Effect of Huazhi Rougan Granules on insulin resistance in patients with non-alcoholic steatohepatitis / 中成药

AIM To observe the clinical efficacy of Huazhi Rougan Granules (Artemisiae scopariae Herba,Cassiae Semen,Rhei Radix et Rhizoma,etc.) in the treatment of damp-heat accumulation type non-alcoholic steatohepatitis (NASH) and its influence on insulin resistance.METHODS During January 2014-January 2016,a total of one hundred and twenty patients with damp-heat accumulation type NASH,given diet and exercise guidance,were randomly and equally divided into control group (polyene phosphatidylcholine) and treatment group (Huazhi Rougan Granules),administrated for twelve weeks.The levels of serum alanine aminotransferase (ALT),aspartate aminotranferase (AST),gamma-glutamyltransferase (GGT),total cholesterol (TC),triglyceride (TG),γ-glutamyl transpeptadase (GGT),fasting plasma glucose (FPG),fasting insulin (FINS),HOMA-IR index,adiponectin (ADPN) and leptin,body mass index (BMI) and uhrasound examination were detected before and after the treatment,respectively.These data were compared in two groups.RESULTS Compared with the control group,the serum ALT,AST,GGT,TC,TG,FPG,FINS and HOMA-IR of the patients in the treatment group decreased significantly,and liver fat were effectively reduced,while serum adiponectin increased markedly (P ＜ 0.05).After the treatment,remarkable reductions in the levels of BMI,leptin were observed in both groups (P ＜ 0.05).CONCLUSION Huazhi Rougan Granules combined with lifestyle modulation can effectively improve the syndrome of damp-heat accumulation type NASH by lowing insulin resistance.

Índice, carga glicémica y fibra dietética de los alimentos y su asociación con resistencia a la insulina en adultos chilenos / Glycemic index, glycemic load and dietary fiber of foods and its association with insulin resistance in Chilean adults

El Índice y Carga Glicémica (IG y CG) categorizan los alimentos según su capacidad de incrementar la glicemia, considerando cantidad y calidad de hidratos de carbono consumidos. Diferentes estudios han postulado que una dieta con IG y CG altos y bajo consumo de fibra incrementan la glicemia e insulinemia, aunque con resultados heterogéneos.El objetivo de este estudio fue analizar la asociación entre IG, CG e ingesta de fibra y valores HOMA-IR en adultos jóvenes. En una muestra representativa de 738 personas que tenían entre 32 y 38 años, nacidos en el Hospital de Limache, Región de Valparaíso, Chile, se recogió información socioeconómica, de salud, se determinó estado nutricional, glicemia, insulina basal y HOMA, y con la encuesta de frecuencia de consumo se estimó IG, CG e ingesta de fibra. Se construyeron modelos de regresión múltiple, controlando efectos de confusión e interacción. En modelos ajustados, se observó que por cada 10 unidades que aumenta el IG y CG de la dieta en individuos con exceso de peso, aumenta el HOMA-IR en 0,31 (p=0,042) y 0,03 (p=0,012), respectivamente y por cada 10 gramos que aumenta la fibra total y soluble, disminuye el HOMA-IR en 0,10 (p=0,04) y 0,62 (p=0,034) respectivamente. En personas sin exceso de peso no hubo estos efectos. Existe una asociación directa entre el aumento de IG y CG de los alimentos y el incremento de HOMA-IR sólo en individuos con exceso de peso y una asociación inversa entre ingesta de fibra dietética total y soluble y HOMA-IR(AU)

Glycemic index, glycemic load and dietary fiber of foods and its association with insulin resistance in Chilean adults. Glycemic index and glycemic load (GI and GL) categorize foods according to their ability to increase blood sugar levels, considering quantity and quality of carbohydrates consumed. Different studies have postulated that a high GI and GL diet and low fiber intake increased glycemia and insulinemia, although with heterogeneous results. The aim of this study was to analyze the association between GI, GL and fiber intake and HOMA-IR values in young adults. In a representative sample of 738 people aged between 32 and 38 years old, born in the Limache’s Hospital, Valparaiso, Chile, socioeconomic and health information, nutritional status, basal glycemia, insulin and HOMA were collected. With a food frequency questionnaire, GI, GL and fiber intake were estimated. Multiple regression models were constructed, controlling confounding and interaction effects. In adjusted models, it was found that for every 10 units that increases diet GI and GL in overweight individuals, HOMA- IR increases in 0.31 (p = 0.042) and 0.03 (p = 0.012) respectively, and for every 10 grams that increases total and soluble fiber intake, HOMA-IR reduces in 0.10 (p = 0.04) and 0.62 (p = 0.034) respectively. In people without overweight such effects were not observed. There was a direct association bet- ween increased GI and GL foods and increased HOMA-IR only in individuals with overweight and an inverse association between total and soluble fiber intake and HOMA-IR(AU)

Sindrome metabólico en niños y adolescentes: qué hay de nuevo? / Metabolic syndrome in children and adolescents: what is new?

El Síndrome Metabólico (SM) comprende alteraciones antropométricas, clínicas y metabólicas predisponentes del desarrollo de diabetes tipo 2 y enfermedades cardiovasculares; resulta de la interacción de factores genéticos y ambientales mediados por regulación epigenética; algunos loci pueden tener mayor efecto en los fenotipos metabólicos modificados por la dieta u otros factores ambientales. Una vez caracterizados los componentes del SM, diversos estudios se enfocan en identificar los mejores predictores de riesgo cardio-metabólico en adultos: obesidad central (CCi) y resistencia a la insulina (RI). La obesidad gestacional y RI en tejidos fetales se asocian a riesgo alto de SM en niños y adolescentes. En adultos jóvenes: mayor prevalencia de HTA y RI en nacidos pretérmino (peso al nacer < 1500 g) vs nacidos a término, sin diferencias significativas en perfil lipídico entre ambos. Estudios recientes reportan asociación entre suministro bajo de ácidos grasos ώ-3 y elevado de ώ-6 en < 2 años con características posteriores del SM: dislipidemia, RI e hiperfagia. Adolescentes obesos no diabéticos con SM tenían menores habilidades aritméticas, de deletreo, atención y flexibilidad mental y más probabilidades de desempeño inadecuado en las evaluaciones cognitivas que sus pares saludables. Se encontraron reducciones de la integridad microestructural en la materia blanca y menores volúmenes del hipocampo, capaces de ocasionar complicaciones cerebrales a corto plazo. Se ha descrito adelanto fisiológico de indicadores de maduración sexual y ósea (MO) en obesos, pero se carece de información en SM; el análisis individual en obesos de 9-16 años con SM evidenció alto porcentaje de MO adelantada(AU)

Metabolic Syndrome (MS) includes anthropometric, clinic and metabolic changes that predispose to the development of diabetes type 2 and cardiovascular diseases. MS results from the interaction of genetic and environmental factors mediated by epigenetic regulation; some loci have greater effect on metabolic phenotypes modified by diet and other environmental factors. Once MS components are characterized, several studies focus on the best predictors to identify cardiometabolic risk in adults: Waist circumference (WC) and insulin resistance (IR). Obesity during pregnancy and IR in fetal tissues is associated to high risk of MS in children and adolescents. In young adults there is a higher prevalence of high blood pressure and IR in children born preterm (weight < 1500 g) vs. children born at term, without significant differences in lipidic profile between both groups. Recent studies have proposed the association between low intake of ώ-3 and high intake of ώ-6 fatty acids in infants with latter appearance of MS characteristics: dyslipidemia, IR and hyperphagia. Non-diabetic obese adolescents with MS were found to have lower arithmetic skills, spelling and mental flexibility and inappropriate performance in cognitive evaluations when compared with their healthy peers. Decreased microstructural integrity of the white matter and smaller hippocampus volume that may cause cerebral complications at short time was found. Early physiological puberty and skeletal development have been described in obesity, but no information is available in obese patients with MS. In obese 9-16 years old, we found high percentage of advanced bone age in those with MS criteria(AU)

The association between insulin resistance and prostatic hyperplasia / 中华老年医学杂志

Objective To evaluate the relationship between insulin resistance and benign prostatic hyperplasia (BPH).Methods Totally 150 male patient from the Department of Geriatrics in Peking University Hospital were included in this study.Blood pressure,body weight,body height,body mass index (BMI) were measured and calculated.Biochemical analyses including serum fasting levels of insulin(FINS),glucose,total cholesterol,triglycerides,low-density lipoprotein cholesterol,high density lipoprotein cholesterol,and prostate-specific antigen (PSA) were performed.Total prostate volume (PV) were measured by ultrasound.Results PV and annual prostate growth rate were more increased in insulin resistance group(40 cases) compared with insulin sensitivity group(110 cases) (t=2.91,3.71 respectively,both P＜0.01).Along with the levels of FINS,HOMA-IR and PSA were increased,the prostate volume was enhanced (t=-3.02,-2.88,-2.84 respectively;all P ＜0.05).PV was positively correlated with insulin resistance,serum fasting insulin and PSA (r=0.16,0.16,0.35;all P＜0.05),while annual prostate growth rate was positively related with insulin resistance,serum fasting insulin,PSA and BMI (r =0.22,0.21,0.24,0.19 ; all P ＜ 0.05).Conclusions Insulin resistance and fasting insulin plays roles in the pathogenesis of prostatic hyperplasia.

The association of fasting insuline and insuline resistance with benign prostatic hyperplasia / 中国综合临床

Objective To reveal the effect of fasting insuline(FINS) and insuline resistance(IR) in the process of benign prostatic hyperplasia(BPH). Methods One hundred and seventeen outpatients( ≥60 ys)with BPH from geriatric department were enrolled into the study. The patients were divided into groups according to their FINS and insulin resistance index (HOMA-IR). The indices of BPH, including volume of prostate ( PV ),prostate specific antigen( PSA ), international prostate symptom score (IPSS), course of BPH were analyzed in both groups. Results The PV ( [ 56. 46 ± 26. 88 ] ml vs [ 44. 84 ± 17.66 ] ml, P = 0. 017 ) and the course ( [ 18. 00 ± 6. 91 ] years vs [ 13.93 ± 7. 74 ] years, P = 0. 031 ) were significantly greater in BPH combined hyperinsulinemias(HINS) group than the BPH with normal FINS group;but we found no significant differences in the comparisons of serum PSA level or IPSS between two groups. The PV( [54. 17 ± 25.38 ] ml vs [42. 26 ±14. 15]ml,P =0. 004)and the course([ 16.58 ±7. 65] years vs [13.49 ±7. 59] years,P = 0. 036) were also significantly greater in BPH combined insuline resistance gruop than the insulin sensitivity group, again we found no significant differences in the comparisons of serum PSA level or IPSS between two groups. Conclusion FINS and IR are risk factors of progressed BPH and can promote the progress of BPH.

Insulin resistance in essential hypertension patients and effect of imidapril on it / 第三军医大学学报

Objective To certify insuline resistance in nonobese patients with essential hypertension(EH) and observe effect of imidapril.Methods An oral glucose tolerance test(OGTT) and insulin releasing test(IRT) were performed on 40 nonobese EH patients before and after imidapril treatment,the plasma levels of glucose and insulin were tested and compared with those of 16 normal subjects.Results The insuline level of fasting or 30,60,120 min after OGTT were significantly higher than those in normal group(P

A case of generalized lipodystrophy / 대한피부과학회지

Generalized lipodyst,rophy is characterized by generalized loss of body fat, and is asociated vith metabolic ahnormalities, including insulin resistance, hyperglycemia., and hypertriglyceridemia. like acanthosis nigricans, generalized lipodystrophy is a cutaneous marker of insulin re.istant diabetes. We report. herein a twenty year old female witti both classic generalized lipodystripin and acanthosis nigricans, in association with insulin resistant diabetes.