Determination of Residual Petroleum Ether (60～90?C) in Kanglaite Capsules by CGC / 中成药

Objective: To establish a HS CGC method for the analysis of residual petroleum ether (60～90?C) in Kanglaite Capsules.Methods: Headspace sampling, a fused silica analytical column with cross linked 95% dimethyl and 5% diphenyl siloxanes station phase (30m?320?m?0.25?m), column temperature at 40?C, a linear velocity of about 19 cm per second, FID detector.Results: The average recovery is 97.2% (RSD=2.87%, n=5). The minimal detection limit is 2.65?10 -8 g?mL -1 (signal/noise=1.3).Conclusion: The method is simple and accurate, and can be used as a control method for the residual organic solvent in the capsules.