Intertrigo-like hand-foot syndrome unaffecting the site of surgery for axillary osmidrosis: the first case reported worldwide / 中华皮肤科杂志

A 25-year-old female patient presented with recurrent painful erythema and blisters on the palms and soles as well as in the axillary and inguinal regions for 1 month. Seven years ago, the patient underwent a small-incision sweat gland resection in the bilateral axillae for the treatment of axillary osmidrosis. One month ago, she underwent chemotherapy with pegylated liposomal doxorubicin (PLD) after surgery for stage-ⅡB cervical synovial sarcoma. During the 3 sessions of chemotherapy, she developed painful edematous erythema on the palms, soles, axillae and groins, which gradually worsened along with the increase in the number of chemotherapy sessions. Skin examination showed large areas of edematous erythema with clear boundaries at bilateral palms, soles, and intertriginous sites including axillae and groins, with millet- to soybean-sized blisters and erosions on the surface; the skin lesions showed relatively high temperature and positive Nikolsky's sign with obvious tenderness; there was no skin lesions or tenderness at the site of small-incision surgery for axillary osmidrosis in bilateral axillae. Histopathological examination of the axillary skin lesions showed formation of blisters under the basal layer and necrosis of some sweat glands. The diagnosis of PLD-associated intertrigo-like hand-foot syndrome was confirmed. The history of surgery for axillary osmidrosis and normal skin at the surgical site in this case suggest that the pathogenesis of this disease may be related to toxic skin reactions to the drug excreted through sweat glands.

Adaptation of the Evidence-Based Nursing Practice Guideline: Prevention and Management of Moisture Associated Skin Damage / 임상간호연구

PURPOSE: This study was done to develop an evidence-based nursing clinical practice guideline for Moisture associated skin damage (MASD) prevention and management for patients in Korea. METHODS: The guideline adaptation process was used and conducted according to the guideline adaptation manual developed by the Korean Hospital Nurses Association. It consists of three main phases and 9 modules including a total of 24 steps. RESULTS: The adapted MASD clinical practice guideline consisted of 4 sections, 8 domains and 28 recommendations. The number of recommendations in each section was: 7 on MASD assessment, 14 on MASD prevention and management, 4 on education, and 3 on organizational policy. Of the recommendations, 3.6% were marked as A grade, 28.6% as B grade, and 67.8% as C grade. CONCLUSION: This MASD clinical practice guideline is the first to be developed in Korea. The developed guideline will contribute to standardized and consistent MASD prevention and management. The guideline can be recommended for dissemination and utilization by nurses nationwide to improve the quality of MASD prevention and management. Regular revision is recommended.

Dermatosis intertriginosa crónica de aparición tardía: pénfigo de Hailey-Hailey / Chronic late-onset intertriginous dermatitis: Hailey-Hailey's pemphigus

El pénfigo familiar benigno o enfermedad de Hailey Hailey, es una genodermatosis vesico-ampollar autosómica dominante, con penetrancia incompleta y expresividad variable de presentación infrecuente. Se presenta el caso de un paciente con un cuadro de cinco años de evolución, caracterizado por lesiones vesiculares intertriginosas, de olor desagradable, con mala respuesta al tratamiento tópico con antifúngicos y corticoides. Se realiza biopsia de piel compatible con pénfigo de Hailey Hailey, el que fue manejado con antibióticoterapia y corticoides sistémicos, evolucionando favorablemente.

The benign familial pemphigus or Hailey Hailey´s disease is a rare autosomal dominant disorder. We present the clinical case of a patient with a five years history, characterized by vesicular intertriginous malodorous lesions with poor response to topical antifungal therapy. Skin biopsy it was compatible with Hailey Hailey´s disease which was managed with antibiotic therapy and systemic corticosteroids. The patient evolved favorably.

The Effect of Powders and Moisturizers on SLS Irritated, Intertriginous Skin / 대한피부과학회지

BACKGROUND: Intertrigo is a form of contact dermatitis of skin folds of the body, for which a large variety of topical medications may be recommended. Application of a suitable barrier preparation is the cornerstone for the prevention and treatment for the intertrigo. OBJECTIVE: There is a notable absence of controlled trials to support and guide the use of barrier preparations for intertrigo. METHODS: We evaluated the effect of powders and moisturizers with non-invasive measuring methods on irritated skin reactions induced by sodium lauryl sulphate in the sintertriginous skin of 21 healthy volunteers. After skin irritation for 24 hours with patch test of 1% sodium lauryl sulphate on both axilla, we applied a powder and a moisturizer respectively. Evaluation was done at 2 weeks by transepidermal water loss, electrical capacitance. RESULTS: TEWL values of the moisturizer treated side were significantly lower than that of the powder treated side. Water holding capacity values of the moisturizer treated side were significantly higher than that of the powder treated side. CONCLUSION: These results suggest that topical application of a moisturizer might improve the disruption of permeability barrier function of intertrigo. We suggest this experimental model for further barrier preparation efficacy testing of intertrigo.

Condiloma acuminado extragenital associado ao intertrigo: relato de caso / Acuminata condyloma extragenital associated to intertrigo: case report

Introdução: papilomavírus humano (HPV) é um vírus de DNA que pode infectar a pele e mucosas, com mais de 100 tipos diferentes descritos, sendo 45 deles considerados sexualmente transmissíveis. Objetivo: relatar o caso de condiloma acuminado extragenital, facilitado pela presença de intertrigo. Métodos: relato de caso de paciente com condiloma acuminado em região hipogástrica. Resultados: mulher atendida no ambulatório de DST/AIDS do setor de Ginecologia da Santa Casa de Misericórdia de Vitória, em 2007, com 46 anos de idade, apresentando lesão condilomatosa extensa associada à intertrigo em região hipogástrica, acima da cicatriz de Pfannestiel e pequenas lesões vulvares compatíveis, clinicamente, com condilomas. Feita a opção pela exérese cirúrgica em lesão de abdome, a qual evidenciou condiloma acuminado e cauterização química de lesões vulvares. Solicitados exames para doenças sexualmente transmissíveis, que foram normais, incluindo citologia oncótica, colposcopia e teste rápido para gonococo e clamídia. Conclusão: a umidade e o calor locais, provocados pelo abdome em avental, com concomitância de área de intertrigo, poderiam justifi car a presença de condiloma acuminado nesta região.

Introduction: the human papillomavirus (HPV) is a DNA virus that can infect skin and mucosa, already described in more than 100 different types,being 45 of those considered to be sexually transmitted. Objective: report the extra-genital case of condyloma acuminata, facilitated by the presenceof intertrigo. Method: report of a case of female patient presenting extensive condylomatous lesions associated to intertrigo in hypogastric region. Results: a 46-year-old female patient assisted in the DST/AIDS Clinic of the Gynecology Sector at Santa Casa de Misericórdia from Vitória in 2007, presenting extensive condylomatous lesions associated to intertrigo in hypogastric region above the Pfannestiel scar and small compatible vulvar verrucosa lesions suggestive of condyloma. Surgical excision was made in the abdomen lesion which evidenced condyloma acuminatum and chemical cauterization of vulvar warts. Tests for sexually transmitted diseases were requested, all of them were normal, including oncotic cytology, colposcopy and fast test for gonococcus and chlamydia. Conclusion: local humidity and heat provoked by abdomen in apron with concurrence of area of intertrigo could justify the presence of condyloma acuminatum in this region.

A Case of Malassezia Intertrigo / 대한의진균학회지

Malassezia intertrigo is a very rare clinical entity in which the clinical lesions occur in intertroginous areas as erythematous scaling macules and direct microscopic examinatons of scales reveal only large numbers of yeast forms of Malassezia organism. A 59-year-old man, developed brown, finely scaling macular lesions on the inguinal areas. Direct microscopy and culture of the scalings taken from the lesional areas of the patient revealed only oval forms of Malassezia organism.