Giant fibroma of left ventricular apex with T wave inversion: 2 cases report and literature review / 中国综合临床

Objective:To investigate the clinical features, diagnostic methods and treatments of left ventricular apical fibroma.Methods:The clinical manifestations, ECG, imaging features and treatment plans of 2 patients with giant fibroma of left ventricular apex diagnosed in September 2020 and May 2022 were analyzed retrospectively, and the related literature was reviewed.Results:Both patients had slight chest distress and discomfort after activities. The ECG showed T-wave inversion of different degrees, which were misdiagnosed as “myocarditis” and “coronary heart disease” respectively. The cardiac magnetic resonance imaging and echocardiography showed left ventricular apical mass. Coronary artery stenosis was not found in coronary angiography. One patient required conservative treatment, and there was no significant change in clinical symptoms and tumor size in the follow-up for half a year; Another patient underwent cardiac mass removal, and the pathological examination after operation confirmed that it was cardiac fibroma, and there was no recurrence in the follow-up 2 years.Conclusion:Fibroma of left ventricular apex is a rare cardiac tumor, which is easy to be missed and misdiagnosed, and is one of the rare causes of T-wave inversion. Cardiac magnetic resonance imaging, CT and echocardiography are commonly used imaging methods to diagnose cardiac fibroma, and surgical resection is an effective treatment.

Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae

Polymyxin B and polymyxin E (colistin) are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales, Acinetobacter baumannii, and Klebsiella pneumoniae. Yet resistance to this last-line drugs is a major public health threat and is rapidly increasing. Polymyxin S2 (S2) is a polymyxin B analogue previously synthesized in our institute with obviously high antibacterial activity and lower toxicity than polymyxin B and colistin. To predict the possible resistant mechanism of S2 for wide clinical application, we experimentally induced bacterial resistant mutants and studied the preliminary resistance mechanisms. Mut-S, a resistant mutant of K. pneumoniae ATCC BAA-2146 (Kpn2146) induced by S2, was analyzed by whole genome sequencing, transcriptomics, mass spectrometry and complementation experiment. Surprisingly, large-scale genomic inversion (LSGI) of approximately 1.1 Mbp in the chromosome caused by IS26 mediated intramolecular transposition was found in Mut-S, which led to mgrB truncation, lipid A modification and hence S2 resistance. The resistance can be complemented by plasmid carrying intact mgrB. The same mechanism was also found in polymyxin B and colistin induced drug-resistant mutants of Kpn2146 (Mut-B and Mut-E, respectively). This is the first report of polymyxin resistance caused by IS26 intramolecular transposition mediated mgrB truncation in chromosome in K. pneumoniae. The findings broaden our scope of knowledge for polymyxin resistance and enriched our understanding of how bacteria can manage to survive in the presence of antibiotics.

Orientadores de la decision de inversion: una conceptualización desde el estilo de liderazgo del emprendedor de impacto / Drivers of the decision-making process for investing: an impact entrepreneur's leadership style conceptualization / Orientadores de decisão de investimento: uma conceituação a partir do estilo de liderança do empresário de impacto

RESUMEN En un contexto de búsqueda de oportunidades de inversion, la impresión inicial que sobre un emprendedor se forme un inversionista influye de manera directa en su propio proceso decisional. En ese sentido, el presente trabajo busca estudiar las implicaciones que subyacen a este panorama inicial, puntualmente en un escenario de decisiones de inversion sobre iniciativas que apuestan por el desarrollo sostenible (i.e., inversiones de impacto). Para ello, haciendo uso de un caso de estudio, se despliega un proceso de análisis cualitativo que permite identificar las especificidades del estilo de liderazgo de un emprendedor de impacto determinado, así como la forma en que este mismo estilo podr'a afectar la eventual decision de un potencial inversionista. En ese orden de ideas, el presente trabajo contribuye a la transferibilidad y profundización del tópico en cuestión, en diversas áreas del conocimiento. СLASIFICACIÓN JEL: 126, Q56

AВSTRАСT In a context of seeking investment opportunities, the initial impression that an investor forms on an entrepreneur influences their own decision-making process. In this sense, the present work seeks to study the implications underlying this initial panorama, specifically in a scenario of investment decisions on initiatives that are committed to reach a sustainable development (i.e., impact investments). For this purpose, and using a case study a qualitative analysis process is deployed, allowing the identification of the corresponding leadership style of a given impact entrepreneur; as well as the way in which this same style could affect the eventual decision of a potential investor In that order of ideas, the present work contributes to the transferability and deepening of the topic at issue in various areas of knowledge. JEL CLASSIFICATION: 126, Q56

RESUMO No contexto da busca de oportunidades de investimento, a impressão inicial que um investidor tem de um empresário tem uma influência direta em seu próprio processo de tomada de decisão. Neste sentido, este documento procura estudar as implicações que estão na base deste panorama inicial, especificamente em um cenário de decisões de investimento em iniciativas comprometidas com o desenvolvimento sustentável (ou seja, investimentos de impacto). Para este fim, utilizando um estudo de caso, é implantado um processo de análise qualitativa para identificar as especificidades do estilo de liderança de um determinado empreendedor de impacto, bem como a forma como este mesmo estilo poderia afetar a eventual decisão de um investidor potencial. Neste sentido, este trabalho contribui para a transferibilidade e aprofundamento do tema em questão, em várias áreas do conhecimento. CLASSIFICAÇÃO JEL: 126, Q56

The Effect of Metallic Dental Restorations and Implants in Causing Patient Discomfort and Artefacts During Magnetic Resonance Imaging of the Head and Neck

Context: Patients with metallic dental objects in their oral cavity are often associated with discomfort or artefacts during magnetic resonance imaging (MRI) of the head and neck. Aim: This study was conducted to evaluate the effects of metallic dental objects in causing patient discomfort and artefacts during MRI of the head and neck region. Design: This is an observational study including 538 participants from various specialized MRI centres in Kozhikode. Methods and Material: MRI records of 538 participants who underwent head and neck MRI as a part of their medical treatment were collected. With the help of questionnaire and clinical examination, the type of metallic dental object in the patient’s oral cavity was identified. After examining the MRI images, four categories of artefacts were established. In MRI brain, artefacts in three different sequences were also studied. Statistical Analysis Used: The significance of the difference between proportions was analysed by the Chi?square test. Results: Artefacts were found in 65 cases with metallic dental objects but none of the participants had experienced any kind of discomfort. The artefact formation significantly depended on the type of metallic dental restoration in the patient’s oral cavity. Orthodontic braces and titanium bone plate created severe artefacts in head and neck MRI making interpretation almost impossible. In the MRI brain, diffusion?weighted imaging is most sensitive to artefact followed by fluid?attenuated inversion recovery. Conclusions: Artefacts were found in 65 cases with metallic dental restorations but none of the participants had experienced any kind of discomfort.

Fluid?attenuated inversion recovery diffusion?weighted imaging (DWI) for evaluating chemotherapy response in patients with acute leukemia: Comparison with conventional DWI

Background: At present, the diagnosis and efficacy evaluation of acute leukemia (AL) are assessed by bone marrow aspiration, which is invasive and subject to sampling errors. Therefore, there is a pressing need to develop a noninvasive and accurate imaging method to evaluate bone marrow changes in patients with AL. This study aimed to compare the apparent diffusion coefficient (ADC) values obtained from fluid?attenuated inversion recovery diffusion?weighted imaging (FLAIR?DWI) and conventional DWI in the lumbar bone marrow of patients with AL and to investigate their performance for evaluating response to induction chemotherapy. Methods: A total of 28 patients with newly diagnosed AL and 25 patients with AL after induction chemotherapy underwent MRI scans at 1.5 Tesla using a conventional DWI and a FLAIR?DWI sequence on sagittal planes covering the lumbar bone marrow. Further, the ADC values from these two sequences, denoted as ADCCON and ADCFLAIR, were measured on multiple vertebrae. The percentage of leukemia cells in bone marrow was recorded, and bone marrow aspiration was performed on treated patients to determine complete remission (CR) and nonremission (NR). Results: ADCFLAIR [(0.453 ± 0.103) × 10?3 mm2/s] was significantly lower than ADCCON [(0.486 ± 0.096) × 10?3 mm2/s] in the 28 untreated patients (t = 3.051, P = 0.005). In the 25 treated patients, ADCFLAIR and ADCCON values [(0.566 ± 0.239) × 10?3 mm2/s] and [(0.716 ± 0.235) × 10?3 mm2/s], respectively, were higher compared with the untreated patients. The ADCCON values showed a nonsignificant difference between the CR (n = 18) and NR (n = 7) groups (t = 1.409, P = 0.305). However, the ADCFLAIR values exhibited statistically significant difference (t = 2.542, P = 0.018) between the two groups. In a receiver operator characteristic (ROC) analysis, the area under the curve (AUC) using ADCFLAIR (0.770) was larger than that of ADCCON (0.611) in distinguishing the CR and NR patients following the chemotherapy. Conclusion: Although both ADCCON and ADCFLAIR are sensitive to tissue changes induced by chemotherapy, FLAIR?DWI outperformed conventional DWI in separating AL patients with CR from NR after chemotherapy. A possible mechanism is that FLAIR?DWI suppresses signals from free water, making the ADC measurement more sensitive to structural changes in the bone marrow

Análisis de las finanzas públicas en el Situado Fiscal Territorial Municipal - Santiago de Cali: comunas 21, 10 y 22 / Analysis of public finances in the Municipal Territorial Taxation - Santiago de Cali: communes 21, 10 and 22 / Análise das finanças públicas no Situado Fiscal Territorial Municipal - Santiago de Cali: comunas 21, 10 e 22

RESUMEN La investigación corresponde al análisis de las finanzas públicas, especificamente al Situado Fiscal Territorial Municipal (SFTM) del municipio de Santiago de Cali, Colombia, en las comunas 21 (estrato socioeconómico bajo-bajo), 10 (estrato socioeconómico medio-medio) y 22 (estrato socioeconómico alto-alto), durante el periodo 2012-2015, en las cuales se realizo una inversion por parte del municipio, en aras de satisfacer las necesidades de la población y mejorar la calidad de vida de las personas. Para la realización del análisis se utilizaron como herramientas los Planes de Desarrollo de Comunas y Corregimientos, los Planes Operativos Anuales de Inversion (POAI) y el presupuesto ejecutado del SFTM, comparando la inversion per cápita de las problemáticas intervenidas entre las comunas estudiadas. Como resultado de este análisis se identificaron fallas en la asignación y ejecución de los recursos, dado que no se priorizaron problemáticas sensibles para las comunas 21 y 10, como lo son la seguridad, la capacitacion para el trabajo, la atencion a los adultos mayores y la participacion política de las organizaciones sociales, las cuales se consideran importantes para el desarrollo economico y social de las comunas menos favorecidas.

ABSTRACT The research presented below corresponds to the analysis of public finances, specifically the Municipal Territorial Tax Site (SFTM), of the municipality of Santiago de Cali, Colombia, in the communes 21 [low-low socioeconomic status], 10 [middle socioeconomic status] and 22 [high-high socioeconomic status], during the period 2012-2015, in which an investment was made by the municipality in order to satisfy the needs of the population and improve people's quality of life. To carry out the analysis, the Development Plans of Communes and Townships, the Annual Operational Investment Plans (POAI) and the executed budget of the SFTM were used as tolos, comparing the per capita investment of the intervened problems between the studied communes. As a result of this analysis, failures in the allocation and execution of resources were identified, since sensitive problems were not prioritized for communes 21 and 10, such as security, job training, care for the elderly and the political participation of social organizations, which are considered important for the economic and social development of the less favored communes.

RESUMO A investigação corresponde à análise das finanças públicas, especificamente o Situado Fiscal Territorial Municipal (SFTM) do município de Santiago de Cali, Colômbia, nas comunas 21 (estrato socioeconomico baixo), 10 (estrato socioeconomico médio médio) e 22 (estrato socioeconomico alto), durante o período 2012-2015, no qual foi feito um investimento pelo município, a fim de satisfazer as necessidades da população e melhorar a qualidade de vida da população. Os instrumentos utilizados para a análise foram os Planos de Desenvolvimento das Comunas e Corregimentos, os Planos Anuais de Investimento Operacional (POAI) e o orçamento executado do SFTM, comparando o investimento per capita dos problemas intervencionados entre as comunas estudadas. Como resultado desta análise, foram identificadas falhas na atribuição e execução de recursos, dado que não foi dada prioridade a questões sensíveis para as comunas 21 e 10, tais como segurança, formação profissional, atenção aos idosos e participação política das organizações sociais, que são consideradas importantes para o desenvolvimento economico e social das comunas menos favorecidas.

Comportamiento de presiones intrapulmonares con inversión de la relación inspiración espiración en colecistectomía laparoscópica / Behavior of intrapulmonary pressures with inversion of the inspiration-expiration ratio in laparoscopic cholecystectomy

Resumen: Objetivo: Evaluar el comportamiento de las presiones intrapulmonares con la inversión del índice inspiración espiración durante la colecistectomía electiva videolaparoscópica. Material y métodos: Se realizó un ensayo clínico controlado fase tres acerca de tales presiones intrapulmonares, durante operaciones de colecistectomía laparoscópica, en el Hospital Universitario «Manuel Ascunce Domenech¼, en el período de septiembre del 2016 a febrero del 2020. El universo estuvo constituido por los pacientes que cumplieron con los criterios de inclusión, y una muestra de 106 de ellos, los cuales se dividieron en dos conjuntos de 53 personas cada uno, por método aleatorio simple. La fuente primaria de obtención de datos la constituyeron las historias clínicas y el resultado de una encuesta. Los datos se recogieron en un modelo diseñado en correspondencia con la bibliografía. Resultados: Se presentó aumentos de la presión inspiratoria pico y presión meseta luego del neumoperitoneo, con descenso de ambas tras la transposición del índice I:E, además de hipertensión arterial, arritmias e hipotensión arterial, sin guardar relación con la aplicación del indicador I:E invertido. Conclusiones: La inversión de la inspiración espiración contribuyó a mejorar los efectos del neumoperitoneo sobre dichas presiones intrapulmonares, manteniendo una oxigenación adecuada y nulos efectos cardiovasculares.

Abstract: Objective: Evaluating the behavior of intrapulmonary pressures with the inversion of the inspiration expiration index, during elective videolaparoscopic cholecystectomy. Material and methods: A phase three controlled clinical trial was conducted on intrapulmonary pressures during laparoscopic cholecystectomies at the «Manuel Ascunce Domenech¼ University Hospital, from September 2016 to February 2020, the universe consisted of patients who met the inclusion criteria, from which a sample of 106 patients was selected, by a simple randomizing method. The primary source of data collection was the medical records and the result of a survey. These data were collected in a model designed in correspondence with the bibliography reviewed. Results: Measured by variation in peak inspiratory pressure and plateau pressure after pneumoperitoneum, with significant decrease of both after inversion of I:E index. More than half of the patients presented arterial hypertension, arrhythmias and arterial hypotension, without them being related to the application of the inverted I:E index. Conclusions: The inversion of inspiratory expiration contributed to improve the effects of pneumoperitoneum on intrapulmonary pressures, with adequate oxygenation and no cardiovascular effects.

Clinical observation of different internal limiting membrane surgeries combined with sterile air tamponade in the treatment of idiopathic macular hole / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To observe the difference of curative effect between internal limiting membrane(ILM)inversion and insertion and ILM peeling and to analyze the influence of different surgical methods on the morphology of hiatus healing.<p>METHODS: A retrospective analysis of the clinical data of 22 patients with macular hole, who received vitrectomy in the First People's Hospital of Zunyi City from June 2017 to June 2020. According to the surgical methods, they were divided into 8 cases and 8 eyes in the ILM peeling group and 14 cases and 14 eyes in the ILM inversion covering group. The two groups of patients underwent best corrected visual acuity(BCVA)test, non-contact intraocular pressure and optical coherence tomography(OCT)examination before and 1wk, 1, and 3mo after operation were analysed. <p>RESULTS: The macular hole closure rate in the ILM peeling group was 75%, and the hole closure rate in the ILM inversion and insertion group was 93%. There was no statistically significant difference in the hole closure rate between the two groups(P=0.527). The trends of BCVA over time in the two groups were similar, but there were differences in time(Ftime=18.426, Ptime<0.001)and no difference between groups and interactions(Fbetween groups=1.319, Pbetween groups=0.289; Fbetween groups×time=1.658, Pbetween groups×time=0.211). The BCVA of the two groups was statistically significant 1wk after operation compared with that before operation(t= -2.200, -3.092; all P<0.05); The BCVA of the ILM inversion and insertion group was improved 3mo after operation compared with that before operation, and the difference in the group was statistically significant(t=2.503, P=0.019). There was no difference in overall foveal thickness between the two groups after surgery(Ftime=1.054, Ptime=0.346; Fbetween groups=0.110, Pbetween groups=0.750; Fbetween groups×time=2.391, Pbetween groups×time=0.152).<p>CONCLUSION: Both ILM inversion and insertion and ILM peeling can effectively increase the rate of macular hole closure. The macular structure healing after the ILM inversion and insertion is better, and the postoperative visual function improvement is more satisfactory.

Research on inversion method of intravascular blood flow velocity based on convolutional neural network / 生物医学工程学杂志

Blood velocity inversion based on magnetoelectric effect is helpful for the development of daily monitoring of vascular stenosis, but the accuracy of blood velocity inversion and imaging resolution still need to be improved. Therefore, a convolutional neural network (CNN) based inversion imaging method for intravascular blood flow velocity was proposed in this paper. Firstly, unsupervised learning CNN is constructed to extract weight matrix representation information to preprocess voltage data. Then the preprocessing results are input to supervised learning CNN, and the blood flow velocity value is output by nonlinear mapping. Finally, angiographic images are obtained. In this paper, the validity of the proposed method is verified by constructing data set. The results show that the correlation coefficients of blood velocity inversion in vessel location and stenosis test are 0.884 4 and 0.972 1, respectively. The above research shows that the proposed method can effectively reduce the information loss during the inversion process and improve the inversion accuracy and imaging resolution, which is expected to assist clinical diagnosis.

Tissue Window versus Time Window? A Review of Patients Receiving Extended Hours Thrombolysis Guided By DWI-FLAIR Mismatch : Case Series

@#Introduction: Intravenous thrombolysis (IVT) is the gold standard for the treatment of patients with acute ischemic stroke (AIS) presenting within four and a half hours of onset. However, development of new thrombolytic agents and advanced imaging has led to extended time for thrombolysis based on advanced imaging. Here we describe four patients who presented in the extended hours; that benefitted from thrombolysis. Case series: We advocate magnetic resonance imaging (MRI) for AIS, that includes diffusion weighted imaging (DWI), apparent diffusion coefficient (ADC), fluid attenuated inversion recovery (FLAIR), susceptibility weighted imaging (SWI), and magnetic resonance angiography (MRA). We included four patients who were more than 18 years old, with National Institute of Health Stroke Scale (NIHSS) of six or more, presenting between four and a half to nine hours after stroke onset with no contraindications for intravenous thrombolysis. The imaging criteria used to determine eligibility for IVT is evidence of DWI-FLAIR mismatch on MRI. If FLAIR detects no signal change in the area of stroke on DWI, it is then termed DWIFLAIR mismatch, or FLAIR-negative – indicating high probability that the brain tissue is still viable, and that patients are good candidates for IVT. Conclusion: For patients with AIS who present within nine hours, DWI-FLAIR mismatch serves as an excellent surrogate marker of salvageable brain tissue, allowing a greater proportion of patients benefiting from this life-saving therapy. Our experience also shows that with careful patient selection, treatment with IVT can safely be given without an increased risk of bleeding or mortality.

Short-term effects of extended adventitial inversion with graft eversion anastomosis technique in the root treatment of acute type A aortic dissection / 中国胸心血管外科临床杂志

@#Objective    To evaluate the short-term therapeutic effect of extended adventitial inversion with graft eversion anastomosis technique in the root treatment of acute type A aortic dissection (ATAAD). Methods    From November 2019 to July 2020, 28 patients with ATAAD were treated by extended adventitial inversion with graft eversion anastomosis technique in the Department of Cardiovascular Surgery, Dalian Municipal Central Hospital, including 19 males and 9 females, aged 60.11±11.11 years. The intima of the ascending aorta was trimed to 5 mm above the sinotubular junction. The adventitia of the ascending aorta was longitudinally cut to the reserved intima margin along the junction of the three aortic valves. The extended adventitial inversion was sutured continuously, no coronary sinus was sutured over the aortic annulus, and the left and right coronary sinus was sutured above the coronary ostium. The anastomotic graft was everted and inserted into the aortic lumen, and the everted graft was continuously sutured at the level of sinotubular junction which was 5 mm away from the edge of graft. Results    There was no intraoperative death, intractable root hemorrhage, residual root false lumen, root dilatation, anastomotic hematoma or other complications. There was no recurrence of the pain in the back of all patients, and the results of the CT angiography were not significantly changed. In 22 patients with no regurgitation, only 1 (4.55%) patient had a mild regurgitation. In 6 patients with mild aortic regurgitation, the disappearance rate of regurgitation was 50.0% (3/6). Conclusion    The treatment of extended adventitial inversion with graft eversion anastomosis technique in the root treatment of aortic dissection eliminates the residual dissection at the root. The anastomotic hemorrhage is prevented, the root structure of aortic dissection is reconstructed and strengthened, the root function is restored, and the possible expansion of the root is prevented. The short-term results are satisfactory.

Short-and mid-term results after adventitial inversion technique for root repair in acute type A aortic dissection / 中华胸心血管外科杂志

Objective:To evaluate the safety and effectiveness of adventitial inversion technique for root repair in patients with acute type A aortic dissection(ATAAD).Methods:Between 2015 and 2018, ATAAD patients with dissected root and underwent open surgery were included. The exclusion criteria were as follows: previous root intervention, traumatic dissection and patient underwent root replacement(Bentall or David procedure). 490 ATAAD patients were included, 366(74.69%) male and 124(25.31%) female, aged(51.28±10.99) years(range 24-77 years). The clinical data were retrospectively analyzed with ANOVA/ nonparametric test and Chi- square test. Follow-up mortality and reoperation were displayed with Kaplan- Meier curve. Results:All patients were technically divided into three groups: adventitial inversion(A), direct suture(B) and Cabrol-shunt(C). The mean age in group A was(53.05±11.09) years, whereas worse cardiac and renal function occurred in group C. The mean duration of HCA, CPB and ACC were shortest, with a highest average of minimum rectal temperature during surgical interval in group A. Postoperative complications and early mortality were similar among groups. There were no significant differences of mid-term mortality and reoperation among these three techniques. Though no late reintervention for aortic root was found in both group A and B, the root diameter was more stable in group A during follow-up period[(33.14±3.74)mm vs.(34.51±3.83)mm vs.(33.89±3.89)mm, P=0.008]. Conclusion:Adventitial inversion technique is safe and effective for root repair in patients with ATAAD, achieving satisfactory short- and mid-term effects.

Manual de organización y funciones de la Unidad de Gestión de Programas y Proyectos de Inversión / Organization and functions manual of the Investment Programs and Projects Management Unit

El presente documento constituye un apoyo administrativo para delimitar el alcance del accionar operativo de la Unidad de Gestión de Programas y Proyectos de Inversión, a efecto de desarrollar sus funciones de manera integrada, eficiente, transparente y oportuna. Se describen los diferentes elementos que componen el presente manual, la misión y visión, los objetivos, las funciones, así como las relaciones de trabajo internas y externas de dicha Unidad

This document constitutes an administrative support to define the scope of the operational actions of the Investment Programs and Projects Management Unit, in order to develop its functions in an integrated, efficient, transparent and timely manner. The different elements that make up this manual, the mission and vision, the objectives, the functions, as well as the internal and external work relationships of said Unit are described

Momentos de "des-existir" e espaços vazios de "des-existência" / Moments of "de-existing" and empty spaces of "de-existence" / Momentos de "des-existir" y espacios vacíos de "des-existencia"

A utilização do conceito des-existir, usado por mim neste e em outros trabalhos, resulta de uma necessidade de nomear e delimitar situações em geral transitórias limitadas à esfera psíquica. Diferencia-se do conceito de matar, verbo ativo que implica na ação de um sujeito, seja em termos físicos ou metafóricos. Assim como diferencia-se também do conceito de morrer, ligado a algo mais definitivo em termos naturais ou figurados. Des-existir refere-se a uma situação momentânea, temporária e às vezes prolongada, em que o sujeito entra em processo de falência como sujeito psíquico por desinvestimento. Pode ser des-existido em diferentes graus de apagamento em um espectro que se estende entre a situação ativa de sujeito e a condição passiva de objeto da pulsão de morte (AU)

I employ the idea of de-existing, in this and other papers, as a result from an urge to name and delimit usually transient situations limited to the psychic sphere. It differs from the idea of killing, active verb that implies the action of a subject, in physical or metaphorical terms. As well as it also differs from the idea of dying, connected to something more definitive in natural or figurative terms. De-existing refers to a momentary, temporary situation, sometimes long-lasting, in which, due to disinvestment, the subject goes into a process of failure as psychic subject. It may be de-existed in different levels of effacement in a spectrum that extends between the active situation as subject and the passive condition of object of the death drive (AU)

El uso del concepto des-existir, que utilizo en este y otros trabajos, resulta de una necesidad de nombrar y delimitar en general situaciones transitorias limitadas a la esfera psíquica. Se diferencia del concepto de matar, verbo activo que implica la acción de un sujeto, ya sea en términos físicos o metafóricos. Además, también se diferencia del concepto de morir, ligado a algo más definitivo en términos naturales o figurativos. El des-existir se refiere a una situación momentánea, temporal y en ocasiones prolongada en la que el sujeto entra en proceso de desplome como sujeto psíquico debido a la desinversión. Puede ser des-existido en diferentes grados de desvanecimiento en un espectro que se extiende entre la situación activa del sujeto y la condición pasiva de objeto de la pulsión de muerte (AU)

The relationship between public and private health investment and economic development based on the overlapping generations (olg) model / Relação entre investimento público e privado em saúde e desenvolvimento econômico com base no modelo de gerações sobrepostas (olg) / Investigación sobre la relación entre la inversión en salud pública y privada y el desarrollo económico a partir del modelo de generación superpuesta

ABSTRACT As an important part of human capital, healthy human capital plays a great role in promoting economic development. Based on the overlapping generations (OLG) model, this study establishes a correlation analysis model between healthy human capital and economic growth. This model takes utility maximization as the theoretical carrier to study how individuals promote economic growth while pursuing the maximization of their own health capital accumulation. The model can analyze the promotion mechanism of healthy human capital on economic growth, so as to provide decision support for relevant personnel. Taking the panel data of 11 provinces and cities in China as samples, this paper makes an empirical analysis of the model. The results show that healthy human capital investment in coastal areas is generally high, and the relationship between healthy human capital and economic growth conforms to the inverted U-shaped development model, so we should pay attention to the reasonable proportion of healthy human capital investment. In addition, from the fitting effect of the regression model, the F-statistic values of model 1 and model 2 are 672.6327 and 1240.188, which shows that the fitting accuracy of the two regression models is higher.

RESUMO Como parte importante do capital humano, o capital humano saudável desempenha um grande papel na promoção do desenvolvimento econômico. Com base no modelo de gerações gerações sobrepostas (OLG), este estudo estabelece um modelo de análise de correlação entre o capital humano saudável e o crescimento econômico. Este modelo leva à maximização da utilidade como suporte teórico para estudar como os indivíduos promovem o crescimento econômico, enquanto procedem à maximização de sua própria acumulação de capital saudável. O modelo pode analisar o mecanismo de promoção de capital humano saudável em crescimento econômico, de modo a fornecer suporte de decisão para os profissionais. Tomando os dados do painel de 11 províncias e cidades da China como amostra, o presente estudo faz uma análise empírica do modelo. Os resultados mostram que o investimento em capital humano para a saúde nas zonas costeiras é geralmente elevado, e a relação entre o capital humano saudável e o crescimento econômico está em conformidade com o modelo de desenvolvimento invertido em forma de U, pelo que devemos prestar atenção à proporção razoável de investimento em capital humano saudável. Além disso, a partir do efeito de ajuste do modelo de regressão, os valores F-estatísticos do modelo 1 e do modelo 2 são 672.6327 e 1240.188, o que mostra que a precisão de ajuste dos dois modelos de regressão é maior.

RESUMEN Como parte importante del capital humano, la salud juega un papel importante en la promoción del desarrollo económico. Basado en el modelo de generaciones superpuestas (OLG), este estudio establece un modelo de análisis de correlación entre capital humano saludable y crecimiento económico. Este modelo toma la maximización de la utilidad como portador teórico para estudiar cómo los individuos promueven el crecimiento económico mientras persiguen la maximización de su propia acumulación de capital en salud. El modelo puede analizar el mecanismo de promoción del capital humano saludable sobre el crecimiento económico, a fin de brindar apoyo a las decisiones del personal relevante. Tomando como muestra los datos de panel de 11 provincias y ciudades de China, este artículo realiza un análisis empírico del modelo. Los resultados muestran que la inversión de capital humano saludable en las áreas costeras es generalmente alta, y la relación entre capital humano saludable y crecimiento económico se ajusta al modelo de desarrollo en forma de U invertida, por lo que debemos prestar atención a la proporción razonable de inversión de capital humano saludable. Además, del efecto de ajuste del modelo de regresión, los valores del estadístico F del modelo 1 y del modelo 2 son 672,6327 y 1240,188, lo que muestra que la precisión de ajuste de los dos modelos de regresión es mayor.

Inversión uterina no puerperal: primer caso reportado en el Perú / Non-puerperal uterine inversion: first case reported in Peru

RESUMEN La inversión uterina no puerperal es muy rara. Se comunica un caso asociado con leiomiomatosis. Se trató de una multípara de 45 años que manifestó sangrado vaginal grave, dolor pélvico y sensación de cuerpo extraño vaginal. Se diagnosticó mioma uterino en fase abortiva. Se programó para miomectomía con probable histerectomía abdominal y se encontró inversión uterina completa. Este reporte constituye un caso anecdótico de inversión uterina no puerperal, cuyo tratamiento quirúrgico fue exitoso.

ABSTRACT Non-puerperal uterine inversion is very rare. A case associated with leiomyomatosis is reported. The case of a 45-year-old multiparous woman with severe vaginal bleeding, pelvic pain and vaginal foreign body sensation is presented. Uterine leiomyoma in abortive phase was diagnosed. She was scheduled for myomectomy with probable abdominal hysterectomy and complete uterine inversion was found. This report is an anecdotal case of non-puerperal uterine inversion, whose surgical treatment was successful.

Prediction of the onset time of acute stroke by deep learning based on DWI and FLAIR / 中华放射学杂志

Objective:To evaluate the effect of deep learning based on DWI and fluid attenuated inversion recovery (FLAIR) to construct a prediction model of the onset time in acute stroke.Methods:A total of 324 cases of acute stroke with clear onset time, from January 2017 to May 2020 in Nanjing First Hospital, were retrospectively enrolled and analyzed. The patients were divided into a training set of 226 patients and a test set of 98 patients according to the complete randomization method using a 7∶3 ratio, and the patients were divided into ≤ 4.5 h and >4.5 h according to symptom onset time in each group. The acute infarction areas on DWI and the corresponding high signal area on FLAIR were manually outlined by physician. Using the InceptionV3 model as the basic model for image features extraction, the deep learning prediction model based on single sequence (DWI, FLAIR) and multi sequences (DWI+FLAIR) were established and verified. Then the area under curve (AUC), accuracy of human readings, single sequence model and multi sequence model in predicting the acute stroke onset time from imaging were compared.Results:DWI-FLAIR mismatch was found in 94 cases (94/207) of patients with symptom onset time from imaging ≤ 4.5 h, while in 28 cases (28/117) of patients with symptom onset time from imaging >4.5 h. ROC analysis showed that the AUC of DWI-FLAIR mismatch in predicting acute stroke onset time from imaging was 0.607, and the accuracy was 60.2%. The prediction model of deep learning based on single sequence showed that the AUC of FLAIR was 0.761 and the accuracy was 71.4%; the AUC of DWI was 0.836 and the accuracy was 81.6%. The AUC of predicting stroke onset time based on the multi-sequence (DWI+FLAIR) deep learning model was 0.852, which was significantly better than that of manual identification ( Z = 0.617, P = 0.002), FLAIR sequence deep learning model ( Z = 2.133, P = 0.006) and DWI sequence deep learning model ( Z = 1.846, P = 0.012). Conclusion:The deep learning model based on DWI and FLAIR is superior to human readings in predicting acute stroke onset time from imaging, which could provide guidance for intravenous thrombolytic therapy for acute stroke patients with unknown onset time.

Reverse and Optimization for Constitutive Parameters of Adipose Tissues Based on Feasible Direction Method / 医用生物力学

Objective To study the constitutive model of adipose tissue at medium strain rate and its parameter inversion. Methods Based on experiments of adipose tissue mechanical properties, the compression experiment of adipose tissues was reconstructed by finite element method, and the parameters for characterizing constitutive models of adipose tissues were screened. Combined with the method of feasible direction (MFD) in optimization method, the reverse calculation for parameters of fat tissue constitutive model at medium strain rate was conducted. ResultsCompared with Ogden constitutive model, the viscoelastic constitutive model was more suitable for characterizing the mechanical response at medium strain rate (260 s-1). The parameters of the constitutive model suitable for simulation were obtained using the reverse method. Conclusions The viscoelastic constitutive model was more suitable for characterizing the mechanical response at medium strain rate. The results provide references for studying the influence of human adipose tissues on body injury in finite element simulation of vehicle collisions.

Plantar Pressure Features under Different Walking Conditions in Patients after Trimalleolar Fracture Surgery / 医用生物力学

Objective To analyze plantar pressure features of patients in injured and healthy sides of the lower limbs under different walking conditions after the trimalleolar fracture surgery, and compare these characteristics with healthy subjects. Methods Twelve Trimalleolar fracture patients and twenty-three healthy subjects were recruited and their plantar pressure characteristics under different walking conditions were tested, including peak pressure, contact area and contact time percentage. Results Comparison between injured and healthy sides: during level walking, peak pressure of the 3rd-5th toe in the injured feet were smaller than those in the healthy sides; in inversion position, peak pressure and contact area of the 3rd-5th toe area in the injured feet were smaller than those in the healthy side; in eversion position, peak pressure, contact area and contact time of the 3rd-5th toe in the injured feet were smaller than those in the healthy sides, and peak pressures of the hindfoot area were larger than those in the healthy sides. Comparison between patients and healthy subjects: under three kinds of walking conditions, peak pressures of the 2nd and 3rd metatarsus bones, the 2nd toe, the 3rd-5th toe, contact area of the 1st-5th toe and contact time percentage of the 2nd toe, the 3rd-5th toe area were all smaller than those of healthy subjects, while contact time of the hindfoot and mid-foot area were all smaller than those of healthy subjects. Conclusions The plantar pressure characteristics of Trimalleolar fracture patients were asymmetrical. Compared with healthy subjects, the plantar pressure features of patients were abnormal during stance phase. Compared with healthy subjects, the motor control ability and stability of patients in eversion positions were decreased. The plantar pressure characteristics at ankle eversion can be used to evaluate ankle joint function.

The reversed intra- and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers

Solid tumors are complex entities, comprising a wide variety of malignancies with very different molecular alterations. Despite this, they share a set of characteristics known as "hallmarks of cancer" that can be used as common therapeutic targets. Thus, every tumor needs to change its metabolism in order to obtain the energy levels required for its high proliferative rates, and these adaptations lead to alterations in extra- and intracellular pH. These changes in pH are common to all solid tumors, and can be used either as therapeutic targets, blocking the cell proton transporters and reversing the pH changes, or as means to specifically deliver anticancer drugs. In this review we will describe how proton transport inhibitors in association with nanocarriers have been designed to block the pH changes that are needed for cancer cells to survive after their metabolic adaptations. We will also describe studies aiming to decrease intracellular pH in cancer using nanoparticles as molecular cages for protons which will be released upon UV or IR light exposure. Finally, we will comment on several studies that have used the extracellular pH in cancer for an enhanced cell internalization and tumor penetration of nanocarriers and a controlled drug delivery, describing how nanocarriers are being used to increase drug stability and specificity.