RESUMO
The present study was performed to determine whether or not that cardiacrenin-angiotensin system (RAS) plays an important role in volume-overload myocardialhypertrophy. In order to control the increase of circulating RAS, aortacava fistula withnephrectomy (ACF+NT) rats were used in the experiment. The ventricular angiotensin Ⅰ,Ⅱ (Ang Ⅰ,Ⅱ) contents and angiotensin-converting enzyme (ACE) activities were measuredby means of radioimmunoassay and biochemical method. It was shown that in ACF+NTrats, the Ang Ⅱ contents and ACE activities in both left and right ventricles increasedsignificantly despite the plasma Ang Ⅰ, Ⅱ and renin activity remained at a lower level.These results indicate that: (1) Cardiac RAS as a relatively independent system, plays aregulatory role in the development of volume-overload cardiac hypertrophy; (2) The in-crease of Ang Ⅱ content was partly caused by the enhancement of ACE activities; (3) Atleast at the early stage of volume-overload cardiac hypertrophy, the circulating RAS maynot be a necessary promoter.
RESUMO
While varicocele were induced in Wistar rats, they were treated with Pan-axadiol Saponins (PDS) at the sametime. Three months after the begining of varicocele,LPO contents of testis and serum, testicular ACE activities and SOD levels were measured.The results showed that: In the varicocele group treated with Panaxadiol Saponins (VPG),the LPO contents of serum and bilateral testis were significantly lower than those ofvaricocele group (VG) (P
RESUMO
We observed the dynamic changes in angiotensin-converting enzyme in serum, pulmonary lymph and lung tissue after acute hemorrhagic pancreatitis induced by injection of trypsin and autobile into the pancreatic duct in dogs, Pulmonary lymph was collected for assessment of the changes in transvascular fluid and protein exchanges. The ACE activity in the mixed venous blood decreased 15 min after injection. The ACE activity in the arterial blood increased 30 rain after injection and declined 45 min later. The ACE activity in pulmonary lymph increased steadily after injection, but in the lung tissue of the pancreatitis dogs it markedly decreased comparing with that of the controls. The pulmonary lymph flow and transvascular protein clearance increased 2 to 3-fold which paralleled with the changes in ACE activity in serum and pulmonary lymph. The results indicate that the changes in ACE activity reflected the impairment of pulmonary vascular endothelial cells and could be used for the diagnosis of acute lung injury.
RESUMO
The effect of endotoxin on serum activity of angiotensin converting enzyme (ACE)in dogs was studied.At a dose of 2 mg/kg intravenously administered, endotoxin from Serratia marcescens increased serum ACE.Histological examination demonstrated severe injuries of the lung and liver.The changes in serum ACE may be due to the injuries of the lung as well as the liver.