Association between cystathionineβsynthase gene T833C polymorphism and essential hypertension in Xinjiang Kazakh population and Han population / 天津医药

Objective To investigate the association between plasma homocysteine (Hcy) levels and cystathionineβsynthase (CBS) T833C gene polymorphism with essential hypertension in Xinjiang Kazakh and Han populations. Methods A total of 239 Kazak patients with hypertension (Kazak EH group), 206 Kazak people with normal blood pressure (Kazak con?trol group), 256 Han patients with hypertension (Han EH group) and 206 Han people with normal blood pressure (Han con?trol group) were selected for the study. Amplification refractory mutation system(ARMS) was used to analyze the polymor?phism of CBS gene T833C,TT,TC and CC genotypes and the various sites of T,C allele frequencies in four groups. In the meantime, the Hcy level and related biochemical indices were detected using automatic biochemical analyzer. Results The plasma Hcy levels were significantly higher in Kazak EH group and Han EH group than those of Kazak control group and Han control group (P0.05).Conclusion The Cystathionineβsynthase gene of T833C polymorphism may be associated with essential hypertension in Kazak people in Xinjiang, but no such association in Han population in Xinji?ang. The mechanism may be related to the altered metabolism of Hcy induced by CBS mutation.

Association between ADAM33 gene polymorphism with chronic obstructive pulmonary disease incidence in Kazakh of Xinjiang / 天津医药

Objective To explore correlation of Xinjiang Kazakh population who suffered from COPD with polymor?phisms of F+1,S2,T1,ST+5 locus of ADAM33 gene. Methods Blood samples (n=193) from healthy controls (Control group, n=193) and COPD patients (Case group, n=197) were detected by SNP SNaP shot. Results Comparing case group with the control group, gene frequency and allele frequency of F+1 locus were of significant differences (P0.05). The gene frequencies and allele frequency of S2、T1 and ST+5 locus were not significantly differ?ent between case group and control group (P>0.05). F+1 and S2 locus were analyzed by haplotype analysis which showed that there was significant differences in Hap1 (CC) haplotype between case group and control group (P1 revealed that its haplotype may increase the risk of COPD . The distri?bution of Hap2 (TG) and Hap4 (CG) were not significantly different (P>0.05) between the 2 groups. T1 and ST+5 locus were analyzed by haplotype analysis which showed significant differences in haplotypes between case group and control group (P<0.05). Conclusion The occurrence of COPD may be related to the polymorphism of ADAM33 gene in F+1 locus in Xinjiang Kazakh.

Study on blood uric acid,lipid levels and perceived stress in Kazakh hypertensive patients / 重庆医学

Objective To study the relationship between Kazakh hypertensive patients with blood uric acid ,lipid levels and psy-chological factors .Methods 90 Kazak patients with hypertension in our hospital from January to August 2012 were randomly se-lected as the hypertension group and contemporaneous 171 non-hypertension patients as the healthy control group .Blood uric acid (UA) ,triglycerides(TG) ,total cholesterol(TC) ,low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein choles-terol(HDL-C) were detected and the perceived stress scale(PSS) was adopted to assess the mental status .Results The mean val-ues of TG ,TC ,HDL and LDL in males of the hypertension group and the mean values of UA ,TG and LDL in females of the hyper-tension group were significantly higher than those in the normal control group after adjusting age and BMI (P<0 .05);in the hyper-tension group ,UA was positively correlated with TC (r=0 .221 ,P<0 .05) .The level of perceived stress was positively correlated TC and LDL(r=0 .473 ,P<0 .05;r=0 .321 ,P<0 .05) and negatively correlated with TG and HDL (r= -0 .461 ,P<0 .05;r= -0 .412 ,P<0 .05) after adjusting age ,sex and BMI .Conclusion The blood lipid level in Kazakh hypertensive patients has certain correlation with the perceived stress .

Radiologic measurement and sexual diagnosis of metacarpal in Kazakh nationality by discriminant analysis / 解剖学报

Objective To study the sex difference and discriminating formulas by measuring both metacarpal bones on X-ray and body height of Kazakh nationality adults,providing anatomical data for physical anthropology and forensic medicine. Methods The metacarpal bones length on X-ray films and body height from 200 adults of Kazakh nationality,including 100 male and 100 females were measured. The obtained date were statistically dealt by SPSS15.0 software. Results The length of the 4th metacarpal bone in male and the 5th in female were statistical significance beside, 4 discriminating formulas were obtained as follows: Y＝2.824r_1+2.563r_4-0.654r_5+0.614l7-0.039l_9+2.452l_(10)-212.186,Y＝2.350r_1+2.377r_4-0.995r_5+0.445l_7+0.046l_9+2.966l_(10)-191.622,Y＝0.393h_1+3.152r_1+0.435r_5+1.250r_(10)-463.734,Y＝0.362h_1+2.785r_1+0.028r_5+1.834 r_(10)-404.748, the accuracy being 89.67%、86.55%、90.00% and 87.50%. Conclusion The data presented in this paper indicates that the body height of male and female kazakh minority is closely related with the enlargement of their metacarpal bones.