Cáncer de laringe en niños: Caso clínico / Laryngeal cancer in children: Case report

El carcinoma escamoso de laringe es muy raro en niños y adolescentes. Suele ser diagnosticado en estadios tardíos debido a los síntomas iniciales, atribuidos al proceso madurativo laríngeo o a otras enfermedades pediátricas más comunes. La visualización temprana de las cuerdas vocales con laringoscopia fexible es importante en niños que se presentan con síntomas sugestivos de patología laríngea. El diagnóstico de certeza de carcinoma lo proporciona la biopsia y el diagnóstico diferencial principal es la papilomatosis laríngea juvenil. El tratamiento constituye un desafío. No existen protocolos establecidos y se debe realizar un esfuerzo especial para preservar las funciones de la laringe y evitar complicaciones a largo plazo. Presentamos un niño de 12 años con carcinoma laríngeo invasor, sin historia previa de papilomatosis juvenil ni radioterapia, que respondió favorablemente al tratamiento con quimioterapia y radioterapia.

Squamous cell carcinoma of the larynx is very rare in children and adolescents. It is usually diagnosed at late stages because early symptoms are often attributed to the maturation process or other common laryngeal pediatric diseases. Early visualization of vocal cords with fexible laryngoscopy is important in children presenting suggestive symptoms of laryngeal pathology. Defnitive diagnosis of carcinoma is made by biopsy, and juvenile laryngeal papillomatosis the most important differential diagnosis. Treatment constitutes a clinical challenge. There are no established protocols, and clinicians should make a special effort to preserve the functions of the larynx, and avoid long term complications. We present a 12-years-old child with invasive laryngeal carcinoma, without prior history of juvenile papillomatosis or radiotherapy, which responded favorably to chemotherapy and radiotherapy.

Secretory Carcinoma of the Breast: A case report

We report a case of secretory carcinoma with axillary lymph node metastasis in a 21-year old woman. She was aware of a mass in her breast for 10 years and noticed a rapid growth of the preexisting mass during the last years. Histologically, the tumor was composed of micropapillary and microcystic or cribriform glandular structures which contained eosinophilic, mucinous, intraluminal secretions. The center had a dense hyalinized strama with a solid infiltrative growth of tumor cells with intracytoplasmic secretory vacuoles at the periphery. In addition, marked intraductal papillary epithelial proliferations were present at the superficial portions of the tumor near the nipple. Prognostic factors and their relationship to juvenile papillomatosis are discussed with a review of the literature.