RESUMO
Abstract: Objectives: 1)To determine the association between food insecurity and excess body weight among Latinos in California, and whether it differs by gender. 2) To examine the role of psychological distress as a mediator in this relationship. Material and Methods: A cross-sectional analysis was conducted in adults participating in the California Health Interview Survey in 2014, who self-reported as Latinos (n=3779). Using logistic regression, we examined the associations of interest while controlling for key covariates. Results: Food insecurity was positive and significantly associated with excess body weight in Latino women, but not men. Psychological distress was positively associated with food insecurity, but not with excess body weight. Conclusions: Psychological distress did not appear to be a mediator in the food insecurity-body weight association in this sample. More studies are needed to fully understand the relationships among mental health, obesity and food insecurity.
Resumen: Objetivos: 1) Determinar la asociación entre la inseguridad alimentaria y el exceso de peso corporal entre los latinos en California, así como, si esta relación difiere según el género. 2) Examinar el papel del malestar psicológico como mediador en esta relación. Materiales y métodos: Se realizó un análisis transversal con las personas adultas que se autodefinieron como latinos en la Encuesta de salud de California en el 2014 (n = 3779). Usando la regresión logística, se examinaron las asociaciones de interés mientras se controlaron las covariables clave. Resultados: La inseguridad alimentaria se asoció positiva y significativamente con el exceso de peso corporal en las mujeres latinas, pero no así en los hombres latinos. El malestar psicológico se asoció positivamente con la inseguridad alimentaria, pero no con el exceso de peso corporal. Conclusiones: El distrés psicológico no parece ser un mediador en la asociación entre la inseguridad alimentaria y el exceso de peso en esta muestra. Se necesitan más estudios para comprender completamente la relación entre la salud mental, el exceso de peso y la inseguridad alimentaria.
Assuntos
Humanos , Hispânico ou Latino , Insegurança Alimentar , Obesidade , Saúde MentalRESUMO
Abstract Acute bacterial skin and skin structure infections are caused mainly by Gram-positive bacteria which are often treated with intravenous vancomycin, daptomycin, or linezolid, with potential step down to oral linezolid for outpatients. Tedizolid phosphate 200 mg once daily treatment for six days demonstrated non-inferior efficacy, with a favourable safety profile, compared with linezolid 600 mg twice daily treatment for 10 days in the Phase 3 ESTABLISH-1 and -2 trials. The objective of the current post-hoc analysis of the integrated dataset of ESTABLISH-1 and -2 was to evaluate the efficacy and safety of tedizolid (N = 182) vs linezolid (N = 171) in patients of Latino origin enrolled into these trials. The baseline demographic characteristics of Latino patients were similar between the two treatment groups. Tedizolid demonstrated comparable efficacy to linezolid at 48–72 h in the intent-to-treat population (tedizolid: 80.2% vs linezolid: 81.9%). Sustained clinical success rates were comparable between tedizolid- and linezolid-treated Latino patients at end-of-therapy (tedizolid: 86.8% vs linezolid: 88.9%). Tedizolid phosphate treatment was well tolerated by Latino patients in the safety population with lower abnormal platelet counts at end-of-therapy (tedizolid: 3.4% vs linezolid: 11.3%, p = 0.0120) and lower incidence of gastrointestinal adverse events (tedizolid: 16.5% vs linezolid: 23.5%). Population pharmacokinetic analysis suggested that estimated tedizolid exposure measures in Latino patients vs non-Latino patients were similar. These findings demonstrate that tedizolid phosphate 200 mg, once daily treatment for six days was efficacious and well tolerated by patients of Latino origin, without warranting dose adjustment.