EFFECTS OF MELATONIN ON THE FUNCTIONS OF LYMPHOCYTES / 中国药理学通报

Effects of melatonin ( MT) on Con A or LPS-induced prolifera-tive responses of splenocytes in mice and Con A induced interleukin 2 ( IL-2 ) production of splenocytes in rats were studied. The results showed that Con A and LPS induced proliferative responses of splenocytes were enhanced by in vitro treatment with MT (0.01~1?mol/L and 0.01~10?mol/L, reinduced-pectively ) . ConA IL-2 production of splenocytes were also enhanced by in vitro treatment with MT (1~10?mol/L), but MT has no effects oa above functions of splenocytes without activating by ConA or LPS. These data suggested that mitogen activated lymphocytes might be one of the target cells for MT.