Physico Chemical Analysis and HPTLC Evaluation of Kokilakshadi Kwatha Churna

Kokilakshadi Kashaya mentioned in Bhaishajya Ratnavali, Vataraktadhikara, it is a therapeutic formulation to treat Vatarakta. It is also used by Ayurvedic practitioners for treating hyperuricemia. The symptoms of hyperuricemia and gouty arthritis are similar to Vatarakta, a disease explained in classical Ayurvedic textbooks. Kokilakshadikwatha contains Kokilaksha and Guduchi and Pippalichurna given as Anupana of this formulation Physico chemical analysis of individual drug and formulation with modern parameters increase their scope and acceptance. The study was based on standard analytical parameters proposed by API. Method: Kokilakshadi Kwatha powder was evaluated for physico chemical analysis and phyto chemical screening. The analysis was done by using the parameters like Organoleptic features, loss on drying, acid soluble extractive, water soluble extractive. Results: Analytical parameters of individual drugs were done. All analytical parameter were within limit. Analytical parameter of Kokilakshadi Kwatha Churna like loss on drying 10.4%w/w, acid insoluble ash 0.79%, alcohol soluble extractive 11.2%w/w, water soluble extractive 7.8%w/w, pH 5.78 were obtained. High Performance Thin Layer Chromatography (HPTLC) profile of Kokilakshadikwatha powder showed 13 peaks at 254nm and 14 peaks at 366nm. Preliminary phytochemical screening test revealed the presence of steroids, alkaloids, phenols, flavonoids. Conclusion: The obtained data can be used for future comparative references

Microbial Stability of Nayopayam Pravahi Kwatha

Pancha vidha kashaya kalpana are five basic medicinal preparations mentioned in Ayurveda pharmaceutics, which includes Swarasa, Kalka, Kwatha, Hima and Phanta. They are the different set of extraction procedures. Among them Kwatha Kalpana is most significant and widely used dosage form. This is prepared by boiling of drugs with water in a specific proportion. Pravahi kwatha is concentrated Kashaya obtained by boiling the ingredients in a given amount of Jala (API part 2 volume 4). Addition of preservatives in Pravahi kwatha is permitted as per API. Nayopayam Pravahi kwatha is a decoction prepared with Bala, Jiraka, Shunti in a ratio 10:2:2 (API Part 2 volume 4). Kwatha Kalpana has more chance to get contaminated with microbes as it is an aqueous preparation. Preservatives help to prevent microbial contamination. As per previous researches it was noted that the amount of preservatives in Kwatha preparation is more than the permitted limit. To determine the microbial stability of Nayopayam Pravahi Kwatha, a long-term shelf life study was conducted. Analytical parameters such as microbial contamination, colour, odour, taste, pH, specific gravity, and total solid content were assessed at specified interval. An online survey was conducted among the GMP certified companies in Kerala preparing concentrated Kashayas to collect the details of preservatives in concentrated Kashaya. As per the study it was observed that Pravahi kwatha with double the permitted amount of preservatives was stable only upto 3 months.

Ethanobotanical Diversity in Practices and Preparation of Punarnavadi Kwatha in Kerala Ayurveda

The Ayurvedic formulary has a long history of endogenous innovation. Its epistemic logic is best understood through the language of Oushadhayogam (polyherbal combination/ dosage forms). Punarnavadi kwatha (PUK) is an Ayurvedic polyherbal formulation, which is also known as Punarnavashtaka kwatha. It is generally used to treat diseases of respiratory system, bronchitis, liver diseases, hepatitis, joint inflammation, kidney stones, wounds, skin diseases, and gout. The present study intended to explore the Ethanobotanical diversity of Punarnavashtaka kwatha in Kerala Ayurveda market. Materials and Methods: Thorough search in classical Ayurvedic literature to collect data in PUK and cross-sectional survey to collect data of ingredients PUK used in Ayurveda industry. Results and Discussions: The ingredients of PUK along with botanical source of 5 Kerala Ayurveda manufactures were analysed and compared with AFI. The ingredients Punarnava, Nimba, Patola, Sunthi, Abhaya was common in all the manufactures. But marked variation in other ingredients were found in market samples of PUK when compared to AFI, except first sample. Conclusions: There are some ethanobotanical diversity in ingredient list of Punarnavadi kwatha (PUK) in Kerala Ayurveda market.

Ayurvedic Management of Hepatitis

Hepatitis is inflammation of liver parenchyma mostly caused by viruses and other factors. It’s a non-specific prodromal illness characterized by headache, myalgia, arthralgia, nausea, anorexia, dark urine, yellow discoloration of skin, mucosa, sclera and other tissues etc. Methodology: A diagnosed case of hepatitis, 37yrs old female patient, admitted in at Government Ayurvedic college & Hospital, Kadam Kaun, Patna, Having IPD No.1006, RN.7178. Based on symptoms, supported by blood investigation reports and Ayurvedic parameters, the condition diagnosed as Yakritsotha. Oral medicines given: Aryogyavardhini Vati, Punarnava Mandur, Shallaki, Syp. Kalmegh, Kasis Bhasm, Liv 52 HB, Phaltrikadi Kwatha, cap. Stresscom along with Pathya apathya ahara vihara were prescribed. Result: There was drastic decrease in all the symptoms. The effect of treatment was monitored during the follow up with routine blood examinations. The bilirubin level decreased from initial 6.2mg/dl to 1.0mg/dl. Discussion: This article is a discussion about a case of Hepatitis which was successfully treated by Ayurvedic line of treatment. The signs and symptoms, causes, pathos-physiology of Hepatitis, along with its co-relation in Ayurveda as Yakritsotha, its line of treatment and possible the mode of action of drugs were the main points of consideration. Conclusion: Use of medicines such as Aryogyavardhini Vati, Punarnava Mandur, Shallaki, Syp. Kalmegh, Kasis Bhasm, Liv 52 HB, Phaltrikadi Kwatha, cap. Stresscom along with Pathya apathy ahara vihara showed good result without any complication in the present study.

Management of Shweta Pradara (Leucorrhoea) Through Ayurveda- A Case Series

Leucorrhoea or vaginal discharge is generally whitish, yellowish or greenish vaginal discharge in females that might be normal or a symptom of infection. It is almost mucus discharge, which exhibit exfoliation of vaginal epithelial cells due to estrogen influence on the vaginal mucosa. It is important to identify the differences between physiological and pathological discharges. In Ayurveda, leucorrhoea is known as Shweta Pradara, where Shweta means white and Pradara mean discharge. Yoni vyapadas which are caused by Kapha or Vatakaphaja doshas are the main causative factors of Shweta pradara. It also depends on the Nidana which may lead to vitiation of any of the Doshas An attempt was made to manage Shweta pradara by Ayurvedic treatment protocol in dispensary at OPD level. This study was conducted on five unmarried female patients having symptoms of Shweta pradara. These patients came with complaints of vaginal discharge, itching in vaginal area, backache etc., and were treated with Shunthi Dhanyak Siddha Jala for Deepan Pachan, Haritaki churna for Anuloman, Jeevak plus capsule, Gynaevin syrup for oral medication, and Triphala Kwatha for Yoni Prakshalan, Himtone forte as Rasyana and Balya aushadhi. The whole treatment was done for 4 weeks and marked improvement was achieved in all the patients

A Review On The Anti-diabetic (pramehahara) Action Of An Ayurvedic Polyherbal Formulation -nisakatakadi Kwatha

Type 2 Diabetes mellitus is one of the major diseases affecting the population world wide. India is no exception with its 69. 1 million people affected as per current statistics. So in the current scenario, search for effective anti diabetic drugs are on the rise. The management of diabetes with modern system of medicine, inspite of many advances still remains unsatisfactory. This led to the search of safe, effective and cheaper herbal remedies. Such remedies can be explored from the huge wealth of Ayurveda which has been practice in India since centuries. One such effective anti diabetic Ayurvedic formulation that has been in use in Kerala by traditional vaidyas since long ago is Nisakatakadi kwatha. It is mentioned in one of the traditional Malayalam text, Sahasrayoga. It is a formulation consisting of 8 drugs viz. Nisa, Kataka, Amalaki, Paranthi, Lodhra, Bhadrika, Saptachakra and Ushira. In this review an attempt has been made to analyse the anti diabetic (pramehahara) action of this formulation by reviewing the pharmacological properties and the recent research updates on each of these 8 drugs by reviewing textbooks of Ayurveda and journal articles. This review also aims to familiarize this effective formulation to the Ayurvedic fraternity and to the general public.

A Clinical Study On Effect Of Gokshura Kwatha In The Management Of Mutraghata W. S. R. To B.p.h

Introduction: 慚utraghata� can be equated with group of obstructive uropathic disorders. As explained in Sushrutha Samhitha, it is of 12 types and 慥atasthila� is one among them, which is closely similar to Benign Prostatic Hyperplasia. BPH is a progressive disease of advancing age. Histologically the inner zone of the periurethral gland undergoes hypertrophy and an adenoma is formed. Usually men around 60 years, suffer from mild, moderate and severe grade of BPH. Objectives: To evaluate the efficacy of Gokshura kwatha in the management of Mutragatha/ B.P.H. and to improve quality of life of BPH sufferer. Method: It is a single blind, clinical study on diagnosed cases of B.P.H, Gokshura kwatha was given for 60 days (20ml BD) with Sita and honey with follow-up of 4 months. Changes in subjective criteria (by IPSS Index) and objective criteria (by USG) were recorded before and after treatment. Result: Gokshurakwatha shown more significant relief on associated symptoms of Mutraghata including, burning sensation, painful micturition, pus and blood discharge etc. Interpretation: On the basis of the beneficial effects of Gokshura kwatha churna, it can be opined that it gives good result symptomatically. Conclusion: The subjective features were relieved significantly. But observed, no much difference in the objective criteria. The effect of Gokshurakwatha on the straining significantly reduced, prostate size has not reduced significantly. As for follow up period, relief of symptoms observed to be sustained up to one month in majority of patients.

Physico-Chemical Evaluation of Guduchyadi Kwatha for Instant Use: An Ayurvedic Herbal Formulation.

Introduction: Kwatha (decoction) preparations are one among commonest practiced Ayurvedic dosage forms, which are highly effective, but they are to be used when freshly prepared due to short shelf life (i.e. 1/2- 1 day), and they are often overlooked due to the preparation method and palatability. In present study, Guduchyadi Kwatha, a known Ayurvedic formulation used in Jwara (~pyrexia), was converted into a different dosage form for instant use by Rasakriya method (to convert into semi solid state), to make it easy to dispense, increase the shelf life, make it palatable, for dose fixation, etc. Aims and Objectives: To evaluate physico-chemical profile of fresh Guduchyadi Kwatha (GKF) and Guduchyadi Kwatha for instant use (GKI). Materials and Methods: Five batches of GKI and GKF were prepared and findings were systematically recorded. Organoleptic evaluation (Hedonic scale method) Physicochemical parameters (Loss on drying, Ash value, Acid insoluble ash, pH, Total solid content, Specific gravity, Water and Methanol soluble extractive, solubility and dissolution rate tests), High performance thin layer chromatography (HPTLC) profile, and microbial over load were carried out. Results and Conclusion: Comparative organoleptic screening of GKF and GKI showed no major differences in color and smell. In GKF, pH value, total solid content, specific gravity, and surface tension were found as 6.0, 95.14%, 1.009 w/w and 27.19 dynes/cm respectively. In finished product (GKI), pH value, loss on drying, Ash value, water soluble and alcohol soluble extractives were obtained as 6.16, 1.93% w/w, 7.90% w/w, 63.69% w/w and 37.29% w/w respectively. No microbial overload was detected in the sample.