RESUMO
RESUMEN El surgimiento de nueva evidencia científica en los últimos años en relación con los síndromes coronarios crónicos (SCC) lleva a reconsiderar las recomendaciones diagnósticas y terapéuticas que históricamente guiaron nuestra práctica médica. Sin embargo, es importante destacar que gran parte de la información difundida carece de un análisis crítico riguroso, lo que nos expone al riesgo de incorporar nuevos algoritmos en la práctica clínica que podrían no ser completamente aplicables a nuestra población. En esta revisión se analiza la literatura científica disponible relacionada a los SCC, para tratar de establecer si realmente el monto isquémico carece de significado clínico y pronóstico tal como se afirma en algunas publicaciones.
ABSTRACT In the last years, new scientific evidence related to chronic coronary syndromes (CCS) has led to reconsider the diagnostic and therapeutic recommendations that historically guided our medical practice. However, it is important to point out that the disseminated information lacks a precise critical analysis, with the risk of incorporating new algorithms in clinical practice that might not be completely applicable to our population. The present review analyses the available scientific CCS literature to establish whether the extent of ischemic myocardium has no real clinical and prognostic significance as reported in some publications.
RESUMO
Objective T o explore the m etabolic characteristics of lethal bradycardia induced by m yocardial ischem ia in rat's serum . Methods A rat m yocardial ischem ia-bradycardia-sudden cardiac death (M I-B-SC D ) m odel w as established, w hich w as com pared w ith the sham-operation group. T he m etabolic pro-file of postm ortem serum w as analyzed by gas chrom atography-m ass spectrom etry (G C-M S ), coupled w ith the analysis of serum m etabolic characteristics using m etabolom ics strategies. Results T he serum m etabolic profiles w ere significantly different betw een the M I-B-SC D rats and the control rats. C om pared to the control rats, the M I-B-SC D rats had significantly higher levels of lysine, ornithine, purine, serine, alanine, urea and lactic acid; and significantly low er levels of succinate, hexadecanoic acid, 2-ketoadipic acid, glyceraldehyde, hexendioic acid and octanedioic acid in the serum . T here w ere som e correlations am ong different m etabolites. Conclusion T here is obvious m etabolic alterations in the serum of M I-B-SC D rat. B oth lysine and purine have a high value in diagnosing M I-B-SC D . T he results are expected to provide references for forensic and clinical applications of prevention and control of sudden cardiac death.