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ObjectiveTo elucidate the mechanism of Osteoking against fracture， femoral head necrosis， osteoarthritis， and lumbar disc herniation by integrating heterogeneous information network mining and experimental validation. MethodOn the basis of the disease-related database and transcriptome expression profiling dataset， as well as the ETCM database， the gene sets related to four target diseases and the candidate target spectrum of Osteoking were obtained through the integration and analysis of bioinformatics data， and a "disease-syndrome-formula-target-pathway-effect" heterogeneous information network was constructed. In addition， by functional enrichment analysis， the core targets of Osteoking in interfering with the imbalance network of four kinds of bone injury diseases， the biological pathways involved， and the corresponding clinical symptoms were screened， and they were verified in animal experiments. ResultHeterogeneous information network mining indicates that Osteoking may commonly reverse the imbalance networks of fracture， femoral head necrosis， osteoarthritis， and lumbar disc herniation via regulating cell function and activity， inhibiting inflammatory response， reducing bone destruction， and improving the immune function of the body by modulating relevant core candidate targets such as RAC-alpha serine/threonine-protein kinase （Akt1）， catenin beta-1 （CTNNB1）， epidermal growth factor receptor （EGFR）， heat shock protein 90-alpha （HSP90AA1）， and phosphatidylinositol 3-kinase catalytic subunit alpha isoform （PI3KCA）， as well as related biological pathways such as phosphatidylinositide 3-kinases/protein kinase B （PI3K/Akt）， janus kinase/signal transducer and activator of transcription （JAK/STAT）， tumor necrosis factor （TNF）， nuclear factor kappa-B （NF-κB）， and Toll-like receptors. In particular， Osteoking may improve the blood supply of the fracture end by regulating blood circulation at the target site of the disease， and it may maintain the balance of bone metabolism by regulating hormone-related pathways to promote fracture healing. In addition， Osteoking may relieve lipid metabolism disorders by targeting and regulating lipid-related pathways， accelerate bone formation and bone repair， and delay the progression of femoral head necrosis. Osteoking may relieve the symptoms of pain by acting on neurological pathways to reduce local nociceptive stimulation in patients with osteoarthritis and lumbar disc herniation. Further experimental validation demonstrates that the PI3K/Akt signaling pathway is the most significantly enriched pathway for the key network targets of Osteoking for the four diseases. The candidate target of Osteoking may have the strongest association with the network of fracture-related genes. Therefore， this study chooses fracture as the target disease to verify the efficacy of Osteoking. The results show that Osteoking can accelerate bone formation and promote fracture healing by inhibiting the activation of the PI3K/Akt signaling axis. ConclusionThe study shows that the main mechanism of "treating different diseases with an identical treatment" of four bone injury diseases with Osteoking involves cell function regulation and immune inflammation-related signaling pathways. Further experimental validation identifies that the PI3K/Akt signaling axis may be one of the key pathways of Osteoking to promote bone regeneration， bone reconstruction， and bone metabolism homeostasis.
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Abstract speciesLink is a large-scale biodiversity information portal that exists thanks to a broad collaborative network of people and institutions. CRIA's involvement with the scientific community of Brazil and other countries is responsible for the significant results achieved, currently reaching more than 15 million primary biodiversity data records, 95% of which are associated with preserved specimens and about 25% with high-quality digital images. The network provides data on over 200,000 species, of which over 110,000 occur in Brazil. This article describes thematic networks within speciesLink, as well as some of the most useful tools developed. The importance and contributions of speciesLink are outlined, as are concerns about securing stable budgetary support for such biodiversity data e-infrastructures. Here we review the value of speciesLink as a major source of biodiversity information for research, education, informed decision-making, policy development, and bioeconomy.
Resumo speciesLink é um portal de informações em larga escala sobre biodiversidade, que existe graças a uma ampla rede colaborativa de pessoas e instituições. O envolvimento do CRIA com a comunidade científica do Brasil e de outros países é responsável pelos resultados expressivos alcançados, atingindo atualmente mais de 15 milhões de registros de dados primários de biodiversidade, sendo 95% associados a espécimes preservados e cerca de 25% a imagens digitais de alta qualidade. A rede fornece dados sobre mais de 200.000 espécies, das quais mais de 110.000 ocorrem no Brasil. Este artigo descreve as redes temáticas do speciesLink, bem como algumas das ferramentas mais úteis desenvolvidas. A importância e as contribuições do speciesLink são destacadas, assim como as preocupações em garantir um apoio financeiro estável para e-infraestruturas de dados sobre biodiversidade. Aqui revisamos o valor do speciesLink como uma das principais fontes de informação sobre biodiversidade para pesquisa, educação, tomada de decisão, desenvolvimento de políticas e bioeconomia.
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RESUMEN Fundamento: El Laboratorio Central de Líquido Cefalorraquídeo arriba casi a sus 17 años de fundado, como una entidad de ciencia e innovación tecnológica que se distingue por su prolífera producción científica. Objetivo: caracterizar la producción científica investigadores y alumnos ayudantes en el Laboratorio Central de Líquido Cefalorraquídeo. Métodos: estudio bibliométrico, descriptivo, de las publicaciones científicas del Laboratorio Central de Líquido Cefalorraquídeo, adscrito a la Facultad de Ciencias Médicas Miguel Enríquez, Universidad de Ciencias Médicas de La Habana. Se analizó la producción científica correspondiente al período comprendido desde abril de 2004 hasta febrero de 2020, según las bases de datos de Google Académico, Scopus y PubMed. Se obtuvieron las variables reportadas por Publish or perish versión 7 avanzada, como los índices h y sus variantes. También se hizo el análisis de redes por VOSviewer, versión 1.6.13. Resultados: se publicaron en total 426 artículos. El investigador fundador mostró un índice h (dado por Google Académico) de 20, el cual disminuyó a medida que se fueron integrando otros autores al grupo. Hubo dos autores con idéntico índice h, pero con índice g superior, o sea, que acumuló un mayor número de citas para igual número de trabajos incluidos en el índice, y el alcance h y g fue inversamente proporcional a los años de experiencia, y por tanto, al número de publicaciones de autores con índice h=1 o superior. Conclusión: La producción científica ha sido amplia, sostenible en número y demuestra lo que ha logrado el equipo con un trabajo sistemático de impacto.
ABSTRACT Background: The Central Cerebrospinal Fluid Laboratory is almost 17 years old, as an entity of science and technological innovation that is distinguished by its prolific scientific production. Objective: to characterize the scientific production of researchers and assistant students in the Central Laboratory of Cerebrospinal Fluid. Methods: bibliometric, descriptive study of the scientific publications of the Cerebrospinal Fluid Central Laboratory, attached to the Miguel Enríquez Faculty of Medical Sciences, Havana University of Medical Sciences. The scientific production from April 2004 to February 2020 was analyzed, according to the Google Scholar, Scopus and PubMed databases. The variables reported by Publish or perish version 7 advanced were obtained, such as h indices and their variants. The network analysis was also done by VOSviewer, version 1.6.13. Results: a total of 426 articles were published. The founding researcher showed an h-index (given by Google Scholar) of 20, which decreased as other authors joined the group. There were two authors with the same h-index, but with a higher g-index, that is, they accumulated a greater number of citations for the same number of works included in the index, and the h and g scope was inversely proportional to the years of experience, and therefore, to the number of publications of authors with index h = 1 or higher. Conclusion: Scientific production has been extensive, sustainable in number and shows what the team has achieved with systematic impact work.
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Objective：To investigate the characteristics of studies registered in the field of rehabilitation medicine.Methods：The university hospital medical information network clinical trials registry database was searched for domestic clinical trials associated with rehabilitation medicine that were registered after June 2005. We extracted information about studies and analyzed their registration trends and overall characteristics.Results：Among the 21,410 registered trials, we found 529 trials associated with rehabilitation. The purpose of this study was to investigate efficacy in 65％ of the studies. Among these studies, 54％ were parallel-group comparison studies, 50％ were registered retrospectively, and 85％ did not publish any results. In comparison studies, 86％ were randomized controlled studies, and 47％ were open-label trials.Conclusion：An increasing trend of registration was observed. However, we found several problems in registration. Prospective registration is important to decrease publication and outcome reporting biases. Education for the relevant study protocol and registration might improve the quality of clinical study in domestic rehabilitation medicine.
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Objective To reveal the status quo and emerging issues of co-authorship in regional health informatization research community in China.Methods The terms or keywords describing and covering regional health informatization were used to search the most relevant literatures about the subject in CNKI,Wanfang database and PubMed.Software tools were used to extract bibliographic,Social network analysis (SNA);co-authorship,and co-word analysis were used in this study.Results ①11,482 articles with 16,449 authors in the period of 1984-2013 were found.Each publication has an average of 1.43 authors,and each author has 0.70 publications.The number of coauthored literature was 7741 (67.42 ％).Both production and collaboration have been growing steadily.② Coauthored knowledge network was build which composed by 150 high-yielding Authors.The largest component comprises 43 authors(28％,43/156).The intermediate centrality of 57 authors were above 0.③ 230 2-plexes were found,and 65 2-plexes scale was 4 and over;and there was overlap among them.There were extensive cooperation between the military institutions,a large number of regional health information technology research talent were found in army research institutes..Cohesive subgroups density showed an E-I index=-0.901,which indicated that factionalism was comparatively weaker in this field,and the relationship tended to occur among subgroups.④ Cooperative network was established between the provinces and municipalities.Beijing,Guangdong,Jiangsu,Hubei were the core area.⑤ The average distance between the author=3.155,and it consistent with the small-world characteristics.⑥ The largest component of the network research can be summarized into three categories:HIS-related research,electronic medical records related research,and regional health informatization related research.Conclusions Although such collaboration is growing steadily,the collaboration behavior about regional health informatization study needs to be enhanced.Policy makers and researchers can refer to the relevant information and promote cooperation,improve the capacity of regional health information research and construction.
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Objective:To supply the rescue and treatment to stroke patients in the first time by the building of green information network platform. Methods:Build green information network platform, which taking the UCC as the entrance, using the IP green alarm bell system as the start point, mixing the Hospital Information System, Picture Archiving and Communication Systems, Laboratory Information System, and office automation system together. The platform attains the features of systems interflowed, equipment connected, information shared and data sending at once. These features make the sharing of patient’s information accurate and faster, so that the emergency rescue process is optimized. Results:In the past, it might cost about 20 minutes between the patients’ arriving and the rescue’s starting. When the green information network platform was used, the time was reduced to about 3 minutes. Conclusion: The green information network platform can optimize the process of emergency rescue effectively.
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The control network is an important developmental orientation in the remote control system. As the control network and information network are comparatively alike in the framework and technology, we can build a control network which is similar to the common information network. In the era when the information network is becoming increasingly mature, it is a royal road to construct or rebuild a control information network in the development of the control network by relying on the achievements made in the information network or current information resources. This paper expounds the construction idea of the control information network, gives the idiographic realization method and then researches into the real-time problem encountered in the control information network, and presents a three-closed-loop control system based on virtualized reality. The feasibility of the idea is validated via experiments and simulations separately.
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The control network is an important developmental orientation in the remote control system. As the control network and information network are comparatively alike in the framework and technology, we can build a control network which is similar to the common information network. In the era when the information network is becoming increasingly mature, it is a royal road to construct or rebuild a control information network in the development of the control network by relying on the achievements made in the information network or current information resources. This paper expounds the construction idea of the control information network, gives the idiographic realization method and then researches into the real-time problem encountered in the control information network, and presents a three-closed-loop control system based on virtualized reality. The feasibility of the idea is validated via experiments and simulations separately.
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Objective To connect the content of clinical immunology and inspection with network,so that it is more convenient for medical students to understand and study this course,and the learners’interest in learning is aroused.Methods FrontPage 2003 web page authoring software,as well as animation software(flash) and picture editing software(Photoshop) were used to make a vivid image of the teaching content be shown through the web page,and effectiveness evaluation was done through peer review and students survey about the software.Results Using FrontPage to create web pages and change knowledge into learning pattern.got good results in studetns’self-study,and the"online self-test"section was added,which would more effectively check study effect.There were good student feedbacks.Conclusion Applying this learning pattern to study will play a very good role in deepening students’understanding of curriculum,improving their study efficiency and stimulating their interest in learning.
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These days, the computer network has become the most popular and widely used source of information. There are two kinds of computer networks, the first one is multimedia internet world wide web site and the second one is text based commercial network (etc. Hitel, Chollian. Nownuri, Unitel). With the rapid development of internet, various kinds of medical-related sites are newly appearing on the internet. Even in Korea, several medical-related information sites are on service, however, there are very few compared with foreign sites. World wide web is popular, and creating the homepage for each hospital is becoming more important. In Korea, the number of homepage of about medicine and medical institutes, is increasing. For the construction of Soonchunhyang University Hospital's Computer Information Network, the authors first investigate Korean medical-related information sites available in internet and commercial network. After researching the authors then construct the Computer Information Network of Soonchunhyang University Hospital. This article is written with the intent of assisting those interested in creating and managing their own computer information network system by means of providing relevant data obtained during this process.
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Academias e Institutos , Serviços de Informação , Internet , Coreia (Geográfico) , MultimídiaRESUMO
Korean Society of Clinical Pathologists' Information Network(KSCPIN) began its service as a Closed User Group (CUG) In HiTEL. one of the major information providers in Korea, on March 2nd, 1995. The KSCPIN is the first and the only society which has its own information network among the Regular Member Society of Korean Medical Association. As the name CUG implies. this network is opened only for the members of the society. The main concept of KSCPCIN is to offer various informations and opinion exchange sites only to the society members. For providing various laboratory related informations to every one, we accepted non-society members as KSCPIN members to make KSCPIN as an opened CUG. KSCPIN now offers various bulletins and library not only for the society members, except for some limitations. KSCPIN consists of 115 clinical pathologists, 60 clinical pathology residents, 34 business men, 26 physicians, and 15 others making the total members of 262 at present. With new definition of members and new menu, KSCPIN was self-estimated as a successful CUG, and we recommend the utilization of CUG for all academic societies. In near future, we are going to move the CUG on the internet. which is our finalgoal.
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Humanos , Masculino , Comércio , Serviços de Informação , Internet , Coreia (Geográfico) , Patologia Clínica , CorridaRESUMO
The authors hold that factors affecting the quality of hospital network data include ideologies of relevant personnel, state of the administrative organization, quality of the staff, standardization level of data, level of the software used, interdepartmental cooperation, feedback of test data, and mechanism of supervisory control. Only by taking corresponding measures can the quality of network data be constantly improved.