The analysis on clinical data of 22 patients with preliminarily diagnosed islet cell adenoma / 中国医师进修杂志

Objective To study and evaluate islet cell adenoma of preliminary diagnosis.Method Retrospective analysis Wag done on 22 patients clinical data of preliminarily diagnosed islet cell adenoma.They were divided into two groups according to final diagnosis,group of islet cell adenoma(n=16)and group of reacfional hypoglycemia n=6).Results There were significant differences between the two groups in term of fames,cold sweat,cataphora,Whipple triad,hungry test,the ratio offasting blood insulin and fasting blood glucose exceeding 0.3 (I/G＞0.3) (P＜0.05).No statistical differences were found on blood glucose level in hypoglycemia onset,psychiatric symptom.Conclusion The clinic data is helpful for preliminary diagnosis,and Whipple triad,hungry test,I/G＞0.3 above all.

Somatostatin Secreting Islet Cell Adenoma: A case report

Somatostatin secreting islet cell adenoma(somatostatinoma) of the pancreas is a rare entity. Less than 30 cases of pancreatic somatostatinoma could be searched in the world literature. We present a case of somatostatinoma of the pancreas in a 64-year-old woman. This patient had suffered from diabetes, cholelithiasis and intermittent diarrhea. Laboratory examination revealed steatorrhea, blood somatostatin level of 30 pg/ml, and fasting blood glucose level of 116 mg/dl. Subtotal pancreatectomy was done after radiological demonstrations of a round tumor mass in the pancreas. It was a 2 cm-sized well demarcated yellowish brown round solid mass located in the proximal pancreas. A retention cyst was seen just distal to the tumor. Histologically, tumor masses consisted of polygonal cells with distinct cell border, having granular eosinophilic cytoplasm and small bland looking nuclei. The tumor cells were arranged in small solid islands and trabeculae, separated by fibrovascular stroma. Immunohistochemical stain for somatostatin was positive in the cytoplasm of the individual tumor cell, and ultrastructurally variable sized membrane bound electron dense granules of 200 nm in average diameter were found in tumor cells.

Pancreatic islet-cell adenoma

Pancreatic islet cell adenoma is a benign tumor of pancreatic beta-cell and a rare cause of hyperinsulinemic hypoglycemia in children. The authors experienced a case of pancreatic islet cell adenoma(Insulinoma)in a 11 year and 8 month old male who had frequent loss of consciousness and seizure. Enucleation was done after localization of tumor by selective celiac artery angiography and abdominal computed tomography. Diagnosis was confirmed by histologic findings as pancreatic-adenoma, gyriform growth pattern. A brief review of related literature was made.