Changes of Serum Troponin-T Concentrations in Patients with Open Heart Surgery / 대한흉부외과학회지

This study was designed to identify the efficiency of serum troponin-T (s-TnT) level as a diagnostic indicator for the perioperative myocardial damage with open heart surgery (OHS) and to compare with the conventional myocardial enzyme tests such as isoenzyme fraction of creatine kinase (% CK-MB) and isoenzyme ratio of lactate dehydrogenase (LDH1/LDH2 ratio). The study was performed on 30 adult patients who underwent OHS from Jan. 1996 to June 1996 at Inje University Pusan Paik Hospital, and they were divided into two groups accorfding to aortic clamping time (ACT) duration : group I (ACT60 minutes, n=15). S-TnT, % CK-MB, and LDH1/LDH2 ratio were measured in serial blood samples from all subjected patients. The results were obtained as follows. 1. In both groups, s-TnT concentrations increased gradually during OHS and elevated significantly at CPB-10 (p0.05). 4. The serial changes of s-TnT were relatively well correlated with those of changes of % CK-MB (r=0.64, p<0.05). 5. The serial s-TnT levels were significantly higher in group II than group I from B-ACR to POD 1 (p<0.05), suggesting that duration of aortic clamping time was a major factor concerned with perioperative myocardial injury. In conclusion, measurement of s-TnT is a very useful indicator in assessing the myocardial cell damage and therefore it is expected that serial checking and evaluation of the s-TnT is very available for identification of the perioperative myocardial damage and for postoperative cares in patients with OHS.

A basic study for establishing a suitable exercise prescription with long distance walking. II / 体力科学

The present study was performed to investigate the effects of 120 km walking, 40 km a day for 3 successive days on the condition that taking rest and foods freely, upon physical functions for healthy male and female subjects. All measurements were enforced at postabsorptive state early in the morning for the 10 successive days including the days of walking. Blood pressure, heart rate, and body weight were measured every morning. Blood samplings enforced, too. Urine collections were enforced from first day to 7 th day. The results obtained were as follows;<BR>1) There were no changes in heart rate, blood pressure, and body weight, which were measured early in the morning, before and after 120 km walking.<BR>2) Serum GOT and GPT activities had little changes, while serum LDH, α-HBDH, and CK activities increased gradually after walking.<BR>3) Serum CK-MB activities, which indicate myocardial injury, increased after walking, on the contrary CK-MB/CK ratio decreased. It was suggested that effects of 120km walking to myocardium were rather than slight ones.<BR>4) In spite of the same sorce in which serum CK-MB and LDH-1 were resulted, both did'nt exhibit same patterns in serum.<BR>5) Serum lipids decreased gradually after walking.<BR>6) Urinary excretion of creatinine and uric acid increased after 120km walking especially.<BR>7) If it is allowed to take sufficient foods and rest, 120km walking, 40km a day for 3 successive days, would not result in such a physical stress over the following days.