RESUMO
It is a mature technology producing single-use syringes by polypropylene(PP). But the traditional sterilization process for single-use syringe pollutes the environment, and the residues endanger the health of users. Irradiation sterilization, instead of traditional sterilization process, is the developing trend. However, the traditional PP does not have the ability of radiation resistance. These methods can improve the radiation resistance ability of PP effectively by adding the stabilizer or floating agent. Toughening or temperature treatment can have the same function. Radiation-resistant PP is introduced in this paper. Furthermore, the developing trends for the materials are discussed.
RESUMO
In this study effect of gamma irradiation sterilization and storage conditions on thermal properties of phase sensitive granisetron in situ forming implant (ISFI) was investigated. ISFI was prepared by mixing Poly (DLlactide- co-glycolide) (PLGA) with dimethylsulfoxide (DMSO) : propylene carbonate (PC) (1:1) solvent combination then granisetron HCl was added and homogenized. Following application of gamma irradiation, ISFI was stored at 25 °C for 4 months. Differential Scanning Calorimeter (DSC) measurements and Thermogravimetric Analysis-Differential Thermal Analysis (TGA-DTA) were carried out on fresh, irradiated and aged forms of granisetron ISFI. According to DSC, TGA and TGA-DTA thermograms and mass loss results application of gamma irradiation and storage of irradiated ISFI at 25 °C for 4 months have not significant effect on thermal stability of ISFI.