RESUMO
Seven cases of unstable Type 1 diabetic patients were treated with IIT (intensive insulin therapy) -multi-injection insulin regimen. The short-acting insulin (Actrapid HM) administered by insulin-pen injector (NOVO-Pen 1) before meals as meal-related incremental insulin. The long-acting insulin (Ultratard HM) injected at 10 p.m. as basal insulin. After run-in period of 4 weeks then the IIT-period ran for 12 weeks. The results showed that the mean fasting/post-prandial glucose concentration was normalized from 10.6?2.5/16.2?3.9 mmol/L to6.5?0.9/7.0?2.2mmol/L. The mean HbA, fell from 10.2% to 8.2% (normal 6-8%) during the three months period. It can be concluded that the IIT-multi-injecdon insulin regimen improves metabolic control. The NOVO-Pen seems to be better than the traditional syringe as besides its painless injection, it is easy to use and carry; thus makes the multiple injection regimen more attractive.