additional cost.

Research on appearance colour information of Rhizoma Alismatis processing pieces / 中草药

Objective To investigate the evaluation method of processing pieces' colour and quantificationally analyse the relactionship between the pieces' colour and the internal quality. Methods Taking different processing techniques on Rhizoma Alismatis as research objects,using a camera and Adobe Photoshop software to acquire the elementary information of processing pieces' colour and determine the contents of the active principle in Rhizoma Alismatis by HPLC. The active principle in Rhizoma Alismatis and the colour of processing pieces are analyzed quantificationally by SPSS 13.0 statistical software and data mining software Clementine 8.0. Results The method for acquiring and handling colour information of processing pieces in Rhizoma Alismatis could be used to quantificationally analyze the correlation of the colour of processing pieces. There is a significant correlation between processing pieces' colour difference and the internal quality. Conclusion The colour difference of processing pieces can be one of target for the quality assessment. The method can be popularized to other precessing pieces control of techniques.